Associate Professor and Senior Lecturer at Karolinska Institutet. Director of Doctoral Studies, Head of Unit, Research Theme Leader at Department of Dental Medicine.
Margaret Sällberg Chen received her D.D.S. and Ph.D. degrees from Karolinska Institutet. Following postdoctoral training at The Scripps Research Institute where she developed T cell receptor transgene models for immunological studies of chronic viral infection, she was recruited to the former Swedish Institute for Infectious Disease Control to continue with immunology and vaccinology studies. In 2004 she was appointed associated professor at Karolinska Institutet, and senior lecturer at Department of Dental Medicine in 2009. She has co-authored more than 50 papers, and has served on national and international scientific and editorial board.
The lab is broadly interested in immunological mechanisms effective in eliminating microbial pathogens associated with chronic diseases and tumors. The research pursues several lines investigating cellular functions capable of sensing and killing intracellular pathogens and tumors, and the target identification. The models are exclusively human infectious diseases and the methodologies employed include synthetic genetics, genetically modified cells and animals, viral and non-viral vectors, and next generation sequencing.
Major research area: Genetic transfer of T cell receptors, redirection of lymphocytes, viral and neo-antigens, therapeutic targets in oral conditions including tumors and endodontic infections.