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About me

Experienced Immunologist working on translational projects with the basis in pre-clinical science.

Current position: Research Group Leader, Associate Professor.

Particular interest in: Infection and Immunology; Innate Immune Responses; Tissue Inflammation and Pathology; Acute and Chronic Inflammation; Tissue Engineering.

Currently leading and managing several pre-clinical research projects. In addition, from 1st of January 2013 this includes the project leadership and management of the EU-FP7 INFECT project, which is a consortium composed of 14 partners, focusing on systems medicine in acute severe soft tissue infections.

Education

1995, MSc in Biology (Immunology), Lund University.

2000, Doctoral Degree (PhD), Immunology, Lunds Universitet.

2010, Associate professor (Docent), Immunology, Karolinska Institutet.

Research description

Although much of my previous research have focused on experimental models of infectious diseases, the current focus of my research has shifted towards research projects based on basic pre-clinical immunology and infection with patient oriented studies. Currently we are developing 3D-tissue models, composed of a stroma (fibroblasts) matrix layer, a stratified epithelium and hematopoietic phagocyte cells. The research now principally concentrates on unraveling pathways controlling differentiation and function of human monocytes, macrophages and dendritic cells, in specific models, that resemble living tissue. The research aim at advancing our insight into the mechanisms regulating immune responses at steady state and during infection and inflammation. This includes exploring host pathogen interaction in lung, skin and oral tissue, as well as mechanisms of chronic inflammation in granulomatous diseases. The 3D tissue organisation are likely to have strong impact on cellular function and allow studies on human phagocyte cell activation and trafficking, in addition to interactions with pathogens in living tissue. We also anticipate that a more complete understanding of phagocyte cell regulation has the potential to generate new strategies of modulating tissue inflammation, by allowing therapeutic targeting of the immunological basis of disease.

Links

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Presentations

Tissue-infiltrating neutrophils represent the main source of IL-23 in the colon of patients with IBD.
Kvedaraite E, Lourda M, Ideström M, Chen P, Olsson-Åkefeldt S, Forkel M, et al
Gut 2016 Oct;65(10):1632-41Technical advance: live-imaging analysis of human dendritic cell migrating behavior under the influence of immune-stimulating reagents in an organotypic model of lung.
Nguyen Hoang A, Chen P, Björnfot S, Högstrand K, Lock J, Grandien A, et al
J. Leukoc. Biol. 2014 Sep;96(3):481-9Detection of IL-17A-producing peripheral blood monocytes in Langerhans cell histiocytosis patients.
Lourda M, Olsson-Åkefeldt S, Gavhed D, Björnfot S, Clausen N, Hjalmars U, et al
Clin. Immunol. 2014 Jul;153(1):112-22Levels of alpha-toxin correlate with distinct phenotypic response profiles of blood mononuclear cells and with agr background of community-associated Staphylococcus aureus isolates.
Mairpady Shambat S, Haggar A, Vandenesch F, Lina G, van Wamel W, Arakere G, et al
PLoS ONE 2014 ;9(8):e106107