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Joy Roy

Senior Lecturer

Visiting address : CMM, L8:03, 17176 Stockholm, Sweden
Postal address : Department of Molecular Medicine and Surgery (MMK), K1, Vascular Surgery , CMM, L8:03, 7176 Stockholm, Sweden
Delivery address : CMM, L8:03, 17176 Stockholm, Sweden

Publications

Biomechanical changes during abdominal aortic aneurysm growth
Stevens Rrf, Grytsan A, Biasetti J, Roy J, Lindquist Liljeqvist M, Gasser Tc
PloS one 2017;12(11):e0187421-

Differential expression of sex hormone receptors in abdominal aortic aneurysms
Villard C, Eriksson P, Kronqvist M, Lengquist M, Jorns C, Hartman J, et al
Maturitas 2017;96():39-44

Gender, smoking, body size, and aneurysm geometry influence the biomechanical rupture risk of abdominal aortic aneurysms as estimated by finite element analysis
Lindquist Liljeqvist M, Hultgren R, Siika A, Gasser Tc, Roy J
Journal of vascular surgery 2017;65(4):1014-1021.e4

Low TLR7 gene expression in atherosclerotic plaques is associated with major adverse cardio- and cerebrovascular events
Karadimou G, Folkersen L, Berg M, Perisic L, Discacciati A, Roy J, et al
Cardiovascular research 2017;113(1):30-39

Management of Atherosclerotic Carotid and Vertebral Artery Disease: 2017 Clinical Practice Guidelines of the European Society for Vascular Surgery (ESVS)
Writing Group , Naylor Ar, Ricco Jb, De Borst Gj, Debus S, De Haro J, et al
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2017;():-

A Majority of Admitted Patients With Ruptured Abdominal Aortic Aneurysm Undergo and Survive Corrective Treatment: A Population-Based Retrospective Cohort Study
Hultgren R, Zommorodi S, Gambe M, Roy J
World journal of surgery 2016;40(12):3080-3087

Commentary on 'Plaque Echolucency and the Risk of Ischaemic Stroke in Patients with Asymptomatic Carotid Stenosis Within the First Asymptomatic Carotid Surgery Trial (ACST-1)'
Roy J, Hedin U
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2016;51(5):622-

Gene expression signatures, pathways and networks in carotid atherosclerosis
Perisic L, Aldi S, Sun Y, Folkersen L, Razuvaev A, Roy J, et al
Journal of internal medicine 2016;279(3):293-308

High proportion of known abdominal aortic aneurysm in patients with rupture indicates surveillance deficiency
Zommorodi S, Roy J, Steuer J, Hultgren R
Journal of vascular surgery 2016;64(4):949-955.e1

Imatinib treatment attenuates growth and inflammation of angiotensin II induced abdominal aortic aneurysm
Vorkapic E, Dugic E, Vikingsson S, Roy J, Mäyränpää Mi, Eriksson P, et al
Atherosclerosis 2016;249():101-9

Local Diameter, Wall Stress, and Thrombus Thickness Influence the Local Growth of Abdominal Aortic Aneurysms
Martufi G, Lindquist Liljeqvist M, Sakalihasan N, Panuccio G, Hultgren R, Roy J, et al
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists 2016;23(6):957-966

Phenotypic Modulation of Smooth Muscle Cells in Atherosclerosis Is Associated With Downregulation of LMOD1, SYNPO2, PDLIM7, PLN, and SYNM
Perisic Matic L, Rykaczewska U, Razuvaev A, Sabater-lleal M, Lengquist M, Miller Cl, et al
Arteriosclerosis, thrombosis, and vascular biology 2016;36(9):1947-61

Prediction of Rupture Sites in Abdominal Aortic Aneurysms After Finite Element Analysis
Erhart P, Roy J, De Vries Jp, Liljeqvist Ml, Grond-ginsbach C, Hyhlik-dürr A, et al
Journal of endovascular therapy : an official journal of the International Society of Endovascular Specialists 2016;23(1):115-20

Volume growth of abdominal aortic aneurysms correlates with baseline volume and increasing finite element analysis-derived rupture risk
Lindquist Liljeqvist M, Hultgren R, Gasser Tc, Roy J
Journal of vascular surgery 2016;63(6):1434-1442.e3

Aneurysm development in patients with a bicuspid aortic valve is not associated with transforming growth factor-β activation
Paloschi V, Gådin Jr, Khan S, Björck Hm, Du L, Maleki S, et al
Arteriosclerosis, thrombosis, and vascular biology 2015;35(4):973-80

Endovascular treatment of true and false aneurysms in hemodialysis access
Hedin U, Engström J, Roy J
The Journal of cardiovascular surgery 2015;56(4):599-605

Glucagon-Like Peptide-1 Receptor Activation Does not Affect Re-Endothelialization but Reduces Intimal Hyperplasia via Direct Effects on Smooth Muscle Cells in a Nondiabetic Model of Arterial Injury
Eriksson L, Saxelin R, Röhl S, Roy J, Caidahl K, Nyström T, et al
Journal of vascular research 2015;52(1):41-52

Proteolytically active ADAM10 and ADAM17 carried on membrane microvesicles in human abdominal aortic aneurysms
Folkesson M, Li Cj, Frebelius S, Swedenborg J, Wagsater D, Williams Kj, et al
THROMBOSIS AND HAEMOSTASIS 2015;114(6):1165-74

A novel strategy to translate the biomechanical rupture risk of abdominal aortic aneurysms to their equivalent diameter risk: method and retrospective validation
Gasser Tc, Nchimi A, Swedenborg J, Roy J, Sakalihasan N, Böckler D, et al
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2014;47(3):288-95

Early changes of gene expression profiles in the rat model of arterial injury
Fedorov A, Kostareva A, Raud J, Roy J, Hedin U, Razuvaev A
Journal of vascular and interventional radiology : JVIR 2014;25(5):789-796.e7

miR-24 limits aortic vascular inflammation and murine abdominal aneurysm development
Maegdefessel L, Spin Jm, Raaz U, Eken Sm, Toh R, Azuma J, et al
Nature communications 2014;5():5214-

Identification of carotid plaque tissue properties using an experimental-numerical approach
Heiland Vm, Forsell C, Roy J, Hedin U, Gasser Tc
Journal of the mechanical behavior of biomedical materials 2013;27():226-38

Multidimensional growth measurements of abdominal aortic aneurysms
Martufi G, Auer M, Roy J, Swedenborg J, Sakalihasan N, Panuccio G, et al
Journal of vascular surgery 2013;58(3):748-55

NOD2-Mediated Innate Immune Signaling Regulates the Eicosanoids in Atherosclerosis
Liu Hq, Zhang Xy, Edfeldt K, Nijhuis Mo, Idborg H, Back M, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2013;33(9):2193-201

The quasi-static failure properties of the abdominal aortic aneurysm wall estimated by a mixed experimental-numerical approach
Forsell C, Swedenborg J, Roy J, Gasser Tc
Annals of biomedical engineering 2013;41(7):1554-66

Vascular training profiles across Europe
Avgerinos Ed, European Vascular Surgeons In Training (evst) Writing Committee
European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 2013;46(6):719-25

CT angiography of abdominal aortic aneurysms: not everything that is not white is thrombus
Labruto F, Lundberg G, Roy J
Journal of vascular and interventional radiology : JVIR 2012;23(10):1387-8

Spatial orientation of collagen fibers in the abdominal aortic aneurysm's wall and its relation to wall mechanics
Gasser Tc, Gallinetti S, Xing X, Forsell C, Swedenborg J, Roy J
Acta biomaterialia 2012;8(8):3091-103

The expression of IGFs and IGF binding proteins in human carotid atherosclerosis, and the possible role of IGF binding protein-1 in the regulation of smooth muscle cell proliferation
Wang J, Razuvaev A, Folkersen L, Hedin E, Roy J, Brismar K, et al
ATHEROSCLEROSIS 2012;220(1):102-9

Correlations Between Clinical Variables and Gene-expression Profiles in Carotid Plaque Instability
Razuvaev A, Ekstrand J, Folkersen L, Agardh H, Markus D, Swedenborg J, et al
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY 2011;42(6):722-30

Impaired Splicing of Fibronectin Is Associated With Thoracic Aortic Aneurysm Formation in Patients With Bicuspid Aortic Valve
Paloschi V, Kurtovic S, Folkersen L, Gomez D, Wagsater D, Roy J, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2011;31(3):691-7

A Specific Inhibitor of IGF-1 Receptor - Picropodophyllin Can Suppress Atheroma Progression and Has a Stabilizing Effect on Atherosclerotic Lesions in ApoE Deficient Mice
Razuvaev A, Larsson O, Axelson M, Hedin U, Roy J
JOURNAL OF VASCULAR SURGERY 2010;:72S-73S

Biomechanical Rupture Risk Assessment of Abdominal Aortic Aneurysms: Model Complexity versus Predictability of Finite Element Simulations
Gasser Tc, Auer M, Labruto F, Swedenborg J, Roy J
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY 2010;40(2):176-85

Regulation of Endothelin-1 and Endothelin Receptors by Shear Stress in Vascular Smooth Muscle Cells
Ekstrand J, Razuvaev A, Roy J, Hedin U
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2010;30(11):E223-E224

Regulation of Endothelin-1 and Endothelin Receptors by Shear Stress in Vascular Smooth Muscle Cells
Ekstrand J, Razuvaev A, Roy J, Hedin U
JOURNAL OF VASCULAR SURGERY 2010;:80S-80S

Tissue factor pathway inhibitor-2 is induced by fluid shear stress in vascular smooth muscle cells and affects cell proliferation and survival
Ekstrand J, Razuvaev A, Folkersen L, Roy J, Hedin U
JOURNAL OF VASCULAR SURGERY 2010;52(1):167-75

Role of Chymase in the Regulation of the Insulin-like Growth Factor System in Human Carotid Atherosclerosis
Wang J, Brismar K, Roy J, Razuvaev A, Hedin U
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2009;29(7):E43-E43

Use of Gene Expression Profiling to Study the Healing Process in Carotid Plaques
Razuvaev A, Ekstrand J, Agardh H, Paulsson-berne G, Hansson G, Swedenborg J, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2009;29(7):E73-E73

Bleeding into the intraluminal thrombus in abdominal aortic aneurysms is associated with rupture
Roy J, Labruto F, Beckman Mo, Danielson J, Johansson G, Swedenborg J
JOURNAL OF VASCULAR SURGERY 2008;48(5):1108-13

Noninvasive real-time imaging of intima thickness after rat carotid artery balloon injury using ultrasound biomicroscopy
Razuvaev A, Lund K, Roy J, Hedin U, Caidahl K
ATHEROSCLEROSIS 2008;199(2):310-6

Cardioprotective effect of rosuvastatin in vivo is dependent on inhibition of geranylgeranyl pyrophosphate and altered RhoA membrane translocation
Bulhak A, Roy J, Hedin U, Sjoquist Po, Pernow J
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2007;292(6):H3158-63

Reduced perlecan expression and accumulation in human carotid atherosclerotic lesions
Tran Pk, Agardh He, Tran-lundmark K, Ekstrand J, Roy J, Henderson B, et al
ATHEROSCLEROSIS 2007;190(2):264-70

The cyclolignan picropodophyllin attenuates intimal hyperplasia after rat carotid balloon injury by blocking insulin-like growth factor-1 receptor signaling
Razuvaev A, Henderson B, Girnita L, Larsson O, Axelson M, Hedin U, et al
JOURNAL OF VASCULAR SURGERY 2007;46(1):108-15

Ultrasound biomicroscopy of rat carotid intima and wall thicknesses
Razuvaev A, Lund K, Roy J, Hedin U, Caidahl K
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 2007;49(9):406A-406A

Geranylgeranyl pyrophosphate blocks cardioprotective effect of rosuvastatin in vivo
Bulhak A, Roy J, Hedin U, Sjoquist Po, Pernow J
EUROPEAN HEART JOURNAL 2006;:67-67

Difference in matrix-degrading protease expression and activity between thrombus-free and thrombus-covered wall of abdominal aortic aneurysm
Kazi M, Zhu Cy, Roy J, Paulsson-berne G, Hamsten A, Swedenborg J, et al
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2005;25(7):1341-6

Control of smooth muscle cell proliferation in vascular disease
Hedin U, Roy J, Tran Pk
CURRENT OPINION IN LIPIDOLOGY 2004;15(5):559-65

Influence of intraluminal thrombus on cellular and structural features of the aneurysm wall
Kazi M, Thyberg J, Religa P, Roy J, Eriksson R, Ulf H, et al
ATHEROSCLEROSIS SUPPLEMENTS 2003;4(2):254-254

Influence of intraluminal thrombus on structural and cellular composition of abdominal aortic aneurysm wall
Kazi M, Thyberg J, Religa P, Roy J, Eriksson P, Hedin U, et al
JOURNAL OF VASCULAR SURGERY 2003;38(6):1283-92

Small GTP-binding protein Rac is an essential mediator of vascular endothelial growth factor-induced endothelial fenestrations and vascular permeability
Eriksson A, Cao Rh, Roy J, Tritsaris K, Wahlestedt C, Dissing S, et al
CIRCULATION 2003;107(11):1532-8

Fibronectin promotes cell cycle entry in smooth muscle cells in primary culture
Roy J, Tran Pk, Religa P, Kazi M, Henderson B, Lundmark K, et al
EXPERIMENTAL CELL RESEARCH 2002;273(2):169-77

Rho regulates extracellular matrix-mediated activation of arterial smooth muscle cells
Roy J, Henderson B, Thyberg J, Hedin U
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 2002;22(5):A45-A45

Phenotypic modulation of arterial smooth muscle coils is associated with prolonged activation of Erk1/2
Roy J, Kazi M, Hedin U, Thyberg J
DIFFERENTIATION 2001;67(1-2):50-8

Control of smooth muscle cell proliferation--the role of the basement membrane
Hedin U, Roy J, Tran Pk, Lundmark K, Rahman A
Thrombosis and haemostasis 1999;82 Suppl 1():23-6

Expression of caveolae on the surface of rat arterial smooth muscle cells is dependent on the phenotypic state of the cells
Thyberg J, Roy J, Tran Pk, Blomgren K, Dumitrescu A, Hedin U
LABORATORY INVESTIGATION 1997;77(1):93-101

Phenotypic modulation of smooth muscle cells after arterial injury is associated with changes in the distribution of laminin and fibronectin
Thyberg J, Blomgren K, Roy J, Tran Pk, Hedin U
JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY 1997;45(6):837-46

Role of tyrosine kinases in extracellular matrix-mediated modulation of arterial smooth muscle cell phenotype
Hedin U, Thyberg J, Roy J, Dumitrescu A, Tran Pk
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY 1997;17(10):1977-84

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