Magnus Bentinger is responsible for synthesis of new compounds with the ability to stimulate the endogenous antioxidant defence, various naturally occurring polyisoprenoids that are chemically modified.
These synthetic products are purified, characterized and tested in both in vitro and in vivo systems. He is responsible for studies on drug development with focus on the ability to stimulate endogenous antioxidant defence including mechanistic studies and for the analyses of CoQ10 in different organs of diabetic and control mice.
Research group Growth and metabolism
Coenzyme Q--biosynthesis and functions.
Biochem. Biophys. Res. Commun. 2010 May;396(1):74-9
Polyisoprenoid epoxides stimulate the biosynthesis of coenzyme Q and inhibit cholesterol synthesis.
J. Biol. Chem. 2008 May;283(21):14645-53
The antioxidant role of coenzyme Q.
Mitochondrion 2007 Jun;7 Suppl():S41-50
Distribution and breakdown of labeled coenzyme Q10 in rat.
Free Radic. Biol. Med. 2003 Mar;34(5):563-75
Involvement of retinoid X receptor alpha in coenzyme Q metabolism.
J. Mol. Biol. 2003 Feb;326(3):795-803