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Karin Broberg

Professor

Visiting address : Scheelelaboratoriet, Nobels Väg 13 Solna, Sweden
Postal address : Institute of Environmental Medicine (IMM), C6, Metals and health, Box 210 171 77 Stockholm, Sweden
Delivery address : Scheelelaboratoriet, Nobels Väg 13 Solna, Sweden

About me

Research in my group is based on my expertise in genetics and epigenetics of metal toxicology. I have extensive experience from research on human epidemiological studies including analysis of exposure and genetic and epigenetic markers. My recent work has been on adverse effects of exposure to toxicants early in life and genetic and epigenetic mechanisms of toxicity for which I use large-scale system biology approaches.

Links

Publications

Alterations of telomere length and DNA methylation in hairdressers: A cross-sectional study
Li H, Akerman G, Liden C, Alhamdow A, Wojdacz Tk, Broberg K, et al
Environmental and molecular mutagenesis 2016;57(2):159-67

Common Polymorphisms in the Solute Carrier SLC30A10 are Associated With Blood Manganese and Neurological Function
Wahlberg K, Kippler M, Alhamdow A, Rahman Sm, Smith Dr, Vahter M, et al
Toxicological sciences : an official journal of the Society of Toxicology 2016;149(2):473-83

A Cross-Sectional Study of the Cardiovascular Effects of Welding Fumes
Li H, Hedmer M, Karedal M, Bjork J, Stockfelt L, Tinnerberg H, et al
PloS one 2015;10(7):e0131648-

Discordant pattern of BRCA1 gene epimutation in blood between mothers and daughters
Wojdacz Tk, Harari F, Vahter M, Broberg K
Journal of clinical pathology 2015;68(7):575-7

Exposure of hairdressers to ortho- and meta-toluidine in hair dyes
Johansson Gm, Jonsson Ba, Axmon A, Lindh Ch, Lind Ml, Gustavsson M, et al
Occupational and environmental medicine 2015;72(1):57-63

Exposure to welding fumes is associated with hypomethylation of the F2RL3 gene: a cardiovascular disease marker
Hossain Mb, Li H, Hedmer M, Tinnerberg H, Albin M, Broberg K
Occupational and environmental medicine 2015;72(12):845-51

Genetic modification of ALAD and VDR on lead-induced impairment of hearing in children
Pawlas N, Broberg K, Olewinska E, Kozlowska A, Skerfving S, Pawlas K
Environmental toxicology and pharmacology 2015;39(3):1091-8

Genetic variation in arsenic (+3 oxidation state) methyltransferase (AS3MT), arsenic metabolism and risk of basal cell carcinoma in a European population
Engstrom Ks, Vahter M, Fletcher T, Leonardi G, Goessler W, Gurzau E, et al
Environmental and molecular mutagenesis 2015;56(1):60-9

Genetic variation in FADS genes is associated with maternal long-chain PUFA status but not with cognitive development of infants in a high fish-eating observational study
Yeates Aj, Love Tm, Engstrom K, Mulhern Ms, Mcsorley Em, Grzesik K, et al
Prostaglandins, leukotrienes, and essential fatty acids 2015;102-103():13-20

Genome-wide gene expression profiling of low-dose, long-term exposure of human osteosarcoma cells to bisphenol A and its analogs bisphenols AF and S
Fic A, Mlakar Sj, Juvan P, Mlakar V, Marc J, Dolenc Ms, et al
Toxicology in vitro : an international journal published in association with BIBRA 2015;29(5):1060-9

Human adaptation to arsenic-rich environments
Schlebusch Cm, Gattepaille Lm, Engstrom K, Vahter M, Jakobsson M, Broberg K
Molecular biology and evolution 2015;32(6):1544-55

Oxidative stress, telomere shortening, and DNA methylation in relation to low-to-moderate occupational exposure to welding fumes
Li H, Hedmer M, Wojdacz T, Hossain Mb, Lindh Ch, Tinnerberg H, et al
Environmental and molecular mutagenesis 2015;56(8):684-93

Selenium metabolism to the trimethylselenonium ion (TMSe) varies markedly because of polymorphisms in the indolethylamine N-methyltransferase gene
Kuehnelt D, Engstrom K, Skroder H, Kokarnig S, Schlebusch C, Kippler M, et al
The American journal of clinical nutrition 2015;102(6):1406-15

Telomere length in children environmentally exposed to low-to-moderate levels of lead
Pawlas N, Plachetka A, Kozlowska A, Broberg K, Kasperczyk S
Toxicology and applied pharmacology 2015;287(2):111-8

The effects of arsenic exposure on blood pressure and early risk markers of cardiovascular disease: Evidence for population differences
Ameer Ss, Engstrom K, Harari F, Concha G, Vahter M, Broberg K
Environmental research 2015;140():32-6

The Epigenetic Effects of Prenatal Cadmium Exposure
Vilahur N, Vahter M, Broberg K
Current environmental health reports 2015;2(2):195-203

Arsenic exposure in early pregnancy alters genome-wide DNA methylation in cord blood, particularly in boys
Broberg K, Ahmed S, Engstrom K, Hossain Mb, Jurkovic Mlakar S, Bottai M, et al
Journal of developmental origins of health and disease 2014;5(4):288-98

Biomarkers of exposure in Monday morning urine samples as a long-term measure of exposure to aromatic diisocyanates
Tinnerberg H, Broberg K, Lindh Ch, Jonsson Ba
International archives of occupational and environmental health 2014;87(4):365-72

Cadmium concentrations in human blood and urine are associated with polymorphisms in zinc transporter genes
Rentschler G, Kippler M, Axmon A, Raqib R, Skerfving S, Vahter M, et al
Metallomics : integrated biometal science 2014;6(4):885-91

Cadmium, mercury, and lead in kidney cortex are not associated with urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxodG) in living kidney donors
Hossain Mb, Barregard L, Sallsten G, Broberg K
International archives of occupational and environmental health 2014;87(3):315-22

Disturbance of posture in children with very low lead exposure, and modification by VDR FokI genotype
Pawlas N, Broberg K, Skerfving S, Pawlas K
Annals of agricultural and environmental medicine : AAEM 2014;21(4):739-44

Exposure to arsenic and intra-chromosomal instability in blood
Wojdacz Tk, Bottai M, Vahter M, Broberg K
Metallomics : integrated biometal science 2014;6(8):1387-9

Polymorphisms in ABC transporter genes and concentrations of mercury in newborns--evidence from two Mediterranean birth cohorts
Llop S, Engstrom K, Ballester F, Franforte E, Alhamdow A, Pisa F, et al
PloS one 2014;9(5):e97172-

Target organ specific activity of drosophila MRP (ABCC1) moderates developmental toxicity of methylmercury
Prince L, Korbas M, Davidson P, Broberg K, Rand Md
Toxicological sciences : an official journal of the Society of Toxicology 2014;140(2):425-35

Efficient arsenic metabolism--the AS3MT haplotype is associated with DNA methylation and expression of multiple genes around AS3MT
Engstrom Ks, Hossain Mb, Lauss M, Ahmed S, Raqib R, Vahter M, et al
PloS one 2013;8(1):e53732-

Human and methodological sources of variability in the measurement of urinary 8-oxo-7,8-dihydro-2'-deoxyguanosine
Barregard L, Moller P, Henriksen T, Mistry V, Koppen G, Rossner P, et al
Antioxidants & redox signaling 2013;18(18):2377-91

Lead concentration in plasma as a biomarker of exposure and risk, and modification of toxicity by δ-aminolevulinic acid dehydratase gene polymorphism
Tian L, Zheng G, Sommar Jn, Liang Y, Lundh T, Broberg K, et al
Toxicology letters 2013;221(2):102-9

N-6-adenine-specific DNA methyltransferase 1 (N6AMT1) polymorphisms and arsenic methylation in Andean women
Harari F, Engstrom K, Concha G, Colque G, Vahter M, Broberg K
Environmental health perspectives 2013;121(7):797-803

Polymorphisms in genes encoding potential mercury transporters and urine mercury concentrations in populations exposed to mercury vapor from gold mining
Engstrom K, Ameer S, Bernaudat L, Drasch G, Baeuml J, Skerfving S, et al
Environmental health perspectives 2013;121(1):85-91

Polymorphisms in glutathione-related genes modify mercury concentrations and antioxidant status in subjects environmentally exposed to methylmercury
Barcelos Gr, Grotto D, De Marco Kc, Valentini J, Lengert Av, De Oliveira Aa, et al
The Science of the total environment 2013;463-464():319-25

Polymorphisms in iron homeostasis genes and urinary cadmium concentrations among nonsmoking women in Argentina and Bangladesh
Rentschler G, Kippler M, Axmon A, Raqib R, Ekstrom Ec, Skerfving S, et al
Environmental health perspectives 2013;121(4):467-72

Possible positive selection for an arsenic-protective haplotype in humans
Schlebusch Cm, Lewis Cm, Vahter M, Engstrom K, Tito Ry, Obregon-tito Aj, et al
Environmental health perspectives 2013;121(1):53-8

Sex-specific effects of early life cadmium exposure on DNA methylation and implications for birth weight
Kippler M, Engstrom K, Mlakar Sj, Bottai M, Ahmed S, Hossain Mb, et al
Epigenetics 2013;8(5):494-503

Telomere length and LINE1 methylation is associated with chromosomal aberrations in peripheral blood
Li H, Hilmarsen Ht, Hossain Mb, Bjork J, Hansteen Il, Albin M, et al
Genes, chromosomes & cancer 2013;52(1):1-10

A polymorphism in metallothionein 1A (MT1A) is associated with cadmium-related excretion of urinary beta 2-microglobulin
Lei L, Chang X, Rentschler G, Tian L, Zhu G, Chen X, et al
Toxicology and applied pharmacology 2012;265(3):373-9

Arsenic exposure through drinking water is associated with longer telomeres in peripheral blood
Li H, Engstrom K, Vahter M, Broberg K
Chemical research in toxicology 2012;25(11):2333-9

ATP13A2 (PARK9) polymorphisms influence the neurotoxic effects of manganese
Rentschler G, Covolo L, Haddad Aa, Lucchini Rg, Zoni S, Broberg K
Neurotoxicology 2012;33(4):697-702

Early life low-level cadmium exposure is positively associated with increased oxidative stress
Kippler M, Hossain Mb, Lindh C, Moore Se, Kabir I, Vahter M, et al
Environmental research 2012;112():164-70

Environmental arsenic exposure and DNA methylation of the tumor suppressor gene p16 and the DNA repair gene MLH1: effect of arsenic metabolism and genotype
Hossain Mb, Vahter M, Concha G, Broberg K
Metallomics : integrated biometal science 2012;4(11):1167-75

Exposure and toxic effects of elemental mercury in gold-mining activities in Ecuador
Harari R, Harari F, Gerhardsson L, Lundh T, Skerfving S, Stromberg U, et al
Toxicology letters 2012;213(1):75-82

Inverse association of intellectual function with very low blood lead but not with manganese exposure in Italian adolescents
Lucchini Rg, Zoni S, Guazzetti S, Bontempi E, Micheletti S, Broberg K, et al
Environmental research 2012;118():65-71

Long-term lead elimination from plasma and whole blood after poisoning
Rentschler G, Broberg K, Lundh T, Skerfving S
International archives of occupational and environmental health 2012;85(3):311-6

Low-level environmental cadmium exposure is associated with DNA hypomethylation in Argentinean women
Hossain Mb, Vahter M, Concha G, Broberg K
Environmental health perspectives 2012;120(6):879-84

Modification by the genes ALAD and VDR of lead-induced cognitive effects in children
Pawlas N, Broberg K, Olewinska E, Prokopowicz A, Skerfving S, Pawlas K
Neurotoxicology 2012;33(1):37-43

Pregnancy and the methyltransferase genotype independently influence the arsenic methylation phenotype
Gardner Rm, Engstrom K, Bottai M, Hoque Wa, Raqib R, Broberg K, et al
Pharmacogenetics and genomics 2012;22(7):508-16

Response to the letter to the editor entitled "Regarding long-term lead elimination from plasma and whole blood after poisoning"
Rentschler G, Broberg K, Lundh T, Skerfving S
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH 2012;85(3):339-339

δ-Aminolevulinic acid dehydratase genotype predicts toxic effects of lead on workers' peripheral nervous system
Zheng G, Tian L, Liang Y, Broberg K, Lei L, Guo W, et al
Neurotoxicology 2011;32(4):374-82

Evaluation of the impact of genetic polymorphisms in glutathione-related genes on the association between methylmercury or n-3 polyunsaturated long chain fatty acids and risk of myocardial infarction: a case-control study
Engstrom Ks, Wennberg M, Stromberg U, Bergdahl Ia, Hallmans G, Jansson Jh, et al
Environmental health : a global access science source 2011;10():33-

Gene expression analysis in induced sputum from welders with and without airway-related symptoms
Jonsson Ls, Nielsen J, Broberg K
International archives of occupational and environmental health 2011;84(1):105-13

Lithium in drinking water and thyroid function
Broberg K, Concha G, Engstrom K, Lindvall M, Grander M, Vahter M
Environmental health perspectives 2011;119(6):827-30

N-nitrosamines are associated with shorter telomere length
Li H, Jonsson Ba, Lindh Ch, Albin M, Broberg K
Scandinavian journal of work, environment & health 2011;37(4):316-24

Polymorphisms in arsenic(+III oxidation state) methyltransferase (AS3MT) predict gene expression of AS3MT as well as arsenic metabolism
Engstrom K, Vahter M, Mlakar Sj, Concha G, Nermell B, Raqib R, et al
Environmental health perspectives 2011;119(2):182-8

Chronic exposure to cadmium and arsenic strongly influences concentrations of 8-oxo-7,8-dihydro-2'-deoxyguanosine in urine
Engstrom Ks, Vahter M, Johansson G, Lindh Ch, Teichert F, Singh R, et al
Free radical biology & medicine 2010;48(9):1211-7

High-level exposure to lithium, boron, cesium, and arsenic via drinking water in the Andes of northern Argentina
Concha G, Broberg K, Grander M, Cardozo A, Palm B, Vahter M
Environmental science & technology 2010;44(17):6875-80

Low 8-oxo-7,8-dihydro-2'-deoxyguanosine levels and influence of genetic background in an Andean population exposed to high levels of arsenic
Engstrom Ks, Vahter M, Lindh C, Teichert F, Singh R, Concha G, et al
Mutation research 2010;683(1-2):98-105

Arsenic metabolism is influenced by polymorphisms in genes involved in one-carbon metabolism and reduction reactions
Schlawicke Engstrom K, Nermell B, Concha G, Stromberg U, Vahter M, Broberg K
Mutation research 2009;667(1-2):4-14

Association between polymorphisms in RMI1, TOP3A, and BLM and risk of cancer, a case-control study
Broberg K, Huynh E, Schlawicke Engstrom K, Bjork J, Albin M, Ingvar C, et al
BMC cancer 2009;9():140-

Gene expression in nasal lavage from hairdressers exposed to persulphate
Jonsson Ls, Broberg K, Paulsson K, Kronholm Diab K, Nielsen J
International archives of occupational and environmental health 2009;82(10):1261-6

Ranking of genome-wide association scan signals by different measures
Stromberg U, Bjork J, Vineis P, Broberg K, Zeggini E
International journal of epidemiology 2009;38(5):1364-73

Research challenges in occupational and environmental medicine until 2030
Albin M, Broberg K, Jakobsson K
Occupational and environmental medicine 2009;66(1):3-5

Smoking as a risk factor for myelodysplastic syndromes and acute myeloid leukemia and its relation to cytogenetic findings: a case-control study
Bjork J, Johansson B, Broberg K, Albin M
Leukemia research 2009;33(6):788-91

Telomeric associations correlate with telomere length reduction and clonal chromosome aberrations in giant cell tumor of bone
Gebre-medhin S, Broberg K, Jonson T, Gorunova L, Von Steyern Fv, Brosjo O, et al
Cytogenetic and genome research 2009;124(2):121-7

Genetic variation in glutathione-related genes and body burden of methylmercury
Schlawicke Engstrom K, Stromberg U, Lundh T, Johansson I, Vessby B, Hallmans G, et al
Environmental health perspectives 2008;116(6):734-9

Influence of genetic factors on toluene diisocyanate-related symptoms: evidence from a cross-sectional study
Broberg K, Tinnerberg H, Axmon A, Warholm M, Rannug A, Littorin M
Environmental health : a global access science source 2008;7():15-

Influence of glutathione-related genes on symptoms and immunologic markers among vulcanization workers in the southern Sweden rubber industries
Jonsson Ls, Jonsson Ba, Axmon A, Littorin M, Broberg K
International archives of occupational and environmental health 2008;81(7):913-9

Influence of polymorphic metabolic enzymes on biotransformation and effects of diphenylmethane diisocyanate
Littorin M, Hou S, Broberg K, Bjork J, Falt S, Abdoulaye G, et al
International archives of occupational and environmental health 2008;81(4):429-41

Levels of 1-hydroxypyrene, symptoms and immunologic markers in vulcanization workers in the southern Sweden rubber industries
Jonsson Ls, Broberg K, Axmon A, Bergendorf U, Littorin M, Jonsson Ba
International archives of occupational and environmental health 2008;82(1):131-7

Lung function in relation to 2-thiothiazolidine-4-carboxylic acid and genetic effect modification among rubber workers in Sweden
Jonsson Ls, Littorin M, Axmon A, Jonsson Ba, Broberg K
Journal of occupational and environmental medicine / American College of Occupational and Environmental Medicine 2008;50(9):1006-12

Selection of influential genetic markers among a large number of candidates based on effect estimation rather than hypothesis testing: an approach for genome-wide association studies
Stromberg U, Bjork J, Broberg K, Mertens F, Vineis P
Epidemiology (Cambridge, Mass.) 2008;19(2):302-8

Eye and airway symptoms in low occupational exposure to toluene diisocyanate
Littorin M, Axmon A, Broberg K, Sennbro Cj, Tinnerberg H
Scandinavian journal of work, environment & health 2007;33(4):280-5

Genetic polymorphisms influencing arsenic metabolism: evidence from Argentina
Schlawicke Engstrom K, Broberg K, Concha G, Nermell B, Warholm M, Vahter M
Environmental health perspectives 2007;115(4):599-605

Genetic variant of the human homologous recombination-associated gene RMI1 (S455N) impacts the risk of AML/MDS and malignant melanoma
Broberg K, Hoglund M, Gustafsson C, Bjork J, Ingvar C, Albin M, et al
Cancer letters 2007;258(1):38-44

Levels of 2-thiothiazolidine-4-carboxylic acid (TTCA) and effect modification of polymorphisms of glutathione-related genes in vulcanization workers in the southern Sweden rubber industries
Jonsson Ls, Broberg K, Bergendorf U, Axmon A, Littorin M, Jonsson Ba
International archives of occupational and environmental health 2007;80(7):589-98

Pooled analysis and meta-analysis of the glutathione S-transferase P1 Ile 105Val polymorphism and bladder cancer: a HuGE-GSEC review
Kellen E, Hemelt M, Broberg K, Golka K, Kristensen Vn, Hung Rj, et al
American journal of epidemiology 2007;165(11):1221-30

Symptoms and immunologic markers among vulcanization workers in rubber industries in southern Sweden
Jonsson Ls, Broberg K, Axmon A, Jonsson Ba, Littorin M
Scandinavian journal of work, environment & health 2007;33(4):272-9

Constitutional short telomeres are strong genetic susceptibility markers for bladder cancer
Broberg K, Bjork J, Paulsson K, Hoglund M, Albin M
Carcinogenesis 2005;26(7):1263-71

Genetic influences on the retention of inorganic mercury
Custodio Hm, Harari R, Gerhardsson L, Skerfving S, Broberg K
Archives of environmental & occupational health 2005;60(1):17-23

Polymorphisms in glutathione-related genes affect methylmercury retention
Custodio Hm, Broberg K, Wennberg M, Jansson Jh, Vessby B, Hallmans G, et al
Archives of environmental health 2004;59(11):588-95

Fusion of RDC1 with HMGA2 in lipomas as the result of chromosome aberrations involving 2q35-37 and 12q13-15
Broberg K, Zhang M, Strombeck B, Isaksson M, Nilsson M, Mertens F, et al
International journal of oncology 2002;21(2):321-6

Proteoglycan production in disomic and trisomy 7-carrying human synovial cells
Eklund E, Broberg K, Westergren-thorsson G, Bjardahlen A, Hedlund M, Malmstrom A
Matrix biology : journal of the International Society for Matrix Biology 2002;21(4):325-35

Analysis of the distribution and frequency of trisomy 7 in vivo in synovia from patients with osteoarthritis and pigmented villonodular synovitis
Dahlen A, Broberg K, Domanski Ha, Toksvig-larsen S, Lindstrand A, Mandahl N, et al
Cancer genetics and cytogenetics 2001;131(1):19-24

The tumor-associated gene HMGIC is expressed in normal and osteoarthritis-affected synovia
Broberg K, Tallini G, Hoglund M, Lindstrand A, Toksvig-larsen S, Mertens F
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc 2001;14(4):311-7

Trisomy 7 accumulates with age in solid tumors and non-neoplastic synovia
Broberg K, Toksvig-larsen S, Lindstrand A, Mertens F
Genes, chromosomes & cancer 2001;30(3):310-5

Cytogenetic polyclonality in hematologic malignancies
Johansson B, Billstrom R, Broberg K, Fioretos T, Nilsson Pg, Ahlgren T, et al
Genes, chromosomes & cancer 1999;24(3):222-9

Rearrangement of the neoplasia-associated gene HMGIC in synovia from patients with osteoarthritis
Broberg K, Hoglund M, Limon J, Lindstrand A, Toksvig-larsen S, Mandahl N, et al
Genes, chromosomes & cancer 1999;24(3):278-82

Polyclonal expansion of cells with trisomy 7 in synovia from patients with osteoarthritis
Broberg K, Hoglund M, Lindstrand A, Toksvig-larsen S, Mandahl N, Mertens F
Cytogenetics and cell genetics 1998;83(1-2):30-4

Clonal chromosome aberrations are present in vivo in synovia and osteophytes from patients with osteoarthritis
Broberg K, Limon J, Palsson E, Lindstrand A, Toksvig-larsen S, Mandahl N, et al
Human genetics 1997;101(3):295-8

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