Denna sida på svenska
Loading profile information...

About me

Assistant Professor, Group leader and PI, Division of Medical inflammation research


 M.Sc, 4 years of university studies. Molecular Biology, Göteborgs Universitet, Sweden, 2000


PhD in rheumatology, Göteborgs Universitet, Sweden, 2004

Title:  Inhibition of T cell responses to auto-antigens and allergens by CD25+ regulatory T cells from thymus, cord and adult blood

Supervisors:    Anna Rudin and Elisabeth Suri-Payer


Postdoctoral position in Pr Shimon Sakaguchis group, Kyoto University, Japan, 2005-2008

Working on the role of CTLA-4 in Foxp3+ Regulatory T cells


Postdoctoral position in Pr Rikard Holmdahls group, Karolinska Institute, Sweden, 2008-2010

Working on the role of ROS in arthritis

Research description

The research of me and my group is focused on basic immunological tolerance mechanisms in autoimmunity and inflammation. To investigate complex multifactorial diseases such as Rheumatoid Arthritis (RA) or Multiple sclerosis (MS), good in vivo models are key. We are using these models to adress specific molecular targets known to have impact on inflammation and autoimmunity. One research project is focused on the role of CTLA-4, a critical negative regulator of T cell activation. CTLA-4 is expressed by all activated T cells but have a specific role in CD4+Foxp3+ Regulatory T cells as a suppressive mechanism. CTLA-4 is used clinically in cancer as well as RA patients and we are investigating its role in different developmental stages of the immune system to deepen our knowledge of the function of this important immune regulator with the aim to improve its use.  

Loading publication list...


Group members:

Katrin Klocke, PhD student

Simon Guerard, PhD student