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About me

I am Associated Professor in Obstetrics and Gynecology at Karolinska Institutet. Currently I am acting as a head for Center of Gender Medicine at the Department of Medicine (Solna) and as a senior scientist at the Department of Clinical Science Intervention and Technology, Unit for Obstetrics and Gynecology (Huddinge),  Karolinska University Hospital. I am also acting as a director for Doctoral program Developmental Biology and Cell Signaling (DECS).

In addition, I am a TEDx Stockholm advisory board member. 

 

Education

National Board of Medical Examiners, Diploma 1986;

Specialist in Obstetrics & Gynecology (1987-1992);

PhD 1997, KI, Obstetrics Gynecology; Title: Regulation of vascular tone in myometrial resistance arteries in normal pregnancy and preeclampsia;

Knut och Alice Wallenberg’s Stiftelse Stipendiat (2000-2002) for Post-Doc  at the Dep. of Maternal and Fetal Health, St Thomas’s Hospital London, King’s College and Inst. for Clinical Science Huddinge University Hospital 1998-2002;

Assistant Professor (2003-2007) Department of Clinical Science Intervention and Technology, Unit for Obstetrics and Gynecology (Huddinge), Karolinska University Hospital;

Senior researcher (2008-2010) granted from KI for strategic researchers, Department of Clinical Science Intervention and Technology, Unit for Obstetrics and Gynecology (Huddinge), Karolinska University Hospital.

Research description

Research interest

Investigations concentrate on vascular physiology and pathophysiology with focus on resistance artery function primarily in women at reproductive age and after menopause. In addition, patients with coronary heart disease, chronic kidney disease and healthy female and male volunteers are included.

Studies involve a range of different isolated small artery bioassays, pharmacological and molecular assessments of endothelial dysfunctional markers and cellular signaling in combination with in in vivo assessment of artery function and measurements of known and recently recognized biochemical markers for increased cardiovascular risk.

Specific projects:

-IMPROvED (IMproved Pregnancy Outcomes by Early Detection) Consortium (EU FP7 collaboration HEALTH-2012-INNOVATION-1.2-1): PI at Swedish site at Karolinska University hospital;

-Small artery function in normal pregnancy and preeclampsia;

-Determination of cardiovascular risk factors and vascular function in women with history of preeclampsia;

-History of preeclampsia and risk for end stage renal disease;

-Targeting androgens for vascular health: beneficial and adverse effects of testosterone on endothelium and the mechanisms behind;

-Small artery function in women after menopause: role of estrogen, 2 Methoxyestradiol , HRT and novel GPER;

-Dietary intervention in PCOS women and endothelial function;

-ET-1-mediated endothelial dysfunction: implications for eNOS uncoupling and screening for mechanisms behind;

-Resistance vasculature in chronic kidney disease: targeting compromised pathways and prerequisites for therapeutic alternatives;

-Effects of different pharmacological agents with proposed cardiovascular benefit on endothelial function in arteries from women and men with and without CVD.

For publications please follow to PubMed. 

 

Teaching interest:

Undergraduate and doctoral education, supervision for master's, PhD and Post Doc studies.

Focus on vascular physiology and pathophysiology with focus on endothelial function.

Particular interest on women's cardiovascular health at reproductive age and after menopause and implementation of sex/gender aspects in preclinical and clinical research towards innovation in health care.

Portfolio: doctoral courses (Sex/gender aspects in biomedical research, Methodologies in clinical research, Artery function in health and disease), undergraduate courses (Gender aspects in health and disease).

As a leader for doctoral program called Developmental Biology and Cell Signalling (DECS), I not only work towards excellent multidisciplinary course curriculum, but also foster initiatives from students and encourage them for collaborative and creative initiatives to become future’s innovative scientists, leaders, company developers, social entrepreneurs and teachers.