Lars Norlen

Publications
CV
Public outreach and news

Articles

Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2021;118(51):e2100687118

A gene-centric approach to biomarker discovery identifies transglutaminase 1 as an epidermal autoantigen.

Landegren N; Ishii N; Aranda-Guillén M; Gunnarsson HI; Sardh F; Hallgren Å; Ståhle M; Hagforsen E; Bradley M; Edqvist P-HD; Pontén F; Mäkitie O; Eidsmo L; Norlén L; Achour A; Dahlbom I; Korponay-Szabó I; Agardh D; Alimohammadi M; Eriksson D; Hashimoto T; Kämpe O
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2021;141(5):1243-1253.e6

Molecular Reorganization during the Formation of the Human Skin Barrier Studied In Situ.

Narangifard A; Wennberg CL; den Hollander L; Iwai I; Han H; Lundborg M; Masich S; Lindahl E; Daneholt B; Norlén L
Article: JOURNAL OF CONTROLLED RELEASE. 2018;283:269-279

Predicting drug permeability through skin using molecular dynamics simulation.

Lundborg M; Wennberg CL; Narangifard A; Lindahl E; Norlén L
Article: JOURNAL OF STRUCTURAL BIOLOGY. 2018;203(2):149-161

Human skin barrier structure and function analyzed by cryo-EM and molecular dynamics simulation.

Lundborg M; Narangifard A; Wennberg CL; Lindahl E; Daneholt B; Norlén L
Article: EXPERIMENTAL CELL RESEARCH. 2018;366(2):139-151

Human skin barrier formation takes place via a cubic to lamellar lipid phase transition as analyzed by cryo-electron microscopy and EM-simulation.

Narangifard A; den Hollander L; Wennberg CL; Lundborg M; Lindahl E; Iwai I; Han H; Masich S; Daneholt B; Norlén L
Article: BIOPHYSICAL JOURNAL. 2018;114(5):1116-1127

Structural Transitions in Ceramide Cubic Phases during Formation of the Human Skin Barrier.

Wennberg CL; Narangifard A; Lundborg M; Norlén L; Lindahl E
Article: BRITISH JOURNAL OF DERMATOLOGY. 2017;176(4):1021-1027

Acute skin and hair symptoms followed by severe, delayed eye complications in subjects using the synthetic opioid MT-45.

Helander A; Bradley M; Hasselblad A; Norlén L; Vassilaki I; Bäckberg M; Lapins J
Article: ACTA DERMATO-VENEREOLOGICA. 2016;96(3):303-308

Skin Lamellar Bodies are not Discrete Vesicles but Part of a Tubuloreticular Network.

den Hollander L; Han H; de Winter M; Svensson L; Masich S; Daneholt B; Norlén L
Article: LAKARTIDNINGEN. 2016;113:DTAF

[Acute cutaneous symptom complex with subsequent cataract. The internet drug MT-45 may be the cause].

Bradley M; Hasselblad A; Norlen L; Lapins J; Bäckberg M; Helander A
Article: SKIN PHARMACOLOGY AND PHYSIOLOGY. 2013;26(4-6):213-216

Current understanding of skin barrier morphology.

Norlén L
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2012;132(9):2215-2225

The human skin barrier is organized as stacked bilayers of fully extended ceramides with cholesterol molecules associated with the ceramide sphingoid moiety.

Iwai I; Han H; den Hollander L; Svensson S; Ofverstedt L-G; Anwar J; Brewer J; Bloksgaard M; Laloeuf A; Nosek D; Masich S; Bagatolli LA; Skoglund U; Norlén L
Article: SKIN PHARMACOLOGY AND PHYSIOLOGY. 2011;24(4):190-198

Sorption properties of the human stratum corneum.

Johnsen GK; Norlen L; Martinsen ØG; Grimnes S
Article: JOURNAL OF MICROSCOPY. 2009;235(3):293-307

Molecular cryo-electron tomography of vitreous tissue sections: current challenges.

Norlén L; Oktem O; Skoglund U
Article: BIOPHYSICAL JOURNAL. 2007;93(9):3142-3155

Direct visualization of lipid domains in human skin stratum corneum's lipid membranes: effect of pH and temperature.

Plasencia I; Norlén L; Bagatolli LA
Article: INTERNATIONAL JOURNAL OF COSMETIC SCIENCE. 2007;29(5):335-352

Nanostructure of the stratum corneum extracellular lipid matrix as observed by cryo-electron microscopy of vitreous skin sections.

Norlén L
Article: JOURNAL OF STRUCTURAL BIOLOGY. 2007;158(3):386-400

Human stratum corneum lipid organization as observed by atomic force microscopy on Langmuir-Blodgett films.

Norlén L; Gil IP; Simonsen A; Descouts P
Article: INTERNATIONAL JOURNAL OF COSMETIC SCIENCE. 2006;28(6):397-425

Stratum corneum keratin structure, function and formation - a comprehensive review.

Norlén L
Article: JOURNAL OF STRUCTURAL BIOLOGY. 2006;156(3):461-468

A procedure to deposit fiducial markers on vitreous cryo-sections for cellular tomography.

Masich S; Ostberg T; Norlén L; Shupliakov O; Daneholt B
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2005;124(4):764-777

Nanostructure of the epidermal extracellular space as observed by cryo-electron microscopy of vitreous sections of human skin.

Al-Amoudi A; Dubochet J; Norlén L
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2004;123(4):715-732

Stratum corneum keratin structure, function, and formation: the cubic rod-packing and membrane templating model.

Norlén L; Al-Amoudi A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2004;279(7):5621-5629

Role for ELOVL3 and fatty acid chain length in development of hair and skin function.

Westerberg R; Tvrdik P; Undén A-B; Månsson J-E; Norlén L; Jakobsson A; Holleran WH; Elias PM; Asadi A; Flodby P; Toftgård R; Capecchi MR; Jacobsson A
Article: SKIN PHARMACOLOGY AND APPLIED SKIN PHYSIOLOGY. 2003;16(4):203-211

Molecular skin barrier models and some central problems for the understanding of skin barrier structure and function.

Norlén L
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2003;120(4):555-560

A cryotransmission electron microscopy study of skin barrier formation.

Norlén L; Al-Amoudi A; Dubochet J
Article: JOURNAL OF CONTROLLED RELEASE. 2000;63(1-2):213-226

Structure-related aspects on water diffusivity in fatty acid-soap and skin lipid model systems.

Norlén L; Engblom J
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 1999;113(4):533-540

A new computer-based evaporimeter system for rapid and precise measurements of water diffusion through stratum corneum in vitro.

Norlén L; Engblom J; Andersson M; Forslind B
Article: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 1999;112(1):72-77

Inter- and intra-individual differences in human stratum corneum lipid content related to physical parameters of skin barrier function in vivo.

Norlén L; Nicander I; Lundh Rozell B; Ollmar S; Forslind B
Article: SKIN RESEARCH AND TECHNOLOGY. 1998;4(4):213-221

Electrical impedance and other physical parameters as related to lipid content of human stratum corneum.

Nicander I; Norlen L; Brockstedt U; Rozell BL; Forslind B; Ollmar S
Article: ARCHIVES OF DERMATOLOGICAL RESEARCH. 1998;290(9):508-516

A new HPLC-based method for the quantitative analysis of inner stratum corneum lipids with special reference to the free fatty acid fraction.

Norlén L; Nicander I; Lundsjö A; Cronholm T; Forslind B
Article: CURRENT PROBLEMS IN DERMATOLOGY. 1998;26:165-176

Lipid content and electrical impedance.

Nicander I; Norlén L; Forslind B; Ollmar S
Article: ARCHIVES OF DERMATOLOGICAL RESEARCH. 1997;289(9):506-513

Stratum corneum swelling. Biophysical and computer assisted quantitative assessments.

Norlén L; Emilson A; Forslind B
Article: JOURNAL OF DERMATOLOGICAL SCIENCE. 1997;14(2):115-125

A novel approach to the understanding of human skin barrier function.

Forslind B; Engström S; Engblom J; Norlén L
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All other publications

Review: JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2022;142(2):285-292

The Skin's Barrier: A Cryo-EM Based Overview of its Architecture and Stepwise Formation.

Norlén L; Lundborg M; Wennberg C; Narangifard A; Daneholt B
Editorial comment: ACTA DERMATO-VENEREOLOGICA. 2016;96(3):291

Is Oil a Balsam for Baby Skin?

Norlén L
Review: BRITISH JOURNAL OF DERMATOLOGY. 2014;171 Suppl 3:13-18

Update of technologies for examining the stratum corneum at the molecular level.

Norlén L
Review: INTERNATIONAL JOURNAL OF COSMETIC SCIENCE. 2008;30(6):391-411

Stratum corneum lipid organization as observed by atomic force, confocal and two-photon excitation fluorescence microscopy.

Norlén L; Plasencia I; Bagatolli L
Review: EUROPEAN JOURNAL OF DERMATOLOGY. 2008;18(3):279-284

Exploring skin structure using cryo-electron microscopy and tomography.

Norlen L
Review: EXPERIMENTAL CELL RESEARCH. 2007;313(10):2217-2227

Structural analysis of vimentin and keratin intermediate filaments by cryo-electron tomography.

Norlén L; Masich S; Goldie KN; Hoenger A

Employments

Affiliated to Research, Department of Medicine, Karolinska Institutet, 2022-2025

Degrees and Education

Docent, Karolinska Institutet, 2004
Doctor Of Philosophy, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 1999
University Medical Degree, Karolinska Institutet, 1994

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