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Karin Lundin

Senior researcher

Visiting address : Molekylär Cell Genetik och Genterapiforskning (MCG); Novum plan 6, Hiss F; Hälsovägen 7-9, 14157 Huddinge, Sweden
Postal address : Department of Laboratory Medicine (LABMED), H5, Clinical research center, Molekylär Cell Genetik och Genterapiforskning (MCG); Novum, plan 5, hiss F, Lab 514; Hälsovägen 7-9, 14157 Huddinge, Sweden
Delivery address : KFC, MCG, Novum plan 5, Lab 514; Karolinska Universitetssjukhuset Huddinge; Vårdarvägen 1, 14152 Huddinge, Sweden

Research description

Research area/interest: Mini-circle DNA and oligonucleotides as tools for anti-gene, anti-sense and splice modification in non-viral gene therapy.

Publications

Fast and efficient synthesis of Zorro-LNA type 3'-5'-5'-3' oligonucleotide conjugates via parallel in situ stepwise conjugation
Gissberg Oi, Jezowska M, Zaghloul Em, Bungsu Ni, Strömberg R, Smith Ci, et al
Organic & biomolecular chemistry 2016;14(14):3584-90

Next-generation bis-locked nucleic acids with stacking linker and 2'-glycylamino-LNA show enhanced DNA invasion into supercoiled duplexes
Geny S, Moreno Pm, Krzywkowski T, Gissberg O, Andersen Nk, Isse Aj, et al
Nucleic acids research 2016;44(5):2007-19

Oligonucleotide Therapies: The Past and the Present
Lundin Ke, Gissberg O, Smith Ci
Human gene therapy 2015;26(8):475-85

RNA therapeutics inactivate PCSK9 by inducing a unique intracellular retention form
Rocha Cs, Wiklander Op, Larsson L, Moreno Pm, Parini P, Lundin Ke, et al
Journal of molecular and cellular cardiology 2015;82():186-93

Susceptibility to infections, without concomitant hyper-IgE, reported in 1976, is caused by hypomorphic mutation in the phosphoglucomutase 3 (PGM3) gene
Lundin Ke, Hamasy A, Backe Ph, Moens Ln, Falk-sörqvist E, Elgstøen Kb, et al
Clinical immunology (Orlando, Fla.) 2015;161(2):366-72

Hypomorphic homozygous mutations in phosphoglucomutase 3 (PGM3) impair immunity and increase serum IgE levels
Sassi A, Lazaroski S, Wu G, Haslam Sm, Fliegauf M, Mellouli F, et al
The Journal of allergy and clinical immunology 2014;133(5):1410-9

Micro-minicircle Gene Therapy: Implications of Size on Fermentation, Complexation, Shearing Resistance, and Expression
Stenler S, Wiklander Op, Badal-tejedor M, Turunen J, Nordin Jz, Hallengärd D, et al
Molecular therapy. Nucleic acids 2014;2():e140-

Repeatable, Inducible Micro-RNA-Based Technology Tightly Controls Liver Transgene Expression
Oprea Ii, Viola Jr, Moreno Pm, Simonson Oe, Rodin S, Teller N, et al
Molecular therapy. Nucleic acids 2014;3():e172-

Splice-correcting oligonucleotides restore BTK function in X-linked agammaglobulinemia model
Bestas B, Moreno Pmd, Blomberg Kem, Mohammad Dk, Saleh Af, Sutlu T, et al
JOURNAL OF CLINICAL INVESTIGATION 2014;124(9):4067-81

Biological activity and biotechnological aspects of locked nucleic acids
Lundin Ke, Højland T, Hansen Br, Persson R, Bramsen Jb, Kjems J, et al
Advances in genetics 2013;82():47-107

Development of bis-locked nucleic acid (bisLNA) oligonucleotides for efficient invasion of supercoiled duplex DNA
Moreno Pm, Geny S, Pabon Yv, Bergquist H, Zaghloul Em, Rocha Cs, et al
Nucleic acids research 2013;41(5):3257-73

Optimizing anti-gene oligonucleotide 'Zorro-LNA' for improved strand invasion into duplex DNA
Zaghloul Em, Madsen As, Moreno Pmd, Oprea Ii, El-andaloussi S, Bestas B, et al
NUCLEIC ACIDS RESEARCH 2011;39(3):1142-54

Formulation and Delivery of Splice-Correction Antisense Oligonucleotides by Amino Acid Modified Polyethylenimine
Zaghloul Em, Viola Jr, Zuber G, Smith Cie, Lundin Ke
MOLECULAR PHARMACEUTICS 2010;7(3):652-63

Temperature-Assisted Cyclic Hybridization (TACH): An Improved Method for Supercoiled DNA Hybridization
Oprea Ii, Simonson Oe, Moreno Pmd, Viola Jr, Lundin Ke, Smith Cie
MOLECULAR BIOTECHNOLOGY 2010;45(2):171-9

A synthetic snRNA m(3)G-CAP enhances nuclear delivery of exogenous proteins and nucleic acids
Moreno Pmd, Wenska M, Lundin Ke, Wrange O, Stromberg R, Smith Cie
NUCLEIC ACIDS RESEARCH 2009;37(6):1925-35

Conjugation of butanoyl to spermine molecules to enhance in vivo gene expression
Viola J, Leijonmarck H, Oprea I, Simonson O, Lundin K, Stromberg R, et al
HUMAN GENE THERAPY 2009;20(11):1518-1518

Fatty acid-spermine conjugates as DNA carriers for nonviral in vivo gene delivery
Viola Jr, Leijonmarck H, Simonson Oe, Oprea Ii, Frithiof R, Purhonen P, et al
GENE THERAPY 2009;16(12):1429-40

Formulation and delivery of splice-correcting antisense RNA oligonucleotides by amino acid-modified polyethylenimine
Zaghloul E, Viola J, Zuber G, Smith Cie, Lundin K
HUMAN GENE THERAPY 2009;20(11):1532-1532

Gene Transfer to Mouse Heart and Skeletal Muscles Using a Minicircle Expressing Human Vascular Endothelial Growth Factor
Stenler S, Andersson A, Simonson Oe, Lundin Ke, Chen Zy, Kay Ma, et al
JOURNAL OF CARDIOVASCULAR PHARMACOLOGY 2009;53(1):18-23

Nanotechnology approaches for gene transfer
Lundin Ke, Simonson Oe, Moreno Pmd, Zaghloul Em, Oprea Ii, Svahn Mg, et al
GENETICA 2009;137(1):47-56

Building biologically active nucleic acid nanocomplexes
Smith Ci, Lundin Ke, Simonson Oe, Moreno Pm, Svahn Mg, Wenska M, et al
Nucleic acids symposium series (2004) 2008;(52):27-8

Sequence-specific inhibition of RNA polymerase III-dependent transcription using Zorro locked nucleic acid (LNA)
Ge R, Svahn Mg, Simonson Oe, Mohamed Aj, Lundin Ke, Smith Cie
JOURNAL OF GENE MEDICINE 2008;10(1):101-9

Self-assembling supramolecular complexes by single-stranded extension from plasmid DNA
Svahn Mg, Hasan M, Sigot V, Valle-delgado Jj, Rutland Mw, Lundin Ke, et al
OLIGONUCLEOTIDES 2007;17(1):80-94

Zorro locked nucleic acid induces sequence-specific gene silencing
Ge Rb, Heinonen Je, Svahn Mg, Mohamed Aj, Lundin Ke, Smith Cie
FASEB JOURNAL 2007;21(8):1902-14

Biological activity and biotechnological aspects of peptide nucleic acid
Lundin Ke, Good L, Stromberg R, Graslund A, Smith Cie
ADVANCES IN GENETICS 2006;:1-51

Bioplex technology: Novel synthetic gene delivery pharmaceutical based on peptides anchored to nucleic acids
Simonson Oe, Svahn Mg, Tornquist E, Lundin Ke, Smith Cie
CURRENT PHARMACEUTICAL DESIGN 2005;11(28):3671-80

Increased stability and specificity through combined hybridization of peptide nucleic acid (PNA) and locked nucleic acid (LNA) to supercoiled plasmids for PNA-anchored "Bioplex" formation
Lundin Ke, Hasan M, Moreno Pm, Tornquist E, Oprea Il, Svahn Mg, et al
BIOMOLECULAR ENGINEERING 2005;22(5-6):185-92

Adding functional entities to plasmids
Svahn Mg, Lundin Ke, Ge R, Tornquist E, Simonson Eo, Oscarsson S, et al
JOURNAL OF GENE MEDICINE 2004;:S36-44

Cooperative strand invasion of supercoiled plasmid DNA by mixed linear PNA and PNA-peptide chimeras
Lundin Ke, Ge Rb, Svahn Mg, Tornquist E, Leijon M, Branden Lj, et al
BIOMOLECULAR ENGINEERING 2004;21(2):51-9

Generation of microglia specific reagents from phage displayed peptide libraries
Lundin K, Aarum J, Appelsved L, Johansson-borg A, Von Garrelts E, Dypbukt J, et al
JOURNAL OF IMMUNOLOGICAL METHODS 2003;278(1-2):235-47

Peptides isolated from random peptide libraries on phage elicit a neutralizing anti-HIV-1 response: Analysis of immunological mimicry
Lundin K, Samuelsson A, Jansson M, Hinkula J, Wahren B, Persson Maa
IMMUNOLOGY 1996;89(4):579-86

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