Michael Alvarsson

About me
Publications
CV
Public outreach and news

Research

Michael Alvarsson is responsible for clinical studies on β-cell rest and the
HPA-axis on metabolic control in diabetics and clinical studies on the
effects of training on patients with type 2-diabetes.
Research group Growth and metabolism [1]
[1] http://default/node/2970

Articles

Article: JOURNAL OF ALZHEIMERS DISEASE. 2022;86(1):245-257

Glucose-Lowering Medications and Post-Dementia Survival in Patients with Diabetes and Dementia.

Secnik J; Xu H; Schwertner E; Hammar N; Alvarsson M; Winblad B; Eriksdotter M; Garcia-Ptacek S; Religa D
Article: DIABETES. 2022;71(2):285-297

Downregulation of Erythrocyte miR-210 Induces Endothelial Dysfunction in Type 2 Diabetes.

Zhou Z; Collado A; Sun C; Tratsiakovich Y; Mahdi A; Winter H; Chernogubova E; Seime T; Narayanan S; Jiao T; Jin H; Alvarsson M; Zheng X; Yang J; Hedin U; Catrina S-B; Maegdefessel L; Pernow J
Article: FRONTIERS IN ENDOCRINOLOGY. 2022;13:772801

Thyroid Status During Pregnancy in Women With Polycystic Ovary Syndrome and the Effect of Metformin.

Trouva A; Alvarsson M; Calissendorff J; Åsvold BO; Vanky E; Hirschberg AL
Article: ALZHEIMERS RESEARCH & THERAPY. 2021;13(1):197

The association of antidiabetic medications and Mini-Mental State Examination scores in patients with diabetes and dementia.

Secnik J; Xu H; Schwertner E; Hammar N; Alvarsson M; Winblad B; Eriksdotter M; Garcia-Ptacek S; Religa D
Article: PRIMARY CARE DIABETES. 2021;15(2):262-268

Risk factor management of type 2 diabetic patients in primary care in the Scandinavian countries between 2003 and 2015.

Knudsen ST; Bodegård J; Birkeland KI; Furuseth K; Thuresson M; Lindh A; Nilsson PM; Alvarsson M; Jørgensen ME; Søndergaard J; Persson F
Article: JOURNAL OF ALZHEIMERS DISEASE. 2020;76(4):1581-1594

Dementia Diagnosis Is Associated with Changes in Antidiabetic Drug Prescription: An Open-Cohort Study of ∼130,000 Swedish Subjects over 14 Years.

Secnik J; Xu H; Schwertner E; Hammar N; Alvarsson M; Winblad B; Eriksdotter M; Garcia-Ptacek S; Religa D
Article: DIABETES CARE. 2020;43(8):1851-1858

The Association of Lipoprotein(a) Plasma Levels With Prevalence of Cardiovascular Disease and Metabolic Control Status in Patients With Type 1 Diabetes.

Littmann K; Wodaje T; Alvarsson M; Bottai M; Eriksson M; Parini P; Brinck J
Article: CELLS. 2020;9(7):E1712-1712

Red Blood Cell Peroxynitrite Causes Endothelial Dysfunction in Type 2 Diabetes Mellitus via Arginase.

Mahdi A; Tengbom J; Alvarsson M; Wernly B; Zhou Z; Pernow J
Article: BMJ OPEN DIABETES RESEARCH & CARE. 2020;8(1):e000833

Cholinesterase inhibitors in patients with diabetes mellitus and dementia: an open-cohort study of ~23 000 patients from the Swedish Dementia Registry.

Secnik J; Schwertner E; Alvarsson M; Hammar N; Fastbom J; Winblad B; Garcia-Ptacek S; Religa D; Eriksdotter M
Article: FRONTIERS IN PHARMACOLOGY. 2020;11:603226

Erythrocytes Induce Endothelial Injury in Type 2 Diabetes Through Alteration of Vascular Purinergic Signaling.

Mahdi A; Tratsiakovich Y; Tengbom J; Jiao T; Garib L; Alvarsson M; Yang J; Pernow J; Zhou Z
Article: ENDOCRINOLOGY, DIABETES AND METABOLISM. 2019;2(1):e00053

Progression of glucose-lowering diabetes therapy in TECOS.

Bethel MA; Engel SS; Stevens SR; Lokhnygina Y; Ding J; Josse RG; Alvarsson M; Hramiak I; Green JB; Peterson ED; Holman RR; TECOS Study Group
Article: FRONTIERS IN PHARMACOLOGY. 2019;10:861

The Effect of Glycemic Control on Endothelial and Cardiac Dysfunction Induced by Red Blood Cells in Type 2 Diabetes.

Mahdi A; Jiao T; Yang J; Kövamees O; Alvarsson M; von Heijne M; Zhou Z; Pernow J
Article: JOURNAL OF INTERNAL MEDICINE. 2018;284(4):388-398

Arginase inhibition improves endothelial function in patients with type 2 diabetes mellitus despite intensive glucose-lowering therapy.

Mahdi A; Kövamees O; Checa A; Wheelock CE; von Heijne M; Alvarsson M; Pernow J
Article: JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY. 2018;72(7):769-780

Erythrocytes From Patients With Type 2 Diabetes Induce Endothelial Dysfunction Via Arginase I.

Zhou Z; Mahdi A; Tratsiakovich Y; Zahorán S; Kövamees O; Nordin F; Uribe Gonzalez AE; Alvarsson M; Östenson C-G; Andersson DC; Hedin U; Hermesz E; Lundberg JO; Yang J; Pernow J
Article: JACC-BASIC TO TRANSLATIONAL SCIENCE. 2018;3(4):450-463

Red Blood Cells in Type 2 Diabetes Impair Cardiac Post-Ischemic Recovery Through an Arginase-Dependent Modulation of Nitric Oxide Synthase and Reactive Oxygen Species.

Yang J; Zheng X; Mahdi A; Zhou Z; Tratsiakovich Y; Jiao T; Kiss A; Kövamees O; Alvarsson M; Catrina S-B; Lundberg JO; Brismar K; Pernow J
Article: LAKARTIDNINGEN. 2018;115:EY3P

Ny era inom terapin för typ 2-diabetes – men vad är nytt? - Metformin fortfarande förstahandsval, men därefter rekommenderas att behandlingen individualiseras.

Alvarsson M; Östgren C-J
Article: LAKARTIDNINGEN. 2018;115:EX4W

Stora framsteg inom diabetes typ 2.

Alvarsson M
Article: DIABETES CARE. 2016;39(12):2304-2310

Effect of Sitagliptin on Kidney Function and Respective Cardiovascular Outcomes in Type 2 Diabetes: Outcomes From TECOS.

Cornel JH; Bakris GL; Stevens SR; Alvarsson M; Bax WA; Chuang L-M; Engel SS; Lopes RD; McGuire DK; Riefflin A; Rodbard HW; Sinay I; Tankova T; Wainstein J; Peterson ED; Holman RR; TECOS Study Group
Article: DIABETES & VASCULAR DISEASE RESEARCH. 2016;13(5):361-366

Improvement of insulin sensitivity in response to exercise training in type 2 diabetes mellitus is associated with vascular endothelial growth factor A expression.

Wagner H; Fischer H; Degerblad M; Alvarsson M; Gustafsson T
Article: DIABETES CARE. 2016;39(3):345-352

No Effect of High-Dose Vitamin D Treatment on β-Cell Function, Insulin Sensitivity, or Glucose Homeostasis in Subjects With Abnormal Glucose Tolerance: A Randomized Clinical Trial.

Wagner H; Alvarsson M; Mannheimer B; Degerblad M; Östenson C-G
Article: DIABETES OBESITY & METABOLISM. 2016;18(2):186-190

Frequency of cancer events with saxagliptin in the SAVOR-TIMI 53 trial.

Leiter LA; Teoh H; Mosenzon O; Cahn A; Hirshberg B; Stahre CAM; Hoekstra JBL; Alvarsson M; Im K; Scirica BM; Bhatt DL; Raz I; SAVOR-TIMI 53 Steering Committee and Investigators
Article: GROWTH HORMONE & IGF RESEARCH. 2015;25(6):298-303

Improved glycemic control due to sitagliptin is not related to cortisol or the surrogate marker IGFBP-1 for hepatic insulin sensitivity.

Arnetz L; Hage C; Ekberg NR; Alvarsson M; Brismar K; Norhammar A; Mellbin L
Article: JOURNAL OF RENAL CARE. 2015;41(3):187-194

A MULTI-DIMENSIONAL SUPPORT PROGRAMME FOR PATIENTS WITH DIABETIC KIDNEY DISEASE.

Pagels AA; Hylander B; Alvarsson M
Article: ENDOCRINE CONNECTIONS. 2015;4(2):92-99

Gender difference in adrenal sensitivity to ACTH is abolished in type 2 diabetes.

Arnetz L; Rajamand Ekberg N; Brismar K; Alvarsson M
Article: LAKARTIDNINGEN. 2013;110(49-50):2246-2248

[HbA1c will complement other methods in the diagnosis of diabetes. Coordinated introduction in Sweden in January 2014].

Lilja M; Jansson S; Alvarsson M; Aldrimer M; Nordin G; Attvall S
Article: NEW ENGLAND JOURNAL OF MEDICINE. 2013;369(14):1317-1326

Saxagliptin and cardiovascular outcomes in patients with type 2 diabetes mellitus.

Scirica BM; Bhatt DL; Braunwald E; Steg PG; Davidson J; Hirshberg B; Ohman P; Frederich R; Wiviott SD; Hoffman EB; Cavender MA; Udell JA; Desai NR; Mosenzon O; McGuire DK; Ray KK; Leiter LA; Raz I; SAVOR-TIMI 53 Steering Committee and Investigators
Article: ISRN ENDOCRINOLOGY. 2013;2013:148497-9

Improved Insulin Sensitivity during Pioglitazone Treatment Is Associated with Changes in IGF-I and Cortisol Secretion in Type 2 Diabetes and Impaired Glucose Tolerance.

Arnetz L; Rajamand Ekberg N; Höybye C; Brismar K; Alvarsson M
Article: LAKARTIDNINGEN. 2012;109(45):2031-2032

[Measuring blood ketones--when, where and how].

Jendle J; Alvarsson M; Hanås R; Attvall S
Article: CARDIOVASCULAR DIABETOLOGY. 2012;11:18

A retrospective analysis of amputation rates in diabetic patients: can lower extremity amputations be further prevented?

Alvarsson A; Sandgren B; Wendel C; Alvarsson M; Brismar K
Article: DIABETOLOGIA. 2011;54(6):1298-1303

Exposure to candesartan during the first trimester of pregnancy in type 1 diabetes: experience from the placebo-controlled DIabetic REtinopathy Candesartan Trials.

Porta M; Hainer JW; Jansson S-O; Malm A; Bilous R; Chaturvedi N; Fuller JH; Klein R; Orchard T; Parving H-H; Sjølie A-K; DIRECT Study Group
Article: REVIEW OF DIABETIC STUDIES. 2010;7(3):225-232

Effects of insulin versus sulphonylurea on beta-cell secretion in recently diagnosed type 2 diabetes patients: a 6-year follow-up study.

Alvarsson M; Berntorp K; Fernqvist-Forbes E; Lager I; Steen L; Orn T; Grill V
Article: LANCET. 2009;374(9683):39-47

Liraglutide once a day versus exenatide twice a day for type 2 diabetes: a 26-week randomised, parallel-group, multinational, open-label trial (LEAD-6).

Buse JB; Rosenstock J; Sesti G; Schmidt WE; Montanya E; Brett JH; Zychma M; Blonde L; LEAD-6 Study Group
Article: DIABETIC MEDICINE. 2009;26(4):345-353

Factors determining normalization of glucose intolerance in middle-aged Swedish men and women: a 8-10-year follow-up.

Alvarsson M; Hilding A; Ostenson C-G
Article: LANCET. 2008;372(9647):1385-1393

Effect of candesartan on progression and regression of retinopathy in type 2 diabetes (DIRECT-Protect 2): a randomised placebo-controlled trial.

Sjølie AK; Klein R; Porta M; Orchard T; Fuller J; Parving HH; Bilous R; Chaturvedi N; DIRECT Programme Study Group
Article: LANCET. 2008;372(9647):1394-1402

Effect of candesartan on prevention (DIRECT-Prevent 1) and progression (DIRECT-Protect 1) of retinopathy in type 1 diabetes: randomised, placebo-controlled trials.

Chaturvedi N; Porta M; Klein R; Orchard T; Fuller J; Parving HH; Bilous R; Sjølie AK; DIRECT Programme Study Group
Article: DIABETES OBESITY & METABOLISM. 2008;10(5):421-429

Effects of insulin vs. glibenclamide in recently diagnosed patients with type 2 diabetes: a 4-year follow-up.

Alvarsson M; Sundkvist G; Lager I; Berntorp K; Fernqvist-Forbes E; Steen L; Orn T; Holberg MA; Kirksaether N; Grill V
Article: DIABETES CARE. 2007;30(6):1364-1369

Initiate Insulin by Aggressive Titration and Education (INITIATE): a randomized study to compare initiation of insulin combination therapy in type 2 diabetic patients individually and in groups.

Yki-Järvinen H; Juurinen L; Alvarsson M; Bystedt T; Caldwell I; Davies M; Lahdenperä S; Nijpels G; Vähätalo M
Article: DIABETOLOGIA. 2005;48(11):2262-2268

K-value and low insulin secretion in a non-obese white population: predicted glucose tolerance after 25 years.

Alvarsson M; Wajngot A; Cerasi E; Efendic S
Article: DIABETES CARE. 2005;28(6):1495-1497

Early microvascular dysfunction in healthy normal-weight males with heredity for type 2 diabetes.

Jörneskog G; Kalani M; Kuhl J; Båvenholm P; Katz A; Allerstrand G; Alvarsson M; Efendic S; Ostenson C-G; Pernow J; Wahren J; Brismar K
Article: DIABETOLOGIA. 2004;47(Suppl 1):a1-a464

40th EASD Annual Meeting of the European Association for the Study of Diabetes : Munich, Germany, 5-9 September 2004.
Article: DIABETES CARE. 2003;26(8):2231-2237

Beneficial effects of insulin versus sulphonylurea on insulin secretion and metabolic control in recently diagnosed type 2 diabetic patients.

Alvarsson M; Sundkvist G; Lager I; Henricsson M; Berntorp K; Fernqvist-Forbes E; Steen L; Westermark G; Westermark P; Orn T; Grill V
Article: AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM. 2002;283(1):E20-E28

Effect of acute hyperketonemia on the cerebral uptake of ketone bodies in nondiabetic subjects and IDDM patients.

Blomqvist G; Alvarsson M; Grill V; Von Heijne G; Ingvar M; Thorell JO; Stone-Elander S; Widén L; Ekberg K
Article: DIABETES CARE. 1999;22(7):1043-1047

Low birth weight, family history of diabetes, and glucose intolerance in Swedish middle-aged men.

Carlsson S; Persson PG; Alvarsson M; Efendic S; Norman A; Svanström L; Ostenson CG; Grill V
Article: DIABETOLOGIA. 1999;42(1):15-23

Family history of diabetes in middle-aged Swedish men is a gender unrelated factor which associates with insulinopenia in newly diagnosed diabetic subjects.

Grill V; Persson G; Carlsson S; Norman A; Alvarsson M; Ostensson CG; Svanström L; Efendic S
Article: AMERICAN JOURNAL OF EPIDEMIOLOGY. 1998;148(6):539-545

Weight history, glucose intolerance, and insulin levels in middle-aged Swedish men.

Carlsson S; Persson PG; Alvarsson M; Efendic S; Norman A; Svanström L; Ostenson CG; Grill V
Article: JOURNAL OF INTERNAL MEDICINE. 1997;241(6):493-500

Enhancement of B-cell secretion by blood glucose normalization in type 2 diabetes is associated with fasting C-peptide levels.

Clauson P; Alvarsson M; Grill V
Article: HEALTH PROMOTION INTERNATIONAL. 1997;12(2):151-160

Strategies and methods for implementing a community-based diabetes primary prevention program in Sweden

Bjaras G; Ahlbom A; Alvarsson M; Burstrom B; Diderichsen F; Efendic S; Grill V; Haglund BJ; Norman A; Persson PG; Svanstrom L; Tillgren P; Ullen H; Ostenson CG
Article: SCANDINAVIAN JOURNAL OF CLINICAL & LABORATORY INVESTIGATION. 1996;56(6):563-570

Impact of nicotinic acid treatment on insulin secretion and insulin sensitivity in low and high insulin responders.

Alvarsson M; Grill V
Article: ACTA DIABETOLOGICA. 1995;32(2):86-91

Relationship between insulin responses to D-glucose and to L-arginine in women with a history of gestational diabetes.

Alvarsson M; Wajngot A; Efendic S; Grill V
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All other publications

Review: ACTA DIABETOLOGICA. 2014;51(2):185-192

Gender differences in non-glycemic responses to improved insulin sensitivity by pioglitazone treatment in patients with type 2 diabetes.

Arnetz L; Dorkhan M; Alvarsson M; Brismar K; Ekberg NR
Review: DIABETES METABOLIC SYNDROME AND OBESITY-TARGETS AND THERAPY. 2014;7:409-420

Sex differences in type 2 diabetes: focus on disease course and outcomes.

Arnetz L; Ekberg NR; Alvarsson M
Published conference paper: ACTA PHYSIOLOGICA. 2008;192(1):117-125

Pathophysiology and treatment of patients with type 2 diabetes exhibiting failure to oral drugs.

Efendic S; Alvarsson M; Brismar K; Wagner H
Published conference paper: DIABETIC MEDICINE. 1996;13(9 Suppl 6):S37-S39

Characteristics of insulin release in healthy subjects and in subjects with a glucokinase (Glu 256 Lys) Mutation.

Grill V; Alvarsson M

Employments

Affiliated to Research, Department of Molecular Medicine and Surgery, Karolinska Institutet, 2023-2025

Degrees and Education

Docent, karolinska institutet, 2009

Research

Articles

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Degrees and Education

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