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About me

In 2000, I received my Pharm.D. degree from the University of Lisbon, Portugal. During the same year, I enrolled in a doctoral program at the Karolinska Institute. My masters and doctoral studies focused on how oxygen levels mediate protein degradation of the hypoxia-inducible factors. These studies culminated in a Licentiate in 2005, and subsequently a Ph.D. in 2009, both in Cell and Molecular Biology.

 

Following my Ph.D., I continued at the Karolinska Institute as a postdoctoral fellow at the department of Clinical Neurosciences. During my postdoc, I investigated the cellular and molecular mechanisms involved in neovascular age-related macular degeneration, a particularly incident sight-threatening disease. My research elucidated a central role for hypoxia-inducible factor-1alpha in this disease.

Research description

Since 2012, I have been assigned as Head of Molecular and Cellular Research at St Erik Eye Hospital, affiliated to the Karolinska Institute. My present research is centered on cell-based and gene therapy strategies to target the hypoxia-inducible factors as potential therapeutic agents in ocular vascular diseases.

Publications

A novel in vivo model of puncture-induced iris neovascularization
Beaujean O, Locri F, Aronsson M, Kvanta A, André H
PloS one 2017;12(6):e0180235-

Efficacy of a Fatty Acids Dietary Supplement in a Polyethylene Glycol-Induced Mouse Model of Retinal Degeneration
Cammalleri M, Dal Monte M, Locri F, Lardner E, Kvanta A, Rusciano D, et al
Nutrients 2017;9(10):-

Gene Transfer of Prolyl Hydroxylase Domain 2 Inhibits Hypoxia-inducible Angiogenesis in a Model of Choroidal Neovascularization
Takei A, Ekström M, Mammadzada P, Aronsson M, Yu M, Kvanta A, et al
Scientific reports 2017;7():42546-

Integration of Subretinal Suspension Transplants of Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells in a Large-Eyed Model of Geographic Atrophy
Petrus-reurer S, Bartuma H, Aronsson M, Westman S, Lanner F, André H, et al
Investigative ophthalmology & visual science 2017;58(2):1314-1322

Differential hypoxic response of human choroidal and retinal endothelial cells proposes tissue heterogeneity of ocular angiogenesis
Mammadzada P, Gudmundsson J, Kvanta A, André H
Acta ophthalmologica 2016;94(8):805-814

The Urokinase Receptor-Derived Peptide UPARANT Mitigates Angiogenesis in a Mouse Model of Laser-Induced Choroidal Neovascularization
Cammalleri M, Dal Monte M, Locri F, Lista L, Aronsson M, Kvanta A, et al
Investigative ophthalmology & visual science 2016;57(6):2600–2611-

Xeno-Free and Defined Human Embryonic Stem Cell-Derived Retinal Pigment Epithelial Cells Functionally Integrate in a Large-Eyed Preclinical Model
Plaza Reyes A, Petrus-reurer S, Antonsson L, Stenfelt S, Bartuma H, Panula S, et al
Stem cell reports 2016;6(1):9-17

Hypoxia-Inducible Factor-1α Is Associated With Sprouting Angiogenesis in the Murine Laser-Induced Choroidal Neovascularization Model
André H, Tunik S, Aronsson M, Kvanta A
Investigative ophthalmology & visual science 2015;56(11):6591-604

In Vivo Imaging of Subretinal Bleb-Induced Outer Retinal Degeneration in the Rabbit
Bartuma H, Petrus-reurer S, Aronsson M, Westman S, Andre H, Kvanta A
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE 2015;56(4):2423-30

HIF-1 alpha and HIF-2 alpha induce angiogenesis and improve muscle energy recovery
Niemi H, Honkonen K, Korpisalo P, Huusko J, Kansanen E, Merentie M, et al
EUROPEAN JOURNAL OF CLINICAL INVESTIGATION 2014;44(10):989-99

Identification of an Alternative Mechanism of Degradation of the Hypoxia-inducible Factor-1 alpha
Andre H, Pereira Ts
JOURNAL OF BIOLOGICAL CHEMISTRY 2008;283(43):29375-84

Stabilized HIF-1 alpha is superior to VEGF for angiogenesis in skeletal muscle via adeno-associated virus gene transfer
Pajusola K, Kunnapuu J, Vuorikoski S, Soronen J, Andre H, Pereira T, et al
FASEB JOURNAL 2005;19(8):1365-7

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