Jonas Spaak, Assoc Prof (Docent) in Cardiology, Department of Cardiology, Danderyd University Hospital and Department of Clinical Sciences, Danderyd University Hospital, Karolinska Institutet
Cardiovascular disease with concomitant kidney disease and diabetes: from vascular dysfunction to integrated complex chronic disease management
My current research focus on the Cardiorenal Syndrome and I have instigated the Karolinska Cardiorenal Theme Centre (KKT) with its associated biobank Stockholmheartbank. In this area I am main supervisor for 5 PhD students trying to better understand vascular dysfunction and associated disturbances in patients with reduced kidney function.
Second; I am clinically head for a unique multiprofessional integrated clinic for patients with concomitant cardiovascular disease, renal failure and diabetes (HND-centrum). At this clinic I conduct the randomised trial CareHND, which will give new insight into chronic complex disease management from several perspectives.
-Main supervisor for PhD student and Nephrologist Josefin Mörtberg on “Hemostasis, Renal insufficiency and Cardiovascular disease”.
-Main supervisor for PhD student and MD Hermine Rietz on “Cardiovascular effects of obstructive sleep apnea”.
-Main supervisor for PhD student and MD Kristina Lundwall on “Vascular function, vitamin D deficiency and hyperphosphatemia in chronic kidney disease”.
-Main supervisor for PhD student and Cardiologist Christina Ekenbäck on “Sympathetic and vascular regulation in myocardial infarction with angiographically normal coronary arteries”.
-Main supervisor for PhD student and MD Masih Khedri on “Renal dysfunction and long term outcome after myocardial infarction”.
-Co-supervisor for PhD student Liyew Desta, Cardiologist.
-Co-supervisor for PhD student Gudrun Evén, RN.
-Co-supervisor for PhD Student George Keel, MA.
-Co-supervisor for PhD Student Muhammad Rafiq, MA.
-Co-supervisor for PhD Student Helge Brandberg, MD
Academic honors, awards and prizes
- Sir Stanley Davidson Lecturer, Royal College of Physicians of Edinburgh, 2016-04-21. - Chair of Steering-committee of KIRCNET; Karolinska Respiration and Circulation research NETwork (researchnetworks.ki.se/converis/area/201). - Scientific Secretary in Swedish Vascular Medicine Society (www.hypertoni.org/). - Swedish representative in VAS, Vascular Independent Research and Education European Organisation. - Swedish representative in European Union Medical Specialists, div. Angiology and vascular medicine. - Member of the departmental PhD admittance board and Research Board. - Scientific Secretary in Swedish Working Group for Renal Denervation.
Regression of vascular calcification in chronic kidney disease - feasible or fantasy? A review of the clinical evidence
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 2013;76(4):560-72
Integrating virtual patients into courses: follow-up seminars and perceived benefit
MEDICAL EDUCATION 2012;46(4):417-25
Dose-related effects of red wine and alcohol on heart rate variability
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2010;298(6):H2226-31
[Vitamin D deficiency in kidney failure. Risk factor for cardiovascular disease]
Effects of deep and superficial experimentally induced acute pain on skin sympathetic nerve activity in human subjects
EXPERIMENTAL BRAIN RESEARCH 2009;195(2):317-24
Dose-related effects of red wine and alcohol on hemodynamics, sympathetic nerve activity, and arterial diameter
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2008;294(2):H605-12
Comparison of muscle sympathetic activity in ischemic and nonischemic heart failure
JOURNAL OF CARDIAC FAILURE 2007;13(6):470-5
Baroreflex impairment during rapid posture changes at rest and exercise after 120 days of bed rest
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY 2006;96(1):37-45
Inhibition of awake sympathetic nerve activity of heart failure patients with obstructive sleep apnea by nocturnal continuous positive airway pressure
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 2005;45(12):2008-11
Long-term bed rest-induced reductions in stroke volume during rest and exercise: cardiac dysfunction vs. volume depletion
JOURNAL OF APPLIED PHYSIOLOGY 2005;98(2):648-54
Muscle sympathetic nerve activity during wakefulness in heart failure patients with and without sleep apnea
Lung function during and after prolonged head-down bed rest
JOURNAL OF APPLIED PHYSIOLOGY 2002;92(1):75-83
Impaired pressor response after spaceflight and bed rest: evidence for cardiovascular dysfunction
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY 2001;85(1-2):49-55
Cardiovascular responses to upright and supine exercise in humans after 6 weeks of head-down tilt (-6 degrees)
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY 2000;83(4-5):303-9
Haemodynamic and baroreflex responses to whole-body tilting in exercising men before and after 6 weeks of bedrest
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY 2000;82(5-6):397-406
Human carotid baroreflex during isometric lower arm contraction and ischemia
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 1998;275(3):H940-5