Mattias Sköld

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About me

I am an associate professor of neurosurgery, senior consultant neurosurgeon
and senior researcher in neuroscience. My research is focused on military
medicine and questions related to traumatic injuries in the nervous
system.
M.D. Karolinska Institutet, Stockholm, Sweden 2003
Ph.D. in Neuroscience Karolinska Institutet, Stockholm, Sweden 2004
Medical Internship Karolinska University Hospital 2004-2006
Postdoc National Defence Research Agency 2005-2006
Neurosurgery resident, Akademiska Sjukhuset Uppsala, 2006-2006
Neurosurgeon, Akademiska Sjukhuset Uppsala 2012-2019
Senior researcher, Department of neuroscience, Karolinska Institutet 2019 -
ongoing
Senior Consultant Neurosurgeon, Akademiska Sjukhuset Uppsala 2019 - ongoing
Associate Professor of Neurosurgery, Uppsala University, 2023

Research

My research is focused on multiple aspects of the injured nervous system and
its responses to trauma. The group has developed a broad array of methods to
investigate responses to high energy traumatic injuries to the nervous
system, from cell culture to animal models. I am member of multiple NATO
human factors and medicine research task groups working on different aspects
of brain injury and performance.

Teaching

At Karolinska Institutet I teach anatomy for undergraduate and graduate
students, specifically neuroanatomy. At Uppsala University I am a lecturer in
neurosurgery for medical students. I supervise Ph.D.-students in both basic
neuroscience and clinical neurosurgery.

Articles

Journal article: JOURNAL OF BRACHIAL PLEXUS AND PERIPHERAL NERVE INJURY. 2024;19(1):e6-e12

Nerve Tracing in Juvenile Rats: A Feasible Model for the Study of Brachial Plexus Birth Palsy and Cocontractions?

Jönsson K; Hultgren T; Risling M; Sköld MK
Article: LAKARTIDNINGEN. 2023;120:22064

[Spinal neurosurgery: radiculopathy and myelopathy].

Elmi Terander A; Corell A; Shahidi S; Richter J; Sköld M; Svensdotter E
Article: OPERATIVE NEUROSURGERY. 2022;23(4):304-311

Dura Management Strategies in the Surgical Treatment of Adult Chiari Type I Malformation: A Retrospective, Multicenter, Population-Based Parallel Cohort Case Series.

Kristiansson H; Fletcher-Sandersjöö A; Cesarini K; Fransson M; Vlachogiannis P; Burström G; Hessington A; Bartek J; Edström E; Holmgren RT; Sköld MK; Elmi-Terander A
Article: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2022;23(2):722

Hippocampal Expression of Cytochrome P450 1B1 in Penetrating Traumatic Brain Injury.

Lidin E; Sköld MK; Angéria M; Davidsson J; Risling M
Article: FASEB JOURNAL. 2021;35(11):e21896

Artificial spider silk supports and guides neurite extension in vitro.

Hansson ML; Chatterjee U; Francis J; Arndt T; Broman C; Johansson J; Sköld MK; Rising A
Article: BRAIN SCIENCES. 2020;10(4):E229-229

Diffuse Axonal Injury in the Rat Brain: Axonal Injury and Oligodendrocyte Activity Following Rotational Injury.

Losurdo M; Davidsson J; Sköld MK
Article: RESTORATIVE NEUROLOGY AND NEUROSCIENCE. 2020;38(1):23-40

Temporal gene expression changes after acute and delayed ventral root avulsion-reimplantation.

Günther M; Sköld MK
Article: BRAIN SCIENCES. 2018;8(8):E151-151

Neurite Growth and Polarization on Vitronectin Substrate after in Vitro Trauma is not Enhanced after IGF Treatment.

Bergen K; Frödin M; von Gertten C; Sandberg-Nordqvist A-C; Sköld MK
Article: FRONTIERS IN NEUROLOGY. 2017;8:49

Expression of Semaphorins, Neuropilins, VEGF, and Tenascins in Rat and Human Primary Sensory Neurons after a Dorsal Root Injury.

Lindholm T; Risling M; Carlstedt T; Hammarberg H; Wallquist W; Cullheim S; Sköld MK
Article: FRONTIERS IN NEUROLOGY. 2016;7:10

Cellular High-Energy Cavitation Trauma - Description of a Novel In Vitro Trauma Model in Three Different Cell Types.

Cao Y; Risling M; Malm E; Sondén A; Bolling MF; Sköld MK
Article: INTENSIVE CARE MEDICINE. 2012;38(6):1061-1068

An evaluation of three measures of intracranial compliance in traumatic brain injury patients.

Howells T; Lewén A; Sköld MK; Ronne-Engström E; Enblad P
Article: FRONTIERS IN NEUROLOGY. 2011;2:29

Karolinska institutet 200-year anniversary. Symposium on traumatic injuries in the nervous system: injuries to the spinal cord and peripheral nervous system - injuries and repair, pain problems, lesions to brachial plexus.

Sköld MK; Svensson M; Tsao J; Hultgren T; Landegren T; Carlstedt T; Cullheim S
Article: FRONTIERS IN NEUROLOGY. 2011;2:30

Activating transcription factor 3, a useful marker for regenerative response after nerve root injury.

Lindå H; Sköld MK; Ochsmann T
Article: FRONTIERS IN NEUROLOGY. 2011;1:159

On acute gene expression changes after ventral root replantation.

Risling M; Ochsman T; Carlstedt T; Lindå H; Plantman S; Rostami E; Angeria M; Sköld MK
Article: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS. 2007;363(4):989-993

VEGF reduces astrogliosis and preserves neuromuscular junctions in ALS transgenic mice.

Zheng C; Sköld MK; Li J; Nennesmo I; Fadeel B; Henter J-I
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2006;23(1):21-34

Inhibition of vascular endothelial growth factor receptor 2 activity in experimental brain contusions aggravates injury outcome and leads to early increased neuronal and glial degeneration.

Sköld MK; Risling M; Holmin S
Article: JOURNAL OF NEUROTRAUMA. 2005;22(3):353-367

VEGF and VEGF receptor expression after experimental brain contusion in rat.

Sköld MK; von Gertten C; Sandberg-Nordqvist A-C; Mathiesen T; Holmin S
Article: EXPERIMENTAL NEUROLOGY. 2004;188(1):20-32

Induction of HIF1alpha but not HIF2alpha in motoneurons after ventral funiculus axotomy-implication in neuronal survival strategies.

Sköld MK; Marti HH; Lindholm T; Lindå H; Hammarberg H; Risling M; Cullheim S
Article: NEUROREPORT. 2004;15(4):649-654

Semaphorin and neuropilin expression in motoneurons after intraspinal motoneuron axotomy.

Lindholm T; Sköld MK; Suneson A; Carlstedt T; Cullheim S; Risling M
Article: EUROPEAN JOURNAL OF NEUROSCIENCE. 2000;12(10):3675-3686

Induction of VEGF and VEGF receptors in the spinal cord after mechanical spinal injury and prostaglandin administration.

Sköld M; Cullheim S; Hammarberg H; Piehl F; Suneson A; Lake S; Sjögren A; Walum E; Risling M

All other publications

Editorial comment: NEUROLOGY. 2020;95(10):445-449

Acute necrotizing encephalopathy with SARS-CoV-2 RNA confirmed in cerebrospinal fluid.

Virhammar J; Kumlien E; Fällmar D; Frithiof R; Jackmann S; Sköld MK; Kadir M; Frick J; Lindeberg J; Olivero-Reinius H; Ryttlefors M; Cunningham JL; Wikström J; Grabowska A; Bondeson K; Bergquist J; Zetterberg H; Rostami E
Book chapter: ANIMAL MODELS OF NEUROTRAUMA: NEUROMETHODS. 2019;p. 251-262

In Vitro Trauma: Description of a Cavitation-Inducing Injury Model

Sköld MK; Sondén A
Editorial comment: FRONTIERS IN NEUROLOGY. 2017;8:510

Editorial: Karolinska Institutet 200-Year Anniversary Symposium on Injuries to the Spinal Cord and Peripheral Nervous System-An Update on Recent Advances in Regenerative Neuroscience.

Sköld MK; Fehlings MG
Editorial comment: FRONTIERS IN NEUROLOGY. 2016;7:91

Editorial: When Physics Meets Biology; Biomechanics and Biology of Traumatic Brain Injury.

Agoston DV; Sköld MK
Conference publication: JOURNAL OF NEUROTRAUMA. 2016;33(3):A12-A13

VENTRAL ROOT AVULSION AND REPLANTATION - DESCRIPTION OF DIFFERENT GENE EXPRESSION PATTERNS IN ACUTE AND DELAYED REPLANTATION

Skold M; Gunther M
Conference publication: JOURNAL OF NEUROTRAUMA. 2014;31(5):A27-A28

A MODEL FOR IN VITRO HIGH-ENERGY TRAUMA

Cao Y; Skold MK; Malm E; Sonden A; Risling M
Conference publication: JOURNAL OF NEUROTRAUMA. 2014;31(12):A105

HYPOTHERMIA AND IN VITRO HIGH-ENERGY TRAUMA

Cao Y; Skold MK; Malm E; Sonden A; Risling M
Review: CURRENT NEUROVASCULAR RESEARCH. 2008;5(4):246-259

Vascular endothelial growth factor in central nervous system injuries - a vascular growth factor getting nervous?

Sköld MK; Kanje M
Conference publication: JOURNAL OF NEUROTRAUMA. 2006;23(5):749

Acute changes in COX-2 mRNA expression and compound EEG after penetrating TBI in the rat

Risling M; Davidsson J; Thelin E; Larsson IL; Angeria M; Skold M
Conference publication: JOURNAL OF NEUROTRAUMA. 2006;23(5):750

Enhanced neurite outgrowth on vitronectin substrate after in vitro neurotrauma

Sköld MK; Frödin M; Brask J; von Gertten C; Sandberg-Nordqvist AC

Grants

Novel strategies for nervous tissue regeneration

Swedish Research Council

1 January 2020 - 31 December 2023
Targeted anti-inflammatory treatment in traumatic brain injuries

Swedish Research Council

1 January 2009 - 31 December 2010

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