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Laura Fratiglioni

Professor/senior physician

Visiting address : Gävlegatan 18 A 113 30 Stockholm, Sweden
Delivery address : Gävlegatan 16 113 30 Stockholm, Sweden

About me

I am a medical doctor from Italy, specialized in both neurology and epidemiology. I moved to Sweden with my family 1996.

I am currently employed as a professor at Karolinska Institutet. Since 2007, I have been the director of the Aging Research Center (ARC). In 2010, I was granted the Distinguished Professor Award by Karolinska Institutet. I have scientific, clinical, and pedagogical commitments.

  •  My scientific production has led to 285 articles in peer-reviewed journals, 23 book chapters, and 12 reports. By October 2014 I had 18,093 citations and an h-index of 70.
  • Under my supervision, 15 PhD students and nine postdocs have completed their studies since 1996. I am currently the main supervisor of 2 PhD students and co-supervisor of 5 students.
  • Since 1996, as principal investigator, I have regularly received grants from the major research councils in Sweden and from international agencies. Together with a multidisciplinary team of senior researchers, I was awarded a 10-year grant to build ARC by The Swedish Council for Working Life and Social Research (Forte; 11 million Swedish krona per year).
  • I have received several prizes, including the Lifetime Achievement Award from the American Alzheimer’s Association, Sohlberg’s Nordic Prize in Gerontology, and the Karolinska Institutet Folksams prize in epidemiologic research.

Relevant issues for the board of research
1. To be able to implement KI’s “Strategy 2018” concerning research quality, research infrastructure, and support for younger researchers
2. To strengthen clinical research
3. To facilitate the integration of basic research within clinical and epidemiological research
4. To reinforce the dialogue and the interaction between research and education 

 

Education

In 2008 in collaboration with other centers at KI and the universities of Lund and Umeå, I started a National Graduate School for Aging Research, which supports an educational program with a biological, psychological, and socio-demographic profile. Preparations for a larger-scale multidisciplinary interaction at the national level are ongoing.

Research description

I am the principal investigator of the SNAC-Kungsholmen population study, the scientific coordinator for the Kungsholmen Project on Aging and Dementia, and co-investigator in several Swedish (Swedish Brian Power) and European consortia (NEW-AGE, HATICE, ESCAPE; MPI-age). My research group consists of 18 people, including two lecturers, two assistant professors, six post-docs, seven PhD students, one research assistant, and one research coordinator. We have four major lines of research: 1) Postponing dementia onset: Risk and protective factors for Alzheimer’s disease and other dementias, 2) Understanding the natural history of the dementias, 3) The body-mind connection, and 4) Health status and health trends in older people.

Postponing dementia onset: Risk and protective factors for Alzheimer’s disease and other dementias. In the last two decades, significant progress has been made regarding the identification of risk and protective factors in dementia. Our group has contributed to the accumulating evidence that lifestyle and cardiovascular risk factors play important roles in the pathogenesis and development of dementia. In addition, we have proposed a life-course model for the development of dementia that is now commonly accepted. This model asserts that a) life-long cumulating lesions (of different kinds) lead to dementia when they no longer can be counteracted by compensatory mechanisms; b) most cases of dementia will occur in late life and most will be of the mixed type (i.e., neurodegenerative and vascular); c) there are specific time windows when some determinants may be active, although not during the whole life period; d) risk and protective factors may interact in both increasing and attenuating their effects on dementia development; e) not all old persons develop dementia, even at advanced ages, and learning from those who “escape” can shed new light on the pathogenesis of dementia; and f) delay of dementia onset seems to be the only realistic endpoint in prevention. Following this model, we are now examining old (vascular and psychosocial factors) and new hypotheses (psychological stress, nutrition, and pollution) with three major goals: a) to identify possible pathways through which protective factors may compensate for previous risk exposures, b) to detect underlying mechanisms, and c) to verify the extent to which established risk and protective factors may anticipate or delay dementia onset.

Understanding the natural history of the dementias from mild cognitive impairment, early detection and progression to disability, institutionalization and death. ~~Cognitive deficits can be observed up to ten years before a dementia diagnosis is made; a sharp decline is more evident in the final three years. My colleagues and I have validated the use of such early cognitive deficits as a predictive tool for incipient dementia in the general population, but to date none of the proposed definitions has shown itself to be a sufficiently good predictor at the community level. This is mainly because cognitive impairment is common in the elderly population and has multiple causes. In our ongoing work on this topic, we are examining various individual-difference variables that might modulate both the onset of dementia and the decline once dementia has started. Of special interest here is whether certain favorable conditions (e.g., high educational level, an active lifestyle, advantageous genetic variants) would lead to a later change point and more rapid decline during the final years preceding dementia diagnosis, reflecting greater cognitive reserve. We are also integrating cognitive data with MRI findings to increase the ability to predict dementia onset, whereas social factors are taken into account when studying disability, institutionalization, and death in people affected by dementia.

The body-mind connection. ~~Ongoing demographic changes are expected to lead not only to an increased number of people with chronic diseases, but also to the development of different patterns of diseases, such as multiple health and functional problems, referred to here as chronic multimorbidity (15). Multimorbidity is a very common syndrome in elderly people. It occurs in more than half of the 75+ old population, and the prevalence is higher in very old persons, women, and people from disadvantaged social classes. Almost nothing is known about risk factors for multimorbidity, but the consequences are well established: functional impairment, poor quality of life, and high health-care utilization and costs. We have recently started a new project to study the effect of multimorbidity on cognitive functions. Preliminary data show that multimorbidity affects both the progression from MCI to dementia and the progression of dementia toward functional dependence. Furthermore, specific chronic disorders such as heart failure, atrial fibrillation, and anemia are associated with an increased risk of dementia, which suggests that dementia may also develop in the absence of neurodegeneration. Finally, we have documented a deleterious effect of polypharmacy and of specific chronic disorders (depression, stroke, diabetes) in the development of cognitive impairment. On the basis of these findings, we hypothesize that chronic multimorbidity is a frail state that may anticipate onset of dementia by several years.

Health status and health trends in old ages.  Human health is a dynamic and multidimensional status, and this is especially evident in aging, when health changes occur more frequently and at an increased rate. Using data already collected in our cohort studies of middle-aged and elderly people, we are now addressing two research questions: 1) How can we measure the health status of older adults in a more comprehensive way? 2) What are the chains of events that culminate in the development of poor health in elderly people? Specifically, we aim to: 1) integrate multiple health dimensions in a score to better describe health and health trajectories among older adults and to relate health to work capability and societal engagement; 2) quantify the effect of the major social, environmental, psychological, and biological determinants and their life-long interactions on health and survival in older adults; 3) assess geographical variation in mental and physical health and their known determinants in Sweden; and 4) explore time trends in mortality and morbidity among the older population. This research line represents a timely initiative after two decades during which researchers in the aging field (including several from our group) have identified numerous factors that contribute to heath in aging. The challenge is now to understand the interplay among these many factors in a life course perspective, taking into account different components and their impact at the societal level.

Academic honours, awards and prizes

PRIZES

  • 2013 Lifetime Achievement Award from the American Alzheimer’s Association
  • 2011 Wajlit och Eric Forsgrens prize for AD researcher - Umeå University
  • 2010 The Sohlberg's Nordic Prize in Gerontology
  • 2010 Sofiahemmet-Research and Education prize in dementia research
  • 2009 Karolinska Institutet Folksams prize in epidemiologic research
  • 2008 The Swedish Society of Medicine – “Inga Sandeborg’s prize”
  • 2001 Italian Society of Neurology - Award “In memory of Prof L Amaducci”

AWARDS & HONORS

  • 2011 Forte- mid-term evaluation of ARC: ‘We recommend support at a higher level’
  • 2011 KI - ERA evaluation (international independent panel): grading ‘Oustanding’
  • 2010-2015 The Karolinska  Institutet - Distinguished Professor Award
  • 1996-1999 Medical Research Council, Sweden – 4-year position as a Research Scientist
  • 1990-1993 Medical Research Council, Sweden – 4-year position as a PhD student
     

Publications

Anticholinergic drug use is associated with episodic memory decline in older adults without dementia
Papenberg G, Bäckman L, Fratiglioni L, Laukka Ej, Fastbom J, Johnell K
Neurobiology of aging 2017;55():27-32

Assessing and Measuring Chronic Multimorbidity in the Older Population: A Proposal for Its Operationalization
Calderón-larrañaga A, Vetrano Dl, Onder G, Gimeno-feliu La, Coscollar-santaliestra C, Carfí A, et al
The journals of gerontology. Series A, Biological sciences and medical sciences 2017;72(10):1417-1423

Association of lifelong exposure to cognitive reserve-enhancing factors with dementia risk: A community-based cohort study
Wang Hx, Macdonald Sw, Dekhtyar S, Fratiglioni L
PLoS medicine 2017;14(3):e1002251-

Cognitive and Physical Function in Relation to the Risk of Injurious Falls in Older Adults: A Population-Based Study
Welmer Ak, Rizzuto D, Laukka Ej, Johnell K, Fratiglioni L
The journals of gerontology. Series A, Biological sciences and medical sciences 2017;72(5):669-675

Cognitive performance in unipolar old-age depression: a longitudinal study
Pantzar A, Atti Ar, Fratiglioni L, Fastbom J, Bäckman L, Laukka Ej
International journal of geriatric psychiatry 2017;32(6):675-684

Defining Health Trajectories in Older Adults With Five Clinical Indicators
Santoni G, Marengoni A, Calderón-larrañaga A, Angleman S, Rizzuto D, Welmer Ak, et al
The journals of gerontology. Series A, Biological sciences and medical sciences 2017;72(8):1123-1129

Erratum to: The societal costs of dementia in Sweden 2012 - relevance and methodological challenges in valuing informal care
Wimo A, Jönsson L, Fratiglioni L, Sandman Po, Gustavsson A, Sköldunger A, et al
Alzheimer's research & therapy 2017;9(1):12-

Formal and Informal Care of Community-Living Older People: A Population-Based Study from the Swedish National Study on Aging and Care
Wimo A, Elmståhl S, Fratiglioni L, Sjölund Bm, Sköldunger A, Fagerström C, et al
The journal of nutrition, health & aging 2017;21(1):17-24

Improving Public Awareness of Multimorbidity
Marengoni A, Fratiglioni L, Onder G
Journal of the American Medical Directors Association 2017;18(5):372-373

Influence of Negative Life Events and Widowhood on Risk for Dementia
Gerritsen L, Wang Hx, Reynolds Ca, Fratiglioni L, Gatz M, Pedersen Nl
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2017;25(7):766-778

Living alone and unplanned hospitalizations among older adults: a population-based longitudinal study
Pimouguet C, Rizzuto D, Lagergren M, Fratiglioni L, Xu W
European journal of public health 2017;27(2):251-256

Long-term exposure to ambient air pollution and traffic noise and incident hypertension in seven cohorts of the European study of cohorts for air pollution effects (ESCAPE)
Fuks Kb, Weinmayr G, Basagaña X, Gruzieva O, Hampel R, Oftedal B, et al
European heart journal 2017;38(13):983-990

Mixed brain lesions mediate the association between cardiovascular risk burden and cognitive decline in old age: A population-based study
Wang R, Fratiglioni L, Kalpouzos G, Lövdén M, Laukka Ej, Bronge L, et al
Alzheimer's & dementia : the journal of the Alzheimer's Association 2017;13(3):247-256

Outdoor air pollution and risk for kidney parenchyma cancer in 14 European cohorts
Raaschou-nielsen O, Pedersen M, Stafoggia M, Weinmayr G, Andersen Zj, Galassi C, et al
International journal of cancer 2017;140(7):1528-1537

Prevalence and Correlates of Olfactory Dysfunction in Old Age: A Population-Based Study
Seubert J, Laukka Ej, Rizzuto D, Hummel T, Fratiglioni L, Bäckman L, et al
The journals of gerontology. Series A, Biological sciences and medical sciences 2017;72(8):1072-1079

The economic burden of dementia in China, 1990-2030: implications for health policy
Xu J, Wang J, Wimo A, Fratiglioni L, Qiu C
Bulletin of the World Health Organization 2017;95(1):18-26

The interactive effect of demographic and clinical factors on hippocampal volume: A multicohort study on 1958 cognitively normal individuals
Ferreira D, Hansson O, Barroso J, Molina Y, Machado A, Hernández-cabrera Ja, et al
Hippocampus 2017;27(6):653-667

Trends in Incidence of Disability in Activities of Daily Living in Chinese Older Adults: 1993-2006
Liang Y, Welmer Ak, Wang R, Song A, Fratiglioni L, Qiu C
Journal of the American Geriatrics Society 2017;65(2):306-312

Use of Medications of Questionable Benefit During the Last Year of Life of Older Adults With Dementia
Morin L, Vetrano Dl, Grande G, Fratiglioni L, Fastbom J, Johnell K
Journal of the American Medical Directors Association 2017;18(6):551.e1-551.e7

Work-related psychosocial stress and the risk of type 2 diabetes in later life
Pan Ky, Xu W, Mangialasche F, Fratiglioni L, Wang Hx
Journal of internal medicine 2017;281(6):601-610

Association of mobility limitations with incident disability among older adults: a population-based study
Heiland Eg, Welmer Ak, Wang R, Santoni G, Angleman S, Fratiglioni L, et al
Age and ageing 2016;45(6):812-819

Association of Vitamin B12, Folate, and Sulfur Amino Acids With Brain Magnetic Resonance Imaging Measures in Older Adults: A Longitudinal Population-Based Study
Hooshmand B, Mangialasche F, Kalpouzos G, Solomon A, Kåreholt I, Smith Ad, et al
JAMA psychiatry 2016;73(6):606-13

Childhood school performance, education and occupational complexity: a life-course study of dementia in the Kungsholmen Project
Dekhtyar S, Wang Hx, Fratiglioni L, Herlitz A
International journal of epidemiology 2016;45(4):1207-1215

Coexisting chronic conditions in the older population: Variation by health indicators
Marengoni A, Angleman S, Meinow B, Santoni G, Mangialasche F, Rizzuto D, et al
European journal of internal medicine 2016;31():29-34

Cost of Dementia and Its Correlation With Dependence
Akerborg O, Lang A, Wimo A, Skoldunger A, Fratiglioni L, Gaudig M, et al
JOURNAL OF AGING AND HEALTH 2016;28(8):1448-1464

Defeating Alzheimer's disease and other dementias: a priority for European science and society
Winblad B, Amouyel P, Andrieu S, Ballard C, Brayne C, Brodaty H, et al
The Lancet. Neurology 2016;15(5):455-532

Dementia in western Europe: epidemiological evidence and implications for policy making
Wu Yt, Fratiglioni L, Matthews Fe, Lobo A, Breteler Mm, Skoog I, et al
The Lancet. Neurology 2016;15(1):116-24

Depression and Depression Treatment in a Population-Based Study of Individuals Over 60 Years Old Without Dementia
Karlsson B, Johnell K, Sigström R, Sjöberg L, Fratiglioni L
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2016;24(8):615-623

Early Cognitive Deficits in Type 2 Diabetes: A Population-Based Study
Marseglia A, Fratiglioni L, Laukka Ej, Santoni G, Pedersen Nl, Bäckman L, et al
Journal of Alzheimer's disease : JAD 2016;53(3):1069-78

Effect of the Interplay Between Genetic and Behavioral Risks on Survival After Age 75
Rizzuto D, Keller L, Orsini N, Graff C, Bäckman L, Bellocco R, et al
Journal of the American Geriatrics Society 2016;64(12):2440-2447

Effects of biological age on the associations of blood pressure with cardiovascular and non-cardiovascular mortality in old age: A population-based study
Liang Y, Fratiglioni L, Wang R, Santoni G, Welmer Ak, Qiu C
International journal of cardiology 2016;220():508-13

Horizontal and vertical targeting: a population-based comparison of public eldercare services in urban and rural areas of Sweden
Lagergren M, Fagerström C, Sjölund Bm, Berglund J, Fratiglioni L, Nordell E, et al
Aging clinical and experimental research 2016;28(1):147-58

Impact of living alone on institutionalization and mortality: a population-based longitudinal study
Pimouguet C, Rizzuto D, Schön P, Shakersain B, Angleman S, Lagergren M, et al
European journal of public health 2016;26(1):182-7

Influence of Incipient Dementia on Hospitalization for Primary Care Sensitive Conditions: A Population-Based Cohort Study
Pimouguet C, Rizzuto D, Fastbom J, Lagergren M, Fratiglioni L, Xu W
Journal of Alzheimer's disease : JAD 2016;52(1):213-22

Nutritional status and survival among old adults: an 11-year population-based longitudinal study
Shakersain B, Santoni G, Faxén-irving G, Rizzuto D, Fratiglioni L, Xu W
European journal of clinical nutrition 2016;70(3):320-5

Particulate matter air pollution components and risk for lung cancer
Raaschou-nielsen O, Beelen R, Wang M, Hoek G, Andersen Zj, Hoffmann B, et al
Environment international 2016;87():66-73

Physical activity and inflammation: effects on gray-matter volume and cognitive decline in aging
Papenberg G, Ferencz B, Mangialasche F, Mecocci P, Cecchetti R, Kalpouzos G, et al
Human brain mapping 2016;37(10):3462-73

Prudent diet may attenuate the adverse effects of Western diet on cognitive decline
Shakersain B, Santoni G, Larsson Sc, Faxén-irving G, Fastbom J, Fratiglioni L, et al
Alzheimer's & dementia : the journal of the Alzheimer's Association 2016;12(2):100-109

Same Ages, Same Genes: Same Brains, Same Pathologies?: Dementia Timings, Co-Occurring Brain Pathologies, ApoE Genotypes in Identical and Fraternal Age-matched Twins at Autopsy
Iacono D, Volkmann I, Nennesmo I, Pedersen Nl, Fratiglioni L, Johansson B, et al
Alzheimer disease and associated disorders 2016;30(2):178-82

Statin Therapy and Dementia in Older Adults: Role of Disease Severity and Multimorbidity
Gnjidic D, Fastbom J, Fratiglioni L, Rizzuto D, Angleman S, Johnell K
Journal of the American Geriatrics Society 2016;64(1):223-4

Telomerase Gene (hTERT) and Survival: Results From Two Swedish Cohorts of Older Adults
Kalpouzos G, Rizzuto D, Keller L, Fastbom J, Santoni G, Angleman S, et al
The journals of gerontology. Series A, Biological sciences and medical sciences 2016;71(2):188-95

The impact of dementia on drug costs in older people: results from the SNAC study
Sköldunger A, Fastbom J, Wimo A, Fratiglioni L, Johnell K
BMC neurology 2016;16():28-

The societal costs of dementia in Sweden 2012 - relevance and methodological challenges in valuing informal care
Wimo A, Jönsson L, Fratiglioni L, Sandman Po, Gustavsson A, Sköldunger A, et al
Alzheimer's research & therapy 2016;8(1):59-

Three-year changes in leisure activities are associated with concurrent changes in white matter microstructure and perceptual speed in individuals aged 80 years and older
Köhncke Y, Laukka Ej, Brehmer Y, Kalpouzos G, Li Tq, Fratiglioni L, et al
Neurobiology of aging 2016;41():173-186

Age-related variation in health status after age 60
Santoni G, Angleman S, Welmer Ak, Mangialasche F, Marengoni A, Fratiglioni L
PloS one 2015;10(3):e0120077-

A major role for cardiovascular burden in age-related cognitive decline
Qiu C, Fratiglioni L
Nature reviews. Cardiology 2015;12(5):267-77

Convergent genetic and expression data implicate immunity in Alzheimer's disease
Mrc Cfas, Int Genomics Alzheimer's Dis Conso, Jones L, Lambert Jc, Wang Ls, Choi Sh, et al
ALZHEIMERS & DEMENTIA 2015;11(6):658-71

Do levels of perceived stress increase with increasing age after age 65? A population-based study
Osmanovic-thunström A, Mossello E, Åkerstedt T, Fratiglioni L, Wang Hx
Age and ageing 2015;44(5):828-34

Effects of vascular risk factors and APOE ε4 on white matter integrity and cognitive decline
Wang R, Fratiglioni L, Laukka Ej, Lövdén M, Kalpouzos G, Keller L, et al
Neurology 2015;84(11):1128-35

HHEX_23 AA Genotype Exacerbates Effect of Diabetes on Dementia and Alzheimer Disease: A Population-Based Longitudinal Study
Xu Wl, Pedersen Nl, Keller L, Kalpouzos G, Wang Hx, Graff C, et al
PLoS medicine 2015;12(7):e1001853-

Impact of Inappropriate Drug Use on Hospitalizations, Mortality, and Costs in Older Persons and Persons with Dementia: Findings from the SNAC Study
Sköldunger A, Fastbom J, Wimo A, Fratiglioni L, Johnell K
Drugs & aging 2015;32(8):671-8

Magnified effects of the COMT gene on white-matter microstructure in very old age
Papenberg G, Lövdén M, Laukka Ej, Kalpouzos G, Keller L, Graff C, et al
Brain structure & function 2015;220(5):2927-38

Microstructural White Matter Properties Mediate the Association between APOE and Perceptual Speed in Very Old Persons without Dementia
Laukka Ej, Lövdén M, Kalpouzos G, Papenberg G, Keller L, Graff C, et al
PloS one 2015;10(8):e0134766-

Multidimensional Prognostic Index in Association with Future Mortality and Number of Hospital Days in a Population-Based Sample of Older Adults: Results of the EU Funded MPI_AGE Project
Angleman Sb, Santoni G, Pilotto A, Fratiglioni L, Welmer Ak, Mpi_age Project Investigators
PloS one 2015;10(7):e0133789-

Natural-Cause Mortality and Long-Term Exposure to Particle Components: An Analysis of 19 European Cohorts within the Multi-Center ESCAPE Project
Beelen R, Hoek G, Raaschou-nielsen O, Stafoggia M, Andersen Zj, Weinmayr G, et al
ENVIRONMENTAL HEALTH PERSPECTIVES 2015;123(6):525-33

Prevalence, pharmacological treatment, and control of cardiometabolic risk factors among older people in central Stockholm: a population-based study
Wang R, Fratiglioni L, Liang Y, Welmer Ak, Xu W, Mangialasche F, et al
PloS one 2015;10(3):e0119582-

Temporal trends of functional dependence and survival among older adults from 1991 to 2010 in Sweden: toward a healthier aging
Angleman Sb, Santoni G, Von Strauss E, Fratiglioni L
The journals of gerontology. Series A, Biological sciences and medical sciences 2015;70(6):746-52

The influence of negative life events on hippocampal and amygdala volumes in old age: a life-course perspective
Gerritsen L, Kalpouzos G, Westman E, Simmons A, Wahlund Lo, Bäckman L, et al
Psychological medicine 2015;45(6):1219-28

Traffic-related air pollution exposure and incidence of stroke in four cohorts from Stockholm
Korek Mj, Bellander Td, Lind T, Bottai M, Eneroth Km, Caracciolo B, et al
Journal of exposure science & environmental epidemiology 2015;25(5):517-23

9th Key symposium introduction: updating Alzheimer's disease diagnosis implications for prevention and treatment
Kivipelto M, Mangialasche F, Solomon A, Johansson G, Lannfelt L, Fratiglioni L, et al
Journal of internal medicine 2014;275(3):202-3

A change in sleep pattern may predict Alzheimer disease
Hahn Ea, Wang Hx, Andel R, Fratiglioni L
The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry 2014;22(11):1262-71

Advances in the prevention of Alzheimer's disease and dementia
Solomon A, Mangialasche F, Richard E, Andrieu S, Bennett Da, Breteler M, et al
Journal of internal medicine 2014;275(3):229-50

Air Pollution and Nonmalignant Respiratory Mortality in 16 Cohorts within the ESCAPE Project
Dimakopoulou K, Samoli E, Beelen R, Stafoggia M, Andersen Zj, Hoffmann B, et al
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 2014;189(6):684-96

Arterial Blood Pressure and Long-Term Exposure to Traffic-Related Air Pollution: An Analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE)
Fuks Kb, Weinmayr G, Foraster M, Dratva J, Hampel R, Houthuijs D, et al
ENVIRONMENTAL HEALTH PERSPECTIVES 2014;122(9):896-905

A self-report risk index to predict occurrence of dementia in three independent cohorts of older adults: the ANU-ADRI
Anstey Kj, Cherbuin N, Herath Pm, Qiu C, Kuller Lh, Lopez Ol, et al
PloS one 2014;9(1):e86141-

Changes in perceptual speed and white matter microstructure in the corticospinal tract are associated in very old age
Lövdén M, Köhncke Y, Laukka Ej, Kalpouzos G, Salami A, Li Tq, et al
NeuroImage 2014;102 Pt 2():520-30

Cognitive decline, dietary factors and gut-brain interactions
Caracciolo B, Xu Wl, Collins S, Fratiglioni L
MECHANISMS OF AGEING AND DEVELOPMENT 2014;:59-69

Cognitive deficits in unipolar old-age depression: a population-based study
Pantzar A, Laukka Ej, Atti Ar, Fastbom J, Fratiglioni L, Bäckman L
Psychological medicine 2014;44(5):937-47

Cognitive functioning among patients with diabetic foot
Marseglia A, Xu W, Rizzuto D, Ferrari C, Whisstock C, Brocco E, et al
Journal of diabetes and its complications 2014;28(6):863-8

Do cardiovascular risk factors explain the link between white matter hyperintensities and brain volumes in old age? A population-based study
Wang R, Fratiglioni L, Laveskog A, Kalpouzos G, Ehrenkrona Ch, Zhang Y, et al
European journal of neurology 2014;21(8):1076-82

Effects of long-term exposure to air pollution on natural-cause mortality: an analysis of 22 European cohorts within the multicentre ESCAPE project
Beelen R, Raaschou-nielsen O, Stafoggia M, Andersen Zj, Weinmayr G, Hoffmann B, et al
Lancet (London, England) 2014;383(9919):785-95

Estimating the burden of early onset dementia; systematic review of disease prevalence
Lambert Ma, Bickel H, Prince M, Fratiglioni L, Von Strauss E, Frydecka D, et al
EUROPEAN JOURNAL OF NEUROLOGY 2014;21(4):563-9

Gene-wide analysis detects two new susceptibility genes for Alzheimer's disease
Escott-price V, Bellenguez C, Wang Ls, Choi Sh, Harold D, Jones L, et al
PloS one 2014;9(6):e94661-

Horizontal and vertical target efficiency - a comparison between users and non-users of public long-term care in Sweden
Lagergren M, Sjolund Bm, Fagerstrom C, Berglund J, Fratiglioni L, Nordell E, et al
AGEING & SOCIETY 2014;34(4):700-719

Incidence and predictors of multimorbidity in the elderly: a population-based longitudinal study
Melis R, Marengoni A, Angleman S, Fratiglioni L
PloS one 2014;9(7):e103120-

Interactive effects of KIBRA and CLSTN2 polymorphisms on episodic memory in old-age unipolar depression
Pantzar A, Laukka Ej, Atti Ar, Papenberg G, Keller L, Graff C, et al
Neuropsychologia 2014;62():137-42

Lifestyle factors related to mortality and survival: a mini-review
Rizzuto D, Fratiglioni L
Gerontology 2014;60(4):327-35

Long-term exposure to air pollution and cardiovascular mortality: an analysis of 22 European cohorts
Beelen R, Stafoggia M, Raaschou-nielsen O, Andersen Zj, Xun Ww, Katsouyanni K, et al
Epidemiology (Cambridge, Mass.) 2014;25(3):368-78

Long term exposure to ambient air pollution and incidence of acute coronary events: prospective cohort study and meta-analysis in 11 European cohorts from the ESCAPE Project
Cesaroni G, Forastiere F, Stafoggia M, Andersen Zj, Badaloni C, Beelen R, et al
BMJ-BRITISH MEDICAL JOURNAL 2014;:f7412-

Long-Term Exposure to Ambient Air Pollution and Incidence of Cerebrovascular Events: Results from 11 European Cohorts within the ESCAPE Project
Stafoggia M, Cesaroni G, Peters A, Andersen Zj, Badaloni C, Beelen R, et al
ENVIRONMENTAL HEALTH PERSPECTIVES 2014;122(9):919-25

Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts: results from the ESCAPE and TRANSPHORM projects
Wang M, Beelen R, Stafoggia M, Raaschou-nielsen O, Andersen Zj, Hoffmann B, et al
Environment international 2014;66():97-106

Mild cognitive impairment: a concept in evolution
Petersen Rc, Caracciolo B, Brayne C, Gauthier S, Jelic V, Fratiglioni L
JOURNAL OF INTERNAL MEDICINE 2014;275(3):214-28

Neuropathologic assessment of dementia markers in identical and fraternal twins
Iacono D, Volkman I, Nennesmo I, Pedersen Nl, Fratiglioni L, Johansson B, et al
Brain pathology (Zurich, Switzerland) 2014;24(4):317-33

Sociodemographic determinants of diet quality of the EU elderly: a comparative analysis in four countries
Irz X, Fratiglioni L, Kuosmanen N, Mazzocchi M, Modugno L, Nocella G, et al
Public health nutrition 2014;17(5):1177-89

Accelerated progression from mild cognitive impairment to dementia among APOE ε4ε4 carriers
Xu Wl, Caracciolo B, Wang Hx, Santoni G, Winblad B, Fratiglioni L
Journal of Alzheimer's disease : JAD 2013;33(2):507-15

Adherence to physical exercise recommendations in people over 65--the SNAC-Kungsholmen study
Rydwik E, Welmer Ak, Kåreholt I, Angleman S, Fratiglioni L, Wang Hx
European journal of public health 2013;23(5):799-804

Air pollution and lung cancer incidence in 17 European cohorts: prospective analyses from the European Study of Cohorts for Air Pollution Effects (ESCAPE)
Raaschou-nielsen O, Andersen Zj, Beelen R, Samoli E, Stafoggia M, Weinmayr G, et al
LANCET ONCOLOGY 2013;14(9):813-22

Association of cardiovascular burden with mobility limitation among elderly people: a population-based study
Welmer Ak, Angleman S, Rydwik E, Fratiglioni L, Qiu C
PloS one 2013;8(5):e65815-

Associations between white matter microstructure and cognitive performance in old and very old age
Laukka Ej, Lövdén M, Kalpouzos G, Li Tq, Jonsson T, Wahlund Lo, et al
PloS one 2013;8(11):e81419-

Genetic effects on old-age cognitive functioning: a population-based study
Laukka Ej, Lövdén M, Herlitz A, Karlsson S, Ferencz B, Pantzar A, et al
Psychology and aging 2013;28(1):262-74

Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease
Gerad Consortium, Eadi Consortium, Lambert Jc, Grenier-boley B, Harold D, Zelenika D, et al
MOLECULAR PSYCHIATRY 2013;18(4):461-70

How can elderly apolipoprotein E ε4 carriers remain free from dementia?
Ferrari C, Xu Wl, Wang Hx, Winblad B, Sorbi S, Qiu C, et al
Neurobiology of aging 2013;34(1):13-21

Is midlife occupational physical activity related to disability in old age? The SNAC-Kungsholmen study
Rydwik E, Welmer Ak, Angleman S, Fratiglioni L, Wang Hx
PloS one 2013;8(7):e70471-

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease
Charge, Adgc, Gerad, Eadi, Lambert Jc, Ibrahim-verbaas Ca, et al
NATURE GENETICS 2013;45(12):1452-8

Natural Progression Model of Cognition and Physical Functioning among People with Mild Cognitive Impairment and Alzheimer's Disease
Handels Rlh, Xu Wl, Rizzuto D, Caracciolo B, Wang R, Winblad B, et al
JOURNAL OF ALZHEIMERS DISEASE 2013;37(2):357-65

Relationship of subjective cognitive impairment and cognitive impairment no dementia to chronic disease and multimorbidity in a nation-wide twin study
Caracciolo B, Gatz M, Xu W, Marengoni A, Pedersen Nl, Fratiglioni L
Journal of Alzheimer's disease : JAD 2013;36(2):275-84

Serum levels of vitamin E forms and risk of cognitive impairment in a Finnish cohort of older adults
Mangialasche F, Solomon A, Kåreholt I, Hooshmand B, Cecchetti R, Fratiglioni L, et al
Experimental gerontology 2013;48(12):1428-35

The dimensionality of between-person differences in white matter microstructure in old age
Lövdén M, Laukka Ej, Rieckmann A, Kalpouzos G, Li Tq, Jonsson T, et al
Human brain mapping 2013;34(6):1386-98

The influence of APOE and TOMM40 polymorphisms on hippocampal volume and episodic memory in old age
Ferencz B, Laukka Ej, Lövdén M, Kalpouzos G, Keller L, Graff C, et al
Frontiers in human neuroscience 2013;7():198-

The influence of multimorbidity on clinical progression of dementia in a population-based cohort
Melis Rj, Marengoni A, Rizzuto D, Teerenstra S, Kivipelto M, Angleman Sb, et al
PloS one 2013;8(12):e84014-

Twenty-year changes in dementia occurrence suggest decreasing incidence in central Stockholm, Sweden
Qiu C, Von Strauss E, Bäckman L, Winblad B, Fratiglioni L
Neurology 2013;80(20):1888-94

An active lifestyle postpones dementia onset by more than one year in very old adults
Paillard-borg S, Fratiglioni L, Xu W, Winblad B, Wang Hx
Journal of Alzheimer's disease : JAD 2012;31(4):835-42

Can chronic multimorbidity explain the age-related differences in strength, speed and balance in older adults?
Welmer Ak, Kåreholt I, Angleman S, Rydwik E, Fratiglioni L
Aging clinical and experimental research 2012;24(5):480-9

Comparison between visual assessment of MTA and hippocampal volumes in an elderly, non-demented population
Cavallin L, Bronge L, Zhang Y, Oksengård Ar, Wahlund Lo, Fratiglioni L, et al
Acta radiologica (Stockholm, Sweden : 1987) 2012;53(5):573-9

Cost of disorders of the brain in Europe 2010 (vol 21, pg 718, 2011)
Cdbe2010 Study Grp, Gustavsson A, Svensson M, Jacobi F, Allgulander C, Alonso J, et al
EUROPEAN NEUROPSYCHOPHARMACOLOGY 2012;22(3):237-238

Dementia after age 75: survival in different severity stages and years of life lost
Rizzuto D, Bellocco R, Kivipelto M, Clerici F, Wimo A, Fratiglioni L
Current Alzheimer research 2012;9(7):795-800

Dementia prevention: current epidemiological evidence and future perspective
Mangialasche F, Kivipelto M, Solomon A, Fratiglioni L
Alzheimer's research & therapy 2012;4(1):6-

Differential Distribution of Subjective and Objective Cognitive Impairment in the Population: A Nation-Wide Twin-Study
Caracciolo B, Gatz M, Xu Wl, Pedersen Nl, Fratiglioni L
JOURNAL OF ALZHEIMERS DISEASE 2012;29(2):393-403

Does Vascular Burden Contribute to the Progression of Mild Cognitive Impairment to Dementia?
Clerici F, Caracciolo B, Cova I, Imperatori Sf, Maggiore L, Galimberti D, et al
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 2012;34(3-4):235-43

Education halves the risk of dementia due to apolipoprotein epsilon 4 allele: a collaborative study from the Swedish Brain Power initiative
Wang Hx, Gustafson Dr, Kivipelto M, Pedersen Nl, Skoog I, Windblad B, et al
NEUROBIOLOGY OF AGING 2012;33(5):1007.e1-7

Lifestyle, social factors, and survival after age 75: population based study
Rizzuto D, Orsini N, Qiu C, Wang Hx, Fratiglioni L
BMJ (Clinical research ed.) 2012;345():e5568-

Medial temporal lobe is vulnerable to vascular risk factors in men: a population-based study
Qiu C, Zhang Y, Bronge L, Herlitz A, Aspelin P, Bäckman L, et al
European journal of neurology 2012;19(6):876-83

Methodological challenges in designing dementia prevention trials - The European Dementia Prevention Initiative (EDPI)
Richard E, Andrieu S, Solomon A, Mangialasche F, Ahtiluoto S, Van Charante Epm, et al
JOURNAL OF THE NEUROLOGICAL SCIENCES 2012;322(1-2):64-70

Preclinical Cognitive Trajectories Differ for Alzheimer's Disease and Vascular Dementia
Laukka Ej, Macdonald Sws, Fratiglioni L, Backman L
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY 2012;18(2):191-9

Psychosocial stress at work is associated with increased dementia risk in late life
Wang Hx, Wahlberg M, Karp A, Winblad B, Fratiglioni L
ALZHEIMERS & DEMENTIA 2012;8(2):114-20

Undertreatment of osteoporosis in persons with dementia? A population-based study
Haasum Y, Fastbom J, Fratiglioni L, Johnell K
OSTEOPOROSIS INTERNATIONAL 2012;23(3):1061-8

Work-Related Stress May Increase the Risk of Vascular Dementia
Andel R, Crowe M, Hahn Ea, Mortimer Ja, Pedersen Nl, Fratiglioni L, et al
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 2012;60(1):60-7

Aging with multimorbidity: A systematic review of the literature
Marengoni A, Angleman S, Melis R, Mangialasche F, Karp A, Garmen A, et al
AGEING RESEARCH REVIEWS 2011;10(4):430-9

Association of Blood Pressure and Hypertension With the Risk of Parkinson Disease The National FINRISK Study
Qiu Cx, Hu G, Kivipelto M, Laatikainen T, Antikainen R, Fratiglioni L, et al
HYPERTENSION 2011;57(6):1094-100

Atrial fibrillation, stroke and dementia in the very old: A population-based study
Marengoni A, Qiu Cx, Winblad B, Fratiglioni L
NEUROBIOLOGY OF AGING 2011;32(7):1336-7

Cost of disorders of the brain in Europe 2010
Cdbe2010 Study Grp, Gustavsson A, Svensson M, Jacobi F, Allgulander C, Alonso J, et al
EUROPEAN NEUROPSYCHOPHARMACOLOGY 2011;21(10):718-79

DEVELOPMENT AND VALIDATION OF A COMPOSITE SCORE AS AN EASY-TO-USE INSTRUMENT FOR CLINICAL MONITORING OF DEMENTIA PROGRESSION: THE COMPOSITE COGNITIVE AND ACTIVITIES OF DAILY LIVING FUNCTIONING SCORE
Melis Rjf, Angleman Sb, Fratiglioni L
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 2011;59(6):1154-5

Disease Clusters in Older Adults: Rationale and Need for Investigation
Marengoni A, Fratiglioni L
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 2011;59(12):2395-6

Epidemiological studies of cognitive impairment and dementia across Eastern and Middle European countries (Epidemiology of Dementia in Eastern and Middle European Countries)
Kiejna A, Frydecka D, Adamowski T, Bickel H, Reynish E, Prince M, et al
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY 2011;26(2):111-7

IAGG Workshop: Health promotion program on prevention of late onset dementia
Andrieu S, Aboderin I, Baeyens Jp, Beard J, Benetos A, Berrut G, et al
JOURNAL OF NUTRITION HEALTH & AGING 2011;15(7):562-75

Midlife overweight and obesity increase late-life dementia risk A population-based twin study
Xu Wl, Atti Ar, Gatz M, Pedersen Nl, Johansson B, Fratiglioni L
NEUROLOGY 2011;76(18):1568-74

Onset and Rate of Cognitive Change Before Dementia Diagnosis: Findings From Two Swedish Population-Based Longitudinal Studies
Thorvaldsson V, Macdonald Sws, Fratiglioni L, Winblad B, Kivipelto M, Laukka Ej, et al
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY 2011;17(1):154-62

Pain Treatment in Elderly Persons With and Without Dementia A Population-Based Study of Institutionalized and Home-Dwelling Elderly
Haasum Y, Fastbom J, Fratiglioni L, Kareholt I, Johnell K
DRUGS & AGING 2011;28(4):283-93

Predictors of Successful Ageing: Epidemiological Evidence
Fratiglioni L
JOURNAL OF ALZHEIMERS DISEASE 2011;:S16-S16

Preventing Alzheimer Disease and Cognitive Decline
Qiu Cx, Kivipelto M, Fratiglioni L
ANNALS OF INTERNAL MEDICINE 2011;154(3):211-author

Prevention of cognitive decline in ageing: dementia as the target, delayed onset as the goal
Fratiglioni L, Qiu Cx
LANCET NEUROLOGY 2011;10(9):778-9

Socioeconomic Status During Lifetime and Cognitive Impairment No-Dementia in Late Life: The Population-Based Aging in the Chianti Area (InCHIANTI) Study
Marengoni A, Fratiglioni L, Bandinelli S, Ferrucci L
JOURNAL OF ALZHEIMERS DISEASE 2011;24(3):559-68

The Obesity Related Gene, FTO, Interacts with APOE and is Associated with Alzheimer's Disease Risk: A Prospective Cohort Study
Keller L, Xu Wl, Wang Hx, Winblad B, Fratiglioni L, Graff C
JOURNAL OF ALZHEIMERS DISEASE 2011;23(3):461-9

The size and burden of mental disorders and other disorders of the brain in Europe 2010
Wittchen Hu, Jacobi F, Rehm J, Gustavsson A, Svensson M, Jonsson B, et al
EUROPEAN NEUROPSYCHOPHARMACOLOGY 2011;21(9):655-79

The symptom of low mood in the prodromal stage of mild cognitive impairment and dementia: a cohort study of a community dwelling elderly population
Caracciolo B, Backman L, Monastero R, Winblad B, Fratiglioni L
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY 2011;82(7):788-93

The World of Dementia Beyond 2020
Brodaty H, Breteler Mmb, Dekosky St, Dorenlot P, Fratiglioni L, Hock C, et al
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 2011;59(5):923-7

Trajectories of Cognitive Decline following Dementia Onset: What Accounts for Variation in Progression?
Macdonald Sws, Karlsson S, Fratiglioni L, Backman L
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 2011;31(3):202-9

UNDERTREATMENT OF OSTEOPOROSIS IN ELDERLY WITH DEMENTIA? A POPULATION-BASED STUDY
Haasum Y, Fastbom J, Fratiglioni L, Johnell K
OSTEOPOROSIS INTERNATIONAL 2011;:280-280

Accelerated Progression From Mild Cognitive Impairment to Dementia in People With Diabetes
Xu Wl, Caracciolo B, Wang Hx, Winblad B, Backman L, Qiu Cx, et al
DIABETES 2010;59(11):2928-35

Acceleration of hippocampal atrophy in a non-demented elderly population: the SNAC-K study
Zhang Y, Qiu C, Lindberg O, Bronge L, Aspelin P, Backman L, et al
INTERNATIONAL PSYCHOGERIATRICS 2010;22(1):14-25

A functional polymorphism in the HMGCR promoter affects transcriptional activity but not the risk for Alzheimer disease in Swedish populations
Keller L, Murphy C, Wang Hx, Fratiglioni L, Olin M, Gafvels M, et al
BRAIN RESEARCH 2010;:185-91

Apolipoprotein E epsilon 4 Status and Cognitive Decline With and Without Dementia
Qiu Cx, Fratiglioni L
ARCHIVES OF NEUROLOGY 2010;67(8):1036-

Brain aging: lessons from community studies
Fratiglioni L, Mangialasche F, Qiu Cx
NUTRITION REVIEWS 2010;68(12):S119-27

Cognitive Impairment after Age 60: Clinical and Social Correlates in the "Faenza Project"
Atti Ar, Forlani C, De Ronchi D, Palmer K, Casadio P, Dalmonte E, et al
JOURNAL OF ALZHEIMERS DISEASE 2010;21(4):1325-34

Genetic and biochemical studies of SNPs of the mitochondrial A beta-degrading protease, hPreP
Pinho Cm, Bjork Bf, Alikhani N, Backman Hg, Eneqvist T, Fratiglioni L, et al
NEUROSCIENCE LETTERS 2010;469(2):204-8

Genetic association to the amyloid plaque associated protein gene COL25A1 in Alzheimer's disease
Forsell C, Bjork Bf, Lilius L, Axelman K, Fabre Sf, Fratiglioni L, et al
NEUROBIOLOGY OF AGING 2010;31(3):409-15

High Plasma Levels of Vitamin E Forms and Reduced Alzheimer's Disease Risk in Advanced Age
Mangialasche F, Kivipelto M, Mecocci P, Rizzuto D, Palmer K, Winblad B, et al
JOURNAL OF ALZHEIMERS DISEASE 2010;20(4):1029-37

Low body mass index predicts progression of MCI to dementia and Alzheimer's disease
Clerici F, Caracciolo B, Cova I, Imperatori Sf, Pomati S, Cucumo V, et al
JOURNAL OF NEUROLOGY 2010;:S164-S165

Midlife Fruit and Vegetable Consumption and Risk of Dementia in Later Life in Swedish Twins
Hughes Tf, Andel R, Small Bj, Borenstein Ar, Mortimer Ja, Wolk A, et al
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY 2010;18(5):413-20

The impact of vascular burden on the progression of MCI to dementia
Clerici F, Caracciolo B, Cova I, Imperatori Sf, Maggiore L, Galimberti D, et al
JOURNAL OF NEUROLOGY 2010;:S165-S166

The Influence of Vascular Disease on Cognitive Performance in the Preclinical and Early Phases of Alzheimer's Disease
Laukka Ej, Fratiglioni L, Backman L
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 2010;29(6):498-503

Vascular and Psychosocial Factors in Alzheimer's Disease: Epidemiological Evidence Toward Intervention
Qiu Cx, Xu Wl, Fratiglioni L
JOURNAL OF ALZHEIMERS DISEASE 2010;20(3):689-97

Vascular Risk Profiles for Dementia and Alzheimer's Disease in Very Old People: A Population-Based Longitudinal Study
Qiu Cx, Xu Wl, Winblad B, Fratiglioni L
JOURNAL OF ALZHEIMERS DISEASE 2010;20(1):293-300

Work-Related Exposure to Extremely Low-Frequency Magnetic Fields and Dementia: Results from the Population-Based Study of Dementia in Swedish Twins
Andel R, Crowe M, Feychting M, Pedersen Nl, Fratiglioni L, Johansson B, et al
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 2010;65(11):1220-7

APOE-related mortality: Effect of dementia, cardiovascular disease and gender
Rosvall L, Rizzuto D, Wang Hx, Winblad B, Graff C, Fratiglioni L
NEUROBIOLOGY OF AGING 2009;30(10):1545-51

Depression as a Risk Factor or Prodromal Feature for Dementia? Findings in a Population-Based Sample of Swedish Twins
Brommelhoff Ja, Gatz M, Johansson B, Mcardle Jj, Fratiglioni L, Pedersen Nl
PSYCHOLOGY AND AGING 2009;24(2):373-84

Do polymorphisms in transcription factors LMX1A and LMX1B influence the risk for Parkinson's disease?
Bergman O, Hayenkansson A, Westberg L, Belin Ac, Sydow O, Olson L, et al
JOURNAL OF NEURAL TRANSMISSION 2009;116(3):333-8

ELECTROMAGNETIC FIELD EXPOSURE AT WORK AND SUBSEQUENT RISK OF DEMENTIA
Andel R, Crowe M, Feychting M, Pedersen Nl, Fratiglioni L, Johansson B, et al
GERONTOLOGIST 2009;:398-398

Homocysteine and holo-transcobalamin and the risk of dementia and Alzheimers disease: a prospective study
Kivipelto M, Annerbo S, Hultdin J, Backman L, Viitanen M, Fratiglioni L, et al
EUROPEAN JOURNAL OF NEUROLOGY 2009;16(7):808-13

Leisure Activities in Late Life in Relation to Dementia Risk: Principal Component Analysis
Paillard-borg S, Fratiglioni L, Winblad B, Wang Hx
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 2009;28(2):136-44

Low Diastolic Pressure and Risk of Dementia in Very Old People: A Longitudinal Study
Qiu Cx, Winblad B, Fratiglioni L
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 2009;28(3):213-9

Mentally Stimulating Activities at Work During Midlife and Dementia Risk After Age 75: Follow-Up Study From the Kungsholmen Project
Karp A, Andel R, Parker Mg, Wang Hx, Winblad B, Fratiglioni L
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY 2009;17(3):227-36

Mid- and Late-Life Diabetes in Relation to the Risk of Dementia A Population-Based Twin Study
Xu Wl, Qiu Cx, Gatz M, Pedersen Nl, Johansson B, Fratiglioni L
DIABETES 2009;58(1):71-7

Pattern of participation in leisure activities among older people in relation to their health conditions and contextual factors: a survey in a Swedish urban area
Paillard-borg S, Wang Hx, Winblad B, Fratiglioni L
AGEING & SOCIETY 2009;:803-821

Patterns of Chronic Multimorbidity in the Elderly Population
Marengoni A, Rizzuto D, Wang Hx, Winblad B, Fratiglioni L
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 2009;57(2):225-30

Personality and lifestyle in relation to dementia incidence
Wang Hx, Karp A, Herlitz A, Crowe M, Kareholt I, Winblad B, et al
NEUROLOGY 2009;72(3):253-9

Prevention of common neurodegenerative disorders in the elderly
Fratiglioni L, Qiu Cx
EXPERIMENTAL GERONTOLOGY 2009;44(1-2):46-50

The impact of chronic multimorbidity and disability on functional decline and survival in elderly persons. A community-based, longitudinal study
Marengoni A, Von Strauss E, Rizzuto D, Winblad B, Fratiglioni L
JOURNAL OF INTERNAL MEDICINE 2009;265(2):288-95

The influence of a history of vascular disorders on cognitive performance in early Alzheimer's disease
Laukka Ej, Fratiglioni L, Backman L
JOURNAL OF THE NEUROLOGICAL SCIENCES 2009;283(1-2):287-287

Uncontrolled diabetes increases the risk of Alzheimer's disease: a population-based cohort study
Xu Wl, Von Strauss E, Qiu Cx, Winblad B, Fratiglioni L
DIABETOLOGIA 2009;52(6):1031-9

Asthma, eczema, rhinitis and the risk for dementia
Eriksson Uk, Gatz M, Dickman Pw, Fratiglioni L, Pedersen Nl
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 2008;25(2):148-56

Early symptoms and signs of cognitive deficits might not always be detectable in persons who develop Alzheimer's disease
Palmer K, Backman L, Winblad B, Fratiglioni L
INTERNATIONAL PSYCHOGERIATRICS 2008;20(2):252-8

In utero and early-life conditions and adult health and disease
Marengoni A, Winblad B, Fratiglioni L
NEW ENGLAND JOURNAL OF MEDICINE 2008;359(14):1523-author

Late-life body mass index and dementia incidence: Nine-year follow-up data from the kungsholmen project
Atti Ar, Palmer K, Volpato S, Winblad B, De Ronchi D, Fratiglioni L
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 2008;56(1):111-6

Mild cognitive impairment in the general population: Occurrence and progression to Alzheimer disease
Palmer K, Backman L, Winblad B, Fratiglioni L
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY 2008;16(7):603-11

Occurrence of cognitive impairment and dementia in the community - A 9-year-long prospective study
Caracciolo B, Palmer K, Monastero R, Winblad B, Backman L, Fratiglioni L
NEUROLOGY 2008;70(19):1778-85

Physical exercise at midlife and risk of dementia three decades later: A population-based study of Swedish twins
Andel R, Crowe M, Pedersen Nl, Fratiglioni L, Johansson B, Gatz M
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 2008;63(1):62-6

Prevalence of chronic diseases and multimorbidity among the elderly population in Sweden
Marengoni A, Winblad B, Karp A, Fratiglioni L
AMERICAN JOURNAL OF PUBLIC HEALTH 2008;98(7):1198-200

Rehabilitation and nursing home admission after hospitalization in acute geriatric patients
Marengoni A, Aguero-torres H, Timpini A, Cossi S, Fratiglioni L
JOURNAL OF THE AMERICAN MEDICAL DIRECTORS ASSOCIATION 2008;9(4):265-70

Accounting for the relationship between low education and dementia: A twin study
Gatz M, Mortimer Ja, Fratiglioni L, Johansson B, Berg S, Andel R, et al
PHYSIOLOGY & BEHAVIOR 2007;92(1-2):232-7

Brain reserve hypothesis in dementia
Fratiglioni L, Wang Hx
JOURNAL OF ALZHEIMERS DISEASE 2007;12(1):11-22

Heterogeneity in risk factors for cognitive impairment, no dementia: Population-based longitudinal study from the Kungsholmen Project
Monastero R, Palmer K, Qiu Cx, Winblad B, Fratiglioni L
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY 2007;15(1):60-9

Positive association between risk for late-onset Alzheimer disease and genetic variation in IDE
Bjork Bf, Katzov H, Kehoe P, Fratiglioni L, Winblad B, Prince Ja, et al
NEUROBIOLOGY OF AGING 2007;28(9):1374-80

Predictors of progression from mild cognitive impairment to Alzheimer disease
Palmer K, Berger Ak, Monastero R, Winblad B, Bachman L, Fratiglioni L
NEUROLOGY 2007;68(19):1596-602

Prevention of Alzheimer's disease and dementia. Major findings from the Kungsholmen project
Fratiglioni L, Winblad B, Von Strauss E
PHYSIOLOGY & BEHAVIOR 2007;92(1-2):98-104

The combined effect of age, education, and stroke on dementia and cognitive impairment no dementia in the elderly
De Ronchi D, Palmer K, Pioggiosi P, Atti Ar, Berardi D, Ferrari B, et al
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 2007;24(4):266-73

The effect of borderline diabetes on the risk of dementia and Alzheimer's disease
Xu Wl, Qiu Cx, Winblad B, Fratiglioni L
DIABETES 2007;56(1):211-6

The epidemiology of the dementias: an update
Qiu Cx, De Ronchi D, Fratiglioni L
CURRENT OPINION IN PSYCHIATRY 2007;20(4):380-5

Anaemia increases the risk of dementia in cognitively intact elderly
Atti Ar, Palmer K, Volpato S, Zuliani G, Winblad B, Fratiglioni L
NEUROBIOLOGY OF AGING 2006;27(2):278-84

Cerebrovascular disease, APOE epsilon 4 allele and cognitive decline in a cognitively normal population
Qiu Cx, Winblad B, Fratiglioni L
NEUROLOGICAL RESEARCH 2006;28(6):650-6

Commentary on "Vascular cognitive impairment: today and tomorrow." Vascular cognitive impairment: time for prevention?
Fratiglioni L, Qiu C, Palmer K
Alzheimer's & dementia : the journal of the Alzheimer's Association 2006;2(3):202-4

Heart failure and risk of dementia and Alzheimer disease - A population-based cohort study
Qiu Cx, Winblad B, Marengoni A, Klarin I, Fastbom J, Fratiglioni L
ARCHIVES OF INTERNAL MEDICINE 2006;166(9):1003-8

Heart failure, dementia, and diuretics: Is uric acid involved? In reply
Qiu Cx, Winblad B, Fratiglioni L
ARCHIVES OF INTERNAL MEDICINE 2006;166(20):2287-2287

Heritability of an age-dependent categorical phenotype: Cognitive dysfunction
Reynolds Ca, Fiske A, Fratiglioni L, Pedersen Nl, Gatz M
TWIN RESEARCH AND HUMAN GENETICS 2006;9(1):17-23

Mental, physical and social components in leisure activities equally contribute to decrease dementia risk
Karp A, Paillard-borg S, Wang Hx, Silverstein M, Winblad B, Fratiglioni L
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 2006;21(2):65-73

Personality and risk of cognitive impairment 25 years later
Crowe M, Andel R, Pedersen Nl, Fratiglioni L, Gatz M
PSYCHOLOGY AND AGING 2006;21(3):573-80

Role of genes and environments for explaining Alzheimer disease
Gatz M, Reynolds Ca, Fratiglioni L, Johansson B, Mortimer Ja, Berg S, et al
ARCHIVES OF GENERAL PSYCHIATRY 2006;63(2):168-74

Aging and multimorbidity: an epidemiological study from The Kungsholmen Project
Marengoni A, Aguero-torres H, Winblad B, Fratiglioni L
INTERNATIONAL PSYCHOGERIATRICS 2005;:281-282

Alzheimer's disease and depression: Preclinical comorbidity effects on cognitive functioning
Berger Ak, Fratiglioni L, Winblad B, Backman L
CORTEX 2005;41(4):603-12

Approaches toward the prevention of dementia
Palmer K, Winblad B, Backman L, Fratiglioni L
INTERNATIONAL PSYCHOGERIATRICS 2005;:118-119

BMI and risk of dementia. Data from the Kungsholmen project
Atti Ar, Volpato S, Palmer K, Kivipelto M, Zuliani G, Winblad B, et al
INTERNATIONAL PSYCHOGERIATRICS 2005;:179-180

Cognitive impairment is the major risk factor for development of geriatric syndromes during hospitalization: Results from the GIFA study
Gifa Study Grp, Mecocci P, Von Strauss E, Cherubini A, Ercolani S, Mariani E, et al
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 2005;20(4):262-9

Complete ascertainment of dementia in the Swedish Twin Registry: the HARMONY study
Gatz M, Fratiglioni L, Johansson B, Berg S, Mortimer Ja, Reynolds Ca, et al
NEUROBIOLOGY OF AGING 2005;26(4):439-47

Global prevalence of dementia: a Delphi consensus study
Alzheimers Dis Intl, Ferri Cp, Prince M, Brayne C, Brodaty H, Fratiglioni L, et al
LANCET 2005;366(9503):2112-7

Inactivity, depressive symptoms, and social isolation increase the risk of dementia: A population-based study
Karp A, Parker M, Wang Hx, Winblad B, Fratiglioni L
INTERNATIONAL PSYCHOGERIATRICS 2005;:227-227

Longitudinal models of growth and survival applied to the early detection of Alzheimer's disease
Mcardle Jj, Small Bj, Backman L, Fratiglioni L
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY 2005;18(4):234-41

Neuropsychiatric symptomatology in mild cognitive impairment: Do anxiety and depressive-related symptoms predict progression to Alzheimer's disease?
Palmer K, Berger Ak, Monastero R, Winblad B, Fratiglioni L
INTERNATIONAL PSYCHOGERIATRICS 2005;:170-170

Obesity and vascular risk factors at midlife and the risk of dementia and Alzheimer disease
Kivipelto M, Ngandu T, Fratiglioni L, Viitanen M, Kareholt I, Winblad B, et al
ARCHIVES OF NEUROLOGY 2005;62(10):1556-60

Occurrence of cognitive impairment and dementia after the age of 60: A population based study from northern Italy
De Ronchi D, Berardi D, Menchetti M, Ferrari G, Serretti A, Dalmonte E, et al
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 2005;19(2-3):97-105

Old age neuroticism and extraversion and risk of cognitive impairment and dementia. A community-based 6-year follow-up study
Wang Hx, Karp A, Herlitz A, Winblad B, Fratiglioni L
INTERNATIONAL PSYCHOGERIATRICS 2005;:226-227

Performance on neurocognitive tests by co-twins to dementia cases compared to normal control twins
Gatz M, Fiske A, Reynolds Ca, Johansson B, Fratiglioni L, Pedersen Nl
JOURNAL OF GERIATRIC PSYCHIATRY AND NEUROLOGY 2005;18(4):202-7

Personality at midlife and cognitive impairment in older adulthood
Crowe M, Andel R, Pedersen N, Fratiglioni L, Gatz M
GERONTOLOGIST 2005;:346-347

Physical and mental functioning in a population over 60 years of age. Data from the SNAC-Kungsholmen Project
Von Strauss E, Backman L, Herlitz A, Fastbom J, Winblad B, Fratiglioni L
INTERNATIONAL PSYCHOGERIATRICS 2005;:213-214

[Risk factors for dementia and Alzheimer' s disease-findings from a community-based cohort study in Stockholm, Sweden]
Qiu Cx, Winblad B, Fratiglioni L
Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi 2005;26(11):882-7

SveDem, how do you do, Sweden?
Spangberg K, Jonhagen Me, Fratiglioni L, Graff C, Minthon L, Sandman Po, et al
INTERNATIONAL PSYCHOGERIATRICS 2005;:337-338

The age-dependent relation of blood pressure to cognitive function and dementia
Qiu Cx, Winblad B, Fratiglioni L
LANCET NEUROLOGY 2005;4(8):487-99

[Variability of epidemiological measures in mild cognitive impairment and dementia]
Fratiglioni L, Caracciolo B, Palmer K
Annali dell'Istituto superiore di sanita 2005;41(1):81-6

Alcohol drinking at midlife and the risk of mild cognitive impairment and dementia in late-life
Anttila T, Helkala El, Viitanen M, Kareholt I, Fratiglioni L, Winblad B, et al
NEUROBIOLOGY OF AGING 2004;:S397-S397

Alcohol drinking in middle age and subsequent risk of mild cognitive impairment and dementia in old age: a prospective population based study
Anttila T, Helkala El, Viitanen M, Kareholt I, Fratiglioni L, Winblad B, et al
BRITISH MEDICAL JOURNAL 2004;329(7465):539-

A longitudinal study integrating population, care and social services data. The Swedish National study on Aging and Care (SNAC)
Lagergren M, Fratiglioni L, Hallberg Ir, Berglund J, Elmstahl S, Hagberg B, et al
AGING CLINICAL AND EXPERIMENTAL RESEARCH 2004;16(2):158-68

An active and socially integrated lifestyle in late life might protect against dementia
Fratiglioni L, Paillard-borg S, Winblad B
LANCET NEUROLOGY 2004;3(6):343-53

APOE and cognitive decline in preclinical Alzheimer disease and non-demented aging
Bunce D, Fratiglioni L, Small Bj, Winblad B, Backman L
NEUROLOGY 2004;63(5):816-21

APOE genotype, family history of dementia, and Alzheimer disease risk - A 6-year follow-up study
Huang Wy, Qiu Cx, Von Strauss E, Winblad B, Fratiglioni L
ARCHIVES OF NEUROLOGY 2004;61(12):1930-4

Apolipoprotein E and cognitive performance: A meta-analysis
Small Bj, Rosnick Cb, Fratiglioni L, Backman L
PSYCHOLOGY AND AGING 2004;19(4):592-600

A preclinical phase in vascular dementia: Cognitive impairment three years before diagnosis
Jones S, Laukka Ej, Small Bj, Fratiglioni L, Backmana L
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS 2004;18(3-4):233-9

Body mass index, clustering of vascular risk factors and the risk of dementia: A longitudinal, population-based study
Kivipelto M, Anttila T, Fratiglioni L, Winblad B, Nissinen A, Soininen H
NEUROBIOLOGY OF AGING 2004;:S311-S311

Cognitive functioning in aging and dementia: The Kungsholmen Project
Backman L, Wahlin A, Small Bj, Herlitz A, Winblad B, Fratiglioni L
AGING NEUROPSYCHOLOGY AND COGNITION 2004;11(2-3):212-244

Cognitive functioning in preclinical vascular dementia - A 6-year follow-up
Laukka Ej, Jones S, Fratiglioni L, Backman L
STROKE 2004;35(8):1805-9

Cognitive impairment is the major risk factor of adverse events in hospitalised elderly patients
Mecocci P, Von Strauss E, Cherubini A, Ercolani S, Senin U, Winblad B, et al
NEUROBIOLOGY OF AGING 2004;:S21-S21

Decline in blood pressure over time and risk of dementia - A longitudinal study from the Kungsholmen project
Qiu Cx, Von Strauss E, Winblad B, Fratiglioni L
STROKE 2004;35(8):1810-5

Decline in blood pressure over time and risk of dementia in the Kungsholmen project
Qiu Cx, Von Strauss E, Winblad B, Fratiglioni L
INTERNATIONAL JOURNAL OF PSYCHOLOGY 2004;39(5-6):175-175

Diabetes mellitus and risk of dementia in the kungsholmen project: A 6-year follow-up study
Xu Wl, Qiu Cx, Wahlin A, Winblad B, Fratiglioni L
NEUROBIOLOGY OF AGING 2004;:S484-S484

Diabetes mellitus and risk of dementia in the Kungsholmen project - A 6-year follow-up study
Xu Wl, Qiu Cx, Wahlin A, Winblad B, Fratiglioni L
NEUROLOGY 2004;63(7):1181-6

Five-years mortality in dementia: The role of co-existing diseases and dementia severity
Marengoni A, Aguero-torres H, Fratiglioni L
NEUROBIOLOGY OF AGING 2004;:S98-S98

Genetic effects do not account for the relationship between education and dementia
Gatz M, Andel R, Berg S, Crowe M, Fratiglioni L, Johansson B, et al
NEUROBIOLOGY OF AGING 2004;:S400-S400

Heart failure and risk of dementia in the kungsholmen project: A six-year follow-up study
Qiu Cx, Winblad B, Marengoni A, Fastbom J, Fratiglioni L
NEUROBIOLOGY OF AGING 2004;:S53-S53

Introduction: Mild cognitive impairment: beyond controversies, towards a consensus
Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L
JOURNAL OF INTERNAL MEDICINE 2004;256(3):181-182

Mild cognitive impairment - beyond controversies, towards a consensus: report of the International Working Group on Mild Cognitive Impairment
Winblad B, Palmer K, Kivipelto M, Jelic V, Fratiglioni L, Wahlund Lo, et al
JOURNAL OF INTERNAL MEDICINE 2004;256(3):240-6

Occupational exposure to electromagnetic fields and risk of Alzheimer's disease
Qiu Cx, Fratiglioni L, Karp A, Winblad B, Bellander T
EPIDEMIOLOGY 2004;15(6):687-94

Occurrence and progression to dementia of MCI subtypes in the general population
Palmer K, Backman L, Winblad B, Fratiglioni L
NEUROBIOLOGY OF AGING 2004;:S26-S27

Poor mental and physical health differentially contributes to disability in hospitalized geriatric patients of different ages
Marengoni A, Aguero-torres H, Cossi S, Ghisla Mk, De Martinis M, Leonardi R, et al
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY 2004;19(1):27-34

Psychosocial risk factors
Fratiglioni L
NEUROBIOLOGY OF AGING 2004;:S5-S5

Relation of education and occupation-based socioeconomic status to incident Alzheimer's disease
Karp A, Kareholt I, Qiu Cx, Bellander T, Winblad B, Fratiglioni L
AMERICAN JOURNAL OF EPIDEMIOLOGY 2004;159(2):175-83

Re: "Relation of education and occupation-based socioeconomic status to incident Alzheimer's disease" - Reply
Karp A, Fratiglioni L
AMERICAN JOURNAL OF EPIDEMIOLOGY 2004;160(4):405-406

Risk and protective effects of the APOE gene towards Alzheimer's disease in the Kungsholmen project: variation by age and sex
Qiu C, Kivipelto M, Aguero-torres H, Winblad B, Fratiglioni L
JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY 2004;75(6):828-33

Similar patterns of cognitive deficits in the preclinical phases of vascular dementia and Alzheimer's disease
Laukka Ej, Jones S, Small Bj, Fratiglioni L, Backman L
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY 2004;10(3):382-91

[A simple three-step model for detection of preclinical dementia among the elderly]
Palmer K, Bäckman L, Winblad B, Fratiglioni L
Lakartidningen 2003;100(34):2606-8

Combined effects of APOE genotype, blood pressure, and antihypertensive drug use on incident AD
Qiu Cx, Winblad B, Fastbom J, Fratiglioni L
NEUROLOGY 2003;61(5):655-60

Detection of Alzheimer's disease and dementia in the preclinical phase: population based cohort study
Palmer K, Backman L, Winblad B, Fratiglioni L
BRITISH MEDICAL JOURNAL 2003;326(7383):245-

Epidemiology of cerebrovascular disease related cognitive decline
Qiu Cx, Fratiglioni L
INTERNATIONAL PSYCHOGERIATRICS 2003;:105-10

Life-time occupational history in relation to dementia: The Kungsholmen Project
Fratiglioni L, Qui C, Karp A, Winblad B, Bellander T
INTERNATIONAL PSYCHOGERIATRICS 2003;:110-110

Lifetime principal occupation and risk of Alzheimer's disease in the Kungsholmen Project
Qiu Cx, Karp A, Von Strauss E, Winblad B, Fratiglioni L, Bellander T
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE 2003;43(2):204-11

Low blood pressure and risk of dementia in the Kungsholmen project - A 6-year follow-up study
Qiu Cx, Von Strauss E, Fastbom J, Winblad B, Fratiglioni L
ARCHIVES OF NEUROLOGY 2003;60(2):223-8

Psychiatric symptoms/syndromes in elderly persons with mild cognitive impairment. Data from a cross-sectional study
Forsell Y, Palmer K, Fratiglioni L
ACTA NEUROLOGICA SCANDINAVICA 2003;:25-8

Pulse pressure and risk of Alzheimer disease in persons aged 75 years and older - A community-based, longitudinal study
Qiu Cx, Winblad B, Viitanen M, Fratiglioni L
STROKE 2003;34(3):594-9

Rate of cognitive decline in preclinical Alzheimer's disease: The role of comorbidity
Backman L, Jones S, Small Bj, Aguero-torres H, Fratiglioni L
JOURNALS OF GERONTOLOGY SERIES B-PSYCHOLOGICAL SCIENCES AND SOCIAL SCIENCES 2003;58(4):P228-36

Terminal decline and cognitive performance in very old age: Does cause of death matter?
Small Bj, Fratiglioni L, Von Strauss E, Backman L
PSYCHOLOGY AND AGING 2003;18(2):193-202

What is mild cognitive impairment? Variations in definitions and evolution of nondemented persons with cognitive impairment
Palmer K, Fratiglioni L, Winblad B
ACTA NEUROLOGICA SCANDINAVICA 2003;:14-20

Women are more disabled in basic activities of daily living than men only in very advanced ages: A study on disability, morbidity, and mortality from the Kungsholmen Project
Von Strauss E, Aguero-torres H, Kareholt I, Winblad B, Fratiglioni L
JOURNAL OF CLINICAL EPIDEMIOLOGY 2003;56(7):669-77

Alcohol consumption and incidence of dementia in a community sample aged 75 years and older
Huang Wy, Qiu Cx, Winblad B, Fratiglioni L
JOURNAL OF CLINICAL EPIDEMIOLOGY 2002;55(10):959-64

An active and socially integrated lifestyle may protect against dementia
Fratiglioni L, Wang Hx, Winblad B
NEUROBIOLOGY OF AGING 2002;23(1):S7-S7

Cognitive impairment, no dementia: Is it possible to identify, with high predictivity, subjects at risk of developing dementia in the general population?
Palmer K, Backman L, Winblad B, Fratiglioni L
NEUROBIOLOGY OF AGING 2002;23(1):S289-+

Dementias and cognitive impairment not dementia (CIND): Distribution by age, gender and education
De Ronchi D, Berardi D, Menchetti M, Fratiglioni L, Dalmonte E
NEUROBIOLOGY OF AGING 2002;23(1):S289-S290

Dementing disorders in the elderly: Evolution of disease severity over 7 years
Aguero-torres H, Qiu Cx, Winblad B, Fratiglioni L
ALZHEIMER DISEASE & ASSOCIATED DISORDERS 2002;16(4):221-7

Differential evolution of cognitive impairment in nondemented older persons: Results from the Kungsholmen project
Palmer K, Wang Hx, Backman L, Winblad B, Fratiglioni L
AMERICAN JOURNAL OF PSYCHIATRY 2002;159(3):436-42

Differential verbal fluency deficits in the preclinical stages of Alzheimer's disease and vascular dementia
Jones S, Laukka Ej, Fratiglioni L, Backman L
NEUROBIOLOGY OF AGING 2002;23(1):S28-S28

Education and occupation-based socio-economic status in relation to incident dementia
Karp A, Kareholt I, Qiu Cx, Winblad B, Fratiglioni L, Bellander T
NEUROBIOLOGY OF AGING 2002;23(1):S296-S296

Incidence of Alzheimer's disease and other dementia disorders. Findings from a population-based study of the oldest old in Stockholm, Sweden
Von Strauss E, Aguero-torres H, Winblad B, Fratiglioni L
NEUROBIOLOGY OF AGING 2002;23(1):S289-S289

Influences of preclinical dementia and impending death on the magnitude of age-related cognitive deficits
Backman L, Laukka Ej, Wahlin A, Small Bj, Fratiglioni L
PSYCHOLOGY AND AGING 2002;17(3):435-42

Late-life engagement in social and leisure activities is associated with a decreased risk of dementia: A longitudinal study from the kungsholmen project
Wang Hx, Karp A, Winblad B, Fratiglioni L
AMERICAN JOURNAL OF EPIDEMIOLOGY 2002;155(12):1081-7

Low blood pressure and risk of incident Alzheimer's disease and dementia in the Kungsholmen Project
Qiu Cx, Von Strauss E, Fastbom J, Winblad B, Fratiglioni L
NEUROBIOLOGY OF AGING 2002;23(1):S419-S419

Mortality-related differences and changes in episodic memory among the oldest old: Evidence from a population-based sample of nonagenarians
Hassing Lb, Small Bj, Von Strauss E, Fratiglioni L, Backman L
AGING NEUROPSYCHOLOGY AND COGNITION 2002;9(1):11-20

Occupational exposure to electromagnetic fields in relation to the risk of dementia: Preliminary results from the Kungsholmen project
Qui C, Bellander T, Karp A, Fratiglioni L
EPIDEMIOLOGY 2002;13(4):S195-S195

Occurrence and progression of severe dementia
Aguero-torres H, Fratiglioni L, Winblad B
NEUROBIOLOGY OF AGING 2002;23(1):S282-S282

Physical activity, emotional support, and intellectual stimulation in relation to dementia risk in the elderly: Results from the Kungsholmen Project
Wang Hx, Paillard-borg S, Winblad B, Fratiglioni L
NEUROBIOLOGY OF AGING 2002;23(1):S289-S289

Preclinical cognitive deficits in vascular dementia 6 years before diagnosis
Laukka Ej, Jones S, Fratiglioni L, Backman L, Small Bj
NEUROBIOLOGY OF AGING 2002;23(1):S56-S56

Risk factors for cognitive impairment in HIV-1-infected persons with different risk behaviors
De Ronchi D, Faranca I, Berardi D, Scudellari P, Borderi N, Manfredi R, et al
ARCHIVES OF NEUROLOGY 2002;59(5):812-8

Study of dementia in the Swedish Twin Registry
Gatz M, Fiske A, Pedersen Nl, Fratiglioni L, Berg S, Johansson B, et al
NEUROBIOLOGY OF AGING 2002;23(1):S309-S309

The impact of somatic and cognitive disorders on the functional status of the elderly
Aguero-torres H, Thomas Vs, Winblad B, Fratiglioni L
JOURNAL OF CLINICAL EPIDEMIOLOGY 2002;55(10):1007-12

Apolipoprotein E genotypes and the incidence of Alzheimer's disease among persons aged 75 years and older: Variation by use of antihypertensive medication?
Guo Zc, Fratiglioni L, Viitanen M, Lannfelt L, Basun H, Fastbom J, et al
AMERICAN JOURNAL OF EPIDEMIOLOGY 2001;153(3):225-31

Blood pressure and dementia in persons 75+ years old: 3-year follow-up results from the Kungsholmen Project
Guo Z, Qiu C, Viitanen M, Fastbom J, Winblad B, Fratiglioni L
Journal of Alzheimer's disease : JAD 2001;3(6):585-591

[Epidemiology of aging with focus on physical and mental functional ability]
Fratiglioni L, Von Strauss E, Winblad B
Lakartidningen 2001;98(6):552-8

Institutionalization in the elderly: The role of chronic diseases and dementia. Cross-sectional and longitudinal data from a population-based study
Aguero-torres H, Von Strauss E, Viitanen M, Winblad B, Fratiglioni L
JOURNAL OF CLINICAL EPIDEMIOLOGY 2001;54(8):795-801

Stability of the preclinical episodic memory deficit in Alzheimer's disease
Backman L, Small Bj, Fratiglioni L
BRAIN 2001;:96-102

The effect of low-dose daily aspirin intake on survival in the Finnish Centenarians cohort
Aguero-torres H, Viitanen M, Fratiglioni L, Louhija J
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 2001;49(11):1578-80

The influence of education on clinically diagnosed dementia incidence and mortality data from the Kungsholmen project
Qiu Cx, Backman L, Winblad B, Aguero-torres H, Fratiglioni L
ARCHIVES OF NEUROLOGY 2001;58(12):2034-9

Vitamin B-12 and folate in relation to the development of Alzheimer's disease
Wang Hx, Wahlin A, Basun H, Fastbom J, Winblad B, Fratiglioni L
NEUROLOGY 2001;56(9):1188-94

Elevation of depressive symptoms in the preclinical phase of Alzheimer's disease
Berger Ak, Backman L, Forsell Y, Fratiglioni L, Winblad B
INTERNATIONAL JOURNAL OF PSYCHOLOGY 2000;35(3-4):366-367

Frequency of stroke in Europe: A collaborative study of population-based cohorts
Ilsa Working Grp, Neurologic Dis Elderly Res Grp, Di Carlo A, Launer Lj, Breteler Mmb, Fratiglioni L, et al
NEUROLOGY 2000;54(11):S28-33

Incidence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts
Neurologic Dis Elderly Res Grp, Fratiglioni L, Launer Lj, Andersen K, Breteler Mmb, Copeland Jrm, et al
NEUROLOGY 2000;54(11):S10-5

Incidence of dementia in relation to stroke and the apolipoprotein E epsilon 4 allele in the very old - Findings from a population-based longitudinal study
Zhu L, Fratiglioni L, Guo Zc, Basun H, Corder Eh, Winblad B, et al
STROKE 2000;31(1):53-60

Incidence of stroke in relation to cognitive function and dementia in the Kungsholmen project
Zhu L, Fratiglioni L, Guo Z, Winblad B, Viitanen M
NEUROLOGY 2000;54(11):2103-7

Influence of social network on occurrence of dementia: a community-based longitudinal study
Fratiglioni L, Wang Hx, Ericsson K, Maytan M, Winblad B
LANCET 2000;355(9212):1315-9

Inherited frailty - ApoE alleles determine survival after a diagnosis of heart disease or stroke at ages 85+
Corder Eh, Basun H, Fratiglioni L, Guo Z, Lannfelt L, Viitanen M, et al
MOLECULAR AND CELLULAR GERONTOLOGY 2000;:295-8

Lead concentrations in elderly urban people related to blood pressure and mental performance: Results from a population-based study
Nordberg M, Winblad B, Fratiglioni L, Basun H
AMERICAN JOURNAL OF INDUSTRIAL MEDICINE 2000;38(3):290-4

Mild cognitive impairment in the population and physical health: Data on 1,435 individuals aged 75 to 95
Frisoni Gb, Fratiglioni L, Fastbom J, Guo Zc, Viiranen M, Winblad B
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 2000;55(6):M322-8

Morbidity and comorbidity in relation to functional status: A community-based study of the oldest old (90+years)
Von Stauss E, Fratigtioni L, Viitanen M, Forsell Y, Winblad B
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 2000;48(11):1462-9

Prevalence of dementia and major subtypes in Europe: A collaborative study of population-based cohorts
Neurologic Dis Elderly Res Grp, Lobo A, Launer Lj, Fratiglioni L, Andersen K, Di Carlo A, et al
NEUROLOGY 2000;54(11):S4-9

Prevalence of Parkinson's disease in Europe: A collaborative study of population-based cohorts
Neurologic Dis Elderly Res Grp, De Rijk Mc, Launer Lj, Berger K, Breteler Mmb, Dartigues Jf, et al
NEUROLOGY 2000;54(11):S21-3

Prognosis with dementia in Europe: A collaborative study of population-based cohorts
Neurologic Dis Elderly Res Grp, Jagger C, Andersen K, Breteler Mmb, Copeland Jrm, Helmer C, et al
NEUROLOGY 2000;54(11):S16-20

Prognosis with Parkinson's disease in Europe: A collaborative study of population-based cohorts
Neurologic Dis Elderly Res Grp, Berger K, Breteler Mmb, Helmer C, Inzitari D, Fratiglioni L, et al
NEUROLOGY 2000;54(11):S24-7

Prognosis with stroke in Europe: A collaborative study of population-based cohorts
Neurologic Dis Elderly Res Grp, Schmidt R, Breteler Mmb, Inzitari D, Fratiglioni L, Hofman A, et al
NEUROLOGY 2000;54(11):S34-7

Smoking and Parkinson's and Alzheimer's disease: review of the epidemiological studies
Fratiglioni L, Wang Hx
BEHAVIOURAL BRAIN RESEARCH 2000;113(1-2):117-20

The course of cognitive impairment in preclinical Alzheimer disease - Three- and 6-year follow-up of a population-based sample
Small Bj, Fratiglioni L, Viitanen M, Winblad B, Backman L
ARCHIVES OF NEUROLOGY 2000;57(6):839-44

Aging and the occurrence of dementia - Findings from a population-based cohort with a large sample of nonagenarians
Von Strauss E, Viitanen M, De Ronchi D, Winblad B, Fratiglioni L
ARCHIVES OF NEUROLOGY 1999;56(5):587-92

Cognitive support at episodic encoding and retrieval: Similar patterns of utilization in community-based samples of Alzheimer's disease and vascular dementia patients
Almkvist O, Fratiglioni L, Aguero-torres H, Viitanen M, Backman L
JOURNAL OF CLINICAL AND EXPERIMENTAL NEUROPSYCHOLOGY 1999;21(6):816-30

Epidemiology of vascular dementia: Some results despite research limitations
Aguero-torres H, Winblad B, Fratiglioni L
ALZHEIMER DISEASE & ASSOCIATED DISORDERS 1999;:S15-20

Low blood pressure and incidence of dementia in a very old sample: Dependent on initial cognition
Guo Zc, Viitanen M, Winblad B, Fratiglioni L
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 1999;47(6):723-6

Mortality from dementia in advanced age: A 5-year follow-up study of incident dementia cases
Aguero-torres H, Fratiglioni L, Guo Z, Viianen M, Winblad B
JOURNAL OF CLINICAL EPIDEMIOLOGY 1999;52(8):737-43

Mortality in nondemented subjects with cognitive impairment: The influence of health-related factors
Frisoni Gb, Fratiglioni L, Fastbom J, Viitanen M, Winblad B
AMERICAN JOURNAL OF EPIDEMIOLOGY 1999;150(10):1031-44

Occurrence and progression of dementia in a community population aged 75 years and older - Relationship of antihypertensive medication use
Guo Zc, Fratiglioni L, Zhu L, Fastbom J, Winbald B, Viitanen M
ARCHIVES OF NEUROLOGY 1999;56(8):991-6

Severe dementia: A common condition entailing high costs at individual and societal levels
Winblad B, Wimo A, Mobius Hj, Fox Jm, Fratiglioni L
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY 1999;14(11):911-4

Smoking and the occurrence of Alzheimer's disease: Cross-sectional and longitudinal data in a population-based study
Wang Hx, Fratiglioni L, Frisoni Gb, Viitanen M, Winblad B
AMERICAN JOURNAL OF EPIDEMIOLOGY 1999;149(7):640-4

Tau gene polymorphisms and apolipoprotein E epsilon 4 may interact to increase risk for Alzheimer's disease
Lilius L, Fabre Sf, Basun H, Forsell C, Axelman K, Mattila K, et al
NEUROSCIENCE LETTERS 1999;277(1):29-32

The occurrence of depressive symptoms in the preclinical phase of AD - A population-based study
Berger Ak, Fratiglioni L, Forsell Y, Winblad B, Backman L
NEUROLOGY 1999;53(9):1998-2002

Worldwide prevalence and incidence of dementia
Fratiglioni L, De Ronchi D, Aguero-torres H
DRUGS & AGING 1999;15(5):365-75

Association of stroke with dementia, cognitive impairment, and functional disability in the very old - A population-based study
Zhu L, Fratiglioni L, Guo Zc, Aguero-torres H, Winblad B, Viitanen M
STROKE 1998;29(10):2094-9

Attitudes and participation of the elderly in population surveys: Data from a longitudinal study on aging and dementia in Stockholm
Von Strauss E, Fratiglioni L, Jorm Af, Viitanen M, Winblad B
JOURNAL OF CLINICAL EPIDEMIOLOGY 1998;51(3):181-7

Blood pressure reduction, cardiovascular diseases, and cognitive decline in the mini-mental state examination in a community population of normal very old people: A three-year follow-up
Zhu L, Viitanen M, Guo Zc, Winblad B, Fratiglioni L
JOURNAL OF CLINICAL EPIDEMIOLOGY 1998;51(5):385-91

Dementia is the major cause of functional dependence in the elderly: 3-year follow-up data from a population-based study
Aguero-torres H, Fratiglioni L, Guo Zc, Viitanen M, Von Strauss E, Winblad B
AMERICAN JOURNAL OF PUBLIC HEALTH 1998;88(10):1452-6

Low blood pressure and early death of elderly people with dementia
Guo Zc, Viitanen M, Fratiglioni L, Winbland B
LANCET 1998;352(9133):1035-6

Natural history of Alzheimer's disease and other dementias: Review of the literature in the light of the findings from the Kungsholmen Project
Aguero-torres H, Fratiglioni L, Winblad B
INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY 1998;13(11):755-66

Prognostic factors in very old demented adults: A seven-year follow-up from a population-based survey in Stockholm
Aguero-torres H, Fratiglioni L, Guo Zc, Viitanen M, Winblad B
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 1998;46(4):444-52

The effect of education on dementia occurrence in an Italian population with middle to high socioeconomic status
De Ronchi D, Fratiglioni L, Rucci P, Paternico A, Graziani S, Dalmonte E
NEUROLOGY 1998;50(5):1231-8

The Human Figure Drawing test as a screen for dementia in the elderly: A community-based study
Wang Hx, Ericsson K, Winblad B, Fratiglioni L
ARCHIVES OF GERONTOLOGY AND GERIATRICS 1998;27(1):25-34

The role of APOE polymorphisms in late-onset dementias
Corder Eh, Lannfelt L, Bogdanovic N, Fratiglioni L, Mori H
CELLULAR AND MOLECULAR LIFE SCIENCES 1998;54(9):928-34

Blood pressure and dementia in the elderly: Epidemiologic perspectives
Guo Z, Viitanen M, Fratiglioni L, Winblad B
BIOMEDICINE & PHARMACOTHERAPY 1997;51(2):68-73

Blood pressure and performance on the Mini-Mental State Examination in the very old - Cross-sectional and longitudinal data from the Kungsholmen Project
Guo Zc, Fratiglioni L, Winblad B, Viitanen M
AMERICAN JOURNAL OF EPIDEMIOLOGY 1997;145(12):1106-13

Cognitive predictors of incident Alzheimer's disease: A prospective longitudinal study
Small Bj, Herlitz A, Fratiglioni L, Almkvist O, Backman L
NEUROPSYCHOLOGY 1997;11(3):413-20

Detection of mild dementia in community surveys - Is it possible to increase the accuracy of our diagnostic instruments?
Herlitz A, Small Bj, Fratiglioni L, Almkvist O, Viitanen M, Backman L
ARCHIVES OF NEUROLOGY 1997;54(3):319-24

Drug use by demented and non-demented elderly people
Wills P, Claesson Cb, Fratiglioni L, Fastbom J, Thorslund M
AGE AND AGEING 1997;26(5):383-91

Very old women at highest risk of dementia and Alzheimer's disease: Incidence data from the Kungsholmen project, Stockholm
Fratiglioni L, Viitanen M, Vonstrauss E, Tontodonati V, Herlitz A, Winblad B
NEUROLOGY 1997;48(1):132-8

Low blood pressure and dementia in elderly people: The Kungsholmen project
Guo Zc, Viitanen M, Fratiglioni L, Winblad B
BRITISH MEDICAL JOURNAL 1996;312(7034):805-8

DETERMINANTS OF FUNCTIONAL ABILITIES IN DEMENTIA
Hill Rd, Backman L, Fratiglioni L
JOURNAL OF THE AMERICAN GERIATRICS SOCIETY 1995;43(10):1092-7

EARLY SYMPTOMS AND NEUROLOGICAL FINDINGS IN DEMENTED SUBJECTS FROM A COMMUNITY SURVEY
Torres Ha, Fratiglioni L, Hofman W, Winblad B
ALZHEIMER DISEASE & ASSOCIATED DISORDERS 1995;9(3):170-5

EPISODIC MEMORY AND VISUOSPATIAL ABILITY IN DETECTING AND STAGING DEMENTIA IN A COMMUNITY-BASED SAMPLE OF VERY OLD ADULTS
Herlitz A, Hill Rd, Fratiglioni L, Backman L
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES 1995;50(2):M107-13

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