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Mikael Altun

Senior researcher

Visiting address : Kisp (Karolinska Institutet Science Park), Scilifelab, Alpha Building Level 4, Tomtebodavägen 23a 171 65 Solna, Sweden
Postal address : Department of Medical Biochemistry and Biophysics (MBB), C2, Thomas Helledays group, Po Box 1031 171 21 Solna, Sweden
Delivery address : Kisp (Karolinska Institutet Science Park), Scilifelab, Alpha Building Level 4, Tomtebodavägen 23a 171 65 Solna, Sweden

Publications

Cancer-Specific Synthetic Lethality between ATR and CHK1 Kinase Activities
Sanjiv K, Hagenkort A, Calderón-montaño Jm, Koolmeister T, Reaper Pm, Mortusewicz O, et al
Cell reports 2016;14(2):298-309

The human otubain2-ubiquitin structure provides insights into the cleavage specificity of poly-ubiquitin-linkages
Altun M, Walter Ts, Kramer Hb, Herr P, Iphöfer A, Boström J, et al
PloS one 2015;10(1):e0115344-

MTH1 inhibition eradicates cancer by preventing sanitation of the dNTP pool
Gad H, Koolmeister T, Jemth As, Eshtad S, Jacques Sa, Ström Ce, et al
Nature 2014;508(7495):215-21

An N-terminal SIAH-interacting motif regulates the stability of the ubiquitin specific protease (USP)-19
Velasco K, Zhao B, Callegari S, Altun M, Liu H, Hassink G, et al
Biochemical and biophysical research communications 2013;433(4):390-5

Deubiquitinating Enzyme Specificity for Ubiquitin Chain Topology Profiled by Di-Ubiquitin Activity Probes
Mcgouran Jf, Gaertner Sr, Altun M, Kramer Hb, Kessler Bm
CHEMISTRY & BIOLOGY 2013;20(12):1447-55

A Small Molecule Inhibitor of Ubiquitin-Specific Protease-7 Induces Apoptosis in Multiple Myeloma Cells and Overcomes Bortezomib Resistance
Chauhan D, Tian Z, Nicholson B, Kumar Kgs, Zhou B, Carrasco R, et al
CANCER CELL 2012;22(3):345-58

Detection of ubiquitin-proteasome enzymatic activities in cells: Application of activity-based probes to inhibitor development
Kramer Hb, Nicholson B, Kessler Bm, Altun M
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH 2012;1823(11):2029-37

Fluorescence-based active site probes for profiling deubiquitinating enzymes
Mcgouran Jf, Kramer Hb, Mackeen Mm, Di Gleria K, Altun M, Kessler Bm
ORGANIC & BIOMOLECULAR CHEMISTRY 2012;10(17):3379-83

Ubiquitin-specific Protease 19 (USP19) Regulates Hypoxia-inducible Factor 1 alpha (HIF-1 alpha) during Hypoxia
Altun M, Zhao B, Velasco K, Liu Hy, Hassink G, Paschke J, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2012;287(3):1962-9

Activity-Based Chemical Proteomics Accelerates Inhibitor Development for Deubiquitylating Enzymes
Altun M, Kramer Hb, Willems Li, Mcdermott Jl, Leach Ca, Goldenberg Sj, et al
CHEMISTRY & BIOLOGY 2011;18(11):1401-12

A Photoreactive Small-Molecule Probe for 2-Oxoglutarate Oxygenases
Rotili D, Altun M, Kawamura A, Wolf A, Fischer R, Leung Ikh, et al
CHEMISTRY & BIOLOGY 2011;18(5):642-54

Label-free quantitative proteomics reveals regulation of interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) and 5 '-3 '-exoribonuclease 2 (XRN2) during respiratory syncytial virus infection
Ternette N, Wright C, Kramer Hb, Altun M, Kessler Bm
VIROLOGY JOURNAL 2011;:-

Photoactivable peptides for identifying enzyme-substrate and protein-protein interactions
Rotili D, Altun M, Hamed Rb, Loenarz C, Thalhammer A, Hopkinson Rj, et al
CHEMICAL COMMUNICATIONS 2011;47(5):1488-90

Muscle Wasting in Aged, Sarcopenic Rats Is Associated with Enhanced Activity of the Ubiquitin Proteasome Pathway
Altun M, Besche Hc, Overkleeft Hs, Piccirillo R, Edelmann Mj, Kessler Bm, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2010;285(51):39597-608

Post-translational modification of the deubiquitinating enzyme otubain 1 modulates active RhoA levels and susceptibility to Yersinia invasion
Edelmann Mj, Kramer Hb, Altun M, Kessler Bm
FEBS JOURNAL 2010;277(11):2515-30

Structural basis and specificity of human otubain 1-mediated deubiquitination
Edelmann Mj, Iphofer A, Akutsu M, Altun M, Di Gleria K, Kramer Hb, et al
BIOCHEMICAL JOURNAL 2009;:379-90

The ER-resident ubiquitin-specific protease 19 participates in the UPR and rescues ERAD substrates
Hassink Gc, Zhao B, Sompallae R, Altun M, Gastaldello S, Zinin Nv, et al
EMBO REPORTS 2009;10(7):755-61

Behavioral impairments of the aging rat
Altun M, Bergman E, Edstrom E, Johnson H, Ulfhake B
PHYSIOLOGY & BEHAVIOR 2007;92(5):911-23

Factors contributing to neuromuscular impairment and sarcopenia during aging
Edstrom E, Altun M, Bergman E, Johnson H, Kullberg S, Ramirez-leon V, et al
PHYSIOLOGY & BEHAVIOR 2007;92(1-2):129-35

Iron load and redox stress in skeletal muscle of aged rats
Altun M, Edstrom E, Spooner E, Flores-moralez A, Bergman E, Tollet-egnell P, et al
MUSCLE & NERVE 2007;36(2):223-33

Atrogin-1/MAFbx and MuRF1 are downregulated in aging-related loss of skeletal muscle
Edstrom E, Altun M, Hagglund M, Ulfhake B
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 2006;61(7):663-74

Effects of PS-341 on the activity and composition of proteasomes in multiple myeloma cells
Altun M, Galardy Pj, Shringarpure R, Hideshima T, Leblanc R, Anderson Kc, et al
CANCER RESEARCH 2005;65(17):7896-901

Differential regulation of Shc adaptor proteins in skeletal muscle, spinal cord and forebrain of aged rats with sensorimotor impairment
Jiang Xg, Edstrom E, Altun M, Ulfhake B
AGING CELL 2003;2(1):47-57

Extended peptide-based inhibitors efficiently target the proteasome and reveal overlapping specificities of the catalytic beta-subunits
Kessler Bm, Tortorella D, Altun M, Kisselev Af, Fiebiger E, Hekking Bg, et al
CHEMISTRY & BIOLOGY 2001;8(9):913-29

Retrograde labeling of primary sensory neurons with fluorescent latex microspheres: a useful tool for long term tagging of neurons
Altun M, Bergman E, Ulfhake B
JOURNAL OF NEUROSCIENCE METHODS 2001;108(1):19-24

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