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About me

Jonas Spaak, Assoc Prof (Docent) in Cardiology, Department of Cardiology, Danderyd University Hospital and Department of Clinical Sciences, Danderyd University Hospital, Karolinska Institutet

Research description

Cardiovascular disease with concomitant kidney disease and diabetes: from vascular dysfunction to integrated complex chronic disease management

My current research focus on the Cardiorenal Syndrome and I have instigated the Karolinska Cardiorenal Theme Centre (KKT) with its associated biobank Stockholmheartbank. In this area I am main supervisor for 5 PhD students trying to better understand vascular dysfunction and associated disturbances in patients with reduced kidney function.

Second; I am clinically head for a unique multiprofessional integrated clinic for patients with concomitant cardiovascular disease, renal failure and diabetes (HND-centrum). At this clinic I conduct the randomised trial CareHND, which will give new insight into chronic complex disease management from several perspectives.

 

Research group

-Main supervisor for PhD student and Nephrologist Josefin Mörtberg on “Hemostasis, Renal insufficiency and Cardiovascular disease”.

-Main supervisor for PhD student and MD Hermine Rietz on “Cardiovascular effects of obstructive sleep apnea”.

-Main supervisor for PhD student and MD Kristina Lundwall on “Vascular function, vitamin D deficiency and hyperphosphatemia in chronic kidney disease”.

-Main supervisor for PhD student and Cardiologist Christina Ekenbäck on “Sympathetic and vascular regulation in myocardial infarction with angiographically normal coronary arteries”.

-Main supervisor for PhD student and MD Masih Khedri on “Renal dysfunction and long term outcome after myocardial infarction”.

-Co-supervisor for PhD student Liyew Desta, Cardiologist.

-Co-supervisor for PhD student Gudrun Evén, RN.

-Co-supervisor for PhD Student George Keel, MA.

-Co-supervisor for PhD Student Muhammad Rafiq, MA.

-Co-supervisor for PhD Student Helge Brandberg, MD

Academic honors, awards and prizes

- Sir Stanley Davidson Lecturer, Royal College of Physicians of Edinburgh, 2016-04-21. - Chair of Steering-committee of KIRCNET; Karolinska Respiration and Circulation research NETwork (researchnetworks.ki.se/converis/area/201). - Scientific Secretary in Swedish Vascular Medicine Society (www.hypertoni.org/). - Swedish representative in VAS, Vascular Independent Research and Education European Organisation. - Swedish representative in European Union Medical Specialists, div. Angiology and vascular medicine. - Member of the departmental PhD admittance board and Research Board. - Scientific Secretary in Swedish Working Group for Renal Denervation.

Publications

Angiotensin-Converting Enzyme Inhibitors and Angiotensin Receptor Blockers in Myocardial Infarction Patients With Renal Dysfunction
Evans M, Carrero Jj, Szummer K, Åkerblom A, Edfors R, Spaak J, et al
Journal of the American College of Cardiology 2016;67(14):1687-97

Heart failure with normal ejection fraction is uncommon in acute myocardial infarction settings but associated with poor outcomes: a study of 91,360 patients admitted with index myocardial infarction between 1998 and 2010
Desta L, Jernberg T, Spaak J, Hofman-bang C, Persson H
European journal of heart failure 2016;18(1):46-53

Increased fibrin formation and impaired fibrinolytic capacity in severe chronic kidney disease
Mörtberg J, Blombäck M, Wallén Å, He S, Jacobson Sh, Spaak J
Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2016;27(4):401-7

Association between the use of fondaparinux vs low-molecular-weight heparin and clinical outcomes in patients with non-ST-segment elevation myocardial infarction
Szummer K, Oldgren J, Lindhagen L, Carrero Jj, Evans M, Spaak J, et al
JAMA 2015;313(7):707-16

Incidence, temporal trends, and prognostic impact of heart failure complicating acute myocardial infarction. The SWEDEHEART Registry (Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies): a study of 199,851 patients admitted with index acute myocardial infarctions, 1996 to 2008
Desta L, Jernberg T, Löfman I, Hofman-bang C, Hagerman I, Spaak J, et al
JACC. Heart failure 2015;3(3):234-42

Paricalcitol, Microvascular and Endothelial Function in Non-Diabetic Chronic Kidney Disease: A Randomized Trial
Lundwall K, Jörneskog G, Jacobson Sh, Spaak J
American journal of nephrology 2015;42(4):265-73

Renal nerve stimulation to predict responders to renal denervation
Kahan T, Spaak J
Journal of human hypertension 2015;29(5):281-2

Risk Factors and Markers for Acute Myocardial Infarction With Angiographically Normal Coronary Arteries
Daniel M, Ekenbäck C, Agewall S, Brolin Eb, Caidahl K, Cederlund K, et al
The American journal of cardiology 2015;116(6):838-44

Time courses of central hemodynamics during rapid changes in posture
Sundblad P, Spaak J, Kaijser L
Journal of applied physiology (Bethesda, Md. : 1985) 2014;116(9):1182-8

Warfarin, kidney dysfunction, and outcomes following acute myocardial infarction in patients with atrial fibrillation
Carrero Jj, Evans M, Szummer K, Spaak J, Lindhagen L, Edfors R, et al
JAMA 2014;311(9):919-28

Regression of vascular calcification in chronic kidney disease - feasible or fantasy? A review of the clinical evidence
Leonard O, Spaak J, Goldsmith D
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 2013;76(4):560-72

Integrating virtual patients into courses: follow-up seminars and perceived benefit
Edelbring S, Brostrom O, Henriksson P, Vassiliou D, Spaak J, Dahlgren Lo, et al
MEDICAL EDUCATION 2012;46(4):417-25

Inverse Relationship of Subjective Daytime Sleepiness to Sympathetic Activity in Patients With Heart Failure and Obstructive Sleep Apnea
Montemurro Lt, Floras Js, Millar Pj, Kasai T, Gabriel Jm, Spaak J, et al
CHEST 2012;142(5):1222-8

Dose-related effects of red wine and alcohol on heart rate variability
Spaak J, Tomlinson G, Mcgowan Cl, Soleas Gj, Morris Bl, Picton P, et al
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2010;298(6):H2226-31

[Vitamin D deficiency in kidney failure. Risk factor for cardiovascular disease]
Ohman K, Larsson T, Spaak J
Lakartidningen 2010;107(46):2884-7

Effects of deep and superficial experimentally induced acute pain on skin sympathetic nerve activity in human subjects
Burton A, Birznieks I, Spaak J, Henderson L, Macefield V
EXPERIMENTAL BRAIN RESEARCH 2009;195(2):317-24

Dose-related effects of red wine and alcohol on hemodynamics, sympathetic nerve activity, and arterial diameter
Spaak J, Merlocco Ac, Soleas Gj, Tomlinson G, Morris Bl, Picton P, et al
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 2008;294(2):H605-12

Comparison of muscle sympathetic activity in ischemic and nonischemic heart failure
Notarius Cf, Spaak J, Morris Bl, Floras Js
JOURNAL OF CARDIAC FAILURE 2007;13(6):470-5

Baroreflex impairment during rapid posture changes at rest and exercise after 120 days of bed rest
Linnarsson D, Spaak J, Sundblad P
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY 2006;96(1):37-45

Inhibition of awake sympathetic nerve activity of heart failure patients with obstructive sleep apnea by nocturnal continuous positive airway pressure
Usui K, Bradley Td, Spaak J, Ryan Cm, Kubo T, Kaneko Y, et al
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 2005;45(12):2008-11

Long-term bed rest-induced reductions in stroke volume during rest and exercise: cardiac dysfunction vs. volume depletion
Spaak J, Montmerle S, Sundblad P, Linnarsson D
JOURNAL OF APPLIED PHYSIOLOGY 2005;98(2):648-54

Muscle sympathetic nerve activity during wakefulness in heart failure patients with and without sleep apnea
Spaak J, Egri Zj, Kubo T, Yu E, Ando S, Kaneko Y, et al
HYPERTENSION 2005;46(6):1327-32

Lung function during and after prolonged head-down bed rest
Montmerle S, Spaak J, Linnarsson D
JOURNAL OF APPLIED PHYSIOLOGY 2002;92(1):75-83

Impaired pressor response after spaceflight and bed rest: evidence for cardiovascular dysfunction
Spaak J, Sundblad P, Linnarsson D
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY 2001;85(1-2):49-55

Cardiovascular responses to upright and supine exercise in humans after 6 weeks of head-down tilt (-6 degrees)
Sundblad P, Spaak J, Linnarsson D
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY 2000;83(4-5):303-9

Haemodynamic and baroreflex responses to whole-body tilting in exercising men before and after 6 weeks of bedrest
Sundblad P, Spaak J, Linnarsson D
EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY 2000;82(5-6):397-406

Human carotid baroreflex during isometric lower arm contraction and ischemia
Spaak J, Sundblad P, Linnarsson D
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 1998;275(3):H940-5

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