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About me

Karima Chergui is a University lecturer and research group leader for Molecular neurophysiology

Research description

Research interests: neurophysiology of the basal ganglia in health and disease.

Short curriculum vitae:

1993: Ph.D. in Neuroscience (Université Claude Bernard, Lyon, France)

2003: Head of the Section of Molecular Neurophysiology, Department of Physiology and Pharmacology, the Karolinska Institute.

Selected publications:

- Chergui K. et al. (1993) Tonic activation of NMDA receptors causes spontaneous burst discharge of rat midbrain dopamine neurons in vivo. European Journal of Neuroscience 5(2):137-144.

- Chergui K. et al. (1994) Subthalamic nucleus modulates burst firing of nigral dopamine neurones via NMDA receptors. Neuroreport 5(10):1185-1188.

- Chergui K. et al. (1994) Nonlinear relationship between impulse flow, dopamine release and dopamine elimination in the rat brain in vivo. Neuroscience 62(3):641-645.

- Chergui K. et al. (1997) Increased expression of NGFI-A mRNA in the rat striatum following burst stimulation of the medial forebrain bundle. European Journal of Neuroscience 9(11):2370-2382.

- Chergui K. and Lacey M.G. (1999) Modulation by dopamine D1-like receptors of synaptic transmission and NMDA receptors in rat nucleus accumbens is attenuated by the protein kinase C inhibitor Ro 32-0432. Neuropharmacology 38(2):223-231.

- Chergui K. et al. (2000) Functional GluR6 kainate receptors in the striatum: indirect downregulation of synaptic transmission. The Journal of Neuroscience 20(6):2175-2182.

- Chergui K. et al. (2004) Cyclin-dependent kinase-5 regulates glutamatergic and dopaminergic transmission in the striatum. Proc. Natl. Acad. Sci. U S A. 101(7):2191-2196.

- Chergui K. et al. (2005) Physiological role for casein kinase 1 in glutamatergic synaptic transmission. The Journal of Neuroscience 25(28):6601-6609.

- Schotanus S.M. and Chergui K. (2008) Dopamine D1 receptors and group I metabotropic glutamate receptors contribute to the induction of long-term potentiation in the nucleus accumbens. Neuropharmacology 54(5): 837-844.

- Chergui K. (2011) Dopamine induces a GluN2A-dependent form of long term depression of NMDA synaptic responses in the nucleus accumbens. Neuropharmacology 60(6):975-81.

- Zhang X. et al. (2014) Allosteric modulation of GluN2C/GluN2D-containing NMDA receptors bidirectionally modulates dopamine release: implication for Parkinson’s disease. British Journal of Pharmacology 171(16):3938-45.

- Zhang X and Chergui K (2015) Dopamine depletion of the striatum causes a cell-type specific reorganization of GluN2B- and GluN2D-containing NMDA receptors. Neuropharmacology, 92:108-115.


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