Marie Wahren-Herlenius

About me
Publications
CV
Public outreach and news

About me

- Professor of Experimental Rheumatology, Karolinska Institutet
- Head, Department of Medicine, Karolinska Institutet (prefekt@meds.ki.se)
- International experience as postdoc/visiting scientist/visiting professor from University of Bergen, Norway, University of Tokyo, Japan and Harvard Medical School, USA
- Recieved the Göran Gustafssons prize in Medicine, the Nanna Svartz prize for Rheumatologic research, Scandinavian Journal of Rheumatology's prize for rheumatologic research, the IMID-prise for research on immune-mediated inflammatory disease from the Swedish societies of dermatology, rheumatology and gastroenterology
- Awarded Best abstract of the year by the Swedish Rheumatology Association (three times)
- Theses from my group awarded Best PhD thesis of the year by the Swedish Rheumatology Association (three times)
- President, The Scandinavian Society for Immunology 2010-2015
- President, Junior Faculty, Karolinska Institutet 2002-2005
- President, PhD student's association, Karolinska Institutet 1991

Education
- PhD, Department of Cell and Molecular Biology, Karolinska Institutet 1994
- Medical Degree, Karolinska Institutet 1995
- Docent of Molecular Immunologi 1999
- Licensed physician 2000

Research

Our research is focused on autoimmune rheumatic diseases, and aims at understanding the pathogenesis and disease mechanisms for development of novel diagnostics and treatment. Our projects include basic cell and molecular biology, studies in experimental models as well as clinical and epidemiological patient-based investigations. The research group includes around 15 scientists from basic and clinicial disciplines.

Articles

Journal article: SEMINARS IN ARTHRITIS AND RHEUMATISM. 2024;65:152378

The Sjögren's Working Group: The 2023 OMERACT meeting and provisional domain generation.

Gordon RA; Nguyen Y; Foulquier N; Beydon M; Gheita TA; Hajji R; Sahbudin I; Hoi A; Ng W-F; Mendonça JA; Wallace DJ; Shea B; Bruyn GA; Goodman SM; Fisher BA; Baldini C; Torralba KD; Bootsma H; Akpek EK; Karakus S; Baer AN; Chakravarty SD; Terslev L; D'Agostino M-A; Mariette X; DiRenzo D; Rasmussen A; Papas A; Montoya C; Arends S; Yusof MYM; Pintilie I; Warner BM; Hammitt KM; Strand V; Bouillot C; Tugwell P; Inanc N; Andreu JL; Wahren-Herlenius M; Devauchelle-Pensec V; Shiboski CH; Benyoussef A; Masli S; Lee AYS; Cornec D; Bowman S; Rischmueller M; McCoy SS; Seror R
Article: EBIOMEDICINE. 2023;96:104804

Distinct HLA associations with autoantibody-defined subgroups in idiopathic inflammatory myopathies.

Leclair V; Galindo-Feria AS; Rothwell S; Kryštůfková O; Zargar SS; Mann H; Diederichsen LP; Andersson H; Klein M; Tansley S; Rönnblom L; Lindblad-Toh K; Syvänen A-C; Wahren-Herlenius M; Sandling JK; Dissect Consortium and The Immunoarray Development; McHugh N; Lamb JA; Vencovský J; Chinoy H; Holmqvist M; Bianchi M; Padyukov L; Lundberg IE; Diaz-Gallo L-M
Article: EUROPEAN JOURNAL OF ENDOCRINOLOGY. 2023;189(2):235-241

Relation between HLA and copy number variation of steroid 21-hydroxylase in a Swedish cohort of patients with autoimmune Addison's disease.

Lundtoft C; Eriksson D; Bianchi M; Aranda-Guillén M; Landegren N; Rantapää-Dahlqvist S; Söderkvist P; Meadows JRS; DISSECT Consortium; ImmunoArray Consortium; Swedish Addison Registry Study Group; Bensing S; Pielberg GR; Lindblad-Toh K; Rönnblom L; Kämpe O
Article: AUTOIMMUNITY REVIEWS. 2023;22(3):103259

Immunology of pregnancy and reproductive health in autoimmune rheumatic diseases. Update from the 11th International Conference on Reproduction, Pregnancy and Rheumatic Diseases.

Andreoli L; Chighizola CB; Iaccarino L; Botta A; Gerosa M; Ramoni V; Tani C; Bermas B; Brucato A; Buyon J; Cetin I; Chambers CD; Clowse MEB; Costedoat-Chalumeau N; Cutolo M; De Carolis S; Dolhain R; Fazzi EM; Förger F; Giles I; Haase I; Khamashta M; Levy RA; Meroni PL; Mosca M; Nelson-Piercy C; Raio L; Salmon J; Villiger P; Wahren-Herlenius M; Wallenius M; Zanardini C; Shoenfeld Y; Tincani A
Article: FRONTIERS IN IMMUNOLOGY. 2023;14:1168684

Skin infiltrating NK cells in cutaneous T-cell lymphoma are increased in number and display phenotypic alterations partially driven by the tumor.

Scheffschick A; Nenonen J; Xiang M; Winther AH; Ehrström M; Wahren-Herlenius M; Eidsmo L; Brauner H
Article: JOURNAL OF AUTOIMMUNITY. 2023;134:102951

Autoantigenic properties of the aminoacyl tRNA synthetase family in idiopathic inflammatory myopathies.

Preger C; Notarnicola A; Hellström C; Wigren E; Fernandes-Cerqueira C; Kvarnström M; Wahren-Herlenius M; Idborg H; Lundberg IE; Persson H; Gräslund S; Jakobsson P-J
Article: RHEUMATOLOGY. 2022;62(1):243-255

Characterization and outcomes of 414 patients with primary SS who developed haematological malignancies.

Hernández-Molina G; Kostov B; Brito-Zerón P; Vissink A; Mandl T; Hinrichs AC; Quartuccio L; Baldini C; Seror R; Szántó A; Isenberg D; Gerli R; Nordmark G; Rasmussen A; Solans-Laque R; Hofauer B; Sène D; Pasoto SG; Rischmueller M; Praprotnik S; Gheita TA; Danda D; Armağan B; Suzuki Y; Valim V; Devauchelle-Pensec V; Retamozo S; Kvarnstrom M; Sebastian A; Atzeni F; Giacomelli R; Carsons SE; Kwok S-K; Nakamura H; Fernandes Moça Trevisani V; Flores-Chávez A; Mariette X; Ramos-Casals M; Sjögren Big Data Consortium
Article: ARTHRITIS & RHEUMATOLOGY. 2022;74(11):1842-1850

Strong Association of Combined Genetic Deficiencies in the Classical Complement Pathway With Risk of Systemic Lupus Erythematosus and Primary Sjögren's Syndrome.

Lundtoft C; Sjöwall C; Rantapää-Dahlqvist S; Bengtsson AA; Jönsen A; Pucholt P; Wu YL; Lundström E; Eloranta M-L; Gunnarsson I; Baecklund E; Jonsson R; Hammenfors D; Forsblad-d'Elia H; Eriksson P; Mandl T; Bucher S; Norheim KB; Auglaend Johnsen SJ; Omdal R; Kvarnström M; Wahren-Herlenius M; Truedsson L; Nilsson B; Kozyrev SV; Bianchi M; Lindblad-Toh K; DISSECT consortium, the ImmunoArray consortium; Yu C-Y; Nordmark G; Sandling JK; Svenungsson E; Leonard D; Rönnblom L
Article: ANNALS OF THE RHEUMATIC DISEASES. 2022;81(8):1151-1161

Auxilin is a novel susceptibility gene for congenital heart block which directly impacts fetal heart function.

Meisgen S; Hedlund M; Ambrosi A; Folkersen L; Ottosson V; Forsberg D; Thorlacius GE; Biavati L; Strandberg L; Mofors J; Ramskold D; Ruhrmann S; Meneghel L; Nyberg W; Espinosa A; Hamilton RM; Franco-Cereceda A; Hamsten A; Olsson T; Greene L; Eriksson P; Gemzell-Danielsson K; Salomonsson S; Kuchroo VK; Herlenius E; Kockum I; Sonesson S-E; Wahren-Herlenius M
Article: ARTHRITIS & RHEUMATOLOGY. 2022;74(8):1440-1450

Complement C4 Copy Number Variation is Linked to SSA/Ro and SSB/La Autoantibodies in Systemic Inflammatory Autoimmune Diseases.

Lundtoft C; Pucholt P; Martin M; Bianchi M; Lundström E; Eloranta M-L; Sandling JK; Sjöwall C; Jönsen A; Gunnarsson I; Rantapää-Dahlqvist S; Bengtsson AA; Leonard D; Baecklund E; Jonsson R; Hammenfors D; Forsblad-d'Elia H; Eriksson P; Mandl T; Magnusson Bucher S; Norheim KB; Auglaend Johnsen SJ; Omdal R; Kvarnström M; Wahren-Herlenius M; Notarnicola A; Andersson H; Molberg Ø; Diederichsen LP; Almlöf J; Syvänen A-C; Kozyrev SV; Lindblad-Toh K; DISSECT Consortium; ImmunoArray Development Consortium; Nilsson B; Blom AM; Lundberg IE; Nordmark G; Diaz-Gallo LM; Svenungsson E; Rönnblom L
Article: NATURE COMMUNICATIONS. 2022;13(1):4287

Genome-wide association study identifies Sjögren's risk loci with functional implications in immune and glandular cells.

Khatri B; Tessneer KL; Rasmussen A; Aghakhanian F; Reksten TR; Adler A; Alevizos I; Anaya J-M; Aqrawi LA; Baecklund E; Brun JG; Bucher SM; Eloranta M-L; Engelke F; Forsblad-d'Elia H; Glenn SB; Hammenfors D; Imgenberg-Kreuz J; Jensen JL; Johnsen SJA; Jonsson MV; Kvarnström M; Kelly JA; Li H; Mandl T; Martín J; Nocturne G; Norheim KB; Palm Ø; Skarstein K; Stolarczyk AM; Taylor KE; Teruel M; Theander E; Venuturupalli S; Wallace DJ; Grundahl KM; Hefner KS; Radfar L; Lewis DM; Stone DU; Kaufman CE; Brennan MT; Guthridge JM; James JA; Scofield RH; Gaffney PM; Criswell LA; Jonsson R; Eriksson P; Bowman SJ; Omdal R; Rönnblom L; Warner B; Rischmueller M; Witte T; Farris AD; Mariette X; Alarcon-Riquelme ME; PRECISESADS Clinical Consortium; Shiboski CH; Sjögren’s International Collaborative Clinical All; Wahren-Herlenius M; Ng W-F; UK Primary Sjögren’s Syndrome Registry; Sivils KL; Adrianto I; Nordmark G; Lessard CJ
Article: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2021;39 Suppl 133(6):166-174

Influence of the age at diagnosis in the disease expression of primary Sjögren syndrome. Analysis of 12,753 patients from the Sjögren Big Data Consortium.

Retamozo S; Acar-Denizli N; Horváth IF; Ng W-F; Rasmussen A; Dong X; Li X; Baldini C; Olsson P; Priori R; Seror R; Gottenberg J-E; Kruize AA; Hernandez-Molina G; Vissink A; Sandhya P; Armagan B; Quartuccio L; Sebastian A; Praprotnik S; Bartoloni E; Kwok S-K; Kvarnstrom M; Rischmueller M; Soláns-Laqué R; Sene D; Pasoto SG; Suzuki Y; Isenberg DA; Valim V; Nordmark G; Nakamura H; Fernandes Moça Trevisani V; Hofauer B; Sisó-Almirall A; Giacomelli R; Devauchelle-Pensec V; Bombardieri M; Atzeni F; Hammenfors D; Maure B; Carsons SE; Gheita T; Sánchez-Berná I; López-Dupla M; Morel J; Inanç N; Fonseca-Aizpuru E; Morcillo C; Vollenweider C; Melchor S; Vázquez M; Díaz-Cuiza E; Consani-Fernández S; de-Miguel-Campo B; Szántó A; Bombardieri S; Gattamelata A; Hinrichs A; Sánchez-Guerrero J; Danda D; Kilic L; De Vita S; Wiland P; Gerli R; Park S-H; Wahren-Herlenius M; Bootsma H; Mariette X; Ramos-Casals M; Brito-Zerón P; Sjögren Big Data Consortium
Article: ARTHRITIS RESEARCH & THERAPY. 2021;23(1):132

Proteome study of cutaneous lupus erythematosus (CLE) and dermatomyositis skin lesions reveals IL-16 is differentially upregulated in CLE.

Niewold TB; Meves A; Lehman JS; Popovic-Silwerfeldt K; Häyry A; Söderlund-Matell T; Charlesworth CM; Madden B; Lundberg IE; Wahren-Herlenius M; Svenungsson E; Oke V
Article: RHEUMATOLOGY. 2021;60(3):1445-1455

Interferon activation status underlies higher antibody response to viral antigens in patients with systemic lupus erythematosus receiving no or light treatment.

Björk A; Da Silva Rodrigues R; Richardsdotter Andersson E; Ramírez Sepúlveda JI; Mofors J; Kvarnström M; Oke V; Svenungsson E; Gunnarsson I; Wahren-Herlenius M
Article: ANNALS OF THE RHEUMATIC DISEASES. 2021;80(2):194-202

Natural killer cells and type II interferon in Ro/SSA and La/SSB autoantibody-exposed newborns at risk of congenital heart block.

Ivanchenko M; Thorlacius GE; Hedlund M; Ottosson V; Meneghel L; Björkander S; Ossoinak A; Tingström J; Bremme K; Sverremark-Ekström E; Gemzell-Danielsson K; Sonesson S-E; Chemin K; Wahren-Herlenius M
Article: RHEUMATOLOGY. 2021;60(2):837-848

Genetic and clinical basis for two distinct subtypes of primary Sjögren's syndrome.

Thorlacius GE; Hultin-Rosenberg L; Sandling JK; Bianchi M; Imgenberg-Kreuz J; Pucholt P; Theander E; Kvarnström M; Forsblad-d'Elia H; Bucher SM; Norheim KB; Johnsen SJA; Hammenfors D; Skarstein K; Jonsson MV; Baecklund E; Aqrawi LA; Jensen JL; Palm Ø; Morris AP; DISSECT consortium; the ImmunoArray consortium; Meadows JRS; Rantapää-Dahlqvist S; Mandl T; Eriksson P; Lind L; Omdal R; Jonsson R; Lindblad-Toh K; Rönnblom L; Wahren-Herlenius M; Nordmark G
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2021;93(1):e12995

Interferons and innate immune activation in autoimmune congenital heart block.

Ambrosi A; Thorlacius GE; Sonesson S-E; Wahren-Herlenius M
Article: FRONTIERS IN IMMUNOLOGY. 2021;12:642173

SOCS3 Expression by Thymic Stromal Cells Is Required for Normal T Cell Development.

Gao Y; Liu R; He C; Basile J; Vesterlund M; Wahren-Herlenius M; Espinoza A; Hokka-Zakrisson C; Zadjali F; Yoshimura A; Karlsson M; Carow B; Rottenberg ME
Article: RMD OPEN. 2020;6(3):e001402

Cigarette smoking patterns preceding primary Sjögren's syndrome.

Mofors J; Björk A; Richardsdotter Andersson E; Kvarnström M; Forsblad d'Elia H; Magnusson-Bucher S; Padyukov L; Kockum I; Hillert J; Eriksson P; Mandl T; Nordmark G; Alfredsson L; Wahren-Herlenius M
Article: RHEUMATOLOGY. 2020;59(9):2350-2359

Epidemiological profile and north-south gradient driving baseline systemic involvement of primary Sjögren's syndrome.

Brito-Zerón P; Acar-Denizli N; Ng W-F; Horváth IF; Rasmussen A; Seror R; Li X; Baldini C; Gottenberg J-E; Danda D; Quartuccio L; Priori R; Hernandez-Molina G; Armagan B; Kruize AA; Kwok S-K; Kvarnstrom M; Praprotnik S; Sene D; Gerli R; Solans R; Rischmueller M; Mandl T; Suzuki Y; Isenberg D; Valim V; Wiland P; Nordmark G; Fraile G; Bootsma H; Nakamura H; Giacomelli R; Devauchelle-Pensec V; Hofauer B; Bombardieri M; Trevisani VFM; Hammenfors D; Pasoto SG; Retamozo S; Gheita TA; Atzeni F; Morel J; Vollenweider C; Zeher M; Sivils K; Xu B; Bombardieri S; Sandhya P; De Vita S; Minniti A; Sánchez-Guerrero J; Kilic L; van der Heijden E; Park S-H; Wahren-Herlenius M; Mariette X; Ramos-Casals M; Sjögren Big Data Consortium
Article: RHEUMATOLOGY. 2020;59(7):1651-1661

Viral antigens elicit augmented immune responses in primary Sjögren's syndrome.

Björk A; Thorlacius GE; Mofors J; Richardsdotter Andersson E; Ivanchenko M; Tingström J; James T; Brokstad KA; Cox RJ; Jonsson R; Kvarnström M; Wahren-Herlenius M
Article: RMD OPEN. 2020;6(1):e000995

Protein and DNA methylation-based scores as surrogate markers for interferon system activation in patients with primary Sjögren's syndrome.

Björk A; Richardsdotter Andersson E; Imgenberg-Kreuz J; Thorlacius GE; Mofors J; Syvänen A-C; Kvarnström M; Nordmark G; Wahren-Herlenius M
Article: FRONTIERS IN IMMUNOLOGY. 2020;11:580547

Single-Stranded Oligonucleotide-Mediated Inhibition of Respiratory Syncytial Virus Infection.

Pålsson SA; Dondalska A; Bergenstråhle J; Rolfes C; Björk A; Sedano L; Power UF; Rameix-Welti M-A; Lundeberg J; Wahren-Herlenius M; Mastrangelo P; Eleouet J-F; Le Goffic R; Galloux M; Spetz A-L
Article: RMD OPEN. 2020;6(1):e000989

Type I IFN system activation in newborns exposed to Ro/SSA and La/SSB autoantibodies in utero.

Hedlund M; Thorlacius GE; Ivanchenko M; Ottosson V; Kyriakidis N; Lagnefeldt L; Tingström J; Sirsjö A; Bengtsson AA; Aronsson E; Gemzell-Danielsson K; Ronnblom L; Bergman G; Espinosa A; Sonesson S-E; Eloranta M-L; Wahren-Herlenius M
Article: BIOLOGY OF SEX DIFFERENCES. 2019;10(1):60

Sex differences in clinical presentation of systemic lupus erythematosus.

Ramírez Sepúlveda JI; Bolin K; Mofors J; Leonard D; Svenungsson E; Jönsen A; Bengtsson C; DISSECT consortium; Nordmark G; Rantapää Dahlqvist S; Bengtsson AA; Rönnblom L; Sjöwall C; Gunnarsson I; Wahren-Herlenius M
Article: EUROPACE. 2019;21(11):1717-1724

Pacing therapy in children with isolated complete atrioventricular block: a retrospective study of pacing system survival and pacing-related complications in a national cohort.

Eliasson H; Sonesson S-E; Salomonsson S; Skog Andreasson A; Wahren-Herlenius M; Gadler F
Article: JOURNAL OF INTERNAL MEDICINE. 2019;286(4):458-468

Concomitant Ro/SSA and La/SSB antibodies are biomarkers for the risk of venous thromboembolism and cerebral infarction in primary Sjögren's syndrome.

Mofors J; Holmqvist M; Westermark L; Björk A; Kvarnström M; Forsblad-d'Elia H; Magnusson Bucher S; Eriksson P; Theander E; Mandl T; Wahren-Herlenius M; Nordmark G
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(30):11404-11419

E3 ubiquitin-protein ligase TRIM21-mediated lysine capture by UBE2E1 reveals substrate-targeting mode of a ubiquitin-conjugating E2.

Anandapadamanaban M; Kyriakidis NC; Csizmók V; Wallenhammar A; Espinosa AC; Ahlner A; Round AR; Trewhella J; Moche M; Wahren-Herlenius M; Sunnerhagen M
Article: ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 2019;54(1):87-95

Benefits of fetal echocardiographic surveillance in pregnancies at risk of congenital heart block: single-center study of 212 anti-Ro52-positive pregnancies.

Sonesson S-E; Ambrosi A; Wahren-Herlenius M
Article: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2019;37 Suppl 118(3):97-106

Systemic manifestations of primary Sjögren's syndrome out of the ESSDAI classification: prevalence and clinical relevance in a large international, multi-ethnic cohort of patients.

Retamozo S; Acar-Denizli N; Rasmussen A; Horváth IF; Baldini C; Priori R; Sandhya P; Hernandez-Molina G; Armagan B; Praprotnik S; Kvarnstrom M; Gerli R; Sebastian A; Solans R; Rischmueller M; Pasoto SG; Valim V; Nordmark G; Kruize A; Nakamura H; Hofauer B; Giacomelli R; Fernandes Moça Trevisani V; Devauchelle-Pensec V; Atzeni F; Gheita TA; Consani-Fernández S; Szántó A; Sivils K; Gattamelata A; Danda D; Kilic L; Bartoloni E; Bombardieri S; Sánchez-Guerrero J; Wahren-Herlenius M; Mariette X; Ramos-Casals M; Brito-Zerón P; Sjögren Big Data Consortium
Article: ANNALS OF THE RHEUMATIC DISEASES. 2019;78(5):696-703

Comorbidity and long-term outcome in patients with congenital heart block and their siblings exposed to Ro/SSA autoantibodies in utero.

Mofors J; Eliasson H; Ambrosi A; Salomonsson S; Skog A; Fored M; Ekbom A; Bergman G; Sonesson S-E; Wahren-Herlenius M
Article: ELIFE. 2019;8:e41608

In-depth human plasma proteome analysis captures tissue proteins and transfer of protein variants across the placenta.

Pernemalm M; Sandberg A; Zhu Y; Boekel J; Tamburro D; Schwenk JM; Björk A; Wahren-Herlenius M; Åmark H; Östenson C-G; Westgren M; Lehtiö J
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2018;194(3):315-326

The Sjögren's syndrome-associated autoantigen Ro52/TRIM21 modulates follicular B cell homeostasis and immunoglobulin production.

Brauner S; Ivanchenko M; Thorlacius GE; Ambrosi A; Wahren-Herlenius M
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2018;193(2):167-177

The rheumatic disease-associated FAM167A-BLK locus encodes DIORA-1, a novel disordered protein expressed highly in bronchial epithelium and alveolar macrophages.

Mentlein L; Thorlacius GE; Meneghel L; Aqrawi LA; Ramírez Sepúlveda JI; Grunewald J; Espinosa A; Wahren-Herlenius M
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2018;192(3):259-270

Diminished CXCR5 expression in peripheral blood of patients with Sjögren's syndrome may relate to both genotype and salivary gland homing.

Aqrawi LA; Ivanchenko M; Björk A; Ramírez Sepúlveda JI; Imgenberg-Kreuz J; Kvarnström M; Haselmayer P; Jensen JL; Nordmark G; Chemin K; Skarstein K; Wahren-Herlenius M
Article: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2018;36 Suppl 112(3):102-112

How immunological profile drives clinical phenotype of primary Sjögren's syndrome at diagnosis: analysis of 10,500 patients (Sjögren Big Data Project).

Brito-Zerón P; Acar-Denizli N; Ng W-F; Zeher M; Rasmussen A; Mandl T; Seror R; Li X; Baldini C; Gottenberg J-E; Danda D; Quartuccio L; Priori R; Hernandez-Molina G; Armagan B; Kruize AA; Kwok S-K; Kvarnström M; Praprotnik S; Sène D; Bartoloni E; Solans R; Rischmueller M; Suzuki Y; Isenberg DA; Valim V; Wiland P; Nordmark G; Fraile G; Bootsma H; Nakamura T; Giacomelli R; Devauchelle-Pensec V; Knopf A; Bombardieri M; Trevisani V-F; Hammenfors D; Pasoto SG; Retamozo S; Gheita TA; Atzeni F; Morel J; Vollenveider C; Horvath I-F; Sivils KL; Olsson P; De Vita S; Sánchez-Guerrero J; Kilic L; Wahren-Herlenius M; Mariette X; Ramos-Casals M; Sjögren Big Data Consortium
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2018;87(5):e12662

Transcription profiling of peripheral B cells in antibody-positive primary Sjögren's syndrome reveals upregulated expression of CX3CR1 and a type I and type II interferon signature.

Imgenberg-Kreuz J; Sandling JK; Björk A; Nordlund J; Kvarnström M; Eloranta M-L; Rönnblom L; Wahren-Herlenius M; Syvänen A-C; Nordmark G
Article: CARDIOVASCULAR RESEARCH. 2018;114(1):158-167

Augmented Th17 differentiation in Trim21 deficiency promotes a stable phenotype of atherosclerotic plaques with high collagen content.

Brauner S; Jiang X; Thorlacius GE; Lundberg AM; Östberg T; Yan Z-Q; Kuchroo VK; Hansson GK; Wahren-Herlenius M
Article: FRONTIERS IN IMMUNOLOGY. 2018;9:1939

Early Resistance of Non-virulent Mycobacterial Infection in C57BL/6 Mice Is Associated With Rapid Up-Regulation of Antimicrobial Cathelicidin Camp.

Adam L; López-González M; Björk A; Pålsson S; Poux C; Wahren-Herlenius M; Fernández C; Spetz A-L
Article: ARTHRITIS & RHEUMATOLOGY. 2017;69(11):2187-2192

Rare X Chromosome Abnormalities in Systemic Lupus Erythematosus and Sjögren's Syndrome.

Sharma R; Harris VM; Cavett J; Kurien BT; Liu K; Koelsch KA; Fayaaz A; Chaudhari KS; Radfar L; Lewis D; Stone DU; Kaufman CE; Li S; Segal B; Wallace DJ; Weisman MH; Venuturupalli S; Kelly JA; Pons-Estel B; Jonsson R; Lu X; Gottenberg J-E; Anaya J-M; Cunninghame-Graham DS; Huang AJW; Brennan MT; Hughes P; Alevizos I; Miceli-Richard C; Keystone EC; Bykerk VP; Hirschfield G; Nordmark G; Bucher SM; Eriksson P; Omdal R; Rhodus NL; Rischmueller M; Rohrer M; Wahren-Herlenius M; Witte T; Alarcón-Riquelme M; Mariette X; Lessard CJ; Harley JB; Ng W-F; Rasmussen A; Sivils KL; Scofield RH
Article: BIOLOGY OF SEX DIFFERENCES. 2017;8(1):34

Sex influences eQTL effects of SLE and Sjögren's syndrome-associated genetic polymorphisms.

Lindén M; Ramírez Sepúlveda JI; James T; Thorlacius GE; Brauner S; Gómez-Cabrero D; Olsson T; Kockum I; Wahren-Herlenius M
Article: ANNALS OF THE RHEUMATIC DISEASES. 2017;76(10):1755-1763

H1N1 vaccination in Sjögren's syndrome triggers polyclonal B cell activation and promotes autoantibody production.

Brauner S; Folkersen L; Kvarnström M; Meisgen S; Petersen S; Franzén-Malmros M; Mofors J; Brokstad KA; Klareskog L; Jonsson R; Westerberg LS; Trollmo C; Malmström V; Ambrosi A; Kuchroo VK; Nordmark G; Wahren-Herlenius M
Article: RHEUMATOLOGY. 2017;56(10):1755-1762

Factors influencing fetal cardiac conduction in anti-Ro/SSA-positive pregnancies.

Sonesson S-E; Hedlund M; Ambrosi A; Wahren-Herlenius M
Article: BIOLOGY OF SEX DIFFERENCES. 2017;8(1):25

Long-term follow-up in primary Sjögren's syndrome reveals differences in clinical presentation between female and male patients.

Ramírez Sepúlveda JI; Kvarnström M; Eriksson P; Mandl T; Norheim KB; Johnsen SJ; Hammenfors D; Jonsson MV; Skarstein K; Brun JG; DISSECT consortium; Rönnblom L; Forsblad-d'Elia H; Magnusson Bucher S; Baecklund E; Theander E; Omdal R; Jonsson R; Nordmark G; Wahren-Herlenius M
Article: EXPERIMENTAL DERMATOLOGY. 2017;26(8):713-720

TRIM21 is important in the early phase of inflammation in the imiquimod-induced psoriasis-like skin inflammation mouse model.

Vinter H; Langkilde A; Ottosson V; Espinosa A; Wahren-Herlenius M; Raaby L; Johansen C; Iversen L
Article: PLOS GENETICS. 2017;13(6):e1006820

Identification of a Sjögren's syndrome susceptibility locus at OAS1 that influences isoform switching, protein expression, and responsiveness to type I interferons.

Li H; Reksten TR; Ice JA; Kelly JA; Adrianto I; Rasmussen A; Wang S; He B; Grundahl KM; Glenn SB; Miceli-Richard C; Bowman S; Lester S; Eriksson P; Eloranta M-L; Brun JG; Gøransson LG; Harboe E; Guthridge JM; Kaufman KM; Kvarnström M; Cunninghame Graham DS; Patel K; Adler AJ; Farris AD; Brennan MT; Chodosh J; Gopalakrishnan R; Weisman MH; Venuturupalli S; Wallace DJ; Hefner KS; Houston GD; Huang AJW; Hughes PJ; Lewis DM; Radfar L; Vista ES; Edgar CE; Rohrer MD; Stone DU; Vyse TJ; Harley JB; Gaffney PM; James JA; Turner S; Alevizos I; Anaya J-M; Rhodus NL; Segal BM; Montgomery CG; Scofield RH; Kovats S; Mariette X; Rönnblom L; Witte T; Rischmueller M; Wahren-Herlenius M; Omdal R; Jonsson R; Ng W-F; for UK Primary Sjögren's Syndrome Registry; Nordmark G; Lessard CJ; Sivils KL
Article: ANNALS OF THE RHEUMATIC DISEASES. 2017;76(6):1042-1050

Influence of geolocation and ethnicity on the phenotypic expression of primary Sjögren's syndrome at diagnosis in 8310 patients: a cross-sectional study from the Big Data Sjögren Project Consortium.

Brito-Zerón P; Acar-Denizli N; Zeher M; Rasmussen A; Seror R; Theander E; Li X; Baldini C; Gottenberg J-E; Danda D; Quartuccio L; Priori R; Hernandez-Molina G; Kruize AA; Valim V; Kvarnstrom M; Sene D; Gerli R; Praprotnik S; Isenberg D; Solans R; Rischmueller M; Kwok S-K; Nordmark G; Suzuki Y; Giacomelli R; Devauchelle-Pensec V; Bombardieri M; Hofauer B; Bootsma H; Brun JG; Fraile G; Carsons SE; Gheita TA; Morel J; Vollenveider C; Atzeni F; Retamozo S; Horvath IF; Sivils K; Mandl T; Sandhya P; De Vita S; Sanchez-Guerrero J; van der Heijden E; Trevisani VFM; Wahren-Herlenius M; Mariette X; Ramos-Casals M; EULAR-SS Task Force Big Data Consortium
Article: RMD OPEN. 2017;3(2):e000520

Environmental and lifestyle factors influencing risk of congenital heart block during pregnancy in anti-Ro/SSA-positive women.

Meisgen S; Tingström J; Skog Andreasson A; Sonesson S-E; Kockum I; Wahren-Herlenius M
Article: BIOLOGY OF SEX DIFFERENCES. 2017;8:16

Difference in clinical presentation between women and men in incident primary Sjögren's syndrome.

Ramírez Sepúlveda JI; Kvarnström M; Brauner S; Baldini C; Wahren-Herlenius M
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2016;186(3):284-291

Identification of discrete epitopes of Ro52p200 and association with fetal cardiac conduction system manifestations in a rodent model.

Hoxha A; Ruffatti A; Ambrosi A; Ottosson V; Hedlund M; Ottosson L; Anandapadamanaban M; Sunnerhagen M; Sonesson S-E; Wahren-Herlenius M
Article: CLINICAL IMMUNOLOGY. 2016;168:25-29

Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome.

Harris VM; Sharma R; Cavett J; Kurien BT; Liu K; Koelsch KA; Rasmussen A; Radfar L; Lewis D; Stone DU; Kaufman CE; Li S; Segal B; Wallace DJ; Weisman MH; Venuturupalli S; Kelly JA; Alarcon-Riquelme ME; Pons-Estel B; Jonsson R; Lu X; Gottenberg J-E; Anaya J-M; Cunninghame-Graham DS; Huang AJW; Brennan MT; Hughes P; Alevizos I; Miceli-Richard C; Keystone EC; Bykerk VP; Hirschfield G; Xie G; Siminovitch KA; Ng W-F; Nordmark G; Bucher SM; Eriksson P; Omdal R; Rhodus NL; Rischmueller M; Rohrer M; Wahren-Herlenius M; Witte T; Mariette X; Lessard CJ; Harley JB; Sivils KL; Scofield RH
Article: ARTHRITIS & RHEUMATOLOGY. 2016;68(5):1290-1300

X Chromosome Dose and Sex Bias in Autoimmune Diseases: Increased Prevalence of 47,XXX in Systemic Lupus Erythematosus and Sjögren's Syndrome.

Liu K; Kurien BT; Zimmerman SL; Kaufman KM; Taft DH; Kottyan LC; Lazaro S; Weaver CA; Ice JA; Adler AJ; Chodosh J; Radfar L; Rasmussen A; Stone DU; Lewis DM; Li S; Koelsch KA; Igoe A; Talsania M; Kumar J; Maier-Moore JS; Harris VM; Gopalakrishnan R; Jonsson R; Lessard JA; Lu X; Gottenberg J-E; Anaya J-M; Cunninghame-Graham DS; Huang AJW; Brennan MT; Hughes P; Illei GG; Miceli-Richard C; Keystone EC; Bykerk VP; Hirschfield G; Xie G; Ng W-F; Nordmark G; Eriksson P; Omdal R; Rhodus NL; Rischmueller M; Rohrer M; Segal BM; Vyse TJ; Wahren-Herlenius M; Witte T; Pons-Estel B; Alarcon-Riquelme ME; Guthridge JM; James JA; Lessard CJ; Kelly JA; Thompson SD; Gaffney PM; Montgomery CG; Edberg JC; Kimberly RP; Alarcón GS; Langefeld CL; Gilkeson GS; Kamen DL; Tsao BP; McCune WJ; Salmon JE; Merrill JT; Weisman MH; Wallace DJ; Utset TO; Bottinger EP; Amos CI; Siminovitch KA; Mariette X; Sivils KL; Harley JB; Scofield RH
Article: LUPUS. 2016;25(5):536-542

Anti-Ro/SSA autoantibody-positive women's experience of information given on the risk of congenital heart block.

Tingström J; Hjelmstedt A; Welin Henriksson E; Ambrosi A; Sonesson S-E; Wahren-Herlenius M
Article: ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA. 2016;95(1):98-105

Outcome in 212 anti-Ro/SSA-positive pregnancies and population-based incidence of congenital heart block.

Skog A; Lagnefeldt L; Conner P; Wahren-Herlenius M; Sonesson S-E
Article: JOURNAL OF IMMUNOLOGY. 2016;196(1):91-96

The Expression of BAFF Is Controlled by IRF Transcription Factors.

Sjöstrand M; Johansson A; Aqrawi L; Olsson T; Wahren-Herlenius M; Espinosa A
Article: JOURNAL OF CLINICAL INVESTIGATION. 2015;125(12):4612-4624

Development of autoantibodies against muscle-specific FHL1 in severe inflammatory myopathies.

Albrecht I; Wick C; Hallgren Å; Tjärnlund A; Nagaraju K; Andrade F; Thompson K; Coley W; Phadke A; Diaz-Gallo L-M; Bottai M; Nennesmo I; Chemin K; Herrath J; Johansson K; Wikberg A; Ytterberg AJ; Zubarev RA; Danielsson O; Krystufkova O; Vencovsky J; Landegren N; Wahren-Herlenius M; Padyukov L; Kämpe O; Lundberg IE
Article: LUPUS. 2015;24(14):1540-1545

Ro/SSA autoantibody-positive pregnancy: reactions to serial fetal Doppler echocardiographic surveillance.

Tingström J; Hjelmstedt A; Welin Henriksson E; Sonesson S-E; Wahren-Herlenius M
Article: HEART RHYTHM. 2015;12(11):2278-2284

Outcome in young patients with isolated complete atrioventricular block and permanent pacemaker treatment: A nationwide study of 127 patients.

Eliasson H; Sonesson S-E; Salomonsson S; Skog A; Wahren-Herlenius M; Gadler F; Swedish Congenital Heart Block Study Group
Article: JOURNAL OF INTERNAL MEDICINE. 2015;278(3):323-332

Reduced expression of TRIM21/Ro52 predicts poor prognosis in diffuse large B-cell lymphoma patients with and without rheumatic disease.

Brauner S; Zhou W; Backlin C; Green TM; Folkersen L; Ivanchenko M; Löfström B; Xu-Monette ZY; Young KH; Møller Pedersen L; Boe Møller M; Sundström C; Enblad G; Baecklund E; Wahren-Herlenius M
Article: CIRCULATION. 2015;132(4):230-240

Pathogenesis of the Novel Autoimmune-Associated Long-QT Syndrome.

Yue Y; Castrichini M; Srivastava U; Fabris F; Shah K; Li Z; Qu Y; El-Sherif N; Zhou Z; January C; Hussain MM; Jiang X-C; Sobie EA; Wahren-Herlenius M; Chahine M; Capecchi P-L; Laghi-Pasini F; Lazzerini P-E; Boutjdir M
Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2015;44(2):135-142

Incident cases of primary Sjögren's syndrome during a 5-year period in Stockholm County: a descriptive study of the patients and their characteristics.

Kvarnström M; Ottosson V; Nordmark B; Wahren-Herlenius M
Article: HUMAN MOLECULAR GENETICS. 2015;24(2):582-596

The IRF5-TNPO3 association with systemic lupus erythematosus has two components that other autoimmune disorders variably share.

Kottyan LC; Zoller EE; Bene J; Lu X; Kelly JA; Rupert AM; Lessard CJ; Vaughn SE; Marion M; Weirauch MT; Namjou B; Adler A; Rasmussen A; Glenn S; Montgomery CG; Hirschfield GM; Xie G; Coltescu C; Amos C; Li H; Ice JA; Nath SK; Mariette X; Bowman S; UK Primary Sjögren's Syndrome Registry; Rischmueller M; Lester S; Brun JG; Gøransson LG; Harboe E; Omdal R; Cunninghame-Graham DS; Vyse T; Miceli-Richard C; Brennan MT; Lessard JA; Wahren-Herlenius M; Kvarnström M; Illei GG; Witte T; Jonsson R; Eriksson P; Nordmark G; Ng W-F; UK Primary Sjögren's Syndrome Registry; Anaya J-M; Rhodus NL; Segal BM; Merrill JT; James JA; Guthridge JM; Scofield RH; Alarcon-Riquelme M; Bae S-C; Boackle SA; Criswell LA; Gilkeson G; Kamen DL; Jacob CO; Kimberly R; Brown E; Edberg J; Alarcón GS; Reveille JD; Vilá LM; Petri M; Ramsey-Goldman R; Freedman BI; Niewold T; Stevens AM; Tsao BP; Ying J; Mayes MD; Gorlova OY; Wakeland W; Radstake T; Martin E; Martin J; Siminovitch K; Moser Sivils KL; Gaffney PM; Langefeld CD; Harley JB; Kaufman KM
Article: MULTIPLE SCLEROSIS JOURNAL. 2014;20(13):1727-1736

Interferon beta treatment of multiple sclerosis increases serum interleukin-7.

Lundström W; Hermanrud C; Sjöstrand M; Brauner S; Wahren-Herlenius M; Olsson T; Karrenbauer V; Hillert J; Fogdell-Hahn A
Article: ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 2014;44(2):171-175

Doppler echocardiographic isovolumetric time intervals in diagnosis of fetal blocked atrial bigeminy and 2:1 atrioventricular block.

Sonesson S-E; Eliasson H; Conner P; Wahren-Herlenius M
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2014;177(1):244-252

Ductal epithelial expression of Ro52 correlates with inflammation in salivary glands of patients with primary Sjögren's syndrome.

Aqrawi LA; Kvarnström M; Brokstad KA; Jonsson R; Skarstein K; Wahren-Herlenius M
Article: ANNALS OF THE RHEUMATIC DISEASES. 2014;73(6):1253-1258

Genetic associations to germinal centre formation in primary Sjogren's syndrome.

Reksten TR; Johnsen SJA; Jonsson MV; Omdal R; Brun JG; Theander E; Eriksson P; Wahren-Herlenius M; Jonsson R; Nordmark G
Article: JOURNAL OF INTERNAL MEDICINE. 2014;275(6):640-651

The HLA locus contains novel foetal susceptibility alleles for congenital heart block with significant paternal influence.

Meisgen S; Östberg T; Salomonsson S; Ding B; Eliasson H; Mälarstig A; Alfredsson L; Klareskog L; Hamsten A; Olsson T; Axelsson T; Swedish Congenital Heart Block Study Group; Gadler F; Jonzon A; Sonesson S-E; Kockum I; Wahren-Herlenius M
Article: ACTA PAEDIATRICA. 2014;103(3):275-281

Late development of complete atrioventricular block may be immune mediated and congenital in origin.

Bergman G; Skog A; Tingström J; Ottosson V; Hoxha A; Ambrosi A; Swedish Congenital Heart Block Study Group; Salomonsson S; Wahren-Herlenius M
Article: RHEUMATOLOGY INTERNATIONAL. 2014;34(2):191-197

A possible genetic association with chronic fatigue in primary Sjögren's syndrome: a candidate gene study.

Norheim KB; Le Hellard S; Nordmark G; Harboe E; Gøransson L; Brun JG; Wahren-Herlenius M; Jonsson R; Omdal R
Article: NATURE GENETICS. 2013;45(11):1284-1292

Variants at multiple loci implicated in both innate and adaptive immune responses are associated with Sjögren's syndrome.

Lessard CJ; Li H; Adrianto I; Ice JA; Rasmussen A; Grundahl KM; Kelly JA; Dozmorov MG; Miceli-Richard C; Bowman S; Lester S; Eriksson P; Eloranta M-L; Brun JG; Gøransson LG; Harboe E; Guthridge JM; Kaufman KM; Kvarnström M; Jazebi H; Cunninghame Graham DS; Grandits ME; Nazmul-Hossain ANM; Patel K; Adler AJ; Maier-Moore JS; Farris AD; Brennan MT; Lessard JA; Chodosh J; Gopalakrishnan R; Hefner KS; Houston GD; Huang AJW; Hughes PJ; Lewis DM; Radfar L; Rohrer MD; Stone DU; Wren JD; Vyse TJ; Gaffney PM; James JA; Omdal R; Wahren-Herlenius M; Illei GG; Witte T; Jonsson R; Rischmueller M; Rönnblom L; Nordmark G; Ng W-F; UK Primary Sjögren's Syndrome Registry; Mariette X; Anaya J-M; Rhodus NL; Segal BM; Scofield RH; Montgomery CG; Harley JB; Sivils KL
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2013;78(5):447-454

Association of genes in the NF-κB pathway with antibody-positive primary Sjögren's syndrome.

Nordmark G; Wang C; Vasaitis L; Eriksson P; Theander E; Kvarnström M; Forsblad-d'Elia H; Jazebi H; Sjöwall C; Reksten TR; Brun JG; Jonsson MV; Johnsen SJ; Wahren-Herlenius M; Omdal R; Jonsson R; Bowman S; Ng W-F; Eloranta M-L; Syvänen A-C; UK Primary Sjögren’s Syndrome Registry
Article: JOURNAL OF IMMUNOLOGY. 2013;191(7):3753-3763

Expression of the immune regulator tripartite-motif 21 is controlled by IFN regulatory factors.

Sjöstrand M; Ambrosi A; Brauner S; Sullivan J; Malin S; Kuchroo VK; Espinosa A; Wahren-Herlenius M
Article: LANCET. 2013;382(9894):819-831

Immunopathogenic mechanisms of systemic autoimmune disease.

Wahren-Herlenius M; Dörner T
Article: SCIENCE TRANSLATIONAL MEDICINE. 2013;5(195):195ra96

NCR3/NKp30 contributes to pathogenesis in primary Sjogren's syndrome.

Rusakiewicz S; Nocturne G; Lazure T; Semeraro M; Flament C; Caillat-Zucman S; Sène D; Delahaye N; Vivier E; Chaba K; Poirier-Colame V; Nordmark G; Eloranta M-L; Eriksson P; Theander E; Forsblad-d'Elia H; Omdal R; Wahren-Herlenius M; Jonsson R; Rönnblom L; Nititham J; Taylor KE; Lessard CJ; Sivils KLM; Gottenberg J-E; Criswell LA; Miceli-Richard C; Zitvogel L; Mariette X
Article: ACTA PAEDIATRICA. 2013;102(7):718-726

Long-term growth of children with autoantibody-mediated congenital heart block.

Skog A; Eliasson H; Tingström J; Källberg H; Salomonsson S; Swedish Congenital Heart Block Study Group; Sonesson S-E; Wahren-Herlenius M
Article: GENES AND IMMUNITY. 2013;14(4):234-237

No association of primary Sjögren's syndrome with Fcγ receptor gene variants.

Haldorsen K; Appel S; Le Hellard S; Bruland O; Brun JG; Omdal R; Kristjansdottir G; Theander E; Fernandes CPD; Kvarnström M; Eriksson P; Rönnblom L; Herlenius MW; Nordmark G; Jonsson R; Bolstad AI
Article: LUPUS. 2013;22(5):477-485

Autoantibodies to the functionally active RING-domain of Ro52/SSA are associated with disease activity in patients with lupus.

Kvarnström M; Dzikaite-Ottosson V; Ottosson L; Gustafsson JT; Gunnarsson I; Svenungsson E; Wahren-Herlenius M
Article: MIDWIFERY. 2013;29(1):18-23

Ro52 autoantibody-positive women's experience of being pregnant and giving birth to a child with congenital heart block.

Tingström J; Henriksson EW; Sonesson S-E; Wahren-Herlenius M
Article: ACTA PAEDIATRICA. 2013;102(1):40-46

Neurodevelopment in children with and without congenital heart block born to anti-Ro/SSA-positive mothers.

Skog A; Tingström J; Salomonsson S; Sonesson S-E; Wahren-Herlenius M
Article: ANNALS OF THE RHEUMATIC DISEASES. 2012;71(6):981-988

Association between genetic variants in the tumour necrosis factor/lymphotoxin α/lymphotoxin β locus and primary Sjogren's syndrome in Scandinavian samples.

Bolstad AI; Le Hellard S; Kristjansdottir G; Vasaitis L; Kvarnström M; Sjöwall C; Johnsen SJA; Eriksson P; Omdal R; Brun JG; Wahren-Herlenius M; Theander E; Syvänen A-C; Rönnblom L; Nordmark G; Jonsson R
Article: ACTA PAEDIATRICA. 2012;101(5):488-493

Progression to first-degree heart block in preschool children exposed in utero to maternal anti-SSA/Ro52 autoantibodies.

Bergman G; Eliasson H; Mohlkert L-A; Wahren-Herlenius M; Sonesson S-E
Article: ARTHRITIS & RHEUMATOLOGY. 2012;64(5):1601-1609

Enhanced interferon regulatory factor 3 binding to the interleukin-23p19 promoter correlates with enhanced interleukin-23 expression in systemic lupus erythematosus.

Smith S; Gabhann JN; Higgs R; Stacey K; Wahren-Herlenius M; Espinosa A; Totaro MG; Sica A; Ball E; Bell A; Johnston J; Browne P; O'Neill L; Kearns G; Jefferies CA
Article: ANNALS OF THE RHEUMATIC DISEASES. 2012;71(3):448-454

Anti-Ro52 monoclonal antibodies specific for amino acid 200-239, but not other Ro52 epitopes, induce congenital heart block in a rat model.

Ambrosi A; Dzikaite V; Park J; Strandberg L; Kuchroo VK; Herlenius E; Wahren-Herlenius M
Article: ANNALS OF THE RHEUMATIC DISEASES. 2012;71(3):334-340

Development of heart block in children of SSA/SSB-autoantibody-positive women is associated with maternal age and displays a season-of-birth pattern.

Ambrosi A; Salomonsson S; Eliasson H; Zeffer E; Skog A; Dzikaite V; Bergman G; Fernlund E; Tingström J; Theander E; Rydberg A; Skogh T; Öhman A; Lundström U; Mellander M; Winqvist O; Fored M; Ekbom A; Alfredsson L; Källberg H; Olsson T; Gadler F; Jonzon A; Kockum I; Sonesson S-E; Wahren-Herlenius M
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2011;74(5):511-517

A population-based investigation of the autoantibody profile in mothers of children with atrioventricular block.

Salomonsson S; Dzikaite V; Zeffer E; Eliasson H; Ambrosi A; Bergman G; Fernlund E; Theander E; Ohman A; Rydberg A; Skogh T; Wållberg-Jonsson S; Elfving A; Fored M; Ekbom A; Lundström U; Mellander M; Winqvist O; Sonesson S-E; Gadler F; Jonzon A; Wahren-Herlenius M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2011;286(42):36478-36491

Anti-Ro52 autoantibodies from patients with Sjögren's syndrome inhibit the Ro52 E3 ligase activity by blocking the E3/E2 interface.

Espinosa A; Hennig J; Ambrosi A; Anandapadmanaban M; Abelius MS; Sheng Y; Nyberg F; Arrowsmith CH; Sunnerhagen M; Wahren-Herlenius M
Article: ANNALS OF THE RHEUMATIC DISEASES. 2011;70(7):1327-1329

Potential association of muscarinic receptor 3 gene variants with primary Sjogren's syndrome.

Appel S; Le Hellard S; Bruland O; Brun JG; Omdal R; Kristjansdottir G; Theander E; Nordmark G; Kvarnström M; Eriksson P; Rönnblom L; Wahren-Herlenius M; Jonsson R
Article: AMERICAN JOURNAL OF CARDIOLOGY. 2011;107(5):761-766

Spontaneous rupture of atrioventricular valve tensor apparatus as late manifestation of anti-Ro/SSA antibody-mediated cardiac disease.

Cuneo BF; Fruitman D; Benson DW; Ngan B-Y; Liske MR; Wahren-Herlineus M; Ho SY; Jaeggi E
Article: GENES AND IMMUNITY. 2011;12(2):100-109

Association of EBF1, FAM167A(C8orf13)-BLK and TNFSF4 gene variants with primary Sjögren's syndrome.

Nordmark G; Kristjansdottir G; Theander E; Appel S; Eriksson P; Vasaitis L; Kvarnström M; Delaleu N; Lundmark P; Lundmark A; Sjöwall C; Brun JG; Jonsson MV; Harboe E; Gøransson LG; Johnsen SJ; Söderkvist P; Eloranta M-L; Alm G; Baecklund E; Wahren-Herlenius M; Omdal R; Rönnblom L; Jonsson R; Syvänen A-C
Article: ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 2011;37(2):172-178

Mechanisms in fetal bradyarrhythmia: 65 cases in a single center analyzed by Doppler flow echocardiographic techniques.

Eliasson H; Wahren-Herlenius M; Sonesson S-E
Article: PLOS ONE. 2010;5(12):e14212

Polymorphisms of the ITGAM gene confer higher risk of discoid cutaneous than of systemic lupus erythematosus.

Järvinen TM; Hellquist A; Koskenmies S; Einarsdottir E; Panelius J; Hasan T; Julkunen H; Padyukov L; Kvarnström M; Wahren-Herlenius M; Nyberg F; D'Amato M; Kere J; Saarialho-Kere U
Article: MUSCULOSKELETAL CARE. 2010;8(4):215-223

The experiences of pregnancy in women with SSA/Ro52 autoantibodies.

Tingström J; Barimani M; Sonesson S-E; Wahren-Herlenius M; Henriksson EW
Article: ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 2010;36(5):561-566

Diagnostic precision of Doppler flow echocardiography in fetuses at risk for atrioventricular block.

Bergman G; Wahren-Herlenius M; Sonesson S-E
Article: JOURNAL OF IMMUNOLOGY. 2010;185(6):3574-3582

Maternal MHC regulates generation of pathogenic antibodies and fetal MHC-encoded genes determine susceptibility in congenital heart block.

Strandberg LS; Ambrosi A; Jagodic M; Dzikaite V; Janson P; Khademi M; Salomonsson S; Ottosson L; Klauninger R; Adén U; Sonesson S-E; Sunnerhagen M; de Graaf KL; Kuchroo VK; Achour A; Winqvist O; Olsson T; Wahren-Herlenius M
Article: PLOS ONE. 2010;5(7):e11776

Self protection from anti-viral responses--Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors.

Higgs R; Lazzari E; Wynne C; Ní Gabhann J; Espinosa A; Wahren-Herlenius M; Jefferies CA
Article: ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 2009;34(5):543-549

Anti-Ro52/SSA antibody-exposed fetuses with prolonged atrioventricular time intervals show signs of decreased cardiac performance.

Bergman G; Eliasson H; Bremme K; Wahren-Herlenius M; Sonesson S-E
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2009;206(8):1661-1671

Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway.

Espinosa A; Dardalhon V; Brauner S; Ambrosi A; Higgs R; Quintana FJ; Sjöstrand M; Eloranta M-L; Ní Gabhann J; Winqvist O; Sundelin B; Jefferies CA; Rozell B; Kuchroo VK; Wahren-Herlenius M
Article: LUPUS. 2009;18(9):792-798

Serologic follow-up of children born to mothers with Ro/SSA autoantibodies.

Klauninger R; Skog A; Horvath L; Winqvist O; Edner A; Bremme K; Sonesson SE; Wahren-Herlenius M
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2009;129(8):2000-2010

High Ro52 expression in spontaneous and UV-induced cutaneous inflammation.

Oke V; Vassilaki I; Espinosa A; Strandberg L; Kuchroo VK; Nyberg F; Wahren-Herlenius M
Article: JOURNAL OF ORAL PATHOLOGY & MEDICINE. 2009;38(3):282-288

Minor salivary gland immunohistology in the diagnosis of primary Sjögren's syndrome.

Salomonsson S; Rozell BL; Heimburger M; Wahren-Herlenius M
Article: EXPERIMENTAL CELL RESEARCH. 2008;314(20):3605-3613

The autoantigen Ro52 is an E3 ligase resident in the cytoplasm but enters the nucleus upon cellular exposure to nitric oxide.

Espinosa A; Oke V; Elfving A; Nyberg F; Covacu R; Wahren-Herlenius M
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2008;154(1):30-37

Antibodies to amino acid 200-239 (p200) of Ro52 as serological markers for the risk of developing congenital heart block.

Strandberg L; Winqvist O; Sonesson S-E; Mohseni S; Salomonsson S; Bremme K; Buyon JP; Julkunen H; Wahren-Herlenius M
Article: JOURNAL OF CLINICAL IMMUNOLOGY. 2008;28(3):220-231

Interferon-alpha induces up-regulation and nuclear translocation of the Ro52 autoantigen as detected by a panel of novel Ro52-specific monoclonal antibodies.

Strandberg L; Ambrosi A; Espinosa A; Ottosson L; Eloranta M-L; Zhou W; Elfving A; Greenfield E; Kuchroo VK; Wahren-Herlenius M
Article: PEDIATRICS. 2008;121(4):e803-e809

Outcome and growth of infants fetally exposed to heart block-associated maternal anti-Ro52/SSA autoantibodies.

Skog A; Wahren-Herlenius M; Sundström B; Bremme K; Sonesson S-E
Article: JOURNAL OF MOLECULAR BIOLOGY. 2008;377(2):431-449

The fellowship of the RING: the RING-B-box linker region interacts with the RING in TRIM21/Ro52, contains a native autoantigenic epitope in Sjögren syndrome, and is an integral and conserved region in TRIM proteins.

Hennig J; Bresell A; Sandberg M; Hennig KDM; Wahren-Herlenius M; Persson B; Sunnerhagen M
Article: ACTA DERMATO-VENEREOLOGICA. 2008;88(4):370-375

Clinical follow-up of 102 anti-Ro/SSA-positive patients with dermatological manifestations.

Popovic K; Wahren-Herlenius M; Nyberg F
Article: METHODS IN MOLECULAR MEDICINE. 2007;136:19-24

Detection of antigen specific B-cells in tissues.

Wahren-Herlenius M; Salomonsson S
Article: LUPUS. 2007;16(10):794-802

Translocation of the novel cytokine HMGB1 to the cytoplasm and extracellular space coincides with the peak of clinical activity in experimentally UV-induced lesions of cutaneous lupus erythematosus.

Barkauskaite V; Ek M; Popovic K; Harris HE; Wahren-Herlenius M; Nyberg F
Article: ARTHRITIS & RHEUMATOLOGY. 2007;56(1):255-264

A serology-based approach combined with clinical examination of 125 Ro/SSA-positive patients to define incidence and prevalence of subacute cutaneous lupus erythematosus.

Popovic K; Nyberg F; Wahren-Herlenius M; Nyberg F
Article: LUPUS. 2007;16(1):10-17

Fine specificity of the Ro/SSA autoantibody response in relation to serological and clinical findings in 96 patients with self-reported cutaneous symptoms induced by the sun.

Popovic K; Brauner S; Ek M; Wahren-Herlenius M; Nyberg F
Article: ULTRASOUND IN OBSTETRICS & GYNECOLOGY. 2006;28(1):57-62

Doppler echocardiographic and electrocardiographic atrioventricular time intervals in newborn infants: evaluation of techniques for surveillance of fetuses at risk for congenital heart block.

Bergman G; Jacobsson L-A; Wahren-Herlenius M; Sonesson S-E
Article: ARTHRITIS & RHEUMATOLOGY. 2006;54(7):2289-2294

Increased extracellular levels of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in minor salivary glands of patients with Sjögren's syndrome.

Ek M; Popovic K; Harris HE; Nauclér CS; Wahren-Herlenius M
Article: ARTHRITIS & RHEUMATOLOGY. 2006;54(6):1917-1927

Induction of interferon-alpha by immune complexes or liposomes containing systemic lupus erythematosus autoantigen- and Sjögren's syndrome autoantigen-associated RNA.

Lövgren T; Eloranta M-L; Kastner B; Wahren-Herlenius M; Alm GV; Rönnblom L
Article: JOURNAL OF IMMUNOLOGY. 2006;176(10):6277-6285

The Sjogren's syndrome-associated autoantigen Ro52 is an E3 ligase that regulates proliferation and cell death.

Espinosa A; Zhou W; Ek M; Hedlund M; Brauner S; Popovic K; Horvath L; Wallerskog T; Oukka M; Nyberg F; Kuchroo VK; Wahren-Herlenius M
Article: MOLECULAR IMMUNOLOGY. 2006;43(6):588-598

Structural, functional and immunologic characterization of folded subdomains in the Ro52 protein targeted in Sjögren's syndrome.

Ottosson L; Hennig J; Espinosa A; Brauner S; Wahren-Herlenius M; Sunnerhagen M
Article: ARTHRITIS RESEARCH & THERAPY. 2006;8(6):R167

Differential effects on BAFF and APRIL levels in rituximab-treated patients with systemic lupus erythematosus and rheumatoid arthritis.

Vallerskog T; Heimbürger M; Gunnarsson I; Zhou W; Wahren-Herlenius M; Trollmo C; Malmström V
Article: LUPUS. 2006;15(6):346-353

Ro52, Ro60 and La IgG autoantibody levels and Ro52 IgG subclass profiles longitudinally throughout pregnancy in congenital heart block risk pregnancies.

Strandberg L; Salomonsson S; Bremme K; Sonesson S-E; Wahren-Herlenius M
Article: ARTHRITIS & RHEUMATOLOGY. 2005;52(11):3639-3645

Increased expression of the novel proinflammatory cytokine high mobility group box chromosomal protein 1 in skin lesions of patients with lupus erythematosus.

Popovic K; Ek M; Espinosa A; Padyukov L; Harris HE; Wahren-Herlenius M; Nyberg F
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2005;280(39):33250-33261

Structural organization and Zn2+-dependent subdomain interactions involving autoantigenic epitopes in the Ring-B-box-coiled-coil (RBCC) region of Ro52.

Hennig J; Ottosson L; Andrésen C; Horvath L; Kuchroo VK; Broo K; Wahren-Herlenius M; Sunnerhagen M
Article: NATURE GENETICS. 2005;37(2):125-127

Mutations in the gene encoding fibroblast growth factor 10 are associated with aplasia of lacrimal and salivary glands.

Entesarian M; Matsson H; Klar J; Bergendal B; Olson L; Arakaki R; Hayashi Y; Ohuchi H; Falahat B; Bolstad AI; Jonsson R; Wahren-Herlenius M; Dahl N
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2005;61(2):109-118

Structurally derived mutations define congenital heart block-related epitopes within the 200-239 amino acid stretch of the Ro52 protein.

Ottosson L; Salomonsson S; Hennig J; Sonesson S-E; Dörner T; Raats J; Kuchroo VK; Sunnerhagen M; Wahren-Herlenius M
Article: JOURNAL OF EXPERIMENTAL MEDICINE. 2005;201(1):11-17

Ro/SSA autoantibodies directly bind cardiomyocytes, disturb calcium homeostasis, and mediate congenital heart block.

Salomonsson S; Sonesson S-E; Ottosson L; Muhallab S; Olsson T; Sunnerhagen M; Kuchroo VK; Thorén P; Herlenius E; Wahren-Herlenius M
Article: ARTHRITIS & RHEUMATOLOGY. 2004;50(4):1253-1261

Signs of first-degree heart block occur in one-third of fetuses of pregnant women with anti-SSA/Ro 52-kd antibodies.

Sonesson S-E; Salomonsson S; Jacobsson L-A; Bremme K; Wahren-Herlenius M
Article: JOURNAL OF AUTOIMMUNITY. 2004;22(2):167-177

Cloning and characterization of two human Ro52-specific monoclonal autoantibodies directed towards a domain associated with congenital heart block.

Salomonsson S; Ottosson L; Säfsten P; Hof D; Brauner H; Sunnerhagen M; Raats J; Wahren-Herlenius M
Article: ARTHRITIS & RHEUMATOLOGY. 2003;48(11):3187-3201

Cellular basis of ectopic germinal center formation and autoantibody production in the target organ of patients with Sjögren's syndrome.

Salomonsson S; Jonsson MV; Skarstein K; Brokstad KA; Hjelmström P; Wahren-Herlenius M; Jonsson R
Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2003;32(2):79-82

Local production of Ro/SSA and La/SSB autoantibodies in the target organ coincides with high levels of circulating antibodies in sera of patients with Sjögren's syndrome.

Salomonsson S; Wahren-Herlenius M
Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2002;31(3):133-139

Serial analysis of Ro/SSA and La/SSB antibody levels and correlation with clinical disease activity in patients with systemic lupus erythematosus.

Hassan AB; Lundberg IE; Isenberg D; Wahren-Herlenius M
Article: ARTHRITIS & RHEUMATOLOGY. 2002;46(5):1233-1241

A serologic marker for fetal risk of congenital heart block.

Salomonsson S; Dörner T; Theander E; Bremme K; Larsson P; Wahren-Herlenius M
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2002;55(4):336-342

Expression of the B cell-attracting chemokine CXCL13 in the target organ and autoantibody production in ectopic lymphoid tissue in the chronic inflammatory disease Sjögren's syndrome.

Salomonsson S; Larsson P; Tengnér P; Mellquist E; Hjelmström P; Wahren-Herlenius M
Article: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2001;115(1):208-213

Ro/SS-A- and La/SS-B-reactive B lymphocytes in peripheral blood of patients with Sjögren's syndrome.

Halse A; Wahren-Herlenius M; Jonsson R
Article: JOURNAL OF RHEUMATOLOGY. 2001;28(2):373-376

Primary Sjögren's syndrome--treatment of fetal incomplete atrioventricular block with dexamethasone.

Theander E; Brucato A; Gudmundsson S; Salomonsson S; Wahren-Herlenius M; Manthorpe R
Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2000;29(2):116-123

Ro 52kD autoantibodies are detected in a subset of ANA-negative sera.

Pourmand N; Blomberg S; Rönnblom L; Karlsson-Parra A; Pettersson I; Wahren-Herlenius M
Article: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2000;29(1):13-19

Isotype distribution of anti-Ro/SS-A and anti-La/SS-B antibodies in plasma and saliva of patients with Sjögren's syndrome.

Halse AK; Marthinussen MC; Wahren-Herlenius M; Jonsson R
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 1999;96(25):14487-14492

Key residues revealed in a major conformational epitope of the U1-70K protein.

Welin Henriksson E; Wahren-Herlenius M; Lundberg I; Mellquist E; Pettersson I
Article: ARTHRITIS & RHEUMATOLOGY. 1999;42(11):2471-2481

Immunoglobulin variable genes and epitope recognition of human monoclonal anti-Ro 52-kd in primary Sjögren's syndrome.

Elagib KE; Tengnér P; Levi M; Jonsson R; Thompson KM; Natvig JB; Wahren-Herlenius M
Article: ANNALS OF THE RHEUMATIC DISEASES. 1999;58(10):623-629

Ro/SSA and La/SSB specific IgA autoantibodies in serum of patients with Sjögren's syndrome and systemic lupus erythematosus.

Pourmand N; Wahren-Herlenius M; Gunnarsson I; Svenungsson E; Löfström B; Ioannou Y; Isenberg DA; Magnusson CG
Article: JOURNAL OF HUMAN VIROLOGY. 1999;2(5):296-307

The La protein from human liver cells interacts specifically with the U-rich region in the hepatitis C virus 3' untranslated region.

Spångberg K; Goobar-Larsson L; Wahren-Herlenius M; Schwartz S
Article: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 1999;49(5):533-538

Increased frequency of cells secreting interleukin-6 and interleukin-10 in peripheral blood of patients with primary Sjögren's syndrome.

Halse A; Tengnér P; Wahren-Herlenius M; Haga H; Jonsson R
Article: ARTHRITIS & RHEUMATOLOGY. 1998;41(12):2238-2248

Detection of anti-Ro/SSA and anti-La/SSB autoantibody-producing cells in salivary glands from patients with Sjögren's syndrome.

Tengnér P; Halse AK; Haga HJ; Jonsson R; Wahren-Herlenius M
Article: JOURNAL OF AUTOIMMUNITY. 1998;11(1):29-38

Ro/SS-A and La/SS-B antibody level variation in patients with Sjögren's syndrome and systemic lupus erythematosus.

Wahren M; Tengnér P; Gunnarsson I; Lundberg I; Hedfors E; Ringertz NR; Pettersson I
Article: RHEUMATOLOGY INTERNATIONAL. 1997;17(4):133-135

Anti-Ro (SSA) antibodies in rheumatoid arthritis patients with gold-induced side effects.

Tishler M; Nyman J; Wahren M; Yaron M
Article: JOURNAL OF AUTOIMMUNITY. 1996;9(4):537-544

Autoantibody repertoire to Ro/SSA and La/SSB antigens in patients with primary and secondary Sjögren's syndrome.

Wahren M; Solomin L; Pettersson I; Isenberg D
Article: EUROPEAN JOURNAL OF CELL BIOLOGY. 1996;70(3):189-197

Nuclear colocalization of the Ro 60 kDa autoantigen and a subset of U snRNP domains.

Wahren M; Mellqvist E; Vene S; Ringertz NR; Pettersson I
Article: AUTOIMMUNITY. 1996;23(1):25-34

Peripheral blood in Sjögren's syndrome does not contain increased levels of T lymphocytes reactive with the recombinant Ro/SS-A 52 kD and La/SS-B 48 kD autoantigens.

Halse AK; Wahren M; Jonsson R
Article: AUTOIMMUNITY. 1995;22(1):9-16

Characterization of T cell receptor repertoire and anti-Ro/SSA autoantibodies in relation to sialadenitis of NOD mice.

Skarstein K; Wahren M; Zaura E; Hattori M; Jonsson R
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All other publications

Preprint: BIORXIV. 2023

Variants in the DDX6-CXCR5 autoimmune disease risk locus influence the regulatory network in immune cells and salivary gland

Wiley MM; Khatri B; Joachims ML; Tessneer KL; Stolarczyk AM; Rasmussen A; Anaya J-M; Aqrawi LA; Bae S-C; Baecklund E; Björk A; Brun JG; Bucher SM; Dand N; Eloranta M-L; Engelke F; Forsblad-d’Elia H; Fugmann C; Glenn SB; Gong C; Gottenberg J-E; Hammenfors D; Imgenberg-Kreuz J; Jensen JL; Johnsen SJA; Jonsson MV; Kelly JA; Khanam S; Kim K; Kvarnström M; Mandl T; Martín J; Morris DL; Nocturne G; Norheim KB; Olsson P; Palm Ø; Pers J-O; Rhodus NL; Sjöwall C; Skarstein K; Taylor KE; Tombleson P; Thorlacius GE; Venuturupalli S; Vital EM; Wallace DJ; Grundahl KM; Radfar L; Brennan MT; James JA; Scofield RH; Gaffney PM; Criswell LA; Jonsson R; Appel S; Eriksson P; Bowman SJ; Omdal R; Rönnblom L; Warner BM; Rischmueller M; Witte T; Farris AD; Mariette X; Shiboski CH; Alliance SICC; Wahren-Herlenius M; Alarcón-Riquelme ME; Consortium PC; Ng W-F; Registry PSS; Sivils KL; Guthridge JM; Adrianto I; Vyse TJ; Tsao BP; Nordmark G; Lessard CJ
Conference publication: EUROPEAN JOURNAL OF CANCER. 2023;190:S4-S5

Skin infiltrating NK cells in cutaneous T-cell lymphoma are increased in number and display phenotypic alterations partially driven by the tumor

Brauner H; Scheffschick A; Nenonen J; Xiang M; Winther A; Ehrstrom M; Wahren-Herlenius M; Eidsmo L
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:1069.2-101070

IMMUNE CELLS AND THEIR EFFECTOR FUNCTIONS IN NEONATES BORN TO ANTI-RO/LA POSITIVE WOMEN

Gerstner C; Rudolph L; Thorlacius GE; Ottosson V; Meneghel L; Nordenstam F; Bergman G; Sonesson SE; Hedlund M; Wahren-Herlenius M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2023;82:705.3-70705

SEX-EQTL ANALYSIS REVEALS A SIGNIFICANT SEXBIAS IN THE EFFECTS OF SJOGREN'S SYNDROME ASSOCIATED ALLELES ON GENE TRANSCRIPTION

Thorlacius GE; Bjork A; Wahren-Herlenius M
Review: ANNALS OF THE RHEUMATIC DISEASES. 2023;82(6):754-762

2022 EULAR points to consider for the measurement, reporting and application of IFN-I pathway activation assays in clinical research and practice.

Rodríguez-Carrio J; Burska A; Conaghan PG; Dik WA; Biesen R; Eloranta M-L; Cavalli G; Visser M; Boumpas DT; Bertsias G; Wahren-Herlenius M; Rehwinkel J; Frémond M-L; Crow MK; Rönnblom L; Versnel MA; Vital EM
Review: NATURE REVIEWS RHEUMATOLOGY. 2023;19(5):288-306

Genetics and epigenetics of primary Sjögren syndrome: implications for future therapies.

Thorlacius GE; Björk A; Wahren-Herlenius M
Review: RMD OPEN. 2023;9(1):e002876

Type I interferon pathway assays in studies of rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider.

Burska A; Rodríguez-Carrio J; Biesen R; Dik WA; Eloranta M-L; Cavalli G; Visser M; Boumpas DT; Bertsias G; Wahren-Herlenius M; Rehwinkel J; Frémond M-L; Crow MK; Ronnblom L; Conaghan PG; Versnel M; Vital E
Review: RMD OPEN. 2023;9(1):e002864

Association between type I interferon pathway activation and clinical outcomes in rheumatic and musculoskeletal diseases: a systematic literature review informing EULAR points to consider.

Rodríguez-Carrio J; Burska A; Conaghan PG; Dik WA; Biesen R; Eloranta M-L; Cavalli G; Visser M; Boumpas DT; Bertsias G; Wahren-Herlenius M; Rehwinkel J; Frémond M-L; Crow MK; Ronnblom L; Vital E; Versnel M
Corrigendum: NATURE COMMUNICATIONS. 2023;14(1):598

Author Correction: Genome-wide association study identifies Sjögren's risk loci with functional implications in immune and glandular cells.

Khatri B; Tessneer KL; Rasmussen A; Aghakhanian F; Reksten TR; Adler A; Alevizos I; Anaya J-M; Aqrawi LA; Baecklund E; Brun JG; Bucher SM; Eloranta M-L; Engelke F; Forsblad-d'Elia H; Glenn SB; Hammenfors D; Imgenberg-Kreuz J; Jensen JL; Johnsen SJA; Jonsson MV; Kvarnström M; Kelly JA; Li H; Mandl T; Martín J; Nocturne G; Norheim KB; Palm Ø; Skarstein K; Stolarczyk AM; Taylor KE; Teruel M; Theander E; Venuturupalli S; Wallace DJ; Grundahl KM; Hefner KS; Radfar L; Lewis DM; Stone DU; Kaufman CE; Brennan MT; Guthridge JM; James JA; Scofield RH; Gaffney PM; Criswell LA; Jonsson R; Eriksson P; Bowman SJ; Omdal R; Rönnblom L; Warner B; Rischmueller M; Witte T; Farris AD; Mariette X; Alarcon-Riquelme ME; PRECISESADS Clinical Consortium; Shiboski CH; Sjögren’s International Collaborative Clinical All; Wahren-Herlenius M; Ng W-F; UK Primary Sjögren’s Syndrome Registry; Sivils KL; Adrianto I; Nordmark G; Lessard CJ
Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2023;41(2):418

ANTI-FHL1 AUTOANTIBODIES IN ADULT MYOSITIS PATIENTS: BASELINE AND LONGITUDINAL FOLLOW-UP ANALYSIS

Galindo-Feria AS; Lodin K; Horuluoglu B; Sarrafzadeh-Zargar S; Wigren E; Graslund S; Danielsson O; Mohammad AJ; Leonard D; Sjowall C; Husmark T; Hemberg M; Puksic S; Lappas T; Hanna B; Wahren-Herlenius M; Dastmalchi M; Lundberg IE
Corrigendum: NATURE COMMUNICATIONS. 2022;13(1):6519

Author Correction: Genome-wide association study identifies Sjögren's risk loci with functional implications in immune and glandular cells.

Khatri B; Tessneer KL; Rasmussen A; Aghakhanian F; Reksten TR; Adler A; Alevizos I; Anaya J-M; Aqrawi LA; Baecklund E; Brun JG; Bucher SM; Eloranta M-L; Engelke F; Forsblad-d'Elia H; Glenn SB; Hammenfors D; Imgenberg-Kreuz J; Jensen JL; Johnsen SJA; Jonsson MV; Kvarnström M; Kelly JA; Li H; Mandl T; Martín J; Nocturne G; Norheim KB; Palm Ø; Skarstein K; Stolarczyk AM; Taylor KE; Teruel M; Theander E; Venuturupalli S; Wallace DJ; Grundahl KM; Hefner KS; Radfar L; Lewis DM; Stone DU; Kaufman CE; Brennan MT; Guthridge JM; James JA; Scofield RH; Gaffney PM; Criswell LA; Jonsson R; Eriksson P; Bowman SJ; Omdal R; Rönnblom L; Warner B; Rischmueller M; Witte T; Farris AD; Mariette X; Alarcon-Riquelme ME; PRECISESADS Clinical Consortium; Shiboski CH; Sjögren’s International Collaborative Clinical All; Wahren-Herlenius M; Ng W-F; UK Primary Sjögren’s Syndrome Registry; Sivils KL; Adrianto I; Nordmark G; Lessard CJ
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2022;81:269-270

SJOGREN'S DISEASE AND SYSTEMIC LUPUS ERYTHEMATOSUS DDX6-CXCR5 RISK INTERVALS REVEAL COMMON SNPS WITH FUNCTIONAL SIGNIFICANCE IN IMMUNE AND SALIVARY GLAND CELLS

Wiley MM; Khatri B; Tessneer KL; Joachims ML; Stolarczyk AM; Nagel A; Rasmussen A; Bowman SJ; Radfar L; Omdal R; Wahren-Herlenius M; Warner BM; Witte T; Jonsson R; Rischmueller M; Gaffney PM; James JA; Ronnblom L; Scofield RH; Mariette X; Ng WF; Sivils K; Nordmark G; Tsao B; Lessard C
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2022;81:72-73

INTEGRATION OF GWAS AND EPIGENETIC STUDIES IDENTIFIES NOVEL GENES THAT ALTER EXPRESSION IN THE MINOR SALIVARY GLAND IN SJOGREN'S DISEASE

Aghakhanian F; Wiley MM; Khatri B; Tessneer KL; Rasmussen A; Bowman SJ; Radfar L; Omdal R; Wahren-Herlenius M; Warner BM; Witte T; Jonsson R; Rischmueller M; Gaffney PM; James JA; Ronnblom L; Scofield RH; Mariette X; Alarcon-Riquelme M; Ng WF; Sivils K; Nordmark G; Deshmukh U; Farris AD; Lessard C
Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2022;40(12):17

TRANSCRIPTOME-WIDE ASSOCIATION STUDY OF SJOGREN'S DISEASE RISK ALLELES IDENTIFIES NOVEL GENES WITH ALTERED EXPRESSION IN MINOR SALIVARY GLAND AND OTHER TISSUES

Radziszewski M; Wiley M; Khatri B; Tessneer K; Rasmussen A; Bowman SJ; Radfar L; Omdal R; Wahren-Herlenius M; Warner B; Witte T; Jonsson R; Rischmueller M; Gaffney P; James JA; Ronnblom L; Scofield RH; Mariette X; Alarcon-Riquelme ME; Ng WF; Sivils K; Nordmark G; Deshmukh U; Farris AD; Lessard CJ
Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2022;40(12):14

FINE MAPPING OF THE DDX6-CXCR5 RISK INTERVAL REVEALS SNPS IN SJOGREN'S DISEASE WITH FUNCTIONAL SIGNIFICANCE IN IMMUNE CELLS AND SALIVARY GLAND

Wiley M; Khatri B; Tessneer K; Joachims M; Stolarczyk A; Nagel A; Rasmussen A; Bowman SJ; Radfar L; Omdal R; Wahren-Herlenius M; Warner B; Witte T; Jonsson R; Rischmueller M; Gaffney P; James JA; Ronnblom L; Scofield RH; Mariette X; Ng WF; Sivils K; Nordmark G; Tsao B; Lessard CJ
Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2022;40(12):26

AUTOPHAGY-RELATED PRDM1-ATG5 RISK LOCUS IN SJOGREN'S DISEASE

Nagel A; Khatri B; Radziszewski M; Wiley M; Stolarczyk A; Joachims M; Tessneer K; Rasmussen A; Bowman SJ; Radfar L; Omdal R; Wahren-Herlenius M; Warner B; Witte T; Jonsson R; Rischmueller M; Gaffney P; James JA; Roennblom L; Scofield RH; Mariette X; Alarcon-Riquelme ME; Ng WF; Nordmark G; Farris AD; Lessard CJ
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2022;74:3981-3982

Fine Mapping of the Sjogren's Disease and Systemic Lupus Erythematosus DDX6-CXCR5 Risk Interval Reveals Common SNPs with Functional Significance in Immune and Salivary Gland Cells

Wiley M; Khatri B; Tessneer K; Joachims M; Stolarczyk A; Nagel A; Rasmussen A; Bowman S; Radfar L; Omdal R; Wahren-Herlenius M; Warner B; Witte T; Jonsson R; Rischmueller M; Gaffney P; James J; Ronnblom L; Scofield H; Mariette X; Ng F; Nordmark G; Tsao B; Lessard C
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2022;74:4557-4560

Fetal Cardiac Targets Identify the Autoantibodies Associated with Congenital Heart Block

Benjamin S; Vi L; Chatterjee D; Jaeggi E; Wahren-Herlenius M; Ruffatti A; Hiraki L; Lohbihler M; Sepiashvili L; Laskin C; Fatah M; Dominguez D; Ng L; Gramolini A; Christoffels V; Protze S; Hamilton R
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2022;74:2223-2225

Transcriptome-Wide Association Study of Sjogren's Disease Risk Alleles Identifies Novel Genes with Altered Expression in Minor Salivary Gland and Other Tissues

Radziszewski M; Wiley M; Khatri B; Tessneer K; Rasmussen A; Bowman S; Radfar L; Omdal R; Wahren-Herlenius M; Warner B; Witte T; Jonsson R; Rischmueller M; Gaffney P; James J; Ronnblom L; Scofield RH; Mariette X; Alarcon-Riquelme M; Ng F; Nordmark G; Deshmukh U; Farris AD; Lessard C
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2022;74:3982-3983

Autophagy-related Risk Loci in Systemic Lupus Erythematous and Sjogren's Disease

Nagel A; Khatri B; Radziszewski M; Wiley M; Stolarczyk A; Joachims M; Tessneer K; Rasmussen A; Bowman S; Radfar L; Omdal R; Wahren-Herlenius M; Warner B; Witte T; Jonsson R; Rischmueller M; Gaffney P; James J; Ronnblom L; Scofield H; Mariette X; Alarcon-Riquelme M; Ng F; Nordmark G; Sun Q; Kim K; Bae S-C; Tsao B; Farris AD; Lessard C
Conference publication: ACTA DERMATO-VENEREOLOGICA. 2022;102:43-44

SKIN INFILTRATING NK CELLS IN PRIMARY CUTANEOUS T-CELL LYMPHOMA ARE INCREASED IN NUMBER AND HAVE AN ALTERED PHENOTYPE PARTLY INDUCED BY THE LYMPHOMA

Scheffschick A; Nenonen J; Winther A; Ehrstrom M; Wahren-Herlenius M; Eidsmo L; Brauner H
Review: RHEUMATOLOGY. 2021;60(6):2561-2573

Innate immunity and interferons in the pathogenesis of Sjögren's syndrome.

Bodewes ILA; Björk A; Versnel MA; Wahren-Herlenius M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2021;80:415

TYPE I INTERFERON PATHWAY ASSAYS IN PATIENTS WITH RHEUMATIC AND MUSCULOSKELETAL DISEASES - SYSTEMATIC LITERATURE REVIEW (SLR) AND DEVELOPMENT OF CONSENSUS TERMINOLOGY FROM A EULAR TASKFORCE

Burska A; Rodriguez Carrio J; Conaghan PG; Dik WA; Biesen R; Eloranta ML; Cavalli G; Visser M; Boumpas D; Bertsias G; Wahren-Herlenius M; Rehwinkel J; Fremond ML; Crow MK; Ronnblom L; Vital E; Versnel M
Corrigendum: RHEUMATOLOGY. 2021;60(3):1575

Erratum to: Interferon activation status underlies higher antibody response to viral antigens in patients with systemic lupus erythematosus receiving no or light treatment.

Björk A; Da Silva Rodrigues R; Richardsdotter Andersson E; Ramírez Sepúlveda JI; Mofors J; Kvarnström M; Oke V; Svenungsson E; Gunnarsson I; Wahren-Herlenius M
Letter: LANCET RHEUMATOLOGY. 2020;2(10):E588-E589

Mortality in congenital heart block.

Sonesson S-E; Wahren-Herlenius M
Editorial comment: ANNALS OF THE RHEUMATIC DISEASES. 2020;79(8):e95

Effects of maternal medication on long-term outcome in congenital heart block remain to be established. Response to: 'Comorbidity and long-term outcome in patients with congenital heart block and their siblings exposed to Ro/SSA autoantibodies in utero' by Satis et al.

Mofors J; Sonesson S-E; Wahren-Herlenius M
Editorial comment: NATURE REVIEWS RHEUMATOLOGY. 2020;16(7):355-356

Learning from similarities between vaccine responses and SLE.

Wahren-Herlenius M; Rönnblom L
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2020;79:335

SKIN PROTEOME INVESTIGATION IN CUTANEOUS LUPUS ERYTHEMATOSUS (CLE) REVEALS NOVEL UNIQUE DISEASE PATHWAYS

Niewold T; Popovic-Silwerfeldt K; Lehman J; Meves A; Charlesworth C; Madden B; Hayry A; Antovic A; Lundberg IE; Wahren-Herlenius M; Svenungsson E; Oke V
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2020;79:30-31

GENOME-WIDE ASSOCIATION STUDY OF SJOGREN'S SYNDROME IDENTIFIES TEN NEW RISK LOCI

Khatri B; Reksten TR; Tessneer KL; Rasmussen A; Scofield RH; Bowman SJ; Guthridge J; James JA; Ronnblom L; Warner BM; Mariette X; Omdal R; Martin Ibanez J; Teruel M; Jensen JL; Aqrawi A; Palm O; Wahren-Herlenius M; Witte T; Jonsson R; Rischmueller M; Farris AD; Alarcon-Riquelme M; Ng WF; Sivils KL; Nordmark G; Lessard C
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2020;79:89-90

FUNCTIONAL EVALUATION OF THE SJOGREN'S SYNDROME AND SYSTEMIC LUPUS ERYTHEMATOSUS DDX6-CXCR5 RISK INTERVAL

Wiley MM; Khatri B; Tessneer KL; Joachims ML; Stolarczyk AM; Rasmussen A; Bowman SJ; Radfar L; Omdal R; Wahren-Herlenius M; Warner BM; Witte T; Jonsson R; Rischmueller M; Gaffney PM; James JA; Ronnblom L; Scofield RH; Mariette X; Ng WF; Sivils KL; Nordmark G; Tsao B; Lessard C
Review: JOURNAL OF INTERNAL MEDICINE. 2020;287(5):475-492

Environmental factors in the pathogenesis of primary Sjögren's syndrome.

Björk A; Mofors J; Wahren-Herlenius M
Letter: LANCET RHEUMATOLOGY. 2020;2(4):E203-E204

Surveillance of congenital heart block in highly specialised care.

Sonesson S-E; Wahren-Herlenius M
Letter: ANNALS OF THE RHEUMATIC DISEASES. 2020;79(2):307-308

Increased risk of multiple myeloma in primary Sjögren's syndrome is limited to individuals with Ro/SSA and La/SSB autoantibodies.

Mofors J; Björk A; Smedby KE; Kvarnström M; Forsblad-d'Elia H; Magnusson-Bucher S; Eriksson P; Mandl T; Baecklund E; Nordmark G; Wahren-Herlenius M
Letter: JOURNAL OF INTERNAL MEDICINE. 2020;287(2):216-217

Response to Letter to the Editor by Bartoloni et al: 'Interplay of anti-SSA/SSB status and hypertension in determining cardiovascular risk in primary Sjögren's syndrome'.

Mofors J; Wahren-Herlenius M; Nordmark G
Letter: EUROPACE. 2020;22(2):330-331

Pacing therapy in children with isolated complete atrioventricular block: a retrospective study of pacing system survival and pacing-related complications in a national cohort-Authors' reply.

Eliasson H; Sonesson S-E; Salomonsson S; Andreasson AS; Wahren-Herlenius M; Gadler F
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2020;72

Genome-wide Association Study of Sjogren's Syndrome Identifies Ten New Risk Loci

Khatri B; Reksten TR; Tessneer K; Rasmussen A; Scofield R; Bowman S; Guthridge J; James J; Ronnblom L; Warner B; Mariette X; Omdal R; Martin J; Teruel M; Jensen JL; Aqrawi L; Palm O; Wahren-Herlenius M; Witte T; Jonsson R; Rischmueller M; Farris AD; Alarcon-Riquelme M; Ng W-F; Sivils K; Nordmark G; Lessard C
Letter: CLINICAL AND EXPERIMENTAL IMMUNOLOGY. 2019;195(3):305-309

FoxP3+ CXCR5+ CD4+ T cell frequencies are increased in peripheral blood of patients with primary Sjögren's syndrome.

Ivanchenko M; Aqrawi LA; Björk A; Wahren-Herlenius M; Chemin K
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2019;71

Systemic Manifestations of Primary Sjogren Syndrome out of the ESSDAI Classification: Prevalence and Clinical Relevance in a Large International, Multi-ethnic Cohort of Patients

Retamozo S; Acar-Denizli N; Rasmussen A; Horvath IF; Baldini C; Priori R; Sandhya P; Hernandez-Molina G; Armagan B; Praprotnik S; Kvarnstrom M; Gerli R; Sebastian A; Solans-Laque R; Rischmueller M; Pasoto SG; Valim V; Nordmark G; Kruize A; Nakamura T; Hofauer B; Giacomelli R; Trevisani VFM; Pensec VD; Atzeni F; Gheita TA; Consani-Fernandez S; Szanto A; Sivils K; Gattamelata A; Danda D; Kilic L; Bartoloni E; Bombardieri S; Sanchez-Guerrero J; Wahren-Herlenius M; Mariette X; Ramos-Casals M; Brito-Zeron P
Letter: ANNALS OF THE RHEUMATIC DISEASES. 2018;77(12):1840-1842

Clinical associations and expression pattern of the autoimmunity susceptibility factor DIORA-1 in patients with primary Sjögren's syndrome.

Aqrawi LA; Mentlein L; Meneghel L; Björk A; Thorlacius GE; Ivanchenko M; Ramírez Sepúlveda JI; Skarstein K; Kvarnström M; Brauner S; Espinosa A; Wahren-Herlenius M
Review: CURRENT OPINION IN RHEUMATOLOGY. 2018;30(5):471-481

An update on the role of type I interferons in systemic lupus erythematosus and Sjögren's syndrome.

Thorlacius GE; Wahren-Herlenius M; Rönnblom L
Letter: ANNALS OF THE RHEUMATIC DISEASES. 2018;77(9):1381-1382

European families reveal MHC class I and II associations with autoimmune-mediated congenital heart block.

Kyriakidis NC; Kockum I; Julkunen H; Hoxha A; Salomonsson S; Meneghel L; Ebbing C; Swedish Congenital Heart Block Study Group; Dilthey A; Eronen M; De Carolis S; Kiserud T; Ruffatti A; Kere J; Meisgen S; Wahren-Herlenius M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2018;77:1190

A NORTH-SOUTH WORLDWIDE GRADIENT IN SYSTEMIC ACTIVITY OF PRIMARY SJOGREN SYNDROME: INCREASED SEVERE DISEASE IN PATIENTS FROM SOUTHERN COUNTRIES

Retamozo S; Acar-Denizli N; Ng WF; Zeher M; Rasmussen A; Seror R; Li X; Baldini C; Gottenberg J-E; Danda D; Quartuccio L; Priori R; Hernandez-Molina G; Armagan B; Kruize AA; Kwok S-K; Wahren-Herlenius M; Praprotnik S; Sene D; Bartoloni E; Solans R; Rischmueller M; Mandi T; Suzuki Y; Isenberg D; Valim V; Wiland P; Nordmark G; Fraile G; Bootsma H; Nakamura T; Giacomelli R; Devauchelle-Pensec V; Hofauer B; Bombardieri M; Fernandes Moca Trevisani V; Hammenfors D; Pasoto SG; Gheita TA; Atzeni F; Morel J; Vollenveider C; Brito-Zeron P; Ramos-Casals M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2018;77:1267

FUNCTIONAL CHARACTERIZATION OF THE SJOGREN'S SYNDROME-ASSOCIATED LOCUS DDX6-CXCR5

Khanam S; Joachims ML; Means N; Omdal R; Wahren-Herlenius M; Alevizos I; Witte T; Jonsson R; Rischmueller M; Rhodus NL; Montgomery C; Ng W-F; Nordmark G; Adrianto I; Sivils K; Lessard C
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2018;77:A19

FAM167A/BLK IS A SUSCEPTIBILITY LOCUS IN AUTOIMMUNE DISEASES: CHARACTERISATION OF THE FAM167 GENE FAMILY

Mentlein L; Thorlacius GE; Meneghel L; Sepulveda JIR; Brauner S; Espinosa A; Wahren-Herlenius M
Corrigendum: CLINICAL IMMUNOLOGY. 2018;187:137-138

Corrigendum to "Klinefelter's syndrome (47,XXY) is in excess among men with Sjögren's syndrome" [Clin. Immunol. 168 (2016) 25-29].

Harris VM; Sharma R; Cavett J; Kurien BT; Liu K; Koelsch KA; Rasmussen A; Radfar L; Lewis D; Stone DU; Kaufman CE; Li S; Segal B; Wallace DJ; Weisman MH; Venuturupalli S; Kelly JA; Alarcon-Riquelme ME; Pons-Estel B; Jonsson R; Lu X; Gottenberg J-E; Anaya J-M; Cunninghame-Graham DS; Huang AJW; Brennan MT; Hughes P; Alevizos I; Miceli-Richard C; Keystone EC; Bykerk VP; Hirschfield G; Xie G; Siminovitch KA; Ng W-F; Nordmark G; Bucher SM; Eriksson P; Omdal R; Rhodus NL; Rischmueller M; Rohrer M; Wahren-Herlenius M; Witte T; Mariette X; Lessard CJ; Harley JB; Sivils KL; Scofield RH
Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2018;36(3):S268-S269

Systemic Sjogren presenting without sicca syndrome: characterization of 240 patients according to the new 2017 ACR/EULAR Classification Criteria

Retamozo S; Acar-Denizli N; Zeher M; Sivils K; Mandl T; Seror R; Li X; Baldini C; Mariette X; Gottenberg J-E; Danda D; Priori R; Quartuccio L; Hernandez-Molina G; Armagan B; Kruize AA; Kwok S-K; Wahren-Herlenius M; Praprotnik S; Sene D; Bartoloni E; Rischmueller M; Solans R; Suzuki Y; Isenberg D; Valim V; Wiland P; Nordmark G; Fraile G; Bootsma H; Nakamura T; Giacomelli R; Devauchelle-Pensec V; Hofauer B; Bombardieri M; Moca Trevisani VF; Hammenfors D; Pasoto SG; Carsons SE; Gheita TA; Atzeni F; Morel J; Vollenveider C; Brito-Zeron P; Ramos-Casals M
Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2018;36(3):S269-S270

Clinical and immunological disease patterns of primary Sjogren syndrome driven by gender and age at diagnosis

Retamozo S; Kostov B; Zeher M; Sivils K; Mandl T; Seror R; Li X; Baldini C; Mariette X; Gottenberg J-E; Danda D; Priori R; Quartuccio L; Hernandez-Molina G; Armagan B; Kruize AA; Kwok S-K; Wahren-Herlenius M; Praprotnik S; Sene D; Bartoloni E; Rischmueller M; Solans R; Suzuki Y; Isenberg D; Valim V; Wiland P; Nordmark G; Fraile G; Bootsma H; Nakamura T; Giacomelli R; Devauchelle-Pensec V; Hofauer B; Bombardieri M; Moca Trevisani VF; Hammenfors D; Pasoto SG; Carsons SE; Gheita TA; Atzeni F; Morel J; Vollenveider C; Brito-Zeron P; Ramos-Casals M
Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2018;36(3):S316-S317

How the different systemic organ involvements are overlapped in patients with primary Sjogren syndrome: analysis using a mathematical model

Retamozo S; Kostov B; Zeher M; Sivils K; Mandl T; Seror R; Li X; Baldini C; Mariette X; Gottenberg J-E; Danda D; Priori R; Quartuccio L; Hernandez-Molina G; Armagan B; Kruize AA; Kwok S-K; Wahren-Herlenius M; Praprotnik S; Sene D; Bartoloni E; Rischmueller M; Solans R; Suzuki Y; Isenberg D; Valim V; Wiland P; Nordmark G; Fraile G; Bootsma H; Nakamura T; Giacomelli R; Devauchelle-Pensec V; Hofauer B; Bombardieri M; Moca Trevisani VF; Hammenfors D; Pasoto SG; Carsons SE; Gheite TA; Atzeni F; Morel J; Vollenveider C; Brito-Zeron P; Ramos-Casals M
Conference publication: JCR-JOURNAL OF CLINICAL RHEUMATOLOGY. 2018;24:S31-S32

HOW ETHNICITY MODIFIES SYSTEMIC ACTIVITY OF PRIMARY SJOGREN SYNDROME: ANALYSIS OF BASELINE ESSDAI SCORES IN A MULTI-ETHNIC INTERNATIONAL COHORT

Retamozo S; Hernandez-Molina G; Valim V; Moca Trevisani VF; Pasoto SG; Acar-Denizli N; Zeher M; Sivils K; Mandl T; Seror R; Li X; Baldini C; Mariette X; Gottenberg J-E; Danda D; Priori R; Quartuccio L; Armagan B; Kruize AA; Kwok S-K; Wahren-Herlenius M; Praprotnik S; Sene D; Bartoloni E; Rischmueller M; Solans R; Suzuki Y; Isenberg D; Wiland P; Nordmark G; Fraile G; Bootsma H; Nakamura T; Giacomelli R; Devauchelle-Pensec V; Hofauer B; Bombardieri M; Hammenfors D; Carsons SE; Gheita TA; Atzeni F; Morel J; Vollenveider C; Ramos-Casals M; Brito-Zeron P
Conference publication: JCR-JOURNAL OF CLINICAL RHEUMATOLOGY. 2018;24:S32-S33

HOW DIFFERENT SYSTEMIC ORGAN INVOLVEMENTS OVERLAP IN PATIENTS WITH PRIMARY SJOGREN SYNDROME: ANALYSIS USING A MATHEMATICAL MODEL

Retamozo S; Hernandez-Molina G; Valim V; Moca Trevisani VF; Pasoto SG; Acar-Denizli N; Zeher M; Sivils K; Mandl T; Seror R; Li X; Baldini C; Mariette X; Gottenberg J-E; Danda D; Priori R; Quartuccio L; Armagan B; Kruize AA; Kwok S-K; Wahren-Herlenius M; Praprotnik S; Sene D; Bartoloni E; Rischmueller M; Solans R; Suzuki Y; Isenberg D; Wiland P; Nordmark G; Fraile G; Bootsma H; Nakamura T; Giacomelli R; Devauchelle-Pensec V; Hofauer B; Bombardieri M; Hammenfors D; Carsons SE; Gheita TA; Atzeni F; Morel J; Vollenveider C; Ramos-Casals M; Brito-Zeron P
Conference publication: JCR-JOURNAL OF CLINICAL RHEUMATOLOGY. 2018;24:S29-S30

SYSTEMIC SJOGREN PRESENTING WITHOUT SICCA SYNDROME: CHARACTERIZATION OF 240 PATIENTS ACCORDING TO THE NEW 2017 ACR/EULAR CLASSIFICATION CRITERIA

Retamozo S; Hernandez-Molina G; Valim V; Moca Trevisani VF; Pasoto SG; Acar-Denizli N; Zeher M; Sivils K; Mandl T; Seror R; Li X; Baldini C; Mariette X; Gottenberg J-E; Danda D; Priori R; Quartuccio L; Armagan B; Kruize AA; Kwok S-K; Wahren-Herlenius M; Praprotnik S; Sene D; Bartoloni E; Rischmueller M; Solans R; Suzuki Y; Isenberg D; Wiland P; Nordmark G; Fraile G; Bootsma H; Nakamura T; Giacomelli R; Devauchelle-Pensec V; Hofauer B; Bombardieri M; Hammenfors D; Carsons SE; Gheita TA; Atzeni F; Morel J; Vollenveider C; Ramos-Casals M; Brito-Zeron P
Conference publication: JCR-JOURNAL OF CLINICAL RHEUMATOLOGY. 2018;24:S30-S31

CLINICAL AND IMMUNOLOGICAL PRIMARY SJOGREN SYNDROME' DISEASE PATTERNS ARE DRIVEN BY GENDER AND AGE AT DIAGNOSIS

Retamozo S; Hernandez-Molina G; Valim V; Moca Trevisani VF; Pasoto SG; Acar-Denizli N; Zeher M; Sivils K; Mandl T; Seror R; Li X; Baldini C; Mariette X; Gottenberg J-E; Danda D; Priori R; Quartuccio L; Armagan B; Kruize AA; Kwok S-K; Wahren-Herlenius M; Praprotnik S; Sene D; Bartoloni E; Rischmueller M; Solans R; Suzuki Y; Isenberg D; Wiland P; Nordmark G; Fraile G; Bootsma H; Nakamura T; Giacomelli R; Devauchelle-Pensec V; Hofauer B; Bombardieri M; Hammenfors D; Carsons SE; Gheita TA; Atzeni F; Morel J; Vollenveider C; Ramos-Casals M; Brito-Zeron P
Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2018;36(3):S270

How ethnicity modifies systemic activity of primary Sjogren syndrome: analysis of baseline ESSDAI scores in a multi-ethnic international cohort

Retamozo S; Kostov B; Zeher M; Sivils K; Mandl T; Seror R; Li X; Baldini C; Mariette X; Gottenberg J-E; Danda D; Priori R; Quartuccio L; Hernandez-Molina G; Armagan B; Kruize AA; Kwok S-K; Wahren-Herlenius M; Praprotnik S; Sene D; Bartoloni E; Rischmueller M; Solans R; Suzuki Y; Isenberg D; Valim V; Wiland P; Nordmark G; Fraile G; Bootsma H; Nakamura T; Giacomelli R; Devauchelle-Pensec V; Hofauer B; Bombardieri M; Moca Trevisani VF; Hammenfors D; Pasoto SG; Carsons SE; Gheita TA; Atzeni F; Morel J; Vollenveider C; Brito-Zeron P; Ramos-Casals M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2018;70

Clinical Correlations and Expression Pattern of the Autoimmunity Susceptibility Factor Diora-1 in Primary Sjogren's Syndrome

Meneghel L; Aqrawi L; Mentlein L; Bjork A; Thorlacius GE; Ivanchenko M; Ramirez J; Skarstein K; Kvarnstrom M; Brauner S; Espinosa A; Wahren-Herlenius M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2018;70

Comparative Analysis of the Total Proteome of the Skin Lesions from Cutaneous Lupus Erythematosus (CLE) and Dermatomyositis (DM)

Niewold TB; Meves A; Lehman JS; Popovic-Silwerfeldt K; Charlesworth C; Wahren-Herlenius M; Svenungsson E; Oke V
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2018;70

How Immunological Profile Drives Clinical Phenotype of Primary Sjogren's Syndrome at Diagnosis: Analysis of 10.500 Patients (Sjogren Big Data Project)

Retamozo S; Acar-Denizli N; Ng W-F; Zeher M; Rasmussen A; Mandl T; Seror R; Li X; Baldini C; Gottenberg J-E; Danda D; Quartuccio L; Priori R; Hernandez-Molina G; Armagan B; Kruize AA; Kwok S-K; Kvarnstrom M; Praprotnik S; Sene D; Bartoloni E; Solans R; Rischmueller M; Suzuki Y; Isenberg DA; Valim V; Wiland P; Nordmark G; Fraile G; Bootsma H; Nakamura T; Giacomelli R; Devauchelle-Pensec V; Knopf A; Bombardieri M; Trevisani VF; Hammenfors DS; Pasoto SG; Gheita TA; Atzeni F; Morel J; Vollenveider C; Horvath I-F; Sivils KL; Olsson P; De Vita S; Sanchez-Guerrero J; Kilic L; Wahren-Herlenius M; Mariette X; Ramos-Casals M; Brito-Zeron P
Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2018;36(3):S330

Cigarette smoking is a risk factor for developing primary Sjogren's syndrome with Ro/SSA and La/SSB autoantibodies

Bjork A; Mofors J; Kvarnstrom M; Forsblad-d'Elia H; Bucher SM; Hillert J; Eriksson P; Mandl T; Nordmark G; Alfredsson L; Wahren-Herlenius M
Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2018;36(3):S331-S332

Primary Sjogren's syndrome increases the risk of cardiovascular events, with the highest risk in SSA/SSB autoantibody positive patients

Mofors J; Westermark L; Bjork A; Kvarnstrom M; Forsblad-d'Elia H; Bucher SM; Eriksson P; Mandl T; Wahren-Herlenius M; Nordmark G
Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2018;36(3):S248-S249

Infections predispose to developing primary Sjogren's syndrome

Mofors J; Arkema EV; Westermark L; Bjorki A; Kvarnstrom M; Forsblad-d'Elia H; Bucher SM; Eriksson P; Mandl T; Nordmark G; Wahren-Herlenius M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2018;70

NRo52/Trim21 Influences Follicular B Cell Homeostasis and Immunoglobulin Production

Ivanchenko M; Brauner S; Thorlacius GE; Ambrosi A; Wahren-Herlenius M
Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2018;36(3):S246-S247

Genetic basis and clinical evidence for two variants of primary Sjogren's syndrome with distinct outcomes

Thorlacius GE; Hultin-Rosenberg L; Sandling JK; Imgenberg-Kreuz J; Theander E; Kvarnstrom M; Forsblad-d'Elia H; Bucher SM; Norheim KB; Johnsen SJ; Hammenfors D; Skarstein K; Jonsson MV; Baecklund E; Mandl T; Eriksson P; Omdal R; Jonsson R; Lindbladh-Toh K; Ronnblom L; Wahren-Herlenius M; Nordmark G
Conference publication: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2018;36(3):S289

Immune activation following seasonal influenza vaccination in patients with primary Sjogren's syndrome

Bjork A; Thorlacius GE; Mofors J; Kvarnstrom M; Wahren-Herlenius M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2017;76:309-310

COMPARISON OF CLASSIFICATION CRITERIA FOR SJOGREN'S SYNDROME FROM 2002 AND 2016 IN AN INCIDENT COHORT DIAGNOSED 2007 TO 2011 FROM STOCKHOLM COUNTY SWEDEN

Kvarnstrom M; Wahren-Herlenius M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2017;76:A7

TYPE I IFN SYSTEM ACTIVATION IN NEWBORNS EXPOSED TO ANTI-RO/SSA AUTOANTIBODIES IN UTERO

Hedlund M; Thorlacius GE; Ivanchenko M; Kyriakidis N; Ronnblom L; Eloranta M-L; Espinosa A; Sonesson S-E; Wahren-Herlenius M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2017;69

Epidemiologic Subsets Drive a Differentiated Clinical and Immunological Presentation of Primary Sjogren Syndrome: Analysis of 9302 Patients from the Big Data International Sjogren Cohort

Retamozo S; Brito-Zeron P; Zeher M; Sivils KL; Seror R; Mandl T; Li X; Baldini C; Gottenberg J-E; Danda D; Priori R; Quartuccio L; Hernandez-Molina G; Kruize AA; Kwok S-K; Wahren-Herlenius M; Praprotnik S; Sene D; Gerli R; Solans R; Suzuki Y; Isenberg DA; Rischmueller M; Nordmark G; Fraile G; Wiland P; Bootsma H; Nakamura T; Valim V; Giacomelli R; Devauchelle-Pensec V; Hofauer B; Bombardieri M; Moca Trevisani VF; Hammenfors DS; Carsons SE; Pasoto SG; Morel J; Gheita T; Atzeni F; Vollenweider CF; Kostov B; Mariette X; Ramos-Casals M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2017;69

Comparison of Classification Criteria for Sjogren's Syndrome from 2002 and 2016 in an Incident Cohort Diagnosed 2007 to 2011 from Stockholm County Sweden

Kvarnstrom M; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):321

Identification of cross-reactive targets of anti-Ro52 antibodies in congenital heart block

Meneghel L; Mattsson C; Meisgen S; Nilsson P; Wahren-Herlenius M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2017;69

Difference in Clinical Presentation between Female and Male Patients with Primary Sjogren's Syndrome at Diagnosis and in Long-Term Follow-up

Ramirez J; Kvarnstrom M; Brauner S; Baldini C; Eriksson P; Mandl T; Norheim KB; Johnsen SJ; Hammenfors DS; Jonsson MV; Skarstein K; Brun JG; Ronnblom L; D'Elia HF; Bucher SM; Theander E; Omdal R; Jonsson R; Nordmark G; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):324

Expression of CXCR5 is decreased in the periphery of patients with primary Sjogren's syndrome

Aqrawi LA; Ivanchenko M; Bjork A; Ramirez J; Kvarnstrom M; Jensen JL; Skarstein K; Wahren-Herlenius M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2017;69

Expression Patterns of Interferon Induced Genes in Newborns Exposed to Ro/SSA Autoantibodies in Utero

Thorlacius GE; Hedlund M; Ivanchenko M; Ottosson V; Ossoinak A; Lagnefeldt L; Ronnblom L; Sonesson S-E; Eloranta M-L; Wahren-Herlenius M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2017;69

Ro/SSA Autoantibody Exposed Neonates Have an Expansion of NK Cells and a Discernible Type II IFN Signature with High IFNγ in Peripheral Blood

Ivanchenko M; Hedlund M; Thorlacius GE; Ottosson V; Chemin K; Sonesson S-E; Wahren-Herlenius M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2017;69

Immune Response to Seasonal Flu Vaccination in Patients with Primary Sjogren's Syndrome

Bjork A; Kvarnstrom M; Thorlacius GE; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):327

Immune response to seasonal flu vaccination in patients with primary Sjogren's syndrome

Bjork A; Kvarnstrom M; Thorlacius G-E; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2017;86(4):320

Characterization of the FAM167 gene family

Mentlein L; Meneghel L; Thorlacius G-E; Ramirez J; Brauner S; Espinosa A; Wahren-Herlenius M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2016;75:772

ETHNIC DIFFERENCES STRONGLY INFLUENCE THE PHENOTYPIC EXPRESSION OF PRIMARY SJOGREN: STUDY OF 7887 PATIENTS FROM 20 COUNTRIES ON 5 CONTINENTS (EULAR-SS TASK FORCE BIG DATA SJOGREN PROJECT)

Brito-Zeron P; Acar-Denizli N; Zeher M; Rasmussen A; Seror R; Mandl T; Li X; Baldini C; Gottenberg J-E; Danda D; Quartuccio L; Priori R; Hernandez-Molina G; Kruize A; Valim V; Kvarnstrom M; Sene D; Gerli R; Praprotnik S; Isenberg D; Solans R; Rischmueller M; Park S-H; Nordmark G; Suzuki Y; Giacomelli R; Saraux A; Bombardieri M; Hofauer B; Bootsma H; Hammenfors D; Fraile G; Carsons S; Gheita T; Morel J; Vollenveider C; Atzeni F; Retamozo S; Horvath I-F; Sivils K; Theander E; Sandhya P; De Vita S; Sanchez-Guerrero J; van der Heijden E; Moca-Trevisano V; Wahren-Herlenius M; Mariette X; Ramos-Casals M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2016;75:314-315

WORLDWIDE HETEROGENEOUS DIAGNOSTIC APPROACH TO PRIMARY SJOGREN SYNDROME IN 8315 PATIENTS (EULAR-SS TASK FORCE BIG DATA SJOGREN PROJECT)

Brito-Zeron P; Acar-Denizli N; Zeher M; Rasmussen A; Seror R; Mandl T; Li X; Baldini C; Gottenberg J-E; Danda D; Quartuccio L; Priori R; Hernandez-Molina G; Kruize A; Valim V; Kvarnstrom M; Sene D; Bartoloni E; Praprotnik S; Isenberg D; Solans R; Rischmueller M; Kwok S-K; Nordmark G; Suzuki Y; Giacomelli R; Devauchelle-Pensec V; Bombardieri M; Hofauer B; Bootsma H; Hammenfors D; Fraile G; Carsons S; Gheita T; Morel J; Vollenveider C; Atzeni F; Retamozo S; Horvath I-F; Sivils K; Theander E; Sandhya P; De Vita S; Sanchez-Guerrero J; van der Heijden E; Moca-Trevisano V; Wahren-Herlenius M; Mariette X; Ramos-Casals M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2016;68

Identification and Characterization of Sjogren's Syndrome-Associated Genetic Variants in the IL12A and DDX6-CXCR5 Loci

Joachims ML; Adrianto I; Johnston A; Ice J; Rasmussen A; Bowman S; Lewis DM; Radfar L; Omdal R; Wahren-Herlenius M; Alevizos I; Witte T; Jonsson R; Rischmueller M; Gaffney PM; James JA; Ronnblom L; Theander E; Rhodus NL; Segal BM; Scofield RH; Montgomery CG; Mariette X; Ng W-F; Nordmark G; Sivils KL; Lessard CJ
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2016;68

Very Rare X Chromosome Abnormalities in SLE and SjoGren's May Localize X Gene Dose Effect

Sharma R; Harris VM; Cavett J; Kurien BT; Liu K; Koelsch KA; Radfar L; Lewis DM; Stone DU; Kaufman CE; Li S; Segal BM; Wallace DJ; Weisman M; Kelly JA; Pons-Estel B; Jonsson R; Gottenberg J-E; Anaya J-M; Cunninghame-Graham DS; Bykerk VP; Hirschfield G; Xie G; Ng W-F; Nordmark G; Eriksson P; Omdal R; Rhodus NL; Rischmueller M; Rohrer MD; Wahren-Herlenius M; Witte T; Mariette X; Lessard CJ; Harley JB; Sivils KL; Rasmussen A; Scofield RH; Venturopalli S; Lu X; Hughes P; Huang AJW; Miceli-Richard C
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2016;68

How Does Primary Sjogren Syndrome Present in Biopsy-Proven Patients without Circulating Ro/La Autoantibodies? Characteristics at Diagnosis of 2073 Patients from the SjoGren Big Data Project

Brito-Zeron P; Acar-Denizli N; Zeher M; Rasmussen A; Seror R; Theander E; Li X; Baldini C; Gottenberg J-E; Danda D; Quartuccio L; Priori R; Hernandez-Molina G; Kruize AA; Valim V; Kvarnstrom M; Sene D; Gerli R; Praprotnik S; Isenberg DA; Solans R; Rischmueller M; Kwok S-K; Nordmark G; Suzuki Y; Giacomelli R; Devauchelle-Pensec V; Bombardieri M; Hofauer B; Bootsma H; Brun JG; Fraile G; Carsons SE; Gheita T; More J; Vollenweider CF; Atzeni F; Retamozo S; Horvath I-F; Sivils K; Mand T; Sandhya P; De Vita S; Sanchez-Guerrero J; van der Heijden E; Trevisano VM; Wahren-Herlenius M; Mariette X; Ramos-Casals M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2016;68

Isolated Anti-La/SS-B Positivity in Patients Diagnosed with Primary Sjogren Syndrome: Analysis of 222 Patients from the Sjogren Big Data Cohort

Brito-Zeron P; Acar-Denizli N; Zeher M; Rasmussen A; Seror R; Theander E; Li X; Baldini C; Gottenberg J-E; Danda D; Quartuccio L; Priori R; Hernandez-Molina G; Kruize AA; Valim V; Kvarnstrom M; Sene D; Gerli R; Praprotnik S; Isenberg DA; Solans R; Rischmueller M; Kwok S-K; Nordmark G; Suzuki Y; Giacomelli R; Devauchelle-Pensec V; Bombardieri M; Hofauer B; Bootsma H; Brun JG; Fraile G; Carsons SE; Gheita T; Morel J; Vollenweider CF; Atzeni F; Retamozo S; Horvath I-F; Sivils K; Mandl T; Sandhya P; De Vita S; Sanchez-Guerrero J; van der Heijden E; Trevisano VM; Wahren-Herlenius M; Ramos-Casals M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2016;68

Sjogren Big Data Project: Influence of Geolocation on the Phenotypic Expression at Diagnosis in 8310 Patients (North-to-South Gradient)

Brito-Zeron P; Retamozo S; Zeher M; Rasmussen A; Seror R; Theander E; Li X; Baldini C; Gottenberg J-E; Danda D; Quartuccio L; Priori R; Hernandez-Molina G; Kruize AA; Valim V; Kvarnstrom M; Sene D; Gerli R; Praprotnik S; Isenberg DA; Solans R; Rischmueller M; Kwok S-K; Nordmark G; Suzuki Y; Giacomelli R; Devauchelle V; Bombardieri M; Hofauer B; Bootsma H; Brun JG; Fraile G; Carsons SE; Gheita T; Morel J; Vollenweider CF; Atzeni F; Acar-Denizli N; Horvath I-F; Sivils K; Mandl T; Sandhya P; De Vita S; Sanchez-Guerrero J; Van der Heijden E; Trevisano VM; Wahren-Herlenius M; Mariette X; Ramos-Casals M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2016;68

Expression of the Chemokine Receptor CXCR5 Is Decreased in the Periphery of Patients with Primary Sjogren's Syndrome

Wahren-Herlenius M; Aqrawi LA; Ivanchenko M; Bjork A; Ramirez J; Kvarnstrom M; Jensen JCL; Skarstein K
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2016;68

Genome-Wide Association Study Identifies Novel Sjogren's Syndrome Risk Loci in the Regions of NAB1, TYK2, and PTTG1-mir146a

Lessard CJ; Adrianto I; Ice J; Rasmussen A; Grundahl K; Kelly JA; Scofield RH; Bowman S; Lester S; Eriksson P; Eloranta M-L; Brun JG; Goransson LG; Harboe E; Kvarnstrom M; Brernnan MT; Chodosh J; Gopalakrishnan R; Huang AJW; Hughes P; Lewis DM; Rohrer MD; Stone DU; Rhodus NL; Segal BM; Radfar L; Farris AD; Guthridge JM; Gaffney PM; James JA; Harley JB; Ronnblom L; Anaya J-M; Cunninghame-Graham DS; Vyse TJ; Alevizos I; Mariette X; Omdal R; Wahren-Herlenius M; Witte T; Jonsson R; Rischmueller M; Criswell LA; Montgomery CG; Ng W-F; Nordmark G; Sivils KL
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2016;68

Expression of IFN-Regulated Genes in Autoantibody Exposed Babies in Utero

Hedlund M; Thorlacius G-E; Ivanchenko M; Ottosson V; Ossoinak A; Lagnefeldt L; Tingstrom J; Espinosa A; Ronnblom L; Eloranta M-L; Sonesson S-E; Wahren-Herlenius M
Review: CURRENT OPINION IN RHEUMATOLOGY. 2015;27(5):468-475

Update on the immunobiology of Sjögren's syndrome.

Ambrosi A; Wahren-Herlenius M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2015;74:578

BIG DATA SJOGREN PROJECT (EULAR-SS TASK FORCE INTERNATIONAL NETWORK): SYSTEMIC INVOLVEMENT AT DIAGNOSIS EVALUATED BY THE ESSDAI IN 3314 PATIENTS WITH PRIMARY SJOGREN SYNDROME

Zeron PB; Kostov BA; Seror R; Baldini C; Quartuccio L; Kvarnstrom M; Kruize A; Molina GH; Praprotnik S; Bartoloni E; Solans R; Theander E; Valim V; Priori R; Zeher M; Isenberg D; Rasmussen A; Giacomelli R; Carsons S; Hammenfors D; Vollenweider C; Atzeni F; Mandl T; De Vita S; Wahren-Herlenius M; Sanchez-Guerrero J; Gerli R; Sivils K; Mowa S; Brun JG; Mariette X; Ramos-Casals M
Review: AUTOIMMUNITY REVIEWS. 2015;14(5):376-386

State of the art: Reproduction and pregnancy in rheumatic diseases.

Østensen M; Andreoli L; Brucato A; Cetin I; Chambers C; Clowse MEB; Costedoat-Chalumeau N; Cutolo M; Dolhain R; Fenstad MH; Förger F; Wahren-Herlenius M; Ruiz-Irastorza G; Koksvik H; Nelson-Piercy C; Shoenfeld Y; Tincani A; Villiger PM; Wallenius M; von Wolff M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2015;67

Klinefelter's Syndrome (47,XXY) Among Men with Sjogren's Syndrome

Harris VM; Cavett J; Kurien B; Liu K; Koelsch KA; Radfar L; Lewis DM; Stone DU; Li S; Segal B; Wallace DJ; Weisman MH; Kelly JA; Alarcon-Riquelme M; Pons-Estel B; Jonsson R; Lu X; Gottenberg J; Anaya J-M; Cunninghame-Graham DS; Keystone EC; Huang AJW; Brennan MT; Hughes P; Illei G; Miceli C; Bykerk VP; Hirschfield G; Xie G; Ng W-F; Nordmark G; Eriksson P; Omdal R; Rhodus NL; Rischmueller M; Rohrer MD; Wahren-Herlenius M; Witte T; Mariette X; Lessard C; Harley JB; Sivils KL; Scofield RH
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2015;67

Big Data International Primary Sjogren Syndrome Registry: Baseline Characterization and Diagnostic Approach in 6047 Patients Fulfilling the 2002 AE Criteria

Brito-Zeron P; Retamozo S; Zeher M; Rasmussen A; Theander E; Gottenberg J; Baldini C; Quartuccio L; Priori R; Valim V; Kvarnstrom M; Kruize A; Hernandez-Molina G; Bartoloni-Bocci E; Praprotnik S; Isenberg DA; Nordmark G; Bombardieri M; Suzuki Y; Solans R; Giacomelli R; Hammenfors DS; Carsons SE; Boostma H; Vollenweider CF; Atzeni F; Sivils K; Mandl T; De Vita S; Wahren-Herlenius M; Kawano M; Gerli R; Vissink A; Brun JG; Trevisani V; Sanchez-Guerrero J; Mariette X; Ramos-Casals M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2015;81(5):444

Characterization of Baseline Systemic Activity Using the New ClinESSDAI in the Big Data Sjogren Project Cohort: Analysis in 3316 Patients

Brito-Zeron P; Kostov BA; Seror R; Baldini C; Quartuccio L; Kvarnstrom M; Kruize A; Hernandez-Molina G; Praprotnik S; Bartoloni E; Solans R; Theander E; Valim V; Priori R; Zeher M; Isenberg D; Rasmussen A; Giacomelli R; Carsons S; Hammenfors D; Vollenweider C; Atzeni F; Mandl T; De Vita S; Wahren-Herlenius M; Sanchez-Guerrero J; Gerli R; Sivils K; Mowa S; Brun JG; Mariette X; Ramos-Casals M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2015;81(5):441-442

Clinical and Immunological Characterization at Diagnosis of 5041 Patients with Primary Sjogren Syndrome Fulfilling the 2002 AE Classification Criteria: The Big Data International Sjogren Project

Brito-Zeron P; Kostov BA; Zeher M; Theander E; Gottenberg JE; Baldini C; Quartuccio L; Priori R; Kvarnstrom M; Kruize A; Hernandez-Molina G; Praprotnik S; Isenberg D; Bartoloni E; Rasmussen A; Solans R; Valim V; Giacomelli R; Carsons S; Hammenfors D; Vollenweider C; Atzeni F; Mandl T; De Vita S; Wahren-Herlenius M; Sanchez-Guerrero J; Gerli R; Sivils K; Mowa S; Brun JG; Mariette X; Ramos-Casals M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2015;67

Identification of Four-and-a-Half-LIM Domain 1 (FHL1) As a New Autoantibody Target in Idiopathic Inflammatory Myopathies

Albrecht I; Wick C; Hallgren A; Tjarnlund A; Nagaraju K; Andrade F; Thompson K; Coley W; Phadke A; Diaz-Gallo L-M; Bottai M; Nennesmo I; Chemin K; Herrath J; Johansson K; Wikberg A; Ytterberg J; Zubarev R; Danielsson O; Krystufkova O; Vencovsky J; Landegren N; Wahren-Herlenius M; Padyukov L; Kampe O; Lundberg IE
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2015;67

Sjogren's Syndrome in Male Patients Presents with Higher Autoantibody Levels and More Extraglandular Manifestations

Ramirez J; Kvarnstrom M; Wahren-Herlenius M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2015;67

Identification of Novel Sjogren's Syndrome Risk Loci in the Regions of TNFAIP3 and PRDM1

Lessard CJ; Li H; Ice J; Adrianto I; Rasmussen A; Grundahl K; Kelly JA; Miceli C; Bowman S; Lester S; Brun JG; Goransson LG; Harboe E; Guthridge JM; Kaufman KM; Eriksson P; Eloranta M-L; Kvarnstrom M; Cunninghame-Graham DS; Farris AD; Brennan MT; Chodosh J; Gopalakrishnan R; Huang AJW; Hughes P; Lewis DM; Radfar L; Rohrer MD; Stone DU; Vyse TJ; Gaffney PM; James JA; Harley JB; Omdal R; Wahren-Herlenius M; Illei GG; Witte T; Jonsson R; Rischmueller M; Ronnblom L; Mariette X; Anaya J-M; Ng W-F; Nordmark G; Montgomery CG; Rhodus NL; Segal BM; Scofield RH; Sivils KL
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2015;81(5):416

Early B Cell Factor 1 is Associated to Clinical Manifestations in Primary Sjogren's Syndrome and SLE

Bolin K; Leonard D; Gunnarsson I; Sjowall C; Eriksson P; Forsblad-d'Elia H; Jonsen A; Theander E; Omdal R; Jonsson R; Sivils K; Wahren-Herlenius M; Ronnblom L; Nordmark G
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2015;81(5):397

Comparison between Multiplex and Routine Clinical Immunology Analysis of Antibodies Against SSA and SSB

Signer L; Brokstad K; Vasaitis L; Kvarnstrom M; Sjowall C; Eriksson P; Theander E; Jonsson R; Wahren-Herlenius M; Nordmark G
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2015;67

Auxilin Is a Novel Susceptibility Gene for Congenital Heart Block Modulating Cardiac Function

Meisgen S; Hedlund M; Ambrosi A; Folkersen L; Dzikaite-Ottosson V; Ding B; Strandberg L; Biavati L; Ramskold D; Forsberg D; Bergin L; Ruhrmann S; Hamilton RM; Franco-Cereceda A; Hamsten A; Olsson T; Greene L; Eriksson P; Gemzell-Danielsson K; Salomonsson S; Kuchroo VK; Herlenius E; Kockum I; Sonesson S-E; Wahren-Herlenius M
Review: EXPERIMENTAL CELL RESEARCH. 2014;325(1):2-9

Molecular mechanisms of congenital heart block.

Ambrosi A; Sonesson S-E; Wahren-Herlenius M
Conference publication: JOURNAL OF IMMUNOLOGY. 2014;192:46.2

X chromosome dose and sex bias in autoimmune diseases: increased 47,XXX in systemic lupus erythematosus and Sjogren's syndrome

Liu K; Kurien B; Zimmerman S; Kaufman K; Mariette X; Kottyan L; Jonsson R; Ng W-F; Omdal R; Rischmueller M; Wahren-herlenius M; James J; Lessard C; Thompson S; Gaffney P; Montgomery C; Siminovitch K; Edberg J; Kimberly R; Tsao B; McCune W; Salmon J; Sivils K; Harley J; Scofield R
Letter: AUTOIMMUNITY REVIEWS. 2014;13(1):70-72

Letter to the Editor in response to the article "Preventing congenital neonatal heart block in offspring of mothers with anti-SSA/Ro and SSB/La antibodies: a review of published literature and registered clinical trials." by Gleicher N, Elkayam U, Autoimmun Rev. 2013 Sep;12(11):1039-45.

Costedoat-Chalumeau N; Izmirly P; Clancy R; Saxena A; Wahren-Herlenius M; Silverman E; Brucato A; Boutjdir M; Khamashta M; Llanos C; Pisoni CN; Friedman DM; Phoon CKL; Buyon JP
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;79(6):461-462

Identification of Molecules Targeted by Ro52 Autoantibodies in the Development of Congenital Heart Block

Tworus K; Meisgen S; Mattson C; Nilsson P; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;79(6):455

Cardiopathogenic Role of Human RO/SSA and LA/SSA Antibodies in a Novel Animal Model of Congenital Heart Block

Ottosson V; Hoxha A; Ruffatti A; Ottosson L; Hedlund M; Del Ross T; Punzi L; Sonesson S-E; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;79(6):453-454

Ro52/TRIM21 Expression is Decreased in Malignant B Cells

Ivanchenko M; Brauner S; Enblad G; Sundstrom C; Backlin C; Baecklund E; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2014;43:87-88

An NFKB1 gene promoter polymorphism is associated with primary Sjogren's syndrome

Nordmark G; Vasaitis L; Theander E; Kvarnstrom M; Johnsen SJ; Brun JG; Jonsson MV; Sjowall C; Forsblad-d'Elia H; Wahren-Herlenius M; Omdal R; Jonsson R; Eloranta M-L; Eriksson P
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;79(6):461

Sex-Biased Expression of Sjogren's Syndrome Susceptibility Genes

Ramirez J; Thorlacius GE; Bergman T; Brauner S; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2014;79(6):454-455

Characterization of the Sjogren's Syndrome Susceptibility Genes Fam167/Blk

Thorlacius GE; Bergman T; Brauner S; Espinosa A; Wahren-Herlenius M
Review: JOURNAL OF INTERNAL MEDICINE. 2013;273(6):544-554

Cutaneous lupus erythematosus: clinical aspects and molecular pathogenesis.

Oke V; Wahren-Herlenius M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2013;71:481

ANTI-R052 AUTOANTIBODY EPITOPE MAPPING IN EUROPEAN COHORT OF MYOSITIS PATIENTS

Krystufkova O; Dzikatite V; Charles PJ; Mann HF; Ekholm L; Vincze M; Putova I; Kasprikova N; Padyukov L; Danko K; Novota P; Vencovsky J; Wahren-Herlenius M; Lundberg IE
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2013;72:A40

Ro52 EXPRESSION IS A PROGNOSTIC FACTOR FOR SURVIVAL IN B CELL LYMPHOMA

Brauner S; Zhou W; Backlin C; Green TM; Young KH; Lofstrom B; Lundberg I; Pedersen LM; Moller MB; Sundstrom C; Enblad G; Baecklund E; Wahren-Herlenius M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2013;72:A56

The HLA Locus Contains Novel Foetal Susceptibility Alleles For Congenital Heart Block with Significant Paternal Influence

Gorgen S; Ostberg T; Salomonsson S; Ding B; Eliasson H; Malarstig A; Alfredsson L; Klareskog L; Hamsten A; Olsson T; Axelsson T; Gadler F; Jonzon A; Sonesson S-E; Kockum I; Wahren-Herlenius M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2013;72:462-463

DEFINING THE PATHOGENETIC AUTOANTIBODIES IN CONGENITAL HEART BLOCK

Hoxha A; Ruffatti A; Ottosson V; Anandapadmanaban M; Tonello M; Punzi L; Sunnerhagen M; Wahren-Herlenius M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2013;65:S379

Sex Bias In Autoimmune Diseases: Increased Risk Of 47,XXX In Systemic Lupus Erythematosus (SLE) and Sjogren's Syndrome (SS) Supports The Gene Dose Hypothesis

Liu K; Kaufman KM; James JA; Jonsson R; Kurien BT; Mariette X; Merrill JT; Omdal R; Rischmueller M; Vyse TJ; Wahren-Herlenius M; Witte T; Lessard CJ; Zimmerman SL; Thompson SD; Hirschfield G; Xie G; Montgomery CG; Ng W-F; Nordmark G; Gaffney PM; Siminovitch KA; Sivils KL; Scofield RH
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2013;65:S1184-S1185

Complex Functional Effects Within The HLA Contribute To Sjogren's Syndrome Pathogenesis and May Influence Both Transcriptional Regulation and Peptide Binding.

Lessard CJ; Li H; Adrianto I; Ice JA; Dozmorov MG; Jonsson R; Rischmueller M; Nordmark G; Mariette X; Miceli-Richard C; Wahren-Herlenius M; Witte T; Brennan MT; Omdal R; Ronnblom L; Gaffney PM; Ng W-F; Rhodus NL; Segal BM; Wren JD; Scofield RH; Anaya J-M; Harley JB; Montgomery CG; Sivils KL
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2013;72:78-79

CARDIOPATHOGENIC ROLE OF HUMAN RO/SSA AND LA/SSA ANTIBODIES DEMONSTRATED IN A NOVEL ANIMAL MODEL OF CONGENITAL HEART BLOCK

Hoxha A; Ruffatti A; Ottosson V; Ottosson L; Hedlund M; Del Ross T; Punzi L; Sonesson S-E; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2013;77(4):316

Elevated Plasma IL-7 Levels in Multiple Sclerosis Patients Treated with Interferon Beta are Caused by Decreased Cell Consumption

Hermanrud C; Lundstrom W; Sjostrand M; Brauner S; Wahren-Herlenius M; Olsson T; Karrenbauer VD; Hillert J; Fogdell-Hahn A
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2013;72:256

EFFICACY AND SAFETY OF A COMBINED TREATMENT PROTOCOL FOR 2ND DEGREE CONGENITAL HEART BLOCK

Hoxha A; Ottosson V; Brauner S; Wahren-Herlenius M; Favaro M; Calligaro A; Facchinetti M; Ruffatti A; Punzi L
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2013;65:S634-S635

Endosomal TLR Triggering Of B Cells In Sjogren's Syndrome Induces Increased Plasma Cells Differentiation, Ig Class Switch and Immunoglobulin Production

Wahren-Herlenius M; Brauner S; Kvarnstrom M; Folkersen L; Gorgen S; Trollmo C; Malmstrom V; Nordmark G
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2013;65:S1185

The NKp30/B7H6 Axis Contributes To Pathogenesis In Primary Sjogren's Syndrome.

Nocturne G; Rusakiewicz S; Sene D; Nordmark G; Eloranta M-L; Eriksson P; Theander E; Forsblad-d'Elia H; Omdal R; Wahren-Herlenius M; Jonsson R; Ronnblom L; Nititham J; Taylor KE; Lessard CJ; Moser KL; Gottenberg J-E; Criswell LA; Miceli-Richard C; Zitvogel L; Mariette X
Review: EUROPEAN JOURNAL OF IMMUNOLOGY. 2012;42(9):2274-2284

IL-17: a new actor in IFN-driven systemic autoimmune diseases.

Ambrosi A; Espinosa A; Wahren-Herlenius M
Review: JOURNAL OF AUTOIMMUNITY. 2012;39(1-2):77-82

The immunobiology of Ro52 (TRIM21) in autoimmunity: a critical review.

Oke V; Wahren-Herlenius M
Editorial comment: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2012;76(2):75-76

3rd Nordic Meeting on Genetics and Pathogenesis of Inflammatory Diseases.

Wahren-Herlenius M; Fogdell-Hahn A
Review: ARTHRITIS RESEARCH & THERAPY. 2012;14(2):208

Congenital heart block: evidence for a pathogenic role of maternal autoantibodies.

Ambrosi A; Wahren-Herlenius M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:A40

AUTOANTIBODIES TO THE FUNCTIONALLY ACTIVE RING-DOMAIN OF RO52/SSA ASSOCIATE WITH CLINICAL ACTIVITY IN A SUBSET OF PATIENTS WITH LUPUS

Kvarnstrom M; Dzikaite V; Ottosson L; Gunnarsson I; Svenungsson E; Wahren-Herlenius M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:a54-A55

MHC GENES DETERMINE FETAL SUSCEPTIBILITY IN A RAT MODEL OF CONGENITAL HEART BLOCK

Dzikaite V; Jagodic M; Kuchroo VK; Olsson T; Wahren-Herlenius M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:A81

TRIM GENES ARE PART OF THE INTERFERON SIGNATURE OBSERVED IN PATIENTS WITH PRIMARY SJOGREN'S SYNDROME

Sjostrand M; Brauner S; Kvarnstrom M; Wahren-Herlenius M; Espinosa A
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:A50

ANTI-RO52 EPITOPE MAPPING IN INFLAMMATORY MYOPATHIES

Krystufkova O; Dzikatite V; Charles P; Mann HF; Ekholm L; Vincze M; Putova I; Kasprikova N; Novota P; Padyukov L; Danko K; Vencovsky J; Wahren-Herlenius M; Lundberg IE
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:a60

IDENTIFICATION OF NOVEL GENETIC RISK LOCI DETERMINE FETAL OUTCOME IN CONGENITAL HEART BLOCK

Gorgen S; Ding B; Salomonsson S; Klareskog L; Hamsten A; Hillert J; Alfredsson L; Olsson T; Kockum I; Wahren-Herlenius M
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2012;71:a86

NEUROPSYCHIATRIC DEVELOPMENT AND HEALTH IN CHILDREN WITH AND WITHOUT CONGENITAL HEART BLOCK BORN TO MOTHERS WITH RO/SSA AUTOANTIBODIES - A RETROSPECTIVE FOLLOW-UP

Skog A; Tingstrom J; Salomonsson S; Sonesson S-E; Wahren-Herlenius M
Conference publication: IMMUNOLOGY. 2012;137:45

Enhanced interferon regulatory factor 3 binding to the IL-23p19 promoter correlates with enhanced IL-23 expression in Systemic Lupus Erythematosus

Smith S; Gabhann JN; Stacey K; Espinosa A; Wahren-Herlenius M; Kearns G; O'Neill L; Ball E; Johnston JA; Bell A; Grazia-Totaro M; Sica A; Jefferies CA
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2012;64(10):S1133

A Genome-Wide Association Study Establishes Muliple Susceptibility Loci for Sjogren's Syndrome

Lessard CJ; Li H; Adrianto I; Ice JA; Jonsson R; Illei GG; Rischmueller M; Nordmark G; Mariette X; Miceli-Richard C; Wahren-Herlenius M; Witte T; Brennan MT; Omdal R; Gaffney PM; Lessard JA; Ng W-F; Rhodus NL; Segal BM; Scofield RH; James JA; Anaya J-M; Harley JB; Montgomery CG; Sivils KM
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2012;76(2):200

Ro/SSA Autoantibody Mediated Congenital Heart Block Indicate Need for Increased Information, Support and Highly Specialized Medical Care - A Questionnaire Study

Tingstrom J; Hjelmstedt A; Henriksson EW; Sonesson S-E; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2012;76(2):208

Identification of Novel Genetic Risk Loci Associated with Fetal Outcome in Congenital Heart Block

Gorgen S; Ding B; Salomonsson S; Klareskog L; Hamsten A; Hillert J; Alfredsson L; Olsson T; Kockum I; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2012;76(2):196

Neuropsychiatric Development in Children with and without CHB Born to Mothers with Anti-Ro52/SSA Autoantibodies

Skog A; Tingstrom J; Salomonsson S; Sonesson S-E; Wahren-Herlenius M
Conference publication: IMMUNOLOGY. 2012;137:31-32

Expression of the immune regulator TRIM21 is controlled by interferon regulatory factors

Sjostrand M; Ambrosi A; Sullivan J; Malin S; Kuchroo VK; Espinosa A; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2012;76(2):210

Expression of the Immune Regulator TRIM21 is Controlled by Interferon Regulatory Factors

Sjostrand M; Ambrosi A; Sullivan J; Malin S; Kuchroo VK; Espinosa A; Wahren-Herlenius M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2012;64(10):S758

Hyperammaglobulinemia in Primary Sjogren's Syndrome Is Induced by Triggering of TLR7 and 9

Brauner S; Kvarnstrom M; Nordmark G; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2012;76(2):199-200

Hyperreactive B Cells Upon Endosomal TLR Triggering Underlying Primary Sjogren's Syndrome

Brauner S; Kvarnstom M; Gorgen S; Franzen-Malmros M; Brokstad KA; Folkersen L; Klareskog CTL; Jonsson R; Nordmark G; Malmstrom V; Wahren-Herlenius M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2012;64(10):S228

Genetic Variation in the NCR3 Locus Is Associated with Anti-SSA/SSB Positive Primary Sjogren's Syndrome in Scandinavian Samples

Nordmark G; Eloranta M-L; Eriksson P; Theander E; Forsblad-d'Elia H; Omdal R; Wahren-Herlenius M; Jonsson R; Ronnblom L
Review: IMMUNOLOGY LETTERS. 2011;141(1):1-9

The complexity of Sjögren's syndrome: novel aspects on pathogenesis.

Jonsson R; Vogelsang P; Volchenkov R; Espinosa A; Wahren-Herlenius M; Appel S
Editorial comment: SEMINARS IN IMMUNOLOGY. 2011;23(2):65-66

Gene-environment interaction in induction of autoimmunity.

Wahren-Herlenius M; Kuchroo VK
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2011;70:A67

VACCINATION OF PATIENTS WITH PRIMARY SJOGREN'S SYNDROME REVEALS HYPERREACTIVE B CELL COMPARTMENT WITH A SKEWED MATURATION PATTERN

Brauner S; Kvarnstom M; Gorgen S; Franzen-Malmros M; Brokstad KA; Folkersen L; Trollmo C; Klareskog L; Jonsson R; Malmstrom V; Wahren-Herlenius M
Meeting abstract: ANNALS OF THE RHEUMATIC DISEASES. 2011;70:a87-A88

DEVELOPMENT OF HEART BLOCK IN SSA/SSB AUTOANTIBODY-POSITIVE PREGNANCIES IS ASSOCIATED WITH MATERNAL AGE AND DISPLAY A SEASON-OF-BIRTH PATTERN

Ambrosi A; Salomonsson S; Eliasson H; Zeffer E; Dzikaite V; Bergman G; Fernlund E; Theander E; Rydberg A; Skogh T; Wallberg-Jonsson S; Ohman A; Lundstrom U; Mellander M; Winqvist O; Fored M; Ekbom A; Alfredsson L; Kallberg H; Gadler F; Jonzon A; Sonesson S-E; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2011;73(4):370

HLA-DRB1*04 is a Novel Fetal Susceptibility Allele in Congenital Heart Block

Ostberg T; Gorgen S; Salomonsson S; Ding B; Eliasson H; Elfving A; Malarstig A; Alfredsson L; Klareskog L; Hamsten A; Olsson T; Padukov L; Axelsson T; Gadler F; Jonzon A; Sonesson S-E; Kockum I; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2011;73(4):350

MHC Genes Determine Fetal Susceptibility in a Rat Model of Congenital Heart Block

Dzikaite V; Jagodic M; Kuchroo VK; Olsson T; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2011;73(4):369

Vaccination of Patients with Primary Sjogren's Syndrome Reveals Hyperreactive B Cell Compartment

Brauner S; Kvarnstom M; Gorgen S; Franzen-Malmros M; Brokstad KA; Trollmo C; Klareskog L; Jonsson R; Malmstrom V; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2011;73(4):364-365

The Expression of the Autoantigen Ro52 is Regulated by Interferon Regulatory Factors

Sjostrand M; Espinosa A; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2011;73(4):349-350

Transfer of Ro52-p200 Monoclonals, but not Other Ro52-Specificities, Induce Congenital Heart Block (CHB) in a Rat Model

Dzikaite V; Ambrosi A; Park J; Ottosson L; Sonesson S-E; Kuchroo VK; Herlenius E; Wahren-Herlenius M
Editorial comment: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):171-172

Immunological contribution to the pathogenesis of congenital heart block.

Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):271-272

Ro52 Autoantibody-Positive Women's Experience of Being Pregnant and Giving Birth to a Child with Congenital Heart Block

Tingstrom J; Sonesson S-E; Henriksson EW; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):274-275

A Population-Based Investigation of the Autoantibody Profile in Mothers of Children with Atrioventricular Block

Zeffer E; Salomonsson S; Dzikaite V; Eliasson H; Ambrosi A; Bergman G; Fernlund E; Theander E; Ohman A; Rydberg A; Skogh T; Rantapaa-Dahlqvist S; Elfving A; Fored M; Blomqvist P; Ekbom A; Lindstrom U; Melander M; Winqvist O; Sonesson S-E; Gadler F; Jonzon A; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):265

Influence of Season of Birth and Maternal Age in the Development of Congenital Heart Block in Anti-Ro-SSA/La-SSB Positive Pregnancies

Ambrosi A; Salomonsson S; Eliasson H; Zeffer E; Dzikaite V; Bergman G; Fernlund E; Theander E; Ryberg A; Ohman A; Skogh T; Rantapaa S; Fored M; Blomqvist P; Ekbom A; Lindsrtom U; Melander M; Winqvist O; Gadler F; Jonzon A; Sonesson S-E; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):269-270

HLA-DRB1*04 is a Novel Fetal Susceptibility Gene Variant in Congenital Heart Block

Ostberg T; Salomonsson S; Ding B; Eliasson H; Elfving A; Malarstig A; Alfredsson L; Klareskog L; Hamsten A; Olsson T; Padukov L; Axelsson T; Gadler F; Jonzon A; Sonesson S-E; Kockum I; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):269

MHC Genes Determine Fetal Susceptibility in a Rat Model of Congenital Heart Block

Dzikaite V; Strandberg LS; Ambrosi A; Jagodic M; Janson P; Khademi M; Salomonsson S; Ottosson L; Klauninger R; Aden U; Sonesson S-E; Sunnerhagen M; de Graaf KL; Kuchroo VK; Achour A; Winqvist O; Olsson T; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):271

Emotional Response to Serial Doppler Echocardiography Examinations as a Screening Method to Detect Developing Congential Heart Block In SSA/Ro Positive Pregnancy

Tingstrom J; Barimani M; Sonesson S-E; Wahren-Herlenius M; Henriksson EW
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):263

Fetal Doppler Echocardiography Predicts Cardiac Conduction Abnormalities Developing in Preschool Children Fetally Exposed to Ro52 Autoantibodies

Bergman G; Eliasson H; Mohlkert L-A; Wahren-Herlenius M; Sonesson S-E
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):272-273

The Expression of the CHB Autoantigen Ro52 is Regulated by Interferon Regulatory Factors

Espinosa A; Sjostrand M; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):273-274

Ring and B-Box Autoantibody Titers in SLE Patients with Ro52 Autoantibodies

Kvarnstrom M; Dzikaite V; Ottosson L; Gunnarsson I; Svenungsson E; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2010;39:36

Fcγ receptor IIA, IIIA and IIIB single nucleotide polymorphisms and Fcγ receptor IIIB copy number variation: No association with primary Sjogren's syndrome

Haldorsen K; Appel S; Bruland O; Le Hellard S; Brun JG; Omdal R; Kristjansdottir G; Theander E; Nordmark G; Kvamstrom M; Eriksson P; Ronnblom L; Wahren-Herlenius M; Jonsson R; Bolstad AI
Conference publication: SCANDINAVIAN JOURNAL OF RHEUMATOLOGY. 2010;39:32

GENE VARIANTS IN FAM167A-BLK AND TNFSF4 ARE ASSOCIATED WITH PRIMARY SJOGREN'S SYNDROME

Nordmark G; Kristjansdotti G; Theander E; Appel S; Eriksson P; Vasaitis L; Wahren-Herlenius M; Omdal R; Ronnblom L; Jonsson R; Syvanen A-C
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):274

Ro52 Autoantibodies Specific for Amino Acid 200-239 Mediate Calcium Dysregulation in Cardiomyocytes

Herlenius E; Park J; Ambrosi A; Dzikate V; Strandberg L; Kuchroo V; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2010;72(3):264-265

Anti-Ro52/p200 Antibodies Induce Heart Block in Rodents Upon Transfer During Gestation in a Time- and Dose-Dependent Manner

Ambrosi A; Dzikaite V; Strandberg L; Kuchroo VK; Wahren-Herlenius M
Letter: JOURNAL OF IMMUNOLOGY. 2009;183(12):7620-7621

Comment on "Gene Disruption Study Reveals a Nonredundant Role for TRIM21/Ro52 in NF-κB-Dependent Cytokine Expression in Fibroblasts Response

Espinosa A; Brauner S; Ambrosi A; Kuchroo V; Wahren-Herlenius M
Conference publication: SWISS MEDICAL WEEKLY. 2009;139(31-32):12S-13S

Outcome and Growth of Infants Fetally Exposed to Heart Block-Associated Maternal Anti-Ro52/SSA Autoantibodies

Skog A; Wahren-Herlenius M; Sundstrom B; Bremme K; Sonesson S-E
Conference publication: SWISS MEDICAL WEEKLY. 2009;139(31-32):13S

Women with anti-Ro/SSA autoantibodies: Experiences during pregnancy and after childbirth

Tingstrom J; Wahren-Herlenius M; Sonesson S-E; Henriksson EW
Conference publication: ARCHIVES OF DERMATOLOGICAL RESEARCH. 2009;301(1):47

High Expression of Ro52 in Skin Lesions in Cutaneous Lupus Erythematosus

Oke V; Strandberg L; Nyberg F; Wahren-Herlenius M
Meeting abstract: CLINICAL IMMUNOLOGY. 2008;127:s94

Identification of the specific Sjogren-syndrome related maternal Ro52 autoantibodies that induce heart block in the fetus during pregnancy

Dzikaite V; Strandberg L; Ambrosi A; Ottosson L; Salomonsson S; Sonesson S-E; Kuchroo V; Wahren-Herlenius M
Meeting abstract: CLINICAL IMMUNOLOGY. 2008;127:S24

Anti-Ro/SSA autoantibodies specific for the RING-domain of ro52 inhibit E3 ligase activity and polyubiquitination

Espinosa A; Hennig J; Ambrosi A; Nyberg F; Sunnerhaqen M; Wahren-Herlenius M
Conference publication: SCANDINAVIAN JOURNAL OF IMMUNOLOGY. 2008;68(2):193

Anti-Ro52 antibodies inducing heart block cross-react with alpha-enolase

Ambrosi A; Strandberg L; Dzikaite V; Ottosson L; Kampe O; Wahren-Herlenius M
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2007;127:S73

High expression of Ro52 in cutaneous Lupus Erythematosus

Barkauskaite V; Nyberg M; Strandberg L; Wahren-Herlenius M
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2007;66:A12

Genetic dissection of congenital heart block in a rat model

Strandberg L; Salomonsson S; Jagodic M; Bechanovic K; Sonesson S-E; Olsson T; Wahren-Herlenius M
Review: CURRENT OPINION IN IMMUNOLOGY. 2006;18(6):690-696

Specificity and effector mechanisms of autoantibodies in congenital heart block.

Wahren-Herlenius M; Sonesson S-E
Conference publication: ANNALS OF THE RHEUMATIC DISEASES. 2006;65:460

Induction of interferon-alpha by immune complexes or liposomes containing autoantigen-associated RNA

Lovgren T; Eloranta ML; Kastner B; Wahren-Herlenius M; Alm GV; Ronnblom L
Meeting abstract: CLINICAL IMMUNOLOGY. 2006;119:S25

The Sjogren's syndrome associated autoantigen Ro52 is a ring-dependent E3 ligase that regulates cell death.

Espinosa A; Zhou W; Oukka M; Kuchroo V; Wahren-Herlenius M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2005;52(9):S370

The Sjogren's syndrome associated autoantigen Ro52 is an E3 ligase with proliferation suppressive and proapoptotic properties.

Espinosa A; Zhou W; Ek M; Nyberg F; Kuchroo V; Wahren-Herlenius M
Conference publication: CLINICAL IMMUNOLOGY. 2005;115:S129

Genetic dissection of congenital heart block in a rat model.

Horvath LS; Salomonsson S; Jagodic M; Becanovic K; Sonesson SE; Olsson T; Wahren-Herlenius M
Conference publication: CLINICAL IMMUNOLOGY. 2005;115:S12

The Sjogren's syndrome associated autoantigen Ro52 is a RING-dependent E3 ligase that suppresses cellular proliferation.

Espinosa A; Hedlund M; Brauner S; Kuchroo VK; Wahren-Herlenius M
Letter: ARTHRITIS & RHEUMATOLOGY. 2005;52(1):366-368

Fetal first-degree heart block, or where to set the confidence limit: comment on the article by Sonesson et al - Reply

Wahren-Herlenius M; Sonesson SE
Conference publication: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2004;123(2)

Increased expression of the novel proinflammatory cytokine HMGB1 is detected in cutaneous lupus erythematosus lesions

Popovic K; Ek M; Erlandsson-Harris H; Wahren-Herlenius M; Nyberg F
Letter: ARTHRITIS & RHEUMATOLOGY. 2003;48(9):2697-2698

Development of systemic lupus erythematosus in a patient with congenital heart block.

Feist E; Keitzer R; Gerhold K; Horvath L; Wahren-Herlenius M; Dörner T
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2003;48(9):S64

Ro52 monoclonal antibodies bind the cell surface of cardiomyocytes

Salomonsson S; Ottosson L; RAats J; Herlenius E; Wahren-Herlenius M
Editorial comment: NATURE BIOTECHNOLOGY. 2002;20(12):1205-1206

Killers come to the rescue.

Wahren-Herlenius M; Kuchroo VK
Conference publication: JOURNAL OF DENTAL RESEARCH. 2002;81:B351

Autoantibodies in autoimmune diseases.

Wahren-Herlenius M
Conference publication: ARTHRITIS & RHEUMATOLOGY. 2002;46(9):S127

Conformation-dependent autoantibodies to the leucine zipper of Ro52 are associated with congenital heart block

Salornosson S; Ottosson L; Sunnerhagen M; Wahren-Herlenius M
Review: TRENDS IN IMMUNOLOGY. 1999;20(5):234-240

Analysis of B-cell epitopes of the Ro/SS-A autoantigen.

Wahren-Herlenius M; Muller S; Isenberg D
Conference publication: ARTHRITIS & RHEUMATOLOGY. 1999;42(9):S114

In vitro mutagenesis reveals key residues in a major conformational epitope the U1-70K protein.

Wahren-Herlenius M; Henriksson EW; Lundberg I; Mellquist E; Pertersson I
Conference publication: ARTHRITIS & RHEUMATOLOGY. 1999;42(9):S61

In vitro mutagenesis reveals key residues in a major conformational epitope of the U1-70K protein

Wahren-Herlenius M; Henriksson EW; Lundberg I; Mellquist E; Pettersson I
Conference publication: ARTHRITIS & RHEUMATOLOGY. 1998;41(9):S298

Increased number of IL-6 and IL-10 secreting cells in peripheral blood from patients with primary Sjogren's syndrome

Tengnér P; Halse AK; Wahren-Herlenius M; Haga HJ; Jonsson R
Letter: LUPUS. 1995;4(6):498

Autoantibodies to calprotectin are not found in patients with systemic lupus erythematosus or other inflammatory rheumatic diseases.

Wahren M; Brun JG; Jonsson R; Haga HJ
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Degrees and Education

Docent, Karolinska Institutet, 1999
University Medical Degree, Karolinska Institutet, 1996

Leadership and responsibility assignments

Head of department, K2 Department of Medicine, Solna, Karolinska Institutet, 2021-

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