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Li Felländer-Tsai

Head of unit

Visiting address : K 54 Huddinge, Sweden
Postal address : Department of Clinical Science, Intervention and Technology (CLINTEC), H9, Division of Orthopedics and Biotechnology., K 54 Enheten för ortopedi, CLINTEC, KI , 141 86 Stockholm, Sweden
Delivery address : , Sweden

About me

Li Felländer-Tsai was appointed professor of orthopaedics at Karolinska Institutet in 2006. She is the chairman of the Department of Clinical Science, Intervention and Technology and Director of the Center for Advanced Medical Simulation and Training (CAMST). She is active in orthopaedic research, education and training as well as advanced surgical technology. She is president of the Swedish Orthopaedic Association and vice president of the Nordic Orthopaedic Federation. Li Felländer-Tsai is past registrar and chairman of the Swedish ACL Register (National quality registry for cruciate ligament reconstruction). She chaired the process of Accreditation of the Center for Advanced Medical Simulation and Training as an American College of Surgeons Level I (Comprehensive) Educational Institute.


MD Karolinska Institutet 1991

PhD Karolinska Institutet 1992

Appointed associate professor at Karolinska Institutet 1996

Internship and residency in orthopaedic surgery 1992-1999

Fellow with professor Lyle Micheli, Childrens Hospital Harvard University, during spring 1996

Consultant in Orthopaedic surgery 1999-2006

Appointed full professor and senior consultant in orthopaedic surgery at Karolinska Institutet and Karolinska University Hospital 2006

Research description

Muscoloskeletal disease and trauma:

Li Felländer-Tsais research focuses on recovery after injury and surgery of the musculoskeletal system, rehabilitation and also tissue metbolism. She has developed and implemented a technique for monitoring of synovial tissue metabolism and inflammation with intraoperative and postoperative microdialysis. Other fields of her research include trauma and tissue regeneration.

Her research includes epidemiological aspects of trauma and surgery.

The goal is optimal pain relief and healing with good joint function, minimizing adverse long term effects including osteoarthritis.

Advanced medical simulation and training:

The vision of this research field is to create a new de-facto standard for training technical and non technical skills (team behaviour) in high stakes healthcare with advanced medical simulators, where ergonomic principles are followed, and thus optimize patient safety. The aim is also to develop valid and reliable training and assessment instruments for technical skills so that individual training programs can be developed in which individual factors such as working memory and visuospatial ability can be targeted. When valid measures of team behavior and surgical skills are established, these can be translated into evidence-based training and education with both theory and practice. The ultimate goal is advanced state-of-the-art courses for trainers ( "train the trainer" course) with modern principles of both team training and advanced skills training. By training instructors and teachers the next generation of healthcare professionals will improve skills and attitudes in favour of patient safety.

Selected publications: Changes in rates of arthroscopy due to degenerative knee disease and traumatic meniscal tears in Finland and Sweden.
Mattila V, Sihvonen R, Paloneva J, Felländer-Tsai L
Acta Orthop 2016 Feb;87(1):5-11

Linear Dendritic Block Copolymers as Promising Biomaterials for the Manufacturing of Soft Tissue Adhesive Patches Using Visible Light Initiated Thiol-Ene Coupling Chemistry

Viktor Granskog, Oliver C. J. Andrén, Yanling Cai, Marcela González-Granillo,

Li Felländer-Tsai, Hans von Holst, Lars-Arne Haldosen, Michael Malkoch

ADVANCED FUNCTIONAL MATERIALS, Volume: 25, Issue: 42, Pages: 6596-6605

DOI: 10.1002/adfm.201503235, Published: NOV 11 2015

 Post-operative bracing after ACL reconstruction has no effect on knee joint effusion. A prospective, randomized study.
Lindström M, Wredmark T, Wretling M, Henriksson M, Felländer-Tsai L
Knee 2015 Dec;22(6):559-64

 Cruciate ligament reconstruction and risk of knee osteoarthritis: the association between cruciate ligament injury and post-traumatic osteoarthritis. a population based nationwide study in Sweden, 1987-2009.
Nordenvall R, Bahmanyar S, Adami J, Mattila V, Felländer-Tsai L
PLoS ONE 2014 ;9(8):e104681

 Predicting early mortality in adult trauma patients admitted to three public university hospitals in urban India: a prospective multicentre cohort study.
Gerdin M, Roy N, Khajanchi M, Kumar V, Dharap S, Felländer-Tsai L, et al
PLoS ONE 2014 ;9(9):e105606

 Early hospital mortality among adult trauma patients significantly declined between 1998-2011: three single-centre cohorts from Mumbai, India.
Gerdin M, Roy N, Dharap S, Kumar V, Khajanchi M, Tomson G, et al
PLoS ONE 2014 ;9(3):e90064

 Incidence of knee dislocation and concomitant vascular injury requiring surgery: a nationwide study.
Sillanpää P, Kannus P, Niemi S, Rolf C, Felländer-Tsai L, Mattila V
J Trauma Acute Care Surg 2014 Mar;76(3):715-9

 Acute achilles tendon ruptures: incidence of injury and surgery in Sweden between 2001 and 2012.
Huttunen T, Kannus P, Rolf C, Felländer-Tsai L, Mattila V
Am J Sports Med 2014 Oct;42(10):2419-23 

Diclofenac and triamcinolone acetonide impair tenocytic differentiation and promote adipocytic differentiation of mesenchymal stem cells.
Fredriksson M, Li Y, Stålman A, Haldosén L, Felländer-Tsai L
J Orthop Surg Res 2013 Sep;8():30

A population-based nationwide study of cruciate ligament injury in Sweden, 2001-2009: incidence, treatment, and sex differences.
Nordenvall R, Bahmanyar S, Adami J, Stenros C, Wredmark T, Felländer-Tsai L
Am J Sports Med 2012 Aug;40(8):1808-13

Systematic video game training in surgical novices improves performance in virtual reality endoscopic surgical simulators: a prospective randomized study.
Schlickum M, Hedman L, Enochsson L, Kjellin A, Felländer-Tsai L
World J Surg 2009 Nov;33(11):2360-7

Temperature-sensitive release of prostaglandin E₂ and diminished energy requirements in synovial tissue with postoperative cryotherapy: a prospective randomized study after knee arthroscopy.
Stålman A, Berglund L, Dungnerc E, Arner P, Felländer-Tsai L
J Bone Joint Surg Am 2011 Nov;93(21):1961-8

Ketorolac but not morphine exerts inflammatory and metabolic effects in synovial membrane after knee arthroscopy: a double-blind randomized prospective study using the microdialysis technique.
Stålman A, Tsai J, Segerdahl M, Dungner E, Arner P, Felländer-Tsai L
Reg Anesth Pain Med ;34(6):557-64

Systematic simulation-based team training in a Swedish intensive care unit: a diverse response among critical care professions.
Meurling L, Hedman L, Sandahl C, Felländer-Tsai L, Wallin C
BMJ Qual Saf 2013 Jun;22(6):485-94