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About me

Senior Researcher, 2015

Associate professor; Epidemiology, Karolinska Institutet 2012

 

 

Education

2005, Doctor of philosophy, KI 

1999, Master of Medical Science with a major in Public Health, KI.

1997, Bachelor of Science in Public Health, KI.

1992-1996 Courses in Business economy, Law, French and Health Economy at Stockholm University and Stockholm School of Economics

Publications

Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
Justice Ae, Winkler Tw, Feitosa Mf, Graff M, Fisher Va, Young K, et al
Nature communications 2017;8():14977-

IgM antibodies to oxidized phosphatidylserine as protection markers in cardiovascular disease among 60-year olds
Frostegård J, Su J, Sing S, Hua X, Vikström M, Leander K, et al
PloS one 2017;12(4):e0171195-

Screening of siblings to patients with abdominal aortic aneurysms in Sweden
Linné A, Forsberg J, Leander K, Hultgren R
Scandinavian cardiovascular journal : SCJ 2017;51(3):167-171

Serum Fatty Acids, Desaturase Activities and Abdominal Obesity - A Population-Based Study of 60-Year Old Men and Women
Alsharari Zd, Risérus U, Leander K, Sjögren P, Carlsson Ac, Vikström M, et al
PloS one 2017;12(1):e0170684-

Circulating Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) Predicts Future Risk of Cardiovascular Events Independently of Established Risk Factors
Leander K, Mälarstig A, Van't Hooft Fm, Hyde C, Hellénius Ml, Troutt Js, et al
Circulation 2016;133(13):1230-9

Cross-sectional relationships between dietary fat intake and serum cholesterol fatty acids in a Swedish cohort of 60-year-old men and women
Laguzzi F, Alsharari Z, Risérus U, Vikström M, Sjögren P, Gigante B, et al
Journal of human nutrition and dietetics : the official journal of the British Dietetic Association 2016;29(3):325-37

FTO gene variation, macronutrient intake and coronary heart disease risk: a gene-diet interaction analysis
Gustavsson J, Mehlig K, Leander K, Berg C, Tognon G, Strandhagen E, et al
European journal of nutrition 2016;55(1):247-55

Human IgM Antibodies to Malondialdehyde Conjugated With Albumin Are Negatively Associated With Cardiovascular Disease Among 60-Year-Olds
Thiagarajan D, Frostegard Ag, Singh S, Rahman M, Liu Aq, Vikstrom M, et al
JOURNAL OF THE AMERICAN HEART ASSOCIATION 2016;5(12):-

Agreement between Myocardial Infarction Patients and Their Spouses on Reporting of Data on 82 Cardiovascular Risk Exposures
Quintana Hk, Vikström M, Andersson T, Hallqvist J, Leander K
PloS one 2015;10(7):e0132601-

Circulating levels of interleukin 6 soluble receptor and its natural antagonist, sgp130, and the risk of myocardial infarction
Moreno Velásquez I, Golabkesh Z, Källberg H, Leander K, De Faire U, Gigante B
Atherosclerosis 2015;240(2):477-81

Does menopausal hormone therapy reduce myocardial infarction risk if initiated early after menopause? A population-based case-control study
Carrasquilla Gd, Berglund A, Gigante B, Landgren Bm, De Faire U, Hallqvist J, et al
Menopause (New York, N.Y.) 2015;22(6):598-606

Duffy antigen receptor genetic variant and the association with Interleukin 8 levels
Moreno Velásquez I, Kumar J, Björkbacka H, Nilsson J, Silveira A, Leander K, et al
Cytokine 2015;72(2):178-84

Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
Gaulton Kj, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen Me, et al
Nature genetics 2015;47(12):1415-25

Genetic studies of body mass index yield new insights for obesity biology
Locke Ae, Kahali B, Berndt Si, Justice Ae, Pers Th, Day Fr, et al
Nature 2015;518(7538):197-206

Interleukin-8 is associated with increased total mortality in women but not in men-findings from a community-based cohort of elderly
Moreno Velásquez I, Ärnlöv J, Leander K, Lind L, Gigante B, Carlsson Ac
Annals of medicine 2015;47(1):28-33

Is the adiposity-associated FTO gene variant related to all-cause mortality independent of adiposity? Meta-analysis of data from 169,551 Caucasian adults
The Fto-mortality Collaborating, Zimmermann E, Angquist Lh, Mirza Ss, Zhao Jh, Chasman Di, et al
OBESITY REVIEWS 2015;16(4):327-340

Long-term effects of elemental composition of particulate matter on inflammatory blood markers in European cohorts
Hampel R, Peters A, Beelen R, Brunekreef B, Cyrys J, De Faire U, et al
Environment international 2015;82():76-84

New genetic loci link adipose and insulin biology to body fat distribution
Shungin D, Winkler Tw, Croteau-chonka Dc, Ferreira T, Locke Ae, Mägi R, et al
Nature 2015;518(7538):187-196

Obesity, metabolic syndrome and risk of atrial fibrillation: a Swedish, prospective cohort study
Nyström Pk, Carlsson Ac, Leander K, De Faire U, Hellenius Ml, Gigante B
PloS one 2015;10(5):e0127111-

Plasma IL-5 concentration and subclinical carotid atherosclerosis
Silveira A, Mcleod O, Strawbridge Rj, Gertow K, Sennblad B, Baldassarre D, et al
Atherosclerosis 2015;239(1):125-30

Polyunsaturated Fat Intake Estimated by Circulating Biomarkers and Risk of Cardiovascular Disease and All-Cause Mortality in a Population-Based Cohort of 60-Year-Old Men and Women
Marklund M, Leander K, Vikström M, Laguzzi F, Gigante B, Sjögren P, et al
Circulation 2015;132(7):586-94

Protein biomarkers for the prediction of cardiovascular disease in type 2 diabetes
Summit Investigators, Looker Hc, Colombo M, Agakov F, Zeller T, Groop L, et al
DIABETOLOGIA 2015;58(6):1363-71

Pulse pressure is not an independent predictor of incident atrial fibrillation in 60-year-old men and women
Miedel C, Leander K, De Faire U, Gigante B
Annals of medicine 2015;47(8):679-86

Sex-Specific Effects of Adiponectin on Carotid Intima-Media Thickness and Incident Cardiovascular Disease
Persson J, Strawbridge Rj, Mcleod O, Gertow K, Silveira A, Baldassarre D, et al
Journal of the American Heart Association 2015;4(8):e001853-

The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
Winkler Tw, Justice Ae, Graff M, Barata L, Feitosa Mf, Chu S, et al
PLoS genetics 2015;11(10):e1005378-

Traffic-related air pollution exposure and incidence of stroke in four cohorts from Stockholm
Korek Mj, Bellander Td, Lind T, Bottai M, Eneroth Km, Caracciolo B, et al
Journal of exposure science & environmental epidemiology 2015;25(5):517-23

Arterial Blood Pressure and Long-Term Exposure to Traffic-Related Air Pollution: An Analysis in the European Study of Cohorts for Air Pollution Effects (ESCAPE)
Fuks Kb, Weinmayr G, Foraster M, Dratva J, Hampel R, Houthuijs D, et al
ENVIRONMENTAL HEALTH PERSPECTIVES 2014;122(9):896-905

A serum 25-hydroxyvitamin D concentration-associated genetic variant in DHCR7 interacts with type 2 diabetes status to influence subclinical atherosclerosis (measured by carotid intima-media thickness)
Strawbridge Rj, Deleskog A, Mcleod O, Folkersen L, Kavousi M, Gertow K, et al
Diabetologia 2014;57(6):1159-72

Association of interleukin 8 with myocardial infarction: results from the Stockholm Heart Epidemiology Program
Velásquez Im, Frumento P, Johansson K, Berglund A, De Faire U, Leander K, et al
International journal of cardiology 2014;172(1):173-8

Differences in anthropometric measures in immigrants and Swedish-born individuals: Results from two community-based cohort studies
Carlsson Ac, Wandell P, Riserus U, Arnlov J, Borne Y, Engstrom G, et al
PREVENTIVE MEDICINE 2014;:151-6

Financial stress in late adulthood and diverse risks of incident cardiovascular disease and all-cause mortality in women and men
Carlsson Ac, Starrin B, Gigante B, Leander K, Hellenius Ml, De Faire U
BMC public health 2014;14():17-

FTO genotype, physical activity, and coronary heart disease risk in Swedish men and women
Gustavsson J, Mehlig K, Leander K, Lissner L, Björck L, Rosengren A, et al
Circulation. Cardiovascular genetics 2014;7(2):171-7

Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
Diabetes Genetics Replication And Meta-analysis (diagram) Consortium, Asian Genetic Epidemiology Network Type 2 Diabetes (agen-t2d) Consortium, South Asian Type 2 Diabetes (sat2d) Consortium, Mexican American Type 2 Diabetes (mat2d) Consortium, Type 2 Diabetes Genetic Exploration By Nex-generation Sequencing In Muylti-ethnic Samples (t2d-genes) Consortium, Mahajan A, et al
Nature genetics 2014;46(3):234-44

Lim domain binding 2: a key driver of transendothelial migration of leukocytes and atherosclerosis
Shang Mm, Talukdar Ha, Hofmann Jj, Niaudet C, Asl Hf, Jain Rk, et al
Arteriosclerosis, thrombosis, and vascular biology 2014;34(9):2068-77

Long term exposure to ambient air pollution and incidence of acute coronary events: prospective cohort study and meta-analysis in 11 European cohorts from the ESCAPE Project
Cesaroni G, Forastiere F, Stafoggia M, Andersen Zj, Badaloni C, Beelen R, et al
BMJ-BRITISH MEDICAL JOURNAL 2014;:f7412-

Long-Term Exposure to Ambient Air Pollution and Incidence of Cerebrovascular Events: Results from 11 European Cohorts within the ESCAPE Project
Stafoggia M, Cesaroni G, Peters A, Andersen Zj, Badaloni C, Beelen R, et al
ENVIRONMENTAL HEALTH PERSPECTIVES 2014;122(9):919-25

Long-term exposure to elemental constituents of particulate matter and cardiovascular mortality in 19 European cohorts: results from the ESCAPE and TRANSPHORM projects
Wang M, Beelen R, Stafoggia M, Raaschou-nielsen O, Andersen Zj, Hoffmann B, et al
Environment international 2014;66():97-106

Low levels of IgM antibodies against phosphorylcholine are associated with fast carotid intima media thickness progression and cardiovascular risk in men
Gigante B, Leander K, Vikström M, Baldassarre D, Veglia F, Strawbridge Rj, et al
Atherosclerosis 2014;236(2):394-9

Plasma autoantibodies against apolipoprotein B-100 peptide 210 in subclinical atherosclerosis
Mcleod O, Silveira A, Fredrikson Gn, Gertow K, Baldassarre D, Veglia F, et al
Atherosclerosis 2014;232(1):242-8

Prediction of cardiovascular disease by abdominal obesity measures is dependent on body weight and sex--results from two community based cohort studies
Carlsson Ac, Riserus U, Ärnlöv J, Borné Y, Leander K, Gigante B, et al
Nutrition, metabolism, and cardiovascular diseases : NMCD 2014;24(8):891-9

Reasons for non-participation in population-based abdominal aortic aneurysm screening
Linne A, Leander K, Lindström D, Törnberg S, Hultgren R
The British journal of surgery 2014;101(5):481-7

Response to: Modifiable lifestyle risks, cardiovascular disease, and all-cause mortality
Carlsson Ac, Wändell Pe, Gigante B, Leander K, Hellénius Ml, De Faire U
International journal of cardiology 2014;173(3):560-

Identifying the odds ratio estimated by a two-stage instrumental variable analysis with a logistic regression model
Burgess S, Crp Chd Genetics Collaboration
Statistics in medicine 2013;32(27):4726-47

Interaction between air pollution exposure and genes in relation to levels of inflammatory markers and risk of myocardial infarction
Panasevich S, Leander K, Ljungman P, Bellander T, De Faire U, Pershagen G, et al
BMJ open 2013;3(9):e003058-

Large-scale association analysis identifies new risk loci for coronary artery disease
Wellcome Trust Case Control, Muther Consortium, Cardiogenenics Consortium, Diagram Consortium, Cardiogramplusc4d Consortium, Deloukas P, et al
NATURE GENETICS 2013;45(1):25-33

Low levels of IgM antibodies to oxidized cardiolipin increase and high levels decrease risk of cardiovascular disease among 60-year olds: a prospective study
Su J, Hua X, Vikström M, Leander K, Gigante B, Hellenius Ml, et al
BMC cardiovascular disorders 2013;13():1-

Novel and established anthropometric measures and the prediction of incident cardiovascular disease: a cohort study
Carlsson Ac, Risérus U, Engström G, Ärnlöv J, Melander O, Leander K, et al
International journal of obesity (2005) 2013;37(12):1579-85

Serum 25-hydroxyvitamin D concentration in subclinical carotid atherosclerosis
Deleskog A, Piksasova O, Silveira A, Gertow K, Baldassarre D, Veglia F, et al
Arteriosclerosis, thrombosis, and vascular biology 2013;33(11):2633-8

Seven modifiable lifestyle factors predict reduced risk for ischemic cardiovascular disease and all-cause mortality regardless of body mass index: a cohort study
Carlsson Ac, Wändell Pe, Gigante B, Leander K, Hellenius Ml, De Faire U
International journal of cardiology 2013;168(2):946-52

The association between plasma homocysteine and coronary heart disease is modified by the MTHFR 677C>T polymorphism
Mehlig K, Leander K, De Faire U, Nyberg F, Berg C, Rosengren A, et al
Heart (British Cardiac Society) 2013;99(23):1761-5

The risk of type 2 diabetes in men is synergistically affected by parental history of diabetes and overweight
Wikner C, Gigante B, Hellénius Ml, De Faire U, Leander K
PloS one 2013;8(4):e61763-

A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
Muther Consortium, Diagram Consortium, Manning Ak, Hivert Mf, Scott Ra, Grimsby Jl, et al
NATURE GENETICS 2012;44(6):659-69

Chromosome 1p13 genetic variants antagonize the risk of myocardial infarction associated with high ApoB serum levels
Gigante B, Leander K, Vikström M, Ye S, De Faire U
BMC cardiovascular disorders 2012;12():90-

Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: Cardiovascular Biomarker Genetics Collaboration
Angelakopoulou A, Shah T, Sofat R, Shah S, Berry Dj, Cooper J, et al
EUROPEAN HEART JOURNAL 2012;33(3):393-407

Elevated ApoB serum levels strongly predict early cardiovascular events
Gigante B, Leander K, Vikstrom M, Frumento P, Carlsson Ac, Bottai M, et al
HEART 2012;98(16):1242-5

Identification of the BCAR1-CFDP1-TMEM170A locus as a determinant of carotid intima-media thickness and coronary artery disease risk
Gertow K, Sennblad B, Strawbridge Rj, Ohrvik J, Zabaneh D, Shah S, et al
Circulation. Cardiovascular genetics 2012;5(6):656-65

Impaired fibrinolytic capacity and increased fibrin formation associate with myocardial infarction
Leander K, Blomback M, Wallen H, He S
THROMBOSIS AND HAEMOSTASIS 2012;107(6):1092-9

Interaction of apolipoprotein E genotype with smoking and physical inactivity on coronary heart disease risk in men and women
Gustavsson J, Mehlig K, Leander K, Strandhagen E, Bjorck L, Thelle Ds, et al
ATHEROSCLEROSIS 2012;220(2):486-92

Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Genetic Invest Anthropometric, Wellcome Trust Case Control, Meta-anal Glucose Insulin-related, Diabet Genetics Replication, Asian Genetic Epidemiology, S Asian Type 2 Diabet Sat2d, et al
NATURE GENETICS 2012;44(9):981-90

NAMPT (visfatin) and AKT1 genetic variants associate with myocardial infarction
Leander K, Gigante B, Silveira A, Vikstrom M, Hamsten A, Hogberg J
CLINICA CHIMICA ACTA 2012;413(7-8):727-32

Regional variation in the incidence of abdominal aortic aneurysm in Sweden
Hultgren R, Forsberg J, Alfredsson L, Swedenborg J, Leander K
BRITISH JOURNAL OF SURGERY 2012;99(5):647-53

Relationships of plasma factor VIIa-antithrombin complexes to manifest and future cardiovascular disease
Silveira A, Scanavini D, Boquist S, Ericsson Cg, Hellenius Ml, Leander K, et al
THROMBOSIS RESEARCH 2012;130(2):221-5

A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease
Coronary Artery Dis C4d Genetics C, Muther Consortium, Peden Jf, Hopewell Jc, Saleheen D, Chambers Jc, et al
NATURE GENETICS 2011;43(4):339-44

Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data
C Reactive Protein Coronary Heart Disease Genetics Collaboration (ccgc), Wensley F, Gao P, Burgess S, Kaptoge S, Di Angelantonio E, et al
BMJ (Clinical research ed.) 2011;342():d548-

Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes
Strawbridge Rj, Dupuis J, Prokopenko I, Barker A, Ahlqvist E, Rybin D, et al
Diabetes 2011;60(10):2624-34

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease
Cardiogram Consortium, Schunkert H, Konig Ir, Kathiresan S, Reilly Mp, Assimes Tl, et al
NATURE GENETICS 2011;43(4):333-8

Large-scale gene-centric analysis identifies novel variants for coronary artery disease
Ibc 50k Cad Consortium
PLoS genetics 2011;7(9):e1002260-

Plasma CD93 concentration is a potential novel biomarker for coronary artery disease
Malarstig A, Silveira A, Wagsater D, Ohrvik J, Backlund A, Samnegard A, et al
JOURNAL OF INTERNAL MEDICINE 2011;270(3):229-36

Apolipoprotein C-I genotype and serum levels of triglycerides, C-reactive protein and coronary heart disease
Olsson B, Gigante B, Mehlig K, Bergsten A, Leander K, De Faire U, et al
METABOLISM-CLINICAL AND EXPERIMENTAL 2010;59(12):1736-41

Associations between a single nucleotide polymorphism of the Visfatin (Nampt) gene and risk of myocardial infarction in young women
Leander K, Gigante B, Hogberg J
EUROPEAN HEART JOURNAL 2010;:537-537

COMMON GENETIC VARIANTS ASSOCIATED WITH LOW Lp(a) KRINGLE-IV COPY NUMBER, HIGH Lp(a) CONCENTRATION, AND INCREASED RISK OF CORONARY HEART DISEASE
Procardis Consortium, Seedorf U, Peden J, Hopewell J, Kyriakou T, Goel A, et al
ATHEROSCLEROSIS SUPPLEMENTS 2010;11(2):13-13

Genetic variants at interleukin 6 receptor and the risk of myocardial infarction
Gigante B, Leander K, Vikstrom M, De Faire U
EUROPEAN HEART JOURNAL 2010;:746-746

Genetic Variation at the Phospholipid Transfer Protein Locus Affects Its Activity and High-Density Lipoprotein Size and Is a Novel Marker of Cardiovascular Disease Susceptibility
Vergeer M, Boekholdt Sm, Sandhu Ms, Ricketts Sl, Wareham Nj, Brown Mj, et al
CIRCULATION 2010;122(5):470-7

The Interaction between Coagulation Factor 2 Receptor and Interleukin 6 Haplotypes Increases the Risk of Myocardial Infarction in Men
Gigante B, Bennet Am, Leander K, Vikstrom M, De Faire U
PLOS ONE 2010;5(6):e11300-

Associations of long- and short-term air pollution exposure with markers of inflammation and coagulation in a population sample
Panasevich S, Leander K, Rosenlund M, Ljungman P, Bellander T, De Faire U, et al
OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 2009;66(11):747-53

ASSOCIATION STUDY OF CORONARY ARTERY DISEASE (CAD) USING HUMANCVD 50K CHIP
Procardis Consortium, Goel A, Clarke R, Hopewell Jc, Kyriakou T, Heath Sc, et al
ATHEROSCLEROSIS 2009;207(1):E4-E4

Common Genetic Variants Associated With Higher Lp(a) Concentrations and Increased Risk of Coronary Heart Disease
Procardis Consortium, Clarke R, Peden J, Hopewell J, Kyriakou T, Goel A, et al
CIRCULATION 2009;120(18):S589-S589

Genetic Variants Associated with Lp(a) Lipoprotein Level and Coronary Disease
Procardis Consortium, Clarke R, Peden Jf, Hopewell Jc, Kyriakou T, Goel A, et al
NEW ENGLAND JOURNAL OF MEDICINE 2009;361(26):2518-28

Long- and Short-Term Air Pollution Exposure and Markers of Inflammation and Coagulation in a Population Sample from Stockholm
Panasevich S, Leander K, Rosenlund M, Ljungman P, Bellander T, De Faire U, et al
EPIDEMIOLOGY 2009;20(6):S156-S157

Multi-Organ Expression Profiling Uncovers a Gene Module in Coronary Artery Disease Involving Transendothelial Migration of Leukocytes and LIM Domain Binding 2: The Stockholm Atherosclerosis Gene Expression (STAGE) Study
Hagg S, Skogsberg J, Lundstrom J, Noori P, Nilsson R, Zhong H, et al
PLOS GENETICS 2009;5(12):e1000754-

Outcome after leg bypass surgery for critical limb ischemia is poor in patients with diabetes - A population-based cohort study
Malmstedt J, Leander K, Wahlberg E, Karlstrom L, Alfredsson L, Swedenborg J
DIABETES CARE 2008;31(5):887-92

Primary risk factors influence risk of recurrent myocardial infarction/death from coronary heart disease: results from the Stockholm Heart Epidemiology Program (SHEEP)
Leander K, Wiman B, Hallqvist J, Andersson T, Ahlbom A, De Faire U
EUROPEAN JOURNAL OF CARDIOVASCULAR PREVENTION & REHABILITATION 2007;14(4):532-7

The association between fibrinogen haplotypes and myocardial infarction in men is partly mediated through pleiotropic effects on the serum IL-6 concentration
Mannila Mn, Eriksson P, Leander K, Wiman B, De Faire U, Hamsten A, et al
JOURNAL OF INTERNAL MEDICINE 2007;261(2):138-47

The complex between tPA and PAI-1: risk factor for myocardial infarction as studied in the SHEEP project
Nordenhem A, Leander K, Hallqvist J, De Faire U, Sten-linder M, Wiman B
THROMBOSIS RESEARCH 2005;116(3):223-32

PAI-1 level and the PAI-1 4G/5G polymorphism in relation to risk of non-fatal myocardial infarction
Leander K, Wiman B, Hallqvist J, Sten-linder M, De Faire U
THROMBOSIS AND HAEMOSTASIS 2003;89(6):1064-71

The G-455A polymorphism of the fibrinogen B beta-gene relates to plasma fibrinogen in male cases, but does not interact with environmental factors in causing myocardial infarction in either men or women
Leander K, Wiman B, Hallqvist J, Falk G, De Faire U
JOURNAL OF INTERNAL MEDICINE 2002;252(4):332-41

Family history of coronary heart disease, a strong risk factor for myocardial infarction interacting with other cardiovascular risk factors: Results from the Stockholm Heart Epidemiology Program (SHEEP)
Leander K, Hallqvist J, Reuterwall C, Ahlbom A, De Faire U
EPIDEMIOLOGY 2001;12(2):215-21

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