Henrik Biverstål

Publications
Grants
CV
Public outreach and news

Articles

Article: NATURE COMMUNICATIONS. 2024;15(1):965

Identification of potential aggregation hotspots on Aβ42 fibrils blocked by the anti-amyloid chaperone-like BRICHOS domain

Kumar R; Le Marchand T; Adam L; Bobrovs R; Chen G; Fridmanis J; Kronqvist N; Biverstal H; Jaudzems K; Johansson J; Pintacuda G; Abelein A
Article: NATURE COMMUNICATIONS. 2023;14(1):5804

Prosaposin maintains lipid homeostasis in dopamine neurons and counteracts experimental parkinsonism in rodents.

He Y; Kaya I; Shariatgorji R; Lundkvist J; Wahlberg LU; Nilsson A; Mamula D; Kehr J; Zareba-Paslawska J; Biverstål H; Chergui K; Zhang X; Andren PE; Svenningsson P
Article: MOLECULAR AND CELLULAR NEUROSCIENCE. 2023;125:103843

Identification of cytoskeletal proteins as binding partners of Bri2 BRICHOS domain.

Shimozawa M; Tigro H; Biverstål H; Shevchenko G; Bergquist J; Moaddel R; Johansson J; Nilsson P
Article: ACS CHEMICAL NEUROSCIENCE. 2023;14(8):1503-1511

Molecular Mechanisms of Amyloid-β Self-Assembly Seeded by In Vivo-Derived Fibrils and Inhibitory Effects of the BRICHOS Chaperone.

Kumar R; Arroyo-García LE; Manchanda S; Adam L; Pizzirusso G; Biverstål H; Nilsson P; Fisahn A; Johansson J; Abelein A
Article: SCIENTIFIC REPORTS. 2023;13(1):985

Food protein-derived amyloids do not accelerate amyloid β aggregation.

Rahman MM; Pires RS; Herneke A; Gowda V; Langton M; Biverstål H; Lendel C
Article: JACS AU. 2022;2(11):2571-2584

Molecular Structure of Cu(II)-Bound Amyloid-β Monomer Implicated in Inhibition of Peptide Self-Assembly in Alzheimer's Disease.

Abelein A; Ciofi-Baffoni S; Mörman C; Kumar R; Giachetti A; Piccioli M; Biverstål H
Article: RSC CHEMICAL BIOLOGY. 2022;3(11):1342-1358

Abilities of the BRICHOS domain to prevent neurotoxicity and fibril formation are dependent on a highly conserved Asp residue.

Chen G; Andrade-Talavera Y; Zhong X; Hassan S; Biverstål H; Poska H; Abelein A; Leppert A; Kronqvist N; Rising A; Hebert H; Koeck PJB; Fisahn A; Johansson J
Article: ACS CHEMICAL BIOLOGY. 2022;17(8):2201-2211

Amyloid Fibril Formation of Arctic Amyloid-β 1-42 Peptide is Efficiently Inhibited by the BRICHOS Domain.

Zhong X; Kumar R; Wang Y; Biverstål H; Ingeborg Jegerschöld C; J B Koeck P; Johansson J; Abelein A; Chen G
Article: CHEMICAL SCIENCE. 2022;13(2):536-553

Chaperones mainly suppress primary nucleation during formation of functional amyloid required for bacterial biofilm formation.

Nagaraj M; Najarzadeh Z; Pansieri J; Biverstål H; Musteikyte G; Smirnovas V; Matthews S; Emanuelsson C; Johansson J; Buxbaum JN; Morozova-Roche L; Otzen DE
Article: FRONTIERS IN MOLECULAR BIOSCIENCES. 2022;9:812808

Molecular Chaperone BRICHOS Inhibits CADASIL-Mutated NOTCH3 Aggregation In Vitro.

Oliveira DV; Svensson J; Zhong X; Biverstål H; Chen G; Karlström H
Article: SCIENTIFIC REPORTS. 2020;10(1):21765

Functionalization of amyloid fibrils via the Bri2 BRICHOS domain.

Biverstål H; Kumar R; Schellhaus AK; Sarr M; Dantuma NP; Abelein A; Johansson J
Article: FEBS JOURNAL. 2020;287(13):2823-2833

High intracellular stability of the spidroin N-terminal domain in spite of abundant amyloidogenic segments revealed by in-cell hydrogen/deuterium exchange mass spectrometry.

Kaldmäe M; Leppert A; Chen G; Sarr M; Sahin C; Nordling K; Kronqvist N; Gonzalvo-Ulla M; Fritz N; Abelein A; Laίn S; Biverstål H; Jörnvall H; Lane DP; Rising A; Johansson J; Landreh M
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2020;295(21):7224-7234

Metal ion coordination delays amyloid-β peptide self-assembly by forming an aggregation-inert complex.

Wallin C; Jarvet J; Biverstål H; Wärmländer S; Danielsson J; Gräslund A; Abelein A
Article: COMMUNICATIONS BIOLOGY. 2020;3(1):32

Augmentation of Bri2 molecular chaperone activity against amyloid-β reduces neurotoxicity in mouse hippocampus in vitro.

Chen G; Andrade-Talavera Y; Tambaro S; Leppert A; Nilsson HE; Zhong X; Landreh M; Nilsson P; Hebert H; Biverstål H; Fisahn A; Abelein A; Johansson J
Article: SCIENTIFIC REPORTS. 2020;10(1):235

High-yield Production of Amyloid-β Peptide Enabled by a Customized Spider Silk Domain.

Abelein A; Chen G; Kitoka K; Aleksis R; Oleskovs F; Sarr M; Landreh M; Pahnke J; Nordling K; Kronqvist N; Jaudzems K; Rising A; Johansson J; Biverstål H
Article: ACS CHEMICAL NEUROSCIENCE. 2019;10(3):1462-1477

Amyloid-β Peptide Targeting Peptidomimetics for Prevention of Neurotoxicity.

Honcharenko D; Juneja A; Roshan F; Maity J; Galán-Acosta L; Biverstål H; Hjorth E; Johansson J; Fisahn A; Nilsson L; Strömberg R
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2019;294(8):2606-2615

Blood-brain and blood-cerebrospinal fluid passage of BRICHOS domains from two molecular chaperones in mice.

Tambaro S; Galan-Acosta L; Leppert A; Chen G; Biverstål H; Presto J; Nilsson P; Johansson J
Article: NATURE COMMUNICATIONS. 2017;8(1):2081

Bri2 BRICHOS client specificity and chaperone activity are governed by assembly state.

Chen G; Abelein A; Nilsson HE; Leppert A; Andrade-Talavera Y; Tambaro S; Hemmingsson L; Roshan F; Landreh M; Biverstål H; Koeck PJB; Presto J; Hebert H; Fisahn A; Johansson J
Article: JOURNAL OF NEUROSCIENCE METHODS. 2017;290:145-150

Improved method for cannula fixation for long-term intracerebral brain infusion.

Sike Á; Wengenroth J; Upīte J; Brüning T; Eiriz I; Sántha P; Biverstål H; Jansone B; Haugen HJ; Krohn M; Pahnke J
Article: ACTA NEUROPATHOLOGICA COMMUNICATIONS. 2017;5(1):49

Expression of endogenous mouse APP modulates β-amyloid deposition in hAPP-transgenic mice.

Steffen J; Krohn M; Schwitlick C; Brüning T; Paarmann K; Pietrzik CU; Biverstål H; Jansone B; Langer O; Pahnke J
Article: NATURE COMMUNICATIONS. 2017;8:15504

Efficient protein production inspired by how spiders make silk.

Kronqvist N; Sarr M; Lindqvist A; Nordling K; Otikovs M; Venturi L; Pioselli B; Purhonen P; Landreh M; Biverstål H; Toleikis Z; Sjöberg L; Robinson CV; Pelizzi N; Jörnvall H; Hebert H; Jaudzems K; Curstedt T; Rising A; Johansson J
Article: BIOCHEMICAL JOURNAL. 2016;473(20):3683-3704

Dementia-related Bri2 BRICHOS is a versatile molecular chaperone that efficiently inhibits Aβ42 toxicity in Drosophila.

Poska H; Haslbeck M; Kurudenkandy FR; Hermansson E; Chen G; Kostallas G; Abelein A; Biverstål H; Crux S; Fisahn A; Presto J; Johansson J
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2015;1854(8):835-843

Dissociation of a BRICHOS trimer into monomers leads to increased inhibitory effect on Aβ42 fibril formation.

Biverstål H; Dolfe L; Hermansson E; Leppert A; Reifenrath M; Winblad B; Presto J; Johansson J
Article: CELLULAR AND MOLECULAR LIFE SCIENCES. 2015;72(8):1599-1611

BRI2 ectodomain affects Aβ42 fibrillation and tau truncation in human neuroblastoma cells.

Del Campo M; Oliveira CR; Scheper W; Zwart R; Korth C; Müller-Schiffmann A; Kostallas G; Biverstal H; Presto J; Johansson J; Hoozemans JJ; Pereira CF; Teunissen CE
Article: NATURE STRUCTURAL & MOLECULAR BIOLOGY. 2015;22(3):207-213

A molecular chaperone breaks the catalytic cycle that generates toxic Aβ oligomers.

Cohen SIA; Arosio P; Presto J; Kurudenkandy FR; Biverstal H; Dolfe L; Dunning C; Yang X; Frohm B; Vendruscolo M; Johansson J; Dobson CM; Fisahn A; Knowles TPJ; Linse S
Article: ORGANIC & BIOMOLECULAR CHEMISTRY. 2014;12(34):6684-6693

Synthesis and evaluation of antineurotoxicity properties of an amyloid-β peptide targeting ligand containing a triamino acid.

Honcharenko D; Bose PP; Maity J; Kurudenkandy FR; Juneja A; Flöistrup E; Biverstål H; Johansson J; Nilsson L; Fisahn A; Strömberg R
Article: JOURNAL OF NEUROSCIENCE. 2014;34(34):11416-11425

Amyloid-β-induced action potential desynchronization and degradation of hippocampal gamma oscillations is prevented by interference with peptide conformation change and aggregation.

Kurudenkandy FR; Zilberter M; Biverstål H; Presto J; Honcharenko D; Strömberg R; Johansson J; Winblad B; Fisahn A
Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2012;287(37):31608-31617

BRICHOS domains efficiently delay fibrillation of amyloid β-peptide.

Willander H; Presto J; Askarieh G; Biverstål H; Frohm B; Knight SD; Johansson J; Linse S
Journal article: ALZHEIMERS & DEMENTIA. 2011;7(4S_Part_24):e21-e22

P4‐316: Stabilization of neurotoxic Alzheimer amyloid‐beta oligomers by protein engineering

Dubnovitsky A; Sandberg A; Luheshi L; Söllvander S; de Barros TP; Macao B; Knowles T; Biverstål H; Lendel C; Ekholm‐Petterson F; Lannfelt L; Dobson C; Härd T
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2011;1808(1):298-306

Laurdan and di-4-ANEPPDHQ do not respond to membrane-inserted peptides and are good probes for lipid packing.

Dinic J; Biverståhl H; Mäler L; Parmryd I
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2010;107(35):15595-15600

Stabilization of neurotoxic Alzheimer amyloid-beta oligomers by protein engineering.

Sandberg A; Luheshi LM; Söllvander S; Pereira de Barros T; Macao B; Knowles TPJ; Biverstål H; Lendel C; Ekholm-Petterson F; Dubnovitsky A; Lannfelt L; Dobson CM; Härd T
Article: MOLECULAR PLANT. 2009;2(6):1298-1309

Dual targeting to mitochondria and chloroplasts: characterization of Thr-tRNA synthetase targeting peptide.

Berglund A-K; Spånning E; Biverståhl H; Maddalo G; Tellgren-Roth C; Mäler L; Glaser E
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2009;1788(9):1976-1986

Biophysical studies of the membrane location of the voltage-gated sensors in the HsapBK and KvAP K(+) channels.

Biverståhl H; Lind J; Bodor A; Mäler L
Article: BIOCHIMICA ET BIOPHYSICA ACTA: INTERNATIONAL JOURNAL OF BIOCHEMISTRY AND BIOPHYSICS. 2007;1768(1):115-121

The membrane-induced structure of melittin is correlated with the fluidity of the lipids.

Andersson A; Biverståhl H; Nordin J; Danielsson J; Lindahl E; Mäler L
Article: BIOPHYSICAL JOURNAL. 2006;91(4):L29-L31

Real-time transmembrane translocation of penetratin driven by light-generated proton pumping.

Björklund J; Biverståhl H; Gräslund A; Mäler L; Brzezinski P
Article: JOURNAL OF MOLECULAR BIOLOGY. 2005;349(4):847-860

Two novel targeting peptide degrading proteases, PrePs, in mitochondria and chloroplasts, so similar and still different.

Ståhl A; Nilsson S; Lundberg P; Bhushan S; Biverståhl H; Moberg P; Morisset M; Vener A; Mäler L; Langel U; Glaser E
Article: BIOCHEMISTRY. 2004;43(47):14940-14947

NMR solution structure and membrane interaction of the N-terminal sequence (1-30) of the bovine prion protein.

Biverståhl H; Andersson A; Gräslund A; Mäler L
Article: FEBS JOURNAL. 2003;270(14):3055-3063

Structure and positioning comparison of two variants of penetratin in two different membrane mimicking systems by NMR.

Lindberg M; Biverståhl H; Gräslund A; Mäler L
Show more

All other publications

Preprint: 2023;bioRxiv

Specific inhibition of α-synuclein oligomer generation and toxicity by the chaperone domain Bri2 BRICHOS

Adam L; Kumar R; Arroyo-Garcia LE; Molenkamp WH; Nowak JS; Klute H; Farzadfard A; Alkenayeh R; Nielsen J; Biverstål H; Otzen DE; Johansson J; Abelein A
Conference publication: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2023;52(SUPPL 1):S54

Structural insights into aggregation hotspots on Alzheimer's associated amyloid-β fibrils blocked by the BRICHOS chaperone

Abelein A; Kumar R; Le Marchand T; Adam L; Chen G; Fridmanis J; Kronqvist N; Biverstal H; Jaudzems K; Johansson J; Pintacuda G
Conference publication: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2023;52(SUPPL 1):S89

Molecular mechanisms of amyloid-β self-assembly and chaperone-mediated inhibition can be translated to in vivo-derived fibril seeds

Kumar R; Garcia LEA; Manchanda S; Adam L; Pizzirusso G; Biverstal H; Nilsson P; Fisahn A; Johansson J; Abelein A
Conference publication: EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS. 2023;52(SUPPL 1):S168

Targeting a-synuclein amyloid aggregates with the BRICHOS domain - basis for treatment of Parkinson's disease

Adam L; Kumar R; Molenkamp W; Alkenayeh R; Biverstal H; Johansson J; Abelein A
Preprint: 2021;bioRxiv

Molecular chaperone ability to inhibit amyloid-derived neurotoxicity, but not amorphous protein aggregation, depends on a conserved pH-sensitive Asp residue

Chen G; Andrade-Talavera Y; Zhong X; Hassan S; Biverstal H; Poska H; Abelein A; Leppert A; Kronqvist N; Rising A; Hebert H; Koeck PJB; Fisahn A; Johansson J
Review: BIOCHIMIE. 2017;140:176-192

Structural studies of amyloid-β peptides: Unlocking the mechanism of aggregation and the associated toxicity.

Aleksis R; Oleskovs F; Jaudzems K; Pahnke J; Biverstål H
Conference publication: PROTEIN SCIENCE. 2017;26:31-32

Bri2 BRICHOS molecular chaperone activity is decoupled from its ability to inhibit amyloid fibril formation

Chen G; Abelein A; Leppert A; Tambaro S; Biverstal H; Presto J; Johansson J
Conference publication: PROTEIN SCIENCE. 2014;23:90

Limited Proteolysis And Dissociation Of Trimeric State Of The BRICHOS Domain Increase Its Anti-Amyloid Activity

Biverstal H; Dolfe L; Hermansson E; Presto J; Johansson J
Conference publication: NEONATOLOGY. 2014;105(4):359

The BRICHOS Domain: Structure, Function and Involvement in Interstitial Lung Disease

Johansson J; Presto J; Biverstal H; Dolfe L

Grants

PET analyses of ABC transporter function for diagnostics and stratification of dementia patients

Swedish Research Council

1 January 2021 - 31 December 2023
Propagation behavior of peripheral amyloid-β towards brain structures: effects of the blood-brain barrier

Swedish Research Council

1 December 2015 - 30 November 2018

Employments

Research Specialist, Department of Medicine, Huddinge, Karolinska Institutet, 2024-
Research Specialist, Department of Biosciences and Nutrition, Karolinska Institutet, 2021-2024

Articles

All other publications

Grants

Employments

News from KI

Events from KI