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About me

I am an associate professor and senior lecturer at the unit of dermatology and venerology unit a senior consultant in dermatology at Karolinska University Hospital. I spend my time between seeing patients, perform research in genetic aspects of atopic dermatitis and teaching students, mainly medical students in the dermatology program but I am also heading a a postgraduate course in tropical dermatology in Ethiopia. I have a global interest and I am actively involved in the Palme-Linnaeus program for teacher and students exchange and a coordinator for a new exchange program in Malawi. 

I think medical education is the key for keeping up a high standard both for health care, research education, research and international competition. I think that medical education for physicians will face challenges within the coming years and it will be important to create an education that can handle the enormous amount of information, the harmonizing with other countries and more specific the harmonizing with the New Karolinska University Hospital. 

Education

1987                        MD

1991                       Fully qualified as a physician

1996                       Board certified in Dermatology and Venereology 

2001                       Ph.D, medical faculty 

2002                       Post Doc Stanford  

30.0                        ECTS credits in university-level teaching          

 

Research description

Genetic studies of skin barrier defects with focus on atopic dermatitis

AD is an inflammatory skin disorder that results from a complex interaction between genetic and environmental factors. 

Our research is aiming to advance our understanding of the development of AD, by both genetic and functional studies mainly focusing on genes underlying the barrier dysfunction seen in AD patients.  Furthermore, we are studying the disease in different ethnic groups and want to increase the knowledge about possible differences regarding the genetic and the environmental contribution in developing AD in various populations in the world.

 We have numerous local, national and international cooperation partners

The research is manly funded by ALF. 

In the group 5 Ph.D students have graduated and I have bee main supervisor for 2 of them and co-supervisor for 2.

I have 46 publications

Selected publications:

Susceptibility loci for atopic dermatitis on chromosomes 3, 13, 15, 17 and 18 in a Swedish population.
Bradley M, Söderhäll C, Luthman H, Wahlgren C, Kockum I, Nordenskjöld M
Hum. Mol. Genet. 2002 Jun;11(13):1539-48

Elevated expression and genetic association links the SOCS3 gene to atopic dermatitis.
Ekelund E, Saaf A, Tengvall-Linder M, Melen E, Link J, Barker J, et al
Am. J. Hum. Genet. 2006 Jun;78(6):1060-5

Global expression profiling in atopic eczema reveals reciprocal expression of inflammatory and lipid genes.
Sääf A, Tengvall-Linder M, Chang H, Adler A, Wahlgren C, Scheynius A, et al
PLoS ONE 2008 ;3(12):e4017

Novel filaggrin mutation but no other loss-of-function variants found in Ethiopian patients with atopic dermatitis.
Winge M, Bilcha K, Liedén A, Shibeshi D, Sandilands A, Wahlgren C, et al
Br. J. Dermatol. 2011 Nov;165(5):1074-80

Whole-exome sequencing of Ethiopian patients with ichthyosis vulgaris and atopic dermatitis.
Taylan F, Nilsson D, Asad S, Lieden A, Wahlgren C, Winge M, et al
J. Allergy Clin. Immunol. 2015 Aug;136(2):507-9.e19

RAC1 activation drives pathologic interactions between the epidermis and immune cells.
Winge M, Ohyama B, Dey C, Boxer L, Li W, Ehsani-Chimeh N, et al
J. Clin. Invest. 2016 Jul;126(7):2661-77

Academic honours, awards and prizes

Delagate (of 2 from Sweden) of European Union of Medical Specialist  (EUMES)

Member of Stockholm County Council Pharmaceuticals Committee Expert Council, for Skin Diseases since 2009

Former secretary, Swedish Dermatological Association

Former secretary, Foundation for International Dermatology

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Presentations

Senior lecturer, Chief physician at the Unit of Dermato-Venereogi