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Manuchehr Abedi-Valugerdi

Research coordinator

Visiting address : Experimentell Cancer Medicin (ECM); Novum, plan 6, hiss F, Lab 601; Hälsovägen 7-9, 14157 Huddinge, Sweden
Postal address : Department of Laboratory Medicine (LABMED), H5, Clinical research center, Experimentell Cancer Medicin (ECM); Novum, plan 6, hiss F, Lab 601; Hälsovägen 7-9, 14157 Huddinge, Sweden
Delivery address : KFC, ECM, Novum plan 6, Lab 601; Karolinska Universitetssjukhuset Huddinge; Vårdarvägen 1, 14152 Huddinge, Sweden


Biodistribution of biodegradable polymeric nano-carriers loaded with busulphan and designed for multimodal imaging
Asem H, Zhao Y, Ye F, Barrefelt Å, Abedi-valugerdi M, El-sayed R, et al
Journal of nanobiotechnology 2016;14(1):82-

Evaluation of interleukin 12 and CD56+ lymphocyte cells in pediatric hematopoietic stem cell transplantation for early diagnosis of acute graft versus host disease
Tootoonchian R, Pak F, Ardekani Am, Sehati N, Abedi-valugerdi M, Kokhaei P
Transplant immunology 2016;39():25-29

Suppressive effects of low-dose 5-fluorouracil, busulfan or treosulfan on the expansion of circulatory neutrophils and myeloid derived immunosuppressor cells in tumor-bearing mice
Abedi-valugerdi M, Wolfsberger J, Pillai Pr, Zheng W, Sadeghi B, Zhao Y, et al
International immunopharmacology 2016;40():41-49

Complement activation is involved in the hepatic injury caused by high-dose exposure of mice to perfluorooctanoic acid
Botelho Sc, Saghafian M, Pavlova S, Hassan M, Depierre Jw, Abedi-valugerdi M
Chemosphere 2015;129():225-31

Cytochrome P450 2J2, a new key enzyme in cyclophosphamide bioactivation and a potential biomarker for hematological malignancies
El-serafi I, Fares M, Abedi-valugerdi M, Afsharian P, Moshfegh A, Terelius Y, et al
The pharmacogenomics journal 2015;15(5):405-13

DNA damage, lysosomal degradation and Bcl-xL deamidation in doxycycline- and minocycline-induced cell death in the K562 leukemic cell line
Fares M, Abedi-valugerdi M, Hassan M, Potácová Z
Biochemical and biophysical research communications 2015;463(3):268-74

Immunotoxicological effects of streptozotocin and alloxan: in vitro and in vivo studies
Diab Ra, Fares M, Abedi-valugerdi M, Kumagai-braesch M, Holgersson J, Hassan M
Immunology letters 2015;163(2):193-8

Biodegradable polymeric vesicles containing magnetic nanoparticles, quantum dots and anticancer drugs for drug delivery and imaging
Ye F, Barrefelt A, Asem H, Abedi-valugerdi M, El-serafi I, Saghafian M, et al
Biomaterials 2014;35(12):3885-94

Cyclophosphamide alters the gene expression profile in patients treated with high doses prior to stem cell transplantation
El-serafi I, Abedi-valugerdi M, Potácová Z, Afsharian P, Mattsson J, Moshfegh A, et al
PloS one 2014;9(1):e86619-

Hematologic malignancies in elderly patients
Hassan M, Abedi-valugerdi M
Haematologica 2014;99(7):1124-7

The nanoparticulate Quillaja saponin KGI exerts anti-proliferative effects by down-regulation of cell cycle molecules in U937 and HL-60 human leukemia cells
Berenjian S, Hu K, Abedi-valugerdi M, Hassan M, Bashir Hassan S, Morein B
Leukemia & lymphoma 2014;55(7):1618-24

Tissue distribution of 35S-labelled perfluorobutanesulfonic acid in adult mice following dietary exposure for 1-5 days
Bogdanska J, Sundström M, Bergström U, Borg D, Abedi-valugerdi M, Bergman Å, et al
Chemosphere 2014;98():28-36

Both sub-acute, moderate-dose and short-term, low-dose dietary exposure of mice to perfluorooctane sulfonate exacerbates concanavalin A-induced hepatitis
Qazi Mr, Hassan M, Nelson Bd, Depierre Jw, Abedi-valugerdi M
Toxicology letters 2013;217(1):67-74

Early-phase GVHD gene expression profile in target versus non-target tissues: kidney, a possible target?
Sadeghi B, Al-chaqmaqchi H, Al-hashmi S, Brodin D, Hassan Z, Abedi-valugerdi M, et al
Bone marrow transplantation 2013;48(2):284-93

Omega-3 from fish oil augments GVHD through the enhancement of chemotherapy conditioning regimen and selective FoxP3 depletion
Al Hashmi S, Sadeghi B, Hassan Z, Abedi-valugerdi M, Lindskog M, Hassan M
Bone marrow transplantation 2013;48(6):843-8

Sub-acute, moderate-dose, but not short-term, low-dose dietary pre-exposure of mice to perfluorooctanoate aggravates concanavalin A-induced hepatitis
Qazi Mr, Hassan M, Nelson Bd, Depierre Jw, Abedi-valugerdi M
Toxicology letters 2013;219(1):1-7

The role of programmed cell death ligand-1 (PD-L1/CD274) in the development of graft versus host disease
Al-chaqmaqchi H, Sadeghi B, Abedi-valugerdi M, Al-hashmi S, Fares M, Kuiper R, et al
PloS one 2013;8(4):e60367-

High-dose dietary exposure of mice to perfluorooctanoate or perfluorooctane sulfonate exerts toxic effects on myeloid and B-lymphoid cells in the bone marrow and these effects are partially dependent on reduced food consumption
Qazi Mr, Nelson Bd, Depierre Jw, Abedi-valugerdi M
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2012;50(9):2955-63

Characterization of the Hepatic and Splenic Immune Status and Immunoglobulin Synthesis in Aged Male Mice Lacking the Peroxisome Proliferator-Activated Receptor-Alpha (PPAR alpha)
Qazi Mr, Abedi Mr, Nelson Bd, Depierre Jw, Abedi-valugerdi M

Tissue distribution of ³⁵S-labelled perfluorooctane sulfonate in adult mice after oral exposure to a low environmentally relevant dose or a high experimental dose
Bogdanska J, Borg D, Sundström M, Bergström U, Halldin K, Abedi-valugerdi M, et al
Toxicology 2011;284(1-3):54-62

28-Day dietary exposure of mice to a low total dose (7 mg/kg) of perfluorooctanesulfonate (PFOS) alters neither the cellular compositions of the thymus and spleen nor humoral immune responses: Does the route of administration play a pivotal role in PFOS-induced immunotoxicity?
Qazi Mr, Nelson Bd, Depierre Jw, Abedi-valugerdi M
TOXICOLOGY 2010;267(1-3):132-9

Dietary exposure to perfluorooctanoate or perfluorooctane sulfonate induces hypertrophy in centrilobular hepatocytes and alters the hepatic immune status in mice
Qazi Mr, Abedi Mr, Nelson Bd, Depierre Jw, Abedi-valugerdi M

Expansion and activation kinetics of immune cells during early phase of GVHD in mouse model based on chemotherapy conditioning
Sadeghi B, Al-hashmi S, Hassan Z, Rozell B, Concha H, Lundmark C, et al
Clinical & developmental immunology 2010;2010():142943-

High-dose, short-term exposure of mice to perfluorooctanesulfonate (PFOS) or perfluorooctanoate (PFOA) affects the number of circulating neutrophils differently, but enhances the inflammatory responses of macrophages to lipopolysaccharide (LPS) in a similar fashion
Qazi Mr, Bogdanska J, Butenhoff Jl, Nelson Bd, Depierre Jw, Abedi-valugerdi M
TOXICOLOGY 2009;262(3):207-14

Isolation of murine intrahepatic immune cells employing a modified procedure for mechanical disruption and functional characterization of the B, T and natural killer T cells obtained
Blom Kg, Rahman Qazi M, Noronha Matos Jb, Nelson Bd, Depierre Jw, Abedi-valugerdi M

Mercury and silver induce B cell activation and anti-nucleolar autoantibody production in outbred mouse stocks: are environmental factors more important than the susceptibility genes in connection with autoimmunity?
Abedi-valugerdi M

The atrophy and changes in the cellular compositions of the thymus and spleen observed in mice subjected to short-term exposure to perfluorooctanesulfonate are high-dose phenomena mediated in part by peroxisome proliferator-activated receptor-alpha (PPAR alpha)
Qazi Mr, Xia Zl, Bogdanska J, Chang Sc, Ehresman Dj, Butenhoff Jl, et al
TOXICOLOGY 2009;260(1-3):68-76

GVHD after chemotherapy conditioning in allogeneic transplanted mice
Sadeghi B, Aghdami N, Hassan Z, Forouzanfar M, Rozell B, Abedi-valugerdi M, et al
Bone marrow transplantation 2008;42(12):807-18

The effect of administration order of BU and CY on engraftment and toxicity in HSCT mouse model
Sadeghi B, Jansson M, Hassan Z, Mints M, Hägglund H, Abedi-valugerdi M, et al
Bone marrow transplantation 2008;41(10):895-904

Myeloablative and immunosuppressive properties of treosulfan in mice
Sjöö F, Hassan Z, Abedi-valugerdi M, Griskevicius L, Nilsson C, Remberger M, et al
Experimental hematology 2006;34(1):115-21

Bacterial lipopolysaccharide both renders resistant mice susceptible to mercury-induced autoimmunity and exacerbates such autoimmunity in susceptible mice
Abedi-valugerdi M, Nilsson C, Zargari A, Gharibdoost F, Depierre Jw, Hassan M
Clinical and experimental immunology 2005;141(2):238-47

Effect of altering administration order of busulphan and cyclophosphamide on the myeloablative and immunosuppressive properties of the conditioning regimen in mice
Nilsson C, Forsman J, Hassan Z, Abedi-valugerdi M, O'connor C, Concha H, et al
Experimental hematology 2005;33(3):380-7

Efficient gene transfer into primary human natural killer cells by retroviral transduction
Guven H, Konstantinidis Kv, Alici E, Aints A, Abedi-valugerdi M, Christensson B, et al
Experimental hematology 2005;33(11):1320-8

Exposure to mercuric chloride during the induction phase and after the onset of collagen-induced arthritis enhances immune/autoimmune responses and exacerbates the disease in DBA/1 mice
Hansson M, Djerbi M, Rabbani H, Mellstedt H, Gharibdoost F, Hassan M, et al
Immunology 2005;114(3):428-37

Exposure to Mycobacteria primes the immune system for evolutionarily diverse heat shock proteins
Qazi Kr, Qazi Mr, Julian E, Singh M, Abedi-valugerdi M, Fernandez C
INFECTION AND IMMUNITY 2005;73(11):7687-96

Mercuric chloride induces a strong immune activation, but does not accelerate the development of dermal fibrosis in tight skin 1 mice
Hansson M, Abedi-valugerdi M

Visualization of 5T33 myeloma cells in the C57BL/KaLwRij mouse: establishment of a new syngeneic murine model of multiple myeloma
Alici E, Konstantinidis Kv, Aints A, Dilber Ms, Abedi-valugerdi M
Experimental hematology 2004;32(11):1064-72

Expression of the long form of human FLIP by retroviral gene transfer of hemopoietic stem cells exacerbates experimental autoimmune encephalomyelitis
Djerbi M, Abdul-majid Kb, Abedi-valugerdi M, Olsson T, Harris Ra, Grandien A
Journal of immunology (Baltimore, Md. : 1950) 2003;170(4):2064-73

Xenobiotic metal-induced autoimmunity: mercury and silver differentially induce antinucleolar autoantibody production in susceptible H-2s, H-2q and H-2f mice
Hansson M, Abedi-valugerdi M
Clinical and experimental immunology 2003;131(3):405-14

Potent suppression of the adaptive immune response in mice upon dietary exposure to the potent peroxisome proliferator, perfluorooctanoic acid
Yang Q, Abedi-valugerdi M, Xie Y, Zhao Xy, Moller G, Nelson Bd, et al

Spontaneous downregulation of antibody/autoantibody synthesis in susceptible mice upon chronic exposure to mercuric chloride is not owing to a general immunosuppression
Roether S, Rabbani H, Mellstedt H, Abedi-valugerdi M
Scandinavian journal of immunology 2002;55(5):493-502

Analysis of mercury-induced immune activation in nonobese diabetic (NOD) mice
Brenden N, Rabbani H, Abedi-valugerdi M

Genetic control of resistance to mercury-induced immune/autoimmune activation
Abedi-valugerdi M, Hansson M, Moller G

Immune complex-induced chronic and intense IL-4 independent IgG1-rheumatoid factor production in NZB mice
Nordström E, Abedi-valugerdi M, Möller E
Scandinavian journal of immunology 2001;53(1):32-9

Contribution of H-2 and non-H-2 genes in the control of mercury-induced autoimmunity
Abedi-valugerdi M, Moller G

Longevity of immune complexes and abnormal germinal centre formation in NZB mice
Nordström E, Abedi-valugerdi M, Möller E
Scandinavian journal of immunology 2000;52(5):477-82

Mechanism of mercury-induced autoimmunity: both T helper 1- and T helper 2-type responses are involved
Hu H, Moller G, Abedi-valugerdi M
IMMUNOLOGY 1999;96(3):348-57

Mercury-induced anti-nucleolar autoantibodies can transgress the membrane of living cells in vivo and in vitro
Abedi-valugerdi M, Hu H, Moller G

Induction of IgG rheumatoid factor (RF) production by antibody-antibody (RF-like) immune complexes: the role of T cells, complement and Fc gamma receptors
Nordström E, Möller E, Abedi-valugerdi M
Journal of autoimmunity 1998;11(2):131-40

Non-responsiveness to mercury-induced autoimmunity in resistant DBA/2 mice is not due to immunosuppression or biased Th1-type response
Hu H, Moller G, Abedi-valugerdi M

Mercury-induced renal immune complex deposits in young (NZB x NZW)F1 mice: characterization of antibodies/autoantibodies
Abedi-valugerdi M, Hu H, Möller G
Clinical and experimental immunology 1997;110(1):86-91

Human IgG rheumatoid factors and RF-like immune complexes induce IgG1 rheumatoid factor production in mice
Abedi-valugerdi M, Ridderstad A, Al-balaghi S, Möller E
Scandinavian journal of immunology 1995;41(6):575-82

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