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Magnus Bäck

Professor

Visiting address : Cmm, L8:03, Karolinska Universitetssjukhuset, Solna 171 76 Stockholm, Sweden
Postal address : Department of Medicine, Solna (MedS), K2, Group G Hansson, Cmm, L8:03, Karolinska Universitetssjukhuset, Solna 171 76 Stockholm, Sweden
Delivery address : Cmm, L8:03, Karolinska Universitetssjukhuset, Solna 171 76 Stockholm, Sweden

Publications

Alcohol consumption, cigarette smoking and incidence of aortic valve stenosis
Larsson Sc, Wolk A, Bäck M
Journal of internal medicine 2017;():-

Aspirin-triggered lipoxin A4 inhibits atherosclerosis progression in apolipoprotein E mice
Petri Mh, Laguna-fernandez A, Arnardottir H, Wheelock Ce, Perretti M, Hansson Gk, et al
British journal of pharmacology 2017;():-

Low salivary resolvin D1 to leukotriene B ratio predicts carotid intima media thickness: A novel biomarker of non-resolving vascular inflammation
Thul S, Labat C, Temmar M, Benetos A, Bäck M
European journal of preventive cardiology 2017;24(9):903-906

NOTCH1 Mutations in Aortic Stenosis: Association with Osteoprotegerin/RANK/RANKL
Irtyuga O, Malashicheva A, Zhiduleva E, Freylikhman O, Rotar O, Bäck M, et al
BioMed research international 2017;2017():6917907-

Overall and abdominal obesity and incident aortic valve stenosis: two prospective cohort studies
Larsson Sc, Wolk A, Håkansson N, Bäck M
European heart journal 2017;():-

Spinal cord stimulation in heart failure: effect on disease-associated biomarkers
Naar J, Jaye D, Linde C, Neužil P, Doškář P, Málek F, et al
European journal of heart failure 2017;19(2):283-286

Cardiovascular Events Associated With Use of Tyrosine Kinase Inhibitors in Chronic Myeloid Leukemia: A Population-Based Cohort Study
Dahlén T, Edgren G, Lambe M, Höglund M, Björkholm M, Sandin F, et al
Annals of internal medicine 2016;165(3):161-6

Chronic adventitial inflammation, vasa vasorum expansion, and 5-lipoxygenase up-regulation in irradiated arteries from cancer survivors
Halle M, Christersdottir T, Bäck M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2016;30(11):3845-3852

Iron alters valvular interstitial cell function and is associated with calcification in aortic stenosis
Laguna-fernandez A, Carracedo M, Jeanson G, Nagy E, Eriksson P, Caligiuri G, et al
European heart journal 2016;37(47):3532-3535

Anti-inflammatory therapies for atherosclerosis
Bäck M, Hansson Gk
Nature reviews. Cardiology 2015;12(4):199-211

Aspirin-triggered 15-epi-lipoxin A₄ signals through FPR2/ALX in vascular smooth muscle cells and protects against intimal hyperplasia after carotid ligation
Petri Mh, Laguna-fernandez A, Tseng Cn, Hedin U, Perretti M, Bäck M
International journal of cardiology 2015;179():370-2

Differential regulation of monocytic expression of leukotriene and lipoxin receptors
Petri Mh, Thul S, Ovchinnikova O, Bäck M
Prostaglandins & other lipid mediators 2015;121(Pt A):138-43

Hemodynamic outcomes of transcatheter aortic valve implantation with the CoreValve system: an early assessment
Da Silva C, Sahlen A, Winter R, Bäck M, Rück A, Settergren M, et al
Clinical physiology and functional imaging 2015;35(3):216-22

Inhibition of indoleamine 2,3-dioxygenase promotes vascular inflammation and increases atherosclerosis in Apoe-/- mice
Polyzos Ka, Ovchinnikova O, Berg M, Baumgartner R, Agardh H, Pirault J, et al
Cardiovascular research 2015;106(2):295-302

Novel methodologies for biomarker discovery in atherosclerosis
Hoefer Ie, Steffens S, Ala-korpela M, Bäck M, Badimon L, Bochaton-piallat Ml, et al
European heart journal 2015;36(39):2635-42

Regulation of atherosclerotic plaque inflammation
Bäck M, Weber C, Lutgens E
Journal of internal medicine 2015;278(5):462-82

THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Catalytic receptors
Cgtp Collaborators, Alexander Sph, Fabbro D, Kelly E, Marrion N, Peters Ja, et al
BRITISH JOURNAL OF PHARMACOLOGY 2015;172(24):5979-6023

THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Enzymes
Cgtp Collaborators, Alexander Sph, Fabbro D, Kelly E, Marrion N, Peters Ja, et al
BRITISH JOURNAL OF PHARMACOLOGY 2015;172(24):6024-109

THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: G protein-coupled receptors
Cgtp Collaborators, Alexander Sph, Davenport Ap, Kelly E, Marrion N, Peters Ja, et al
BRITISH JOURNAL OF PHARMACOLOGY 2015;172(24):5744-869

THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Ligand-gated ion channels
Cgtp Collaborators, Alexander Sph, Peters Ja, Kelly E, Marrion N, Benson He, et al
BRITISH JOURNAL OF PHARMACOLOGY 2015;172(24):5870-903

THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Nuclear hormone receptors
Cgtp Collaborators, Alexander Sph, Cidlowski Ja, Kelly E, Marrion N, Peters Ja, et al
BRITISH JOURNAL OF PHARMACOLOGY 2015;172(24):5956-78

THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Other ion channels
Cgtp Collaborators, Alexander Sph, Kelly E, Marrion N, Peters Ja, Benson He, et al
BRITISH JOURNAL OF PHARMACOLOGY 2015;172(24):5942-55

THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Overview
Cgtp Collaborators, Alexander Sph, Kelly E, Marrion N, Peters Ja, Benson He, et al
BRITISH JOURNAL OF PHARMACOLOGY 2015;172(24):5729-43

THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Transporters
Cgtp Collaborators, Alexander Sph, Kelly E, Marrion N, Peters Ja, Benson He, et al
BRITISH JOURNAL OF PHARMACOLOGY 2015;172(24):6110-202

THE CONCISE GUIDE TO PHARMACOLOGY 2015/16: Voltage-gated ion channels
Cgtp Collaborators, Alexander Sph, Catterall Wa, Kelly E, Marrion N, Peters Ja, et al
BRITISH JOURNAL OF PHARMACOLOGY 2015;172(24):5904-41

The leukotriene B4 receptor (BLT) antagonist BIIL284 decreases atherosclerosis in ApoE-/- mice
Ketelhuth Df, Hermansson A, Hlawaty H, Letourneur D, Yan Zq, Bäck M
Prostaglandins & other lipid mediators 2015;121(Pt A):105-9

The role of the FPR2/ALX receptor in atherosclerosis development and plaque stability
Petri Mh, Laguna-fernández A, Gonzalez-diez M, Paulsson-berne G, Hansson Gk, Bäck M
Cardiovascular research 2015;105(1):65-74

2014 ESC Guidelines on the diagnosis and treatment of aortic diseases: Document covering acute and chronic aortic diseases of the thoracic and abdominal aorta of the adult. The Task Force for the Diagnosis and Treatment of Aortic Diseases of the European Society of Cardiology (ESC)
Erbel R, Aboyans V, Boileau C, Bossone E, Bartolomeo Rd, Eggebrecht H, et al
European heart journal 2014;35(41):2873-926

Biomechanical factors in atherosclerosis: mechanisms and clinical implications
Kwak Br, Bäck M, Bochaton-piallat Ml, Caligiuri G, Daemen Mj, Davies Pf, et al
European heart journal 2014;35(43):3013-20

Differential association of chronic obstructive pulmonary disease with myocardial infarction and ischemic stroke in a nation-wide cohort
Yin L, Lensmar C, Ingelsson E, Bäck M
International journal of cardiology 2014;173(3):601-3

Docosahexaenoic acid supplementation modifies fatty acid incorporation in tissues and prevents hypoxia induced-atherosclerosis progression in apolipoprotein-E deficient mice
Van Noolen L, Bäck M, Arnaud C, Rey A, Petri Mh, Levy P, et al
Prostaglandins, leukotrienes, and essential fatty acids 2014;91(4):111-7

Impact of vascular thromboxane prostanoid receptor activation on hemostasis, thrombosis, oxidative stress, and inflammation
Capra V, Bäck M, Angiolillo Dj, Cattaneo M, Sakariassen Ks
Journal of thrombosis and haemostasis : JTH 2014;12(2):126-37

Leukotriene production is increased in abdominal obesity
Bäck M, Avignon A, Stanke-labesque F, Boegner C, Attalin V, Leprieur E, et al
PloS one 2014;9(12):e104593-

Leukotrienes as a molecular link between obstructive sleep apnoea and atherosclerosis
Stanke-labesque F, Pépin Jl, Gautier-veyret E, Lévy P, Bäck M
Cardiovascular research 2014;101(2):187-93

Mycobacterium bovis BCG killed by extended freeze-drying induces an immunoregulatory profile and protects against atherosclerosis
Ovchinnikova Oa, Berge N, Kang C, Urien C, Ketelhuth Df, Pottier J, et al
Journal of internal medicine 2014;275(1):49-58

Prosthesis-patient mismatch after transcatheter aortic valve implantation: impact of 2D-transthoracic echocardiography versus 3D-transesophageal echocardiography
Da Silva C, Sahlen A, Winter R, Bäck M, Rück A, Settergren M, et al
The international journal of cardiovascular imaging 2014;30(8):1549-57

Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7
Bäck M, Powell Ws, Dahlén Se, Drazen Jm, Evans Jf, Serhan Cn, et al
British journal of pharmacology 2014;171(15):3551-74

Biomechanical factors in the biology of aortic wall and aortic valve diseases
Bäck M, Gasser Tc, Michel Jb, Caligiuri G
Cardiovascular research 2013;99(2):232-41

Effects of the dual TP receptor antagonist and thromboxane synthase inhibitor EV-077 on human endothelial and vascular smooth muscle cells
Petri Mh, Tellier C, Michiels C, Ellertsen I, Dogné Jm, Bäck M
Biochemical and biophysical research communications 2013;441(2):393-8

Eicosanoids and their drugs in cardiovascular diseases: focus on atherosclerosis and stroke
Capra V, Bäck M, Barbieri Ss, Camera M, Tremoli E, Rovati Ge
Medicinal research reviews 2013;33(2):364-438

Inflammatory mediators in saliva associated with arterial stiffness and subclinical atherosclerosis
Labat C, Temmar M, Nagy E, Bean K, Brink C, Benetos A, et al
Journal of hypertension 2013;31(11):2251-8

Intermittent hypoxia-activated cyclooxygenase pathway: role in atherosclerosis
Gautier-veyret E, Arnaud C, Bäck M, Pépin Jl, Petri Mh, Baguet Jp, et al
The European respiratory journal 2013;42(2):404-13

NOD2-mediated innate immune signaling regulates the eicosanoids in atherosclerosis
Liu Hq, Zhang Xy, Edfeldt K, Nijhuis Mo, Idborg H, Bäck M, et al
Arteriosclerosis, thrombosis, and vascular biology 2013;33(9):2193-201

Release of Leukotriene B-4, Transforming Growth Factor-beta 1 and Microparticles in Relation to Aortic Valve Calcification
Kochtebane N, Passefort S, Choqueux C, Ainoun F, Achour L, Michel Jb, et al
JOURNAL OF HEART VALVE DISEASE 2013;22(6):782-8

The leukotriene receptor antagonist montelukast and aortic stenosis
Bäck M, Yin L, Nagy E, Ingelsson E
British journal of clinical pharmacology 2013;75(1):280-1

Transesophageal echocardiography measurements of aortic annulus diameter using biplane mode in patients undergoing transcatheter aortic valve implantation
Shahgaldi K, Da Silva C, Bäck M, Rück A, Manouras A, Sahlén A
Cardiovascular ultrasound 2013;11():5-

Urinary leukotriene E4 is associated with renal function but not with endothelial function in type 2 diabetes
Rafnsson A, Bäck M
Disease markers 2013;35(5):475-80

Valvular osteoclasts in calcification and aortic valve stenosis severity
Nagy E, Eriksson P, Yousry M, Caidahl K, Ingelsson E, Hansson Gk, et al
International journal of cardiology 2013;168(3):2264-71

Cyclooxygenase-2 inhibitors and cardiovascular risk in a nation-wide cohort study after the withdrawal of rofecoxib
Bäck M, Yin L, Ingelsson E
European heart journal 2012;33(15):1928-33

Cysteinyl leukotriene signaling through perinuclear CysLT(1) receptors on vascular smooth muscle cells transduces nuclear calcium signaling and alterations of gene expression
Eaton A, Nagy E, Pacault M, Fauconnier J, Bäck M
Journal of molecular medicine (Berlin, Germany) 2012;90(10):1223-31

Epigenetic regulation of 5-lipoxygenase in the phenotypic plasticity of valvular interstitial cells associated with aortic valve stenosis
Nagy E, Bäck M
FEBS letters 2012;586(9):1325-9

Increased transcript level of poly(ADP-ribose) polymerase (PARP-1) in human tricuspid compared with bicuspid aortic valves correlates with the stenosis severity
Nagy E, Caidahl K, Franco-cereceda A, Bäck M
Biochemical and biophysical research communications 2012;420(3):671-5

Leukotriene B4 pathway activation and atherosclerosis in obstructive sleep apnea
Stanke-labesque F, Pépin Jl, De Jouvencel T, Arnaud C, Baguet Jp, Petri Mh, et al
Journal of lipid research 2012;53(9):1944-51

Leukotrienes as modifiers of preclinical atherosclerosis?
Riccioni G, Bäck M
TheScientificWorldJournal 2012;2012():490968-

Nationwide cohort study of the leukotriene receptor antagonist montelukast and incident or recurrent cardiovascular disease
Ingelsson E, Yin L, Back M
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2012;129(3):702-707.e2

International Union of Basic and Clinical Pharmacology. LXXXIV: Leukotriene Receptor Nomenclature, Distribution, and Pathophysiological Functions
Back M, Dahlen Se, Drazen Jm, Evans Jf, Serhan Cn, Shimizu T, et al
PHARMACOLOGICAL REVIEWS 2011;63(3):539-84

The Role of Matrix Metalloproteinases in Atherothrombosis
Ketelhuth Dfj, Back M
CURRENT ATHEROSCLEROSIS REPORTS 2011;13(2):162-9

Upregulation of the 5-Lipoxygenase Pathway in Human Aortic Valves Correlates With Severity of Stenosis and Leads to Leukotriene-Induced Effects on Valvular Myofibroblasts
Nagy E, Andersson Dc, Caidahl K, Eriksson Mj, Eriksson P, Franco-cereceda A, et al
CIRCULATION 2011;123(12):1316-25

Leukotrienes and Atherosclerosis
Riccioni G, Back M, Capra V
CURRENT DRUG TARGETS 2010;11(7):882-7

Matrix Metalloproteinases in Atherothrombosis
Back M, Ketelhuth Dfj, Agewall S
PROGRESS IN CARDIOVASCULAR DISEASES 2010;52(5):410-28

Thromboxane synthase expression and thromboxane A(2) production in the atherosclerotic lesion
Gabrielsen A, Qiu H, Back M, Hamberg M, Hemdahl Al, Agardh H, et al
JOURNAL OF MOLECULAR MEDICINE-JMM 2010;88(8):795-806

Altered reactivity to norepinephrine through COX-2 induction by vascular injury in hypercholesterolemic rabbits
Foudi N, Norel X, Rienzo M, Louedec L, Brink C, Michel Jb, et al
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2009;297(5):H1882-8

Differential inflammatory activity across human abdominal aortic aneurysms reveals neutrophil-derived leukotriene B-4 as a major chemotactic factor released from the intraluminal thrombus
Houard X, Ollivier V, Louedec L, Michel Jb, Back M
FASEB JOURNAL 2009;23(5):1376-83

Increased urinary leukotriene E-4 excretion in obstructive sleep apnea: Effects of obesity and hypoxia
Stanke-labesque F, Back M, Lefebvre B, Tamisier R, Baguet Jp, Arnol N, et al
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 2009;124(2):364-70

Inhibitors of the 5-Lipoxygenase Pathway in Atherosclerosis
Back M
CURRENT PHARMACEUTICAL DESIGN 2009;15(27):3116-32

Leukotriene Receptor Antagonism and the Prevention of Extracellular Matrix Degradation During Atherosclerosis and In-Stent Stenosis
Hlawaty H, Jacob Mp, Louedec L, Letourneur D, Brink C, Michel Jb, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2009;29(4):518-24

Leukotriene Signaling in Atherosclerosis and Ischemia
Back M
CARDIOVASCULAR DRUGS AND THERAPY 2009;23(1):41-8

Specific mediator inhibition by the NO donors SNP and NCX 2057 in the peripheral lung: implications for allergen-induced bronchoconstriction
Larsson Ak, Back M, Lundberg Jo, Dahlen Se
RESPIRATORY RESEARCH 2009;:46-

Inflammatory Signaling Through Leukotriene Receptors in Atherosclerosis
Back M
CURRENT ATHEROSCLEROSIS REPORTS 2008;10(3):244-51

Endothelium-dependent vascular responses induced by leukotriene B-4
Back M, Sakata K, Qiu H, Haeggstrom Jz, Dahlen Se
PROSTAGLANDINS & OTHER LIPID MEDIATORS 2007;83(3):209-12

Gamma-glutamyltransferase, leukotrienes, and cardiovascular risk
Back M
EUROPEAN HEART JOURNAL 2007;28(2):269-

Increased leukotriene concentrations in gingival crevicular fluid from subjects with periodontal disease and atherosclerosis
Back M, Airila-mansson S, Jogestrand T, Soder B, Soder Po
ATHEROSCLEROSIS 2007;193(2):389-94

Leukotriene receptors: Crucial components in vascular inflammation
Back M
THESCIENTIFICWORLDJOURNAL 2007;:1422-39

The Oral Cavity and Age: A Site of Chronic Inflammation?
Back M, Hlawaty H, Labat C, Michel Jb, Brink C
PLOS ONE 2007;2(12):e1351-

Effect of cold storage on cholinergic responses induced by electrical field stimulation in human bronchi
Back M, Costantino M, Brink C, Norel X
PULMONARY PHARMACOLOGY & THERAPEUTICS 2006;19(4):297-302

Leukotriene receptors in atherosclerosis
Back M, Hansson Gk
ANNALS OF MEDICINE 2006;38(7):493-502

Leukotrienes: potential therapeutic targets in cardiovascular diseases
Back M
BULLETIN DE L ACADEMIE NATIONALE DE MEDECINE 2006;190(7):1511-8

Inhibition of nitric-oxide synthase enhances antigen-induced contractions and increases release of cysteinyl-leukotrienes in guinea pig lung parenchyma: Nitric oxide as a protective factor
Larsson Ak, Back M, Hjoberg J, Dahlen Se
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 2005;315(1):458-65

Leukotriene B-4 signaling through NF-kappa B-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia
Back M, Bu Dx, Branstrom R, Sheikine Y, Yan Zq, Hansson Gk
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2005;102(48):17501-6

Leukotriene B-4 is an indirectly acting vasoconstrictor in guinea pig aorta via an inducible type of BLT receptor
Back M, Qiu H, Haeggstrom Jz, Sakata K
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2004;287(1):H419-24

The contractile action of leukotriene B-4 in the guinea-pig lung involves a vascular component
Sakata K, Dahlen Se, Back M
BRITISH JOURNAL OF PHARMACOLOGY 2004;141(3):449-56

Functional characteristics of cysteinyl-leukotriene receptor subtypes
Back M
LIFE SCIENCES 2002;71(6):611-22

Modulation of vascular tone and reactivity by nitric oxide in porcine pulmonary arteries and veins
Back M, Walch L, Norel X, Gascard Jp, Mazmanian G, Brink C
ACTA PHYSIOLOGICA SCANDINAVICA 2002;174(1):9-15

Pharmacological evidence for a novel cysteinyl-leukotriene receptor subtype in human pulmonary artery smooth muscle
Walch L, Norel X, Back M, Gacard Jp, Dahlen Se, Brink C
BRITISH JOURNAL OF PHARMACOLOGY 2002;137(8):1339-45

Receptor preferences of cysteinyl-leukotrienes in the guinea pig lung parenchyma
Sakata K, Back M
EUROPEAN JOURNAL OF PHARMACOLOGY 2002;436(1-2):119-26

Studies of receptors and modulatory mechanisms in functional responses to cysteinyl-leukotrienes in smooth muscle
Back M
ACTA PHYSIOLOGICA SCANDINAVICA 2002;:9-+

Studies of receptors and modulatory mechanisms in functional responses to cysteinyl-leukotrienes in smooth muscle
Bäck M
Acta physiologica Scandinavica. Supplementum 2002;648():1-55

The contraction of the human pulmonary artery by LTC4 is resistant to cysLT(1) antagonists and counteracted by prostacyclin release
Back M, Norel X, Walch L, Gascard Jp, Dahlen Se, Brink C
EICOSANOIDS AND OTHER BIOACTIVE LIPIDS IN CANCER, INFLAMMATION, AND RADIATION INJURY, 5 2002;:315-9

An alternative pathway for metabolism of leukotriene D-4: effects on contractions to cysteinyl-leukotrienes in the guinea-pig trachea
Back M, Kumlin M, Cotgreave Ia, Dahlen Se
BRITISH JOURNAL OF PHARMACOLOGY 2001;133(7):1134-44

Antagonist resistant contractions of the porcine pulmonary artery by cysteinyl-leukotrienes
Back M, Norel X, Walch L, Gascard Jp, Mazmanian G, Dahlen Se, et al
EUROPEAN JOURNAL OF PHARMACOLOGY 2000;401(3):381-8

Prostacyclin modulation of contractions of the human pulmonary artery by cysteinyl-leukotrienes
Back M, Norel X, Walch L, Gascard Jp, De Montpreville V, Dahlen Se, et al
EUROPEAN JOURNAL OF PHARMACOLOGY 2000;401(3):389-95

The cysteinyl-leukotriene receptor antagonist BAY u9773 is a competitive antagonist of leukotriene C-4 in the guinea-pig ileum
Back M, Jonsson Ew, Dahlen Se
EUROPEAN JOURNAL OF PHARMACOLOGY 1996;317(1):107-13

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