Marie Schaffer

Publications
CV
Public outreach and news

Articles

Article: SCIENCE IMMUNOLOGY. 2020;5(50):eabd6832

Natural killer cell immunotypes related to COVID-19 disease severity.

Maucourant C; Filipovic I; Ponzetta A; Aleman S; Cornillet M; Hertwig L; Strunz B; Lentini A; Reinius B; Brownlie D; Cuapio A; Ask EH; Hull RM; Haroun-Izquierdo A; Schaffer M; Klingström J; Folkesson E; Buggert M; Sandberg JK; Eriksson LI; Rooyackers O; Ljunggren H-G; Malmberg K-J; Michaëlsson J; Marquardt N; Hammer Q; Strålin K; Björkström NK; Karolinska COVID-19 Study Group
Article: GASTROENTEROLOGY. 2019;157(4):1067-1080.e9

Imbalance of Genes Encoding Natural Killer Immunoglobulin-Like Receptors and Human Leukocyte Antigen in Patients With Biliary Cancer.

Cornillet M; Jansson H; Schaffer M; Hertwig L; Berglin L; Zimmer CL; Johansson H; Ellis E; Isaksson B; Gonzalez-Galarza FF; Middleton D; Malmberg K-J; Sparrelid E; Björkström NK
Article: FRONTIERS IN IMMUNOLOGY. 2019;10:2085

Systemic and Intra-Nodal Activation of NK Cells After Rituximab Monotherapy for Follicular Lymphoma.

Enqvist M; Jacobs B; Junlén HR; Schaffer M; Melén CM; Friberg D; Wahlin BE; Malmberg K-J
Article: CLINICAL CANCER RESEARCH. 2018;24(8):1834-1844

Complete Remission with Reduction of High-Risk Clones following Haploidentical NK-Cell Therapy against MDS and AML.

Björklund AT; Carlsten M; Sohlberg E; Liu LL; Clancy T; Karimi M; Cooley S; Miller JS; Klimkowska M; Schaffer M; Watz E; Wikström K; Blomberg P; Wahlin BE; Palma M; Hansson L; Ljungman P; Hellström-Lindberg E; Ljunggren H-G; Malmberg K-J
Article: CANCER IMMUNOLOGY RESEARCH. 2017;5(8):654-665

Ex Vivo Expanded Adaptive NK Cells Effectively Kill Primary Acute Lymphoblastic Leukemia Cells.

Liu LL; Béziat V; Oei VYS; Pfefferle A; Schaffer M; Lehmann S; Hellström-Lindberg E; Söderhäll S; Heyman M; Grandér D; Malmberg K-J
Article: CLINICAL TRANSPLANTATION. 2017;31(8)

No effect of HLA-C mismatch after allogeneic hematopoietic stem cell transplantation with unrelated donors and T-cell depletion in patients with hematological malignancies.

Magalhaes I; Uhlin M; Schaffer M; Sundin M; Hauzenberger D; Remberger M; Mattsson J
Article: JOURNAL OF IMMUNOLOGY. 2016;197(7):2762-2771

NK Cell Responses to Human Tick-Borne Encephalitis Virus Infection.

Blom K; Braun M; Pakalniene J; Lunemann S; Enqvist M; Dailidyte L; Schaffer M; Lindquist L; Mickiene A; Michaëlsson J; Ljunggren H-G; Gredmark-Russ S
Article: CELL REPORTS. 2016;15(5):1088-1099

Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans.

Liu LL; Landskron J; Ask EH; Enqvist M; Sohlberg E; Traherne JA; Hammer Q; Goodridge JP; Larsson S; Jayaraman J; Oei VYS; Schaffer M; Taskén K; Ljunggren H-G; Romagnani C; Trowsdale J; Malmberg K-J; Béziat V
Article: JOURNAL OF IMMUNOLOGY. 2016;196(3):1400-1411

Naive Donor NK Cell Repertoires Associated with Less Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation.

Björklund AT; Clancy T; Goodridge JP; Béziat V; Schaffer M; Hovig E; Ljunggren H-G; Ljungman PT; Malmberg K-J
Article: PLOS ONE. 2016;11(5):e0154737

Long-Term Stable Mixed Chimerism after Hematopoietic Stem Cell Transplantation in Patients with Non-Malignant Disease, Shall We Be Tolerant?

Stikvoort A; Sundin M; Uzunel M; Gertow J; Sundberg B; Schaffer M; Mattsson J; Uhlin M
Article: JOURNAL OF IMMUNOLOGY. 2015;194(9):4518-4527

Coordinated expression of DNAM-1 and LFA-1 in educated NK cells.

Enqvist M; Ask EH; Forslund E; Carlsten M; Abrahamsen G; Béziat V; Andersson S; Schaffer M; Spurkland A; Bryceson Y; Önfelt B; Malmberg K-J
Article: IMMUNITY. 2015;42(3):443-456

Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function.

Schlums H; Cichocki F; Tesi B; Theorell J; Beziat V; Holmes TD; Han H; Chiang SCC; Foley B; Mattsson K; Larsson S; Schaffer M; Malmberg K-J; Ljunggren H-G; Miller JS; Bryceson YT
Article: BLOOD. 2013;121(14):2678-2688

NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs.

Béziat V; Liu LL; Malmberg J-A; Ivarsson MA; Sohlberg E; Björklund AT; Retière C; Sverremark-Ekström E; Traherne J; Ljungman P; Schaffer M; Price DA; Trowsdale J; Michaëlsson J; Ljunggren H-G; Malmberg K-J
Article: BONE MARROW TRANSPLANTATION. 2013;48(4):537-543

Graft failure in the modern era of allogeneic hematopoietic SCT.

Olsson R; Remberger M; Schaffer M; Berggren DM; Svahn B-M; Mattsson J; Ringden O
Article: INTERNATIONAL JOURNAL OF IMMUNOGENETICS. 2013;40(1):39-45

16(th) IHIW: population global distribution of killer immunoglobulin-like receptor (KIR) and ligands.

Hollenbach JA; Augusto DG; Alaez C; Bubnova L; Fae I; Fischer G; Gonzalez-Galarza FF; Gorodezky C; Karabon L; Kusnierczyk P; Noble J; Rickards O; Roberts C; Schaffer M; Shi L; Tavoularis S; Trachtenberg E; Yao Y; Middleton D
Article: PLOS ONE. 2012;7(5):e36779

Importance of human leukocyte antigen (HLA) class I and II alleles on the risk of multiple sclerosis.

Link J; Kockum I; Lorentzen AR; Lie BA; Celius EG; Westerlind H; Schaffer M; Alfredsson L; Olsson T; Brynedal B; Harbo HF; Hillert J
Article: TRANSPLANTATION AND CELLULAR THERAPY. 2011;17(11):1688-1697

Improved survival after allogeneic hematopoietic stem cell transplantation in recent years. A single-center study.

Remberger M; Ackefors M; Berglund S; Blennow O; Dahllöf G; Dlugosz A; Garming-Legert K; Gertow J; Gustafsson B; Hassan M; Hassan Z; Hauzenberger D; Hägglund H; Karlsson H; Klingspor L; Kumlien G; Le Blanc K; Ljungman P; Machaczka M; Malmberg K-J; Marschall H-U; Mattsson J; Olsson R; Omazic B; Sairafi D; Schaffer M; Svahn B-M; Svenberg P; Swartling L; Szakos A; Uhlin M; Uzunel M; Watz E; Wernerson A; Wikman A; Wikström A-C; Winiarski J; Ringdén O
Article: PEDIATRIC RESEARCH. 2010;68(3):199-204

Maternal microchimerism in juvenile tonsils and adenoids.

Jonsson AM; Papadogiannakis N; Granath A; Haggstrom J; Schaffer M; Uzunel M; Westgren M
Article: BLOOD. 2010;115(13):2686-2694

NK cells expressing inhibitory KIR for non-self-ligands remain tolerant in HLA-matched sibling stem cell transplantation.

Björklund AT; Schaffer M; Fauriat C; Ringdén O; Remberger M; Hammarstedt C; Barrett AJ; Ljungman P; Ljunggren H-G; Malmberg K-J
Article: TRANSPLANTATION AND CELLULAR THERAPY. 2009;15(9):1108-1115

Lymphocyte recovery is a major determinant of outcome after matched unrelated myeloablative transplantation for myelogenous malignancies.

Le Blanc K; Barrett AJ; Schaffer M; Hägglund H; Ljungman P; Ringdén O; Remberger M
Article: HLA. 2008;72(6):549-558

Outcome of haematopoietic stem cell transplantation in patients transplanted with matched unrelated donors vs allele-mismatched donors: a single centre study.

Hauzenberger D; Schaffer M; Ringdén O; Hassan Z; Omazic B; Mattsson J; Wikström A-C; Remberger M
Article: JOURNAL OF IMMUNOLOGY. 2008;181(9):6010-6019

Estimation of the size of the alloreactive NK cell repertoire: studies in individuals homozygous for the group A KIR haplotype.

Fauriat C; Andersson S; Björklund AT; Carlsten M; Schaffer M; Björkström NK; Baumann BC; Michaëlsson J; Ljunggren H-G; Malmberg K-J
Article: EUROPEAN JOURNAL OF HAEMATOLOGY. 2008;80(5):419-428

Genomic tissue typing and optimal antithymocyte globuline dose using unrelated donors results in similar survival and relapse as HLA-identical siblings in haematopoietic stem-cell transplantation for leukaemia.

Remberger M; Mattsson J; Hausenberger D; Schaffer M; Svahn B-M; Ringdén O
Article: TRANSPLANTATION. 2004;78(7):1081-1085

Increased infection-related mortality in KIR-ligand-mismatched unrelated allogeneic hematopoietic stem-cell transplantation.

Schaffer M; Malmberg K-J; Ringdén O; Ljunggren H-G; Remberger M
Article: TRANSPLANTATION AND CELLULAR THERAPY. 2004;10(2):128-134

Which donor should be chosen for hematopoietic stem cell transplantation among unrelated HLA-A, -B, and -DRB1 genomically identical volunteers?

Ringdén O; Schaffer M; Le Blanc K; Persson U; Hauzenberger D; Abedi MR; Olerup O; Ljungman P; Remberger M
Article: HLA. 2003;62(3):243-250

Roles of HLA-B, HLA-C and HLA-DPA1 incompatibilities in the outcome of unrelated stem-cell transplantation.

Schaffer M; Aldener-Cannavá A; Remberger M; Ringdén O; Olerup O
Article: HLA. 2001;58(5):299-307

HLA-AB typing by polymerase-chain reaction with sequence-specific primers: more accurate, less errors, and increased resolution compared to serological typing.

Schaffer M; Olerup O
Article: HLA. 1997;49(2):186-188

A novel DRB1*13 allele (DRB1*1327) on a DR17, DQ2 haplotype with a DRB1*0301 sequence motif in the 2nd hyperpolymorphic region.

Schaffer M; Olerup O
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All other publications

Editorial comment: HLA. 2010;76(1):74-75

Identification of a novel KIR3DL1*072 allele by sequence-based typing.

Schellekens J; Schaffer M; Malmberg K-J; Madrigal JA; Marsh SGE
Meeting abstract: HUMAN IMMUNOLOGY. 2009;70:S100

MAINTAINED TOLERANCE OF NK CELLS EXPRESSING INHIBITORY KIR FOR NON-SELF LIGANDS IN HLA-MATCHED SIBLING STEM CELL TRANSPLANTATION

Schaffer M; Bjorklund A; Fauriat C; Ringden O; Remberger M; Ljungman P; Ljunggren H-G; Malmberg K-J
Meeting abstract: HUMAN IMMUNOLOGY. 2006;67(10):S129

KIR-HLA mismatch in T-cell replete HLA-identical sibling hematopoietic stem cell transplantation for acute myelogenous leukemia

Schaffer M; Remberger M; Ringden O; Ljunggren H-G; Malmberg K-J
Published conference paper: MOLECULAR IMMUNOLOGY. 2005;42(4):531-534

KIR-ligand mismatch in allogeneic hematopoietic stem cell transplantation.

Malmberg K-J; Schaffer M; Ringdén O; Remberger M; Ljunggren H-G

Employments

Affiliated to Research, Department of Medicine, Huddinge, Karolinska Institutet, 2024-2024

Degrees and Education

Doctor Of Philosophy, Department of Laboratory Medicine, Karolinska Institutet, 2006
Licentiate Degree, Department of Laboratory Medicine, Karolinska Institutet, 2001

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