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Hans-Gustaf Ljunggren

Visiting address : C2:94, Karolinska Universitetssjukhuset Huddinge 141 86 Stockholm, Sweden
Delivery address : C2:94, Karolinska Universitetssjukhuset Huddinge 141 86 Stockholm, Sweden

About me

MD and PhD Karolinska Institutet (KI), 1982-1992. Post doc M.I.T., Boston, USA, 1992-1994. Group leader, Dept of Microbiology Tumor and Cell Biology (MTC), KI, 1994-2000. Professor at the Department of Medicine (H7), KI, 2001-. 

Commission of trust

Chairman Medical Student Association, KI, 1985. Scientific Secretary, Swedish Cancer Society, 1998-2002. Member Board of Research, KI, 2005-2011, and KI University Board, KI, 2011-2013. Vice department head, Department of Medicine (H7), 2008-2013. Member of the Nobel Assembly at KI, 2008-. Dean of Research, KI, 2013-2016. 

Research description

Our group has a long-term interest in exploring the function of human natural killer (NK) cells in health and in different disease settings including viral infections and cancer.

NK cells are innate immune cells. Studies in our group involve phenotypic and functional characterization of NK cells in healthy humans as well as in humans with primarily virus infections and cancer. A particular interest is focused towards the NK cell response to severe viral infections including flavivirus infections, such as infections by Denguevirus, tick born encephalitis virus and hepatitis C virus. A focus is also directed towards Bunyavirus infections causing severe hemorrhagic fevers including hantaviruses. In the case of human cancer, we are interested in using NK cells in therapeutic settings, in particular in the context of treating hematological malignancies such as myeloma, myelodysplastic syndromes and acute myeloid leukemia.

Keywords: NK cells, innate immunity, virus, cancer, hematology, immunotherapy

Publications

Composition and functionality of the intrahepatic innate lymphoid cell-compartment in human nonfibrotic and fibrotic livers
Forkel M, Berglin L, Kekäläinen E, Carlsson A, Svedin E, Michaëlsson J, et al
European journal of immunology 2017;47(8):1280-1294

Contribution of inhibitory receptor TIGIT to NK cell education
He Y, Peng H, Sun R, Wei H, Ljunggren Hg, Yokoyama Wm, et al
Journal of autoimmunity 2017;81():1-12

Cytomegalovirus-Driven Adaptive-Like Natural Killer Cell Expansions Are Unaffected by Concurrent Chronic Hepatitis Virus Infections
Malone Dfg, Lunemann S, Hengst J, Ljunggren Hg, Manns Mp, Sandberg Jk, et al
Frontiers in immunology 2017;8():525-

Differences in Granule Morphology yet Equally Impaired Exocytosis among Cytotoxic T Cells and NK Cells from Chediak-Higashi Syndrome Patients
Chiang Scc, Wood Sm, Tesi B, Akar Hh, Al-herz W, Ammann S, et al
Frontiers in immunology 2017;8():426-

Human hantavirus infection elicits pronounced redistribution of mononuclear phagocytes in peripheral blood and airways
Scholz S, Baharom F, Rankin G, Maleki Kt, Gupta S, Vangeti S, et al
PLoS pathogens 2017;13(6):e1006462-

Human lung natural killer cells are predominantly comprised of highly differentiated hypofunctional CD69CD56 cells
Marquardt N, Kekäläinen E, Chen P, Kvedaraite E, Wilson Jn, Ivarsson Ma, et al
The Journal of allergy and clinical immunology 2017;139(4):1321-1330.e4

Immune selection during tumor checkpoint inhibition therapy paves way for NK-cell "missing self" recognition
Malmberg Kj, Sohlberg E, Goodridge Jp, Ljunggren Hg
Immunogenetics 2017;69(8-9):547-556

Natural killer cell-mediated immunosurveillance of human cancer
Malmberg Kj, Carlsten M, Björklund A, Sohlberg E, Bryceson Yt, Ljunggren Hg
Seminars in immunology 2017;31():20-29

Perturbed CD8 T cell TIGIT/CD226/PVR axis despite early initiation of antiretroviral treatment in HIV infected individuals
Tauriainen J, Scharf L, Frederiksen J, Naji A, Ljunggren Hg, Sönnerborg A, et al
Scientific reports 2017;7():40354-

Prospects for induction of CD8 T cell-mediated immunity to Zika virus infection by yellow fever virus vaccination
Blom K, Sandberg Jt, Loré K, Ljunggren Hg
Journal of internal medicine 2017;282(3):206-208

Reply
Marquardt N, Ljunggren Hg, Michaëlsson J
The Journal of allergy and clinical immunology 2017;140(1):318-

Critical Role of CD2 Co-stimulation in Adaptive Natural Killer Cell Responses Revealed in NKG2C-Deficient Humans
Liu Ll, Landskron J, Ask Eh, Enqvist M, Sohlberg E, Traherne Ja, et al
Cell reports 2016;15(5):1088-1099

Diversification and Functional Specialization of Human NK Cell Subsets
Cichocki F, Schlums H, Theorell J, Tesi B, Miller Js, Ljunggren Hg, et al
NATURAL KILLER CELLS 2016;:63-94

Emerging insights into natural killer cells in human peripheral tissues
Björkström Nk, Ljunggren Hg, Michaëlsson J
Nature reviews. Immunology 2016;16(5):310-20

In vivo engineering of mobilized stem cell grafts with the immunomodulatory drug FTY720 for allogeneic transplantation
Lakshmikanth T, Heuts F, Muvva Ss, Wallin Rp, Persson Ak, Fauriat C, et al
European journal of immunology 2016;46(7):1758-69

Naive Donor NK Cell Repertoires Associated with Less Leukemia Relapse after Allogeneic Hematopoietic Stem Cell Transplantation
Björklund At, Clancy T, Goodridge Jp, Béziat V, Schaffer M, Hovig E, et al
Journal of immunology (Baltimore, Md. : 1950) 2016;196(3):1400-11

NK Cell Responses to Human Tick-Borne Encephalitis Virus Infection
Blom K, Braun M, Pakalniene J, Lunemann S, Enqvist M, Dailidyte L, et al
Journal of immunology (Baltimore, Md. : 1950) 2016;197(7):2762-71

Nonreversible MAIT cell-dysfunction in chronic hepatitis C virus infection despite successful interferon-free therapy
Hengst J, Strunz B, Deterding K, Ljunggren Hg, Leeansyah E, Manns Mp, et al
European journal of immunology 2016;46(9):2204-10

Cutting edge: identification and characterization of human intrahepatic CD49a+ NK cells
Marquardt N, Béziat V, Nyström S, Hengst J, Ivarsson Ma, Kekäläinen E, et al
Journal of immunology (Baltimore, Md. : 1950) 2015;194(6):2467-71

Cytomegalovirus infection drives adaptive epigenetic diversification of NK cells with altered signaling and effector function
Schlums H, Cichocki F, Tesi B, Theorell J, Beziat V, Holmes Td, et al
Immunity 2015;42(3):443-56

Dear Readers of Scandinavian Journal of Immunology and ECI2015 Attendees
Jonsson R, Ljunggren Hg
Scandinavian journal of immunology 2015;82(3):161-2

Effects of HDV infection and pegylated interferon α treatment on the natural killer cell compartment in chronically infected individuals
Lunemann S, Malone Df, Grabowski J, Port K, Béziat V, Bremer B, et al
Gut 2015;64(3):469-82

High-resolution determination of human immune cell signatures from fine-needle liver aspirates
Hengst J, Theorell J, Deterding K, Potthoff A, Dettmer A, Ljunggren Hg, et al
European journal of immunology 2015;45(7):2154-7

Next generation partnerships in translational science and medicine: Partnerships between academics, big pharma, biotech firms, philanthropists and patients look set to change the way science advances
Ljunggren Hg, Chien Kr
EMBO reports 2015;16(10):1246-9

Polyclonal Expansion of NKG2C(+) NK Cells in TAP-Deficient Patients
Béziat V, Sleiman M, Goodridge Jp, Kaarbø M, Liu Ll, Rollag H, et al
Frontiers in immunology 2015;6():507-

Scandinavian Journal of Immunology embraces 21st century publishing: moving to online-only publication
Jonsson R, Ljunggren Hg
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2015;81(1):1-1

Specificity and dynamics of effector and memory CD8 T cell responses in human tick-borne encephalitis virus infection
Blom K, Braun M, Pakalniene J, Dailidyte L, Béziat V, Lampen Mh, et al
PLoS pathogens 2015;11(1):e1004622-

Academia and big pharma United
Ljunggren Hg
Science translational medicine 2014;6(217):217ed1-

Angiostatic effects of NK cell-derived IFN-γ counteracted by tumour cell Bcl-xL expression
Wallin Rp, Sundquist Vs, Bråkenhielm E, Cao Y, Ljunggren Hg, Grandien A
Scandinavian journal of immunology 2014;79(2):90-7

Compromised Function of Natural Killer Cells in Acute and Chronic Viral Hepatitis
Lunemann S, Malone Dfg, Hengst J, Port K, Grabowski J, Deterding K, et al
JOURNAL OF INFECTIOUS DISEASES 2014;209(9):1362-73

Immunomodulatory activity of commonly used drugs on Fc-receptor-mediated human natural killer cell activation
Theorell J, Gustavsson Al, Tesi B, Sigmundsson K, Ljunggren Hg, Lundbäck T, et al
Cancer immunology, immunotherapy : CII 2014;63(6):627-41

Increased risk for lymphoma following hemorrhagic fever with renal syndrome
Klingström J, Granath F, Ekbom A, Björkström Nk, Ljunggren Hg
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2014;59(8):1130-2

NK cell activation in human hantavirus infection explained by virus-induced IL-15/IL15Rα expression
Braun M, Björkström Nk, Gupta S, Sundström K, Ahlm C, Klingström J, et al
PLoS pathogens 2014;10(11):e1004521-

Tracing dynamic expansion of human NK-cell subsets by high-resolution analysis of KIR repertoires and cellular differentiation
Béziat V, Traherne J, Malmberg Ja, Ivarsson Ma, Björkström Nk, Retière C, et al
European journal of immunology 2014;44(7):2192-6

Comparison of primary human cytotoxic T-cell and natural killer cell responses reveal similar molecular requirements for lytic granule exocytosis but differences in cytokine production
Chiang Sc, Theorell J, Entesarian M, Meeths M, Mastafa M, Al-herz W, et al
Blood 2013;121(8):1345-56

Hantavirus-infection confers resistance to cytotoxic lymphocyte-mediated apoptosis
Gupta S, Braun M, Tischler Nd, Stoltz M, Sundström Kb, Björkström Nk, et al
PLoS pathogens 2013;9(3):e1003272-

NK cell responses to cytomegalovirus infection lead to stable imprints in the human KIR repertoire and involve activating KIRs
Béziat V, Liu Ll, Malmberg Ja, Ivarsson Ma, Sohlberg E, Björklund At, et al
Blood 2013;121(14):2678-88

Temporal dynamics of the primary human T cell response to yellow fever virus 17D as it matures from an effector- to a memory-type response
Blom K, Braun M, Ivarsson Ma, Gonzalez Vd, Falconer K, Moll M, et al
Journal of immunology (Baltimore, Md. : 1950) 2013;190(5):2150-8

The ICI2013 Scandinavian Journal of Immunology issue
Jonsson R, Ljunggren Hg
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2013;78(2):111-111

CD8 T cells express randomly selected KIRs with distinct specificities compared with NK cells
Björkström Nk, Béziat V, Cichocki F, Liu Ll, Levine J, Larsson S, et al
Blood 2012;120(17):3455-65

Dear readers of Scandinavian Journal of Immunology and ECI2012 attendees
Jonsson R, Ljunggren Hg
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2012;76(3):211-212

Dendritic cells, dendritic cell-based vaccines and Ralph Steinman
Ljunggren Hg
JOURNAL OF INTERNAL MEDICINE 2012;271(2):174-6

Interferon alpha-Stimulated Natural Killer Cells From Patients With Acute Hepatitis C Virus (HCV) Infection Recognize HCV-Infected and Uninfected Hepatoma Cells via DNAX accessory molecule-1
Stegmann Ka, Bjorkstrom Nk, Ciesek S, Lunemann S, Jaroszewicz J, Wiegand J, et al
JOURNAL OF INFECTIOUS DISEASES 2012;205(9):1351-62

Kinome Analysis of Receptor-Induced Phosphorylation in Human Natural Killer Cells
Konig S, Nimtz M, Scheiter M, Ljunggren Hg, Bryceson Yt, Jansch L
PLOS ONE 2012;7(1):e29672-

NK Cells Inhibit T-bet-deficient, Autoreactive Th17 Cells
Wu W, Shi S, Ljunggren Hg, Cava Al, Kaer L, Shi Fd, et al
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2012;76(6):559-66

Proatherogenic role of interleukin-18: effects on inflammation and action on vascular cells
Elhage R, Ljunggren Hg, Hansson Gk
CARDIOVASCULAR RESEARCH 2012;96(2):176-180

Spotlight on NKG2C and the human NK-cell response to CMV infection
Malmberg Kj, Beziat V, Ljunggren Hg
European journal of immunology 2012;42(12):3141-5

Characterization of Natural Killer Cell Phenotype and Function during Recurrent Human HSV-2 Infection
Bjorkstrom Nk, Svensson A, Malmberg Kj, Eriksson K, Ljunggren Hg
PLOS ONE 2011;6(11):e27664-

Familial hemophagocytic lymphohistiocytosis type 3 (FHL3) caused by deep intronic mutation and inversion in UNC13D
Meeths M, Chiang Scc, Wood Sm, Entesarian M, Schlums H, Bang B, et al
BLOOD 2011;118(22):5783-93

Insights into NK cell biology from human genetics and disease associations
Wood Sm, Ljunggren Hg, Bryceson Yt
CELLULAR AND MOLECULAR LIFE SCIENCES 2011;68(21):3479-93

Killer Cell Immunoglobulin-like Receptor Workshop: Insights into Evolution, Genetics, Function, and Translation
Malmberg Kj, Michaelsson J, Parham P, Ljunggren Hg
IMMUNITY 2011;35(5):653-7

Longitudinal Analysis of the Human T Cell Response during Acute Hantavirus Infection
Lindgren T, Ahlm C, Mohamed N, Evander M, Ljunggren Hg, Bjorkstrom Nk
JOURNAL OF VIROLOGY 2011;85(19):10252-60

Natural Killer Cells: Biology, Physiology and Medicine - Part 1
Bryceson Yt, Ljunggren Hg
JOURNAL OF INNATE IMMUNITY 2011;3(3):213-5

Natural Killer Cells: Biology, Physiology and Medicine - Part 2
Bryceson Yt, Ljunggren Hg
JOURNAL OF INNATE IMMUNITY 2011;3(4):327-8

NKG2D performs two functions in invariant NKT cells: Direct TCR-independent activation of NK-like cytolysis and co-stimulation of activation by CD1d
Kuylenstierna C, Bjorkstrom Nk, Andersson Sk, Sahlstrom P, Bosnjak L, Paquin-proulx D, et al
EUROPEAN JOURNAL OF IMMUNOLOGY 2011;41(7):1913-23

Organ-specific features of natural killer cells
Shi Fd, Ljunggren Hg, La Cava A, Van Kaer L
NATURE REVIEWS IMMUNOLOGY 2011;11(10):658-71

Rapid expansion and long-term persistence of elevated NK cell numbers in humans infected with hantavirus
Bjorkstrom Nk, Lindgren T, Stoltz M, Fauriat C, Braun M, Evander M, et al
JOURNAL OF EXPERIMENTAL MEDICINE 2011;208(1):13-21

Selenite Induces Posttranscriptional Blockade of HLA-E Expression and Sensitizes Tumor Cells to CD94/NKG2A-Positive NK Cells
Enqvist M, Nilsonne G, Hammarfjord O, Wallin Rpa, Bjorkstrom Nk, Bjornstedt M, et al
JOURNAL OF IMMUNOLOGY 2011;187(7):3546-54

Analysis of the KIR repertoire in human NK cells by flow cytometry
Björkström Nk, Fauriat C, Bryceson Yt, Sandberg Jk, Ljunggren Hg, Malmberg Kj
Methods in molecular biology (Clifton, N.J.) 2010;612():353-64

CD56 negative NK cells: origin, function, and role in chronic viral disease
Bjorkstrom Nk, Ljunggren Hg, Sandberg Jk
TRENDS IN IMMUNOLOGY 2010;31(11):401-6

Clinical Presentation of Griscelli Syndrome Type 2 and Spectrum of RAB27A Mutations
Meeths M, Bryceson Yt, Rudd E, Zheng Cy, Wood Sm, Ramme K, et al
PEDIATRIC BLOOD & CANCER 2010;54(4):563-72

Education of human natural killer cells by activating killer cell immunoglobulin-like receptors
Fauriat C, Ivarsson Ma, Ljunggren Hg, Malmberg Kj, Michaelsson J
BLOOD 2010;115(6):1166-74

Expression patterns of NKG2A, KIR, and CD57 define a process of CD56(dim) NK-cell differentiation uncoupled from NK-cell education
Bjorkstrom Nk, Riese P, Heuts F, Andersson S, Fauriat C, Ivarsson Ma, et al
BLOOD 2010;116(19):3853-64

Functional analysis of human NK cells by flow cytometry
Bryceson Yt, Fauriat C, Nunes Jm, Wood Sm, Björkström Nk, Long Eo, et al
Methods in molecular biology (Clifton, N.J.) 2010;612():335-52

IFN alpha ACTIVATED NK CELLS REQUIRE DNAM-1 FOR RECOGNITION OF INFECTED CELLS DURING ACUTE HCV INFECTION
Stegmann Ka, Bjorkstrom Nk, Ciesek S, Jaroszewicz J, Wiegand J, Malinski P, et al
HEPATOLOGY 2010;52(4):740A-741A

Interferon-alpha-Induced TRAIL on Natural Killer Cells Is Associated With Control of Hepatitis C Virus Infection
Stegmann Ka, Bjorkstrom Nk, Veber H, Ciesek S, Riese P, Wiegand J, et al
GASTROENTEROLOGY 2010;138(5):1885-97

NK cells expressing inhibitory KIR for non-self-ligands remain tolerant in HLA-matched sibling stem cell transplantation
Bjorklund At, Schaffer M, Fauriat C, Ringden O, Remberger M, Hammarstedt C, et al
BLOOD 2010;115(13):2686-94

Reduced DNAM-1 expression on bone marrow NK cells associated with impaired killing of CD34(+) blasts in myelodysplastic syndrome
Carlsten M, Baumann Bc, Simonsson M, Jadersten M, Forsblom Am, Hammarstedt C, et al
LEUKEMIA 2010;24(9):1607-16

Regulation of human NK-cell cytokine and chemokine production by target cell recognition
Fauriat C, Long Eo, Ljunggren Hg, Bryceson Yt
BLOOD 2010;115(11):2167-76

Unique features of NK cell development during ontogeny revealed in studies of RAG-1-deficient mice
Chambers Bj, Ljunggren Hg
IMMUNOLOGY AND CELL BIOLOGY 2010;88(2):105-6

Different NK cell-activating receptors preferentially recruit Rab27a or Munc13-4 to perforin-containing granules for cytotoxicity
Wood Sm, Meeths M, Chiang Scc, Bechensteen Ag, Boelens Jj, Heilmann C, et al
BLOOD 2009;114(19):4117-27

Expansion of Functionally Skewed CD56-Negative NK Cells in Chronic Hepatitis C Virus Infection: Correlation with Outcome of Pegylated IFN-alpha and Ribavirin Treatment
Gonzalez Vd, Falconer K, Bjorkstrom Nk, Blom Kg, Weiland O, Ljunggren Hg, et al
JOURNAL OF IMMUNOLOGY 2009;183(10):6612-8

IFN-ALPHA STIMULATED NK CELLS ARE CAPABLE OF KILLING HCV-INFECTED HEPATOMA CELLS VIA TRAIL
Stegmann Ka, Ciesek S, Bjorkstrom Nk, Cornberg M, Manns Mp, Pietschmann T, et al
HEPATOLOGY 2009;50(4):933A-933A

Increasing probabilities of kir expression characterize the formation of inhibitory kir repertoires: evidence against selection of human NK cells
Andersson S, Fauriat C, Malmberg Ja, Ljunggren Hg, Malmberg Kj
BONE MARROW TRANSPLANTATION 2009;:S302-S303

KIR acquisition probabilities are independent of self-HLA class I ligands and increase with cellular KIR expression
Andersson S, Fauriat C, Malmberg Ja, Ljunggren Hg, Malmberg Kj
BLOOD 2009;114(1):95-104

Maintained hyporesponsiveness of NK cells expressing inhibitory KIR for non-self ligands in HLA-matched sibling stem cell transplantation
Bjorklund At, Schaffer M, Fauriat C, Ringden O, Remberger M, Ljungman P, et al
BONE MARROW TRANSPLANTATION 2009;:S303-S303

Maintained hyporesponsiveness of NK cells expressing inhibitory KIR for non-self ligands in HLA-matched sibling stem cell transplantation
Schaffer M, Bjorklund A, Fauriat C, Ringden O, Remberger M, Ljungman P, et al
TISSUE ANTIGENS 2009;73(5):397-397

MAINTAINED TOLERANCE OF NK CELLS EXPRESSING INHIBITORY KIR FOR NON-SELF LIGANDS IN HLA-MATCHED SIBLING STEM CELL TRANSPLANTATION
Schaffer M, Bjorklund A, Fauriat C, Ringden O, Remberger M, Ljungman P, et al
HUMAN IMMUNOLOGY 2009;:S100-S100

Minimal requirement for induction of natural cytotoxicity and intersection of activation signals by inhibitory receptors
Bryceson Yt, Ljunggren Hg, Long Eo
BLOOD 2009;114(13):2657-66

Natural killer cell-mediated lysis of freshly isolated human tumor cells
Carlsten M, Malmberg Kj, Ljunggren Hg
INTERNATIONAL JOURNAL OF CANCER 2009;124(4):757-62

Natural killer cells in human autoimmunity
Flodstrom-tullberg M, Bryceson Yt, Shi Fd, Hoglund P, Ljunggren Hg
CURRENT OPINION IN IMMUNOLOGY 2009;21(6):634-40

Professor emeritus Jacob B. Natvig, one of the founders of Scandinavian Journal of immunology, turns 75
Capra Jd, Froland Ss, Harboe M, Jonsson R, Ljunggren Hg, Wigzell H
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2009;70(6):503-4

Safety analysis of ex vivo-expanded NK and NK-like T cells administered to cancer patients: a Phase I clinical study
Barkholt L, Alici E, Conrad R, Sutlu T, Gilljam M, Stellan B, et al
IMMUNOTHERAPY 2009;1(5):753-64

Spotlight on IL-22-producing NK cell receptor-expressing mucosal lymphocytes
Malmberg Kj, Ljunggren Hg
NATURE IMMUNOLOGY 2009;10(1):11-2

Transmission of Toxoplasma gondii from Infected Dendritic Cells to Natural Killer Cells
Persson Cm, Lambert H, Vutova Pp, Dellacasa-lindberg I, Nederby J, Yagita H, et al
INFECTION AND IMMUNITY 2009;77(3):970-6

Transmission of Toxoplasma gondii from Infected Dendritic Cells to Natural Killer Cells (vol 77, pg 972, 2009)
Persson Cm, Lambert H, Vutova Pp, Dellacasa-lindberg I, Nederby J, Yagita H, et al
INFECTION AND IMMUNITY 2009;77(8):3516-3516

Altered receptor repertoire and impaired function of tumor associated natural killer cells in ovarian carcinoma
Carlsten M, Norell H, Bryceson Y, Schedvins K, Ljunggren Hg, Kiessling R, et al
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2008;68(2):185-185

Application of nine-color flow cytometry for detailed studies of the phenotypic complexity and functional heterogeneity of human lymphocyte subsets
Gonzalez Vd, Bjorkstroem Nk, Malmberg Kj, Moll M, Kuylenstierna C, Michalsson J, et al
JOURNAL OF IMMUNOLOGICAL METHODS 2008;330(1-2):64-74

Arrestin NK cell cytotoxicity
Bryceson Yt, Ljunggren Hg
NATURE IMMUNOLOGY 2008;9(8):835-6

Autologous antitumor activity by NK cells expanded from myeloma patients using GMP-compliant components
Alici E, Sutlu T, Bojrkstrand B, Gilljam M, Stellan B, Nahi H, et al
BLOOD 2008;111(6):3155-62

Cancer immunosurveillance: NKG2D breaks cover
Ljunggren Hg
IMMUNITY 2008;28(4):492-4

Cannabinoids affect dendritic cell (DC) potassium channel function and modulate DC T cell stimulatory capacity
Wacnik Pw, Luhr Km, Hill Rh, Ljunggren Hg, Kristensson K, Svensson M
JOURNAL OF IMMUNOLOGY 2008;181(5):3057-66

Comprehensive phenotypic analysis of NK cells in acute hepatitis C virus infection
Stegmann Ka, Bjorkstrom Nk, Wiegand J, Ljunggren Hg, Manns Mp, Wedemeyer H
JOURNAL OF HEPATOLOGY 2008;:S233-S233

Comprehensive phenotypic analysis of NK cells in patients with acute hepatitis C virus infection
Stegmann Ka, Bjorkstrom Nk, Wiegand J, Ljunggren Hg, Manns Mp, Wedemeyer H
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2008;68(2):246-246

Elevated numbers of Fc gamma RIIIA+ (CD16(+)) effector CD8 T-cells with NK cell-like function in chronic HCV infection
Bjorkstrom N, Gonzalez V, Malmberg Kj, Falconer K, Alaeus A, Nowak G, et al
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2008;68(2):238-239

Elevated numbers of Fc gamma RIIIA(+) (CD16(+)) effector CD8 T cells with NK cell-like function in chronic hepatitis C virus infection
Bjorkstrom Nk, Gonzalez Vd, Malmberg Kj, Falconer K, Alaeus A, Nowak G, et al
JOURNAL OF IMMUNOLOGY 2008;181(6):4219-28

Estimation of the Size of the Alloreactive NK Cell Repertoire: Studies in Individuals Homozygous for the Group A KIR Haplotype
Fauriat C, Andersson S, Bjorklund At, Carlsten M, Schaffer M, Bjorkstrom Nk, et al
JOURNAL OF IMMUNOLOGY 2008;181(9):6010-9

Evidence for end-stage maturational fine-tuning within the human NK cell receptor repertoire
Riese P, Bjorkstrom Nk, Fauriat C, Andersson S, Guzman Ca, Ljunggren Hg, et al
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2008;68(2):250-250

Human cytomegalovirus-derived protein UL18 alters the phenotype and function of monocyte-derived dendritic cells
Wagner Cs, Walther-jallow L, Buentke E, Ljunggren Hg, Achour A, Chambers Bj
JOURNAL OF LEUKOCYTE BIOLOGY 2008;83(1):56-63

IFN-gamma production dominates the early human natural killer cell response to Coxsackievirus infection
Huhn Mh, Hultcrantz M, Lind K, Ljunggren Hg, Malmberg Kj, Flodstrom-tullberg M
CELLULAR MICROBIOLOGY 2008;10(2):426-36

Immune modulation by the human cytomegalovirus-encoded molecule UL18, a mystery yet to be solved
Wagner Cs, Ljunggren Hg, Achour A
JOURNAL OF IMMUNOLOGY 2008;180(1):19-24

Influence of cognate Ligands on the functional maturation of KIR3DL2 Positive NK cells
Bjorklund A, Fauriat C, Andersson S, Schaffer M, Bjorkstrom N, Ljunggren Hg, et al
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2008;68(2):224-224

NK cell-mediated targeting of human cancer and possibilities for new means of immunotherapy
Malmberg Kj, Bryceson Yt, Carlsten M, Andersson S, Bjorklund A, Bjorkstrom Nk, et al
CANCER IMMUNOLOGY IMMUNOTHERAPY 2008;57(10):1541-52

NKG2D mediates TCR-independent degranulation and antiviral cytolytic activity in CD4-CD1d restricted NKT cells
Kuylenstierna C, Bjorkstrom Nk, Malmberg Kj, Ljunggren Hg, Moll M, Sandberg Jk
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2008;68(2):245-245

Role of Rab27a and Munc13-4 in NK cell granule exocytosis and disease
Wood S, Meeths M, Henter Ji, Stow J, Ljunggren Hg, Bryceson Y
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2008;68(2):219-219

Spectrum, and clinical and functional implications of UNC13D mutations in familial haemophagocytic lymphohistiocytosis
Rudd E, Bryceson Yt, Zheng C, Edner J, Wood Sm, Ramme K, et al
JOURNAL OF MEDICAL GENETICS 2008;45(3):134-41

Sustained NK cell receptor imprinting caused by acute Puumala Hantavirus infection in humans
Bjorkstrom N, Klingstrom J, Fauriat C, Stoltz M, Michaelsson J, Malmberg Kj, et al
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2008;68(2):186-186

The size of the alloreactive NK cell subset: Implications for donor selection in allogeneic stem cell transplantation
Andersson S, Fauriat C, Bjorklund A, Carlsten M, Schaffer M, Bjorkstrom Nk, et al
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2008;68(2):223-223

Tumor cell recognition by the NK cell activating receptor NKG2D
Bryceson Yt, Ljunggren Hg
European journal of immunology 2008;38(11):2957-61

Aggravation of experimental autoimmune neuritis in TNF-alpha receptor 1 deficient mice
Lu Mo, Duan Rs, Quezada Hc, Chen Zg, Mix E, Jin T, et al
JOURNAL OF NEUROIMMUNOLOGY 2007;186(1-2):19-26

Alpha production dominates the early human natural killer cell response to coxsackievirus infection
Huhn Mh, Hultcrantz M, Lind K, Ljunggren Hg, Malmberg Kj, Flodstrom-tullberg M
ACTA DIABETOLOGICA 2007;:S23-S23

Anti-myeloma activity of endogenous and adoptively transferred activated natural killer cells in experimental multiple myeloma model
Alici E, Konstantinidis Kv, Sutlu T, Aints A, Gahrton G, Ljunggren Hg, et al
EXPERIMENTAL HEMATOLOGY 2007;35(12):1839-46

Association of class I major histocompatibility heavy and light chains induced by viral peptides (Reprinted from Nature, vol 340, pg 443-448, 1989)
Townsend A, Ohlen C, Bastin J, Ljunggren Hg, Foster L, Karre K
JOURNAL OF IMMUNOLOGY 2007;179(7):4301-6

Defective cytotoxic lymphocyte degranulation in syntaxin-11-deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients
Bryceson Yt, Rudd E, Zheng Cy, Edner J, Ma D, Wood Sm, et al
BLOOD 2007;110(6):1906-15

DNAX accessory molecule-1 mediated recognition of freshly isolated ovarian carcinoma by resting natural killer cells
Carlsten M, Bjorkstrom Nk, Norell H, Bryceson Y, Van Hall T, Baumann Bc, et al
CANCER RESEARCH 2007;67(3):1317-25

Induction of protective CTL immunity against peptide transporter TAP-deficient tumors through dendritic cell vaccination
Chambers B, Grufman P, Fredriksson V, Andersson K, Roseboom M, Laban S, et al
CANCER RESEARCH 2007;67(18):8450-5

Lymphocyte effector functions: armed for destruction?
Bryceson Yt, Ljunggren Hg
CURRENT OPINION IN IMMUNOLOGY 2007;19(3):337-8

NK cell-mediated destruction of influenza A virus-infected peripheral but not central neurones
Backstrom E, Ljunggren Hg, Kristensson K
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2007;65(4):353-61

Prospects for the use of NK cells in immunotherapy of human cancer
Ljunggren Hg, Malmberg Kj
NATURE REVIEWS IMMUNOLOGY 2007;7(5):329-39

Severe defect in thymic development in an insertional mutant mouse model
Assarsson E, Chambers Bj, Hogstrand K, Berntman E, Lundmark C, Fedorova L, et al
JOURNAL OF IMMUNOLOGY 2007;178(8):5018-27

Structural elements underlying the high binding affinity of human cytomegalovirus UL18 to leukocyte immunoglobulin-like receptor-1
Wagner Cs, Rolle A, Cosman D, Ljunggren Hg, Berndt Kd, Achour A
JOURNAL OF MOLECULAR BIOLOGY 2007;373(3):695-705

Activation, coactivation, and costimulation of resting human natural killer cells
Bryceson Yt, March Me, Ljunggren Hg, Long Eo
IMMUNOLOGICAL REVIEWS 2006;:73-91

Cytokine-induced killer T cells kill immature dendritic cells by TCR-independent and perforin-dependent mechanisms
Joshi Ps, Liu Jq, Wang Y, Chang X, Richards J, Assarsson E, et al
JOURNAL OF LEUKOCYTE BIOLOGY 2006;80(6):1345-53

Dissection of the interaction of the human cytomegalovirus-derived US2 protein with major histocompatibility complex class I molecules - Prominent role of a single arginine residue in human leukocyte antigen-A2
Thilo C, Berglund P, Applequist Se, Yewdell Jw, Ljunggren Hg, Achour A
JOURNAL OF BIOLOGICAL CHEMISTRY 2006;281(13):8950-7

Escape from immune- and nonimmune-mediated tumor surveillance
Malmberg Kj, Ljunggren Hg
SEMINARS IN CANCER BIOLOGY 2006;16(1):16-31

Evaluation of ex vivo expanded human NK cells on antileukemia activity in SCID-beige mice
Guimaraes F, Guven H, Donati D, Christensson B, Ljunggren Hg, Bejarano Mt, et al
LEUKEMIA 2006;20(5):833-9

Non-CD1d-restricted NKT cells recognize dendritic cells by TCR-independent but CD2 family member-regulated mechanisms
Joshi Ps, Liu Jq, Wang Y, Chang X, Richards J, Shi Fd, et al
JOURNAL OF IMMUNOLOGY 2006;:S207-S208

Selective cytotoxic T-lymphocyte targeting of tumor immune escape variants
Van Hall T, Wolpert Ez, Van Veelen P, Laban S, Van Der Veer M, Roseboom M, et al
NATURE MEDICINE 2006;12(4):417-24

Structural basis of the differential stability and receptor specificity of H-2D(b) in complex with murine versus human beta(2)-microglobulin
Achour A, Michaelsson T, Harris Ra, Ljunggren Hg, Karre M, Schneider G, et al
JOURNAL OF MOLECULAR BIOLOGY 2006;356(2):382-96

Synergy among receptors on resting NK cells for the activation of natural cytotoxicity and cytokine secretion
Bryceson Yt, March Me, Ljunggren Hg, Long Eo
BLOOD 2006;107(1):159-66

The neuronal chemokine CX3CL1/fractalkine selectively recruits NK cells that modify experimental autoimmune encephalomyelitis within the central nervous system
Huang D, Shi Fd, Jung S, Pien Gc, Wang J, Salazar-mather Tp, et al
FASEB JOURNAL 2006;20(7):896-905

2B4/CD48-mediated regulation of lymphocyte activation and function
Assarsson E, Kambayashi T, Persson Cm, Chambers Bj, Ljunggren Hg
JOURNAL OF IMMUNOLOGY 2005;175(4):2045-9

2B4 co-stimulation: NK cells and their control of adaptive immune responses
Assarsson E, Kambayashi T, Persson Cm, Ljunggren Hg, Chambers Bj
MOLECULAR IMMUNOLOGY 2005;42(4):419-23

Activation of innate immunity, inflammation, and potentiation of DNA vaccination through mammalian expression of the TLR5 agonist flagellin
Applequist Se, Rollman E, Wareing Ma, Liden M, Rozell B, Hinkula J, et al
JOURNAL OF IMMUNOLOGY 2005;175(6):3882-91

Blockade of CTLA-4 promotes airway inflammation in naive mice exposed to aerosolized allergen but fails to prevent inhalation tolerance
Alenmyr L, Matheu V, Uller L, Greiff L, Malm-erjefalt M, Ljunggren Hg, et al
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2005;62(5):437-44

Cytolytic granule polarization and degranulation controlled by different receptors in resting NK cells
Bryceson Yt, March Me, Barber Df, Ljunggren Hg, Long Eo
JOURNAL OF EXPERIMENTAL MEDICINE 2005;202(7):1001-12

Development and function of CD1d-restricted NKT cells: influence of sphingolipids, SAP and sex
Sandberg Jk, Ljunggren Hg
TRENDS IN IMMUNOLOGY 2005;26(7):347-9

Effects on synaptic activity in cultured hippocampal neurons by influenza A viral proteins
Brask J, Chauhan A, Hill Rh, Ljunggren Hg, Kristensson K
JOURNAL OF NEUROVIROLOGY 2005;11(4):395-402

Efficient gene transfer into primary human natural killer cells by retroviral transduction
Guven H, Konstantinidis Kv, Alici E, Aints A, Abedi-valugerdi M, Christensson B, et al
EXPERIMENTAL HEMATOLOGY 2005;33(11):1320-8

Expression, refolding and crystallization of murine MHC class IH-2D(b) in complex with human beta(2)-microglobulin
Sandalova T, Michaelsson J, Harris Ra, Ljunggren Hg, Karre K, Schneider G, et al
ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY AND CRYSTALLIZATION COMMUNICATIONS 2005;:1090-3

Impact of FASL-induced apoptosis in the elimination of tumor cells by NK cells
Screpanti V, Wallin Rpa, Grandien A, Ljunggren Hg
MOLECULAR IMMUNOLOGY 2005;42(4):495-9

KIR-ligand mismatch in allogeneic hematopoietic stem cell transplantation
Malmberg Kj, Schaffer M, Ringden O, Remberger M, Ljunggren Hg
MOLECULAR IMMUNOLOGY 2005;42(4):531-4

Selective rejection of H-2-deficient lymphoma variants suggests alternative immune defence strategy (Reprinted from Nature 319 : 675-678 (1986))
Karre K, Ljunggren Hg, Piontek G, Kiessling R
JOURNAL OF IMMUNOLOGY 2005;174(11):6566-9

Targeting IL-2 to the endoplasmic reticulum confines autocrine growth stimulation to NK-92 cells
Konstantinidis Kv, Alici E, Aints A, Christensson B, Ljunggren Hg, Dilber Ms
EXPERIMENTAL HEMATOLOGY 2005;33(2):159-64

Activation of natural killer cells: Underlying molecular mechanisms revealed
Backstrom E, Kristensson K, Ljunggren Hg
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2004;60(1-2):14-22

CD1d-dependent activation of NKT cells aggravates atherosclerosis
Tupin E, Nicoletti A, Elhage R, Rudling M, Ljunggren Hg, Hansson Gk, et al
JOURNAL OF EXPERIMENTAL MEDICINE 2004;199(3):417-22

CTL TARGETING OF TUMORS WITH DEFECTS IN MHC CLASS I ANTIGEN PROCESSING
Wolpert Ez, Van Hall T, Grufman P, Van Der Veer M, Laban S, Fredriksson V, et al
ANTICANCER RESEARCH 2004;24(5D):3672-3672

Determination of structural principles underlying three different modes of lymphocytic choriomeningitis virus escape from CTL recognition
Velloso Lm, Michaelsson J, Ljunggren Hg, Schneider G, Achour A
JOURNAL OF IMMUNOLOGY 2004;172(9):5504-11

Enhanced dendritic cell antigen capture via toll-like receptor-induced actin remodeling
West Ma, Wallin Rpa, Matthews Sp, Svensson Hg, Zaru R, Ljunggren Hg, et al
SCIENCE 2004;305(5687):1153-7

IL-12p35 deficiency alleviates kainic acid-induced hippocampal neurodegeneration in C57BL/6 mice
Chen Zg, Duan Rs, Q Hc, Wu Qy, Mix E, Winblad B, et al
NEUROBIOLOGY OF DISEASE 2004;17(2):171-8

Increased infection-related mortality in KIR-ligand-mismatched unrelated allogeneic hematopoietic stem-cell transplantation
Schaffer M, Malmberg Kj, Ringden O, Ljunggren Hg, Remberger M
TRANSPLANTATION 2004;78(7):1081-5

Increased susceptibility to experimental autoimmune neuritis after upregulation of the autoreactive T cell response to peripheral myelin antigen in apolipoprotein E-deficient mice
Yu S, Duan Rs, Chen Zg, Quezada Hc, Bao L, Nennesmo I, et al
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 2004;63(2):120-8

Kainic acid-induced excitotoxic hippocampal neurodegeneration in C57BL/6 mice: B cell and T cell subsets may contribute differently to the pathogenesis
Chen Zg, Yu S, Concha Hq, Zhu Y, Mix E, Winblad B, et al
BRAIN BEHAVIOR AND IMMUNITY 2004;18(2):175-85

NK cells stimulate proliferation of T and NK cells through 2B4/CD48 interactions
Assarsson E, Kambayashi T, Schatzle Jd, Cramer So, Von Bonin A, Jensen Pe, et al
JOURNAL OF IMMUNOLOGY 2004;173(1):174-80

NK cell TRAIL eliminates immature dendritic cells in vivo and limits dendritic cell vaccination efficacy
Hayakawa Y, Screpanti V, Yagita H, Grandien A, Ljunggren Hg, Smyth Mj, et al
JOURNAL OF IMMUNOLOGY 2004;172(1):123-9

Reduced susceptibility to kainic acid-induced excitoxicity in T-cell deficient CD4/CD8(-/-) and middle-aged C57BL/6 mice
Chen Zg, Ljunggren Hg, Zhu Sw, Winblad B, Zhu J
JOURNAL OF NEUROIMMUNOLOGY 2004;146(1-2):33-8

Regulation of natural killer cell stimulatory and inhibitory molecules in mouse nervous system
Backstrom E, Drenth Afj, Sjolin H, Ljunggren Hg, Kristensson K
JOURNAL OF NEUROIMMUNOLOGY 2004;154(1-2):205-205

Scrapie protein degradation by cysteine proteases in CD11c(+) dendritic cells and GT1-1 neuronal cells
Luhr Km, Nordstrom Ek, Low P, Ljunggren Hg, Taraboulos A, Kristensson K
JOURNAL OF VIROLOGY 2004;78(9):4776-82

Tumor necrosis factor receptor 1-mediated signaling is required for skin cancer development induced by NF-kappa B inhibition
Lind Mh, Rozell B, Wallin Rpa, Van Hogerlinden M, Ljunggren Hg, Toftgard R, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2004;101(14):4972-7

Exogenous soluble tumor necrosis factor receptor type I ameliorates murine experimental autoimmune neuritis
Bao L, Lindgren Ju, Zhu Y, Ljunggren Hg, Zhu J
NEUROBIOLOGY OF DISEASE 2003;12(1):73-81

Expansion of natural killer (NK) and natural killer-like T (NKT)-cell populations derived from patients with B-chronic lymphocytic leukemia (B-CLL): a potential source for cellular immunotherapy
Guven H, Gilljam M, Chambers Bj, Ljunggren Hg, Christensson B, Kimby E, et al
LEUKEMIA 2003;17(10):1973-80

Invasion and persistence of the neuroadapted influenza virus A/WSN/33 in the mouse olfactory system
Aronsson F, Robertson B, Ljunggren Hg, Kristensson K
VIRAL IMMUNOLOGY 2003;16(3):415-23

Memory CD8(+) T cells provide an early source of IFN-gamma
Kambayashi T, Assarsson E, Lukacher Ae, Ljunggren Hg, Jensen Pe
JOURNAL OF IMMUNOLOGY 2003;170(5):2399-408

Natural killer cell-mediated lysis of dorsal root ganglia neurons via RAE1/NKG2D interactions
Backstrom E, Chambers Bj, Ho El, Naidenko Ov, Mariotti R, Fremont Dh, et al
EUROPEAN JOURNAL OF IMMUNOLOGY 2003;33(1):92-100

Production, crystallization and preliminary crystallographic study of the major cat allergen Fel d I
Kaiser L, Gronlund H, Sandalova T, Ljunggren Hg, Schneider G, Van Hage-hamsten M, et al
ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 2003;:1103-5

Reduced atherosclerosis in interleukin-18 deficient apolipoprotein E-knockout mice
Elhage R, Jawien J, Rudling M, Ljunggren Hg, Takeda K, Akira S, et al
CARDIOVASCULAR RESEARCH 2003;59(1):234-40

Regulation of perforin-independent NK cell-mediated cytotoxicity
Wallin Rpa, Screpanti V, Michaelsson J, Grandien A, Ljunggren Hg
EUROPEAN JOURNAL OF IMMUNOLOGY 2003;33(10):2727-35

The crystal structure of the major cat allergen Fel d 1, a member of the secretoglobin family
Kaiser L, Gronlund H, Sandalova T, Ljunggren Hg, Van Hage-hamsten M, Achour A, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2003;278(39):37730-5

Three-dimensional structure of Fel d 1, the major allergen in cat
Kaiser L, Gronlund H, Sandalova T, Ljunggren Hg, Achour A, Schneider G, et al
INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY 2003;132(1):25-6

CD4 and CD8 T cells, but not B cells, are critical to the control of murine experimental autoimmune neuritis
Zhu Y, Bao L, Zhu Sw, Chen Zg, Van Der Meide P, Nennesmo I, et al
EXPERIMENTAL NEUROLOGY 2002;177(1):314-20

Co-stimulatory molecules in islet xenotransplantation: CTLA4Ig treatment in CD40 ligand-deficient mice
Benda B, Ljunggren Hg, Peach R, Sandberg Jo, Korsgren O
CELL TRANSPLANTATION 2002;11(7):715-20

Derivation of expanded killer cells from patients with B-chronic lymphocytic leukemia (B-CLL): A potential source for cellular immunotherapy.
Guven H, Gilljam M, Chambers Bj, Ljunggren Hg, Christensson B, Kimby E, et al
BLOOD 2002;100(11):595A-595A

Excitotoxic neurodegeneration induced by intranasal administration of kainic acid in C57BL/6 mice
Chen Zg, Ljunggren Hg, Bogdanovic N, Nennesmo I, Winblad B, Zhu J
BRAIN RESEARCH 2002;931(2):135-45

Heat-shock proteins as activators of the innate immune system
Wallin Rpa, Lundqvist A, More Sh, Von Bonin A, Kiessling R, Ljunggren Hg
TRENDS IN IMMUNOLOGY 2002;23(3):130-5

Natural killer and dendritic cell contact in lesional atopic dermatitis skin - Malassezia-influenced cell interaction
Buentke E, Heffler Lc, Wilson Jl, Wallin Rpa, Lofman C, Chambers Bj, et al
JOURNAL OF INVESTIGATIVE DERMATOLOGY 2002;119(4):850-7

Neutralizing antibodies to IL-18 ameliorate experimental autoimmune neuritis by counter-regulation of autoreactive Th1 responses to peripheral myelin antigen
Yu S, Chen Zg, Mix E, Zhu Sw, Winblad B, Ljunggren Hg, et al
JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY 2002;61(7):614-22

Processing and degradation of exogenous prion protein by CD11c(+) myeloid dendritic cells in vitro
Luhr Km, Wallin Rpa, Ljunggren Hg, Low P, Taraboulos A, Kristensson K
JOURNAL OF VIROLOGY 2002;76(23):12259-64

The critical role of IL-12p40 in initiating, enhancing, and perpetuating pathogenic events in murine experimental autoimmune neuritis
Bao L, Lindgren Ju, Van Der Meide P, Zhu Sw, Ljunggren Hg, Zhu J
BRAIN PATHOLOGY 2002;12(4):420-9

The natural killer cell - Friend or foe in autoimmune disease?
Flodstrom M, Shi Fd, Sarvetnick N, Ljunggren Hg
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2002;55(5):432-41

Variable expression of Toll-like receptor in murine innate and adaptive immune cell lines
Applequist Se, Wallin Rpa, Ljunggren Hg
INTERNATIONAL IMMUNOLOGY 2002;14(9):1065-74

A central role for death receptor-mediated apoptosis in the rejection of tumors by NK cells
Screpanti V, Wallin Rpa, Ljunggren Hg, Grandien A
JOURNAL OF IMMUNOLOGY 2001;167(4):2068-73

A new method for in vitro expansion of cytotoxic human CD3(-)CD56(+) natural killer cells
Carlens S, Gilljam M, Chambers Bj, Aschan J, Guven H, Ljunggren Hg, et al
HUMAN IMMUNOLOGY 2001;62(10):1092-8

Anti-CTLA-4 antibody treatment triggers determinant spreading and enhances murine myasthenia gravis
Wang Hb, Shi Fd, Li Hl, Chambers Bj, Link H, Ljunggren Hg
JOURNAL OF IMMUNOLOGY 2001;166(10):6430-6

Assembly of tapasin-associated MHC class I in the absence of the transporter associated with antigen processing (TAP)
Paulsson Km, Anderson Po, Chen Sw, Sjogren Ho, Ljunggren Hg, Wang P, et al
INTERNATIONAL IMMUNOLOGY 2001;13(1):23-9

Autoimmunity mediated by innate immune effector cells - Response from Shi et al.
Shi Fd, Sarvetnick N, Ljunggren Hg
TRENDS IN IMMUNOLOGY 2001;22(6):301-301

cAMP-elevating agents suppress dendritic cell function
Kambayashi T, Wallin Rpa, Ljunggren Hg
JOURNAL OF LEUKOCYTE BIOLOGY 2001;70(6):903-10

CD28-B7 costimulation: a critical role for initiation and development of experimental autoimmune neuritis in C57BL/6 mice
Zhu Y, Ljunggren Hg, Mix E, Li Hl, Van Der Meide P, Elhassan Am, et al
JOURNAL OF NEUROIMMUNOLOGY 2001;114(1-2):114-21

Control of the autoimmune response by type 2 nitric oxide synthase
Shi Fd, Flodstrom M, Kim Sh, Pakala S, Cleary M, Ljunggren Hg, et al
JOURNAL OF IMMUNOLOGY 2001;167(5):3000-6

Cutting edge: Regulation of CD8(+) T cell proliferation by 2B4/CD48 interactions
Kambayashi T, Assarsson E, Chambers Bj, Ljunggren Hg
JOURNAL OF IMMUNOLOGY 2001;167(12):6706-10

Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) blockade enhances incidence and severity of experimental autoimmune neuritis in resistant mice
Zhu J, Zou Lp, Zhu Sw, Mix E, Shi Fd, Wang Hb, et al
JOURNAL OF NEUROIMMUNOLOGY 2001;115(1-2):111-7

Differentiation of Ly49s-positive or -negative natural killer cells is inhibited by anti-H-2(b) monoclonal antibodies acting at the level of bone marrow progenitors from B6 mice
Delfino Dv, Salcedo M, Di Marco B, Ayroldi E, Nocentini G, Bruscoli S, et al
CELL GROWTH & DIFFERENTIATION 2001;12(1):51-60

Disruption of the IL-1 beta gene diminishes acetylcholine receptor-induced immune responses in a murine model of myasthenia gravis
Huang Dr, Shi Fd, Giscombe R, Zhou Yh, Ljunggren Hg, Lefvert Ak
EUROPEAN JOURNAL OF IMMUNOLOGY 2001;31(1):225-32

Expression of the DX5 antigen on CD8(+) T cells is associated with activation and subsequent cell death or memory during influenza virus infection
Kambayashi T, Assarsson E, Chambers Bj, Ljunggren Hg
EUROPEAN JOURNAL OF IMMUNOLOGY 2001;31(5):1523-30

IL-2 down-regulates the expression of TCR and TCR-associated surface molecules on CD8(+) T cells
Kambayashi T, Assarsson E, Chambers Bj, Ljunggren Hg
EUROPEAN JOURNAL OF IMMUNOLOGY 2001;31(11):3248-54

Innate immunity and autoimmunity: from self-protection to self-destruction
Shi Fd, Ljunggren Hg, Sarvetnick N
TRENDS IN IMMUNOLOGY 2001;22(2):97-101

In vivo activation of dendritic cells and T cells during Salmonella enterica serovar typhimurium infection
Yrlid U, Svensson M, Hakansson A, Chambers Bj, Ljunggren Hg, Wick Mj
INFECTION AND IMMUNITY 2001;69(9):5726-35

Persistence of the influenza A/WSN/33 virus RNA at midbrain levels of immunodefective mice
Aronsson F, Karlsson H, Ljunggren Hg, Kristensson K
JOURNAL OF NEUROVIROLOGY 2001;7(2):117-24

Purified MHC class I molecules inhibit activated NK cells in a cell-free system in vitro
Kambayashi T, Michaelsson J, Fahlen L, Chambers Bj, Sentman Cl, Karre K, et al
EUROPEAN JOURNAL OF IMMUNOLOGY 2001;31(3):869-75

Reduced susceptibility of human immature dendritic cells (IDC) to NK cell lysis after interaction with the opportunistic yeast Malassezia furfur (MF)
Buentke E, Heffler Lc, Wilson J, Wallin Rpa, Chambers Bj, Ljunggren Hg, et al
JOURNAL OF INVESTIGATIVE DERMATOLOGY 2001;117(3):804-804

Soluble MHC class I molecules induce cellular death in a CD8(+) T-cell hybridoma tumor model
Kambayashi T, Ichihara F, Jensen Pe, Ljunggren Hg
INTERNATIONAL JOURNAL OF CANCER 2001;91(3):373-8

Suppression of autoimmune neuritis in IFN-gamma receptor-deficient mice
Zhu Y, Ljunggren Hg, Mix E, Li Hl, Van Der Meide P, Elhassan Am, et al
EXPERIMENTAL NEUROLOGY 2001;169(2):472-8

The allergenic yeast Malassezia furfur induces maturation of human dendritic cells
Buentke E, Heffler Lc, Wallin Rpa, Lofman C, Ljunggren Hg, Scheynius A
CLINICAL AND EXPERIMENTAL ALLERGY 2001;31(10):1583-93

Abolished angiogenicity and tumorigenicity of Burkitt lymphoma by interleukin-10
Cervenak L, Morbidelli L, Donati D, Donnini S, Kambayashi T, Wilson Jl, et al
BLOOD 2000;96(7):2568-73

beta(2)-microglobulin/CD8-/- mice reveal significant role for CD8(+) T cells in graft rejection responses in beta(2)-microglobulin -/- mice
Freland S, Ljunggren Hg
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 2000;51(3):219-23

CD8(+) T cells rapidly acquire NK1.1 and NK cell-associated molecules upon stimulation in vitro and in vivo
Assarsson E, Kambayashi T, Sandberg Jk, Hong S, Taniguchi M, Van Kaer L, et al
JOURNAL OF IMMUNOLOGY 2000;165(7):3673-9

Control B cell-mediated autoimmune response by type 2 nitric oxide synthase (NOS2)
Shi Fd, Flodstrom M, Kim Sh, Cleary Mm, Ljunggren Hg, Sarvetnick N
JOURNAL OF LEUKOCYTE BIOLOGY 2000;:33-33

Direct NK cell-mediated lysis of syngenic dorsal root ganglia neurons in vitro
Backstrom E, Chambers Bj, Kristensson K, Ljunggren Hg
JOURNAL OF IMMUNOLOGY 2000;165(9):4895-900

Efficient presentation of exogenous antigen by liver endothelial cells to CD8(+) T cells results in antigen-specific T-cell tolerance
Limmer A, Ohl J, Kurts C, Ljunggren Hg, Reiss Y, Groettrup M, et al
NATURE MEDICINE 2000;6(12):1348-54

Emergence of CD8(+) T cells expressing NK cell receptors in influenza A virus-infected mice
Kambayashi T, Assarsson E, Michaelsson J, Berglund P, Diehl Ap, Chambers Bj, et al
JOURNAL OF IMMUNOLOGY 2000;165(9):4964-9

IL-18 directs autoreactive T cells and promotes autodestruction in the central nervous system via induction of IFN-gamma by NK cells
Shi Fd, Takeda K, Akira S, Sarvetnick N, Ljunggren Hg
JOURNAL OF IMMUNOLOGY 2000;165(6):3099-104

Impaired immune responses and altered peptide repertoire in tapasin-deficient mice
Garbi N, Tan P, Diehl Ad, Chambers Bj, Ljunggren Hg, Momburg F, et al
NATURE IMMUNOLOGY 2000;1(3):234-8

Natural killer cells determine the out-come of B cell-mediated autoimmunity
Shi Fd, Wang Hb, Li Hl, Hong S, Taniguchi M, Link H, et al
NATURE IMMUNOLOGY 2000;1(3):245-51

P0 protein peptide 180-199 together with pertussis toxin induces experimental autoimmune neuritis in resistant C57BL/6 mice
Zou Lp, Ljunggren Hg, Levi M, Nennesmo I, Wahren B, Mix E, et al
JOURNAL OF NEUROSCIENCE RESEARCH 2000;62(5):717-21

Role for interferon-gamma in rat strains with different susceptibility to experimental autoimmune myasthenia gravis
Wang Hb, Shi Fd, Li Hl, Van Der Meide Ph, Ljunggren Hg, Link H
CLINICAL IMMUNOLOGY 2000;95(2):156-62

Role of Qa-1(b)-binding receptors in the specificity of developing NK cells
Salcedo M, Colucci F, Dyson Pj, Cotterill La, Lemonnier Fa, Kourilsky P, et al
EUROPEAN JOURNAL OF IMMUNOLOGY 2000;30(4):1094-101

Tumor necrosis factor receptor-1 is critically involved in the development of experimental autoimmune myasthenia gravis
Wang Hb, Li H, Shi Fd, Chambers Bj, Link H, Ljunggren Hg
INTERNATIONAL IMMUNOLOGY 2000;12(10):1381-8

Induction of experimental autoimmune neuritis in CD4(-)8(-) C57BL/6J mice
Zhu J, Nennesmo I, Deng Gm, Levi M, Wahren B, Diab A, et al
JOURNAL OF NEUROIMMUNOLOGY 1999;94(1-2):196-203

Mechanisms of nasal tolerance induction in experimental autoimmune myasthenia gravis: Identification of regulatory cells
Shi Fd, Li Hl, Wang Hb, Bai Xf, Van Der Meide Ph, Link H, et al
JOURNAL OF IMMUNOLOGY 1999;162(10):5757-63

Natural killer cells determine development of allergen-induced eosinophilic airway inflammation in mice
Korsgren M, Persson Cga, Sundler F, Bjerke T, Hansson T, Chambers Bj, et al
JOURNAL OF EXPERIMENTAL MEDICINE 1999;189(3):553-62

NK cell triggering by the human costimulatory molecules CD80 and CD86
Wilson Jl, Charo J, Martin-fontecha A, Dellabona P, Casorati G, Chambers Bj, et al
JOURNAL OF IMMUNOLOGY 1999;163(8):4207-12

Processing of bacterial antigens for peptide presentation on MHC class I molecules
Wick Mj, Ljunggren Hg
IMMUNOLOGICAL REVIEWS 1999;:153-62

Selective targeting of habenular, thalamic midline and monoaminergic brainstem neurons by neurotropic influenza A virus in mice
Mori I, Diehl Ad, Chauhan A, Ljunggren Hg, Kristensson K
JOURNAL OF NEUROVIROLOGY 1999;5(4):355-62

Targeting of human dendritic cells by autologous NK cells
Wilson Jl, Heffler Lc, Charo J, Scheynius A, Bejarano Mt, Ljunggren Hg
JOURNAL OF IMMUNOLOGY 1999;163(12):6365-70

Triggering of murine NK cells by CD40 and CD86 (B7-2)
Martin-fontecha A, Assarsson E, Carbone E, Karre K, Ljunggren Hg
JOURNAL OF IMMUNOLOGY 1999;162(10):5910-6

Differential requirements for CD28 and CD40 ligand in the induction of experimental autoimmune myasthenia gravis
Shi Fd, He B, Li Hl, Matusevicius D, Link H, Ljunggren Hg
EUROPEAN JOURNAL OF IMMUNOLOGY 1998;28(11):3587-93

Fine tuning of natural killer cell specificity and maintenance of self tolerance in MHC class I-deficient mice
Salcedo M, Andersson M, Lemieux S, Van Kaer L, Chambers Bj, Ljunggren Hg
EUROPEAN JOURNAL OF IMMUNOLOGY 1998;28(4):1315-21

MHC class I mosaic mice reveal insights into control of Ly49C inhibitory receptor expression in NK cells
Andersson M, Freland S, Johansson Mh, Wallin R, Sandberg Jk, Chambers Bj, et al
JOURNAL OF IMMUNOLOGY 1998;161(12):6475-9

Rejection of allogeneic and syngeneic but not MHC class I-deficient tumor grafts by MHC class I-deficient mice
Freland S, Chambers Bj, Andersson M, Van Kaer L, Ljunggren Hg
JOURNAL OF IMMUNOLOGY 1998;160(2):572-9

The Qa-1(b) molecule binds to a large subpopulation of murine NK cells
Salcedo M, Bousso P, Ljunggren Hg, Kourilsky P, Abastado Jp
EUROPEAN JOURNAL OF IMMUNOLOGY 1998;28(12):4356-61

Triggering of natural killer cell mediated cytotoxicity by costimulatory molecules
Chambers Bj, Wilson Jl, Salcedo M, Markovic K, Bejarano Mt, Ljunggren Hg
SPECIFICITY, FUNCTION, AND DEVELOPMENT OF NK CELLS 1998;:53-61

Altered expression of Ly49 inhibitory receptors on natural killer cells from MHC class I-deficient mice
Salcedo M, Diehl Ad, Olssonalheim My, Sundback J, Vankaer L, Karre K, et al
JOURNAL OF IMMUNOLOGY 1997;158(7):3174-80

Constitutive macropinocytosis allows TAP-dependent major histocompatibility complex class I presentation of exogenous soluble antigen by bone marrow-derived dendritic cells
Norbury Cc, Chambers Bj, Prescott Ar, Ljunggren Hg, Watts C
EUROPEAN JOURNAL OF IMMUNOLOGY 1997;27(1):280-8

Down-regulation of the expression and function of the transporter associated with antigen processing in murine tumor cell lines expressing IL-10
Salazaronfray F, Charo J, Petersson M, Freland S, Noffz G, Qin Zh, et al
JOURNAL OF IMMUNOLOGY 1997;159(7):3195-202

Generation of CD8(+) T cells specific for transporter associated with antigen processing deficient cells
Wolpert Ez, Petersson M, Chambers Bj, Sandberg Jk, Kiessling R, Ljunggren Hg, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1997;94(21):11496-501

Host MHC class I gene control of NK-cell specificity in the mouse
Hoglund P, Sundback J, Olssonalheim My, Johansson M, Salcedo M, Ohlen C, et al
IMMUNOLOGICAL REVIEWS 1997;:11-28

Major histocompatibility complex class I-independent killing of xenogenic targets by rat allospecific natural killer cells
Torgersen Km, Salcedo M, Vaage Jt, Naper C, Rolstad B, Ljunggren Hg, et al
TRANSPLANTATION 1997;63(1):119-23

MHC class I presentation of live and heat-inactivated Sendai virus antigen in T2K(b) cells depends on an intracellular compartment with endosomal characteristics
Liu T, Zhou X, Abdelmotal Um, Ljunggren Hg, Jondal M
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 1997;45(5):527-33

NK cell receptor calibration: effects of MHC class I induction on killing by Ly49Ahigh and Ly49Alow NK cells
Olsson-alheim My, Salcedo M, Ljunggren Hg, Kärre K, Sentman Cl
Journal of immunology (Baltimore, Md. : 1950) 1997;159(7):3189-94

NK cell receptor calibration - Effects of MHC class I induction on killing by Ly49A(high) and Ly49A(low) NK cells
Olssonalheim My, Salcedo M, Ljunggren Hg, Karre K, Sentman Cl
JOURNAL OF IMMUNOLOGY 1997;159(7):3189-3194

Spread of measles virus through axonal pathways into limbic structures in the brain of TAP1 -/- mice
Urbanska Em, Chambers Bj, Ljunggren Hg, Norrby E, Kristensson K
JOURNAL OF MEDICAL VIROLOGY 1997;52(4):362-9

TAP peptide transporter-independent presentation of heat-killed Sendai virus antigen on MHC class I molecules by splenic antigen-presenting cells
Liu Tm, Chambers B, Diehl Ad, Van Kaer L, Jondal M, Ljunggren Hg
JOURNAL OF IMMUNOLOGY 1997;159(11):5364-71

Binding of H-2K(b)-specific peptides to TAP and major histocompatibility complex class I in microsomes from wild-type, TAP1, and beta(2)-microglobulin mutant mice
Wang P, Raynoschek C, Svensson K, Ljunggren Hg
JOURNAL OF BIOLOGICAL CHEMISTRY 1996;271(40):24830-5

Chemically induced sarcomas from nude mice are more immunogenic than similar sarcomas from congenic normal mice
Svane Im, Engel Am, Nielsen Mb, Ljunggren Hg, Rygaard J, Werdelin O
EUROPEAN JOURNAL OF IMMUNOLOGY 1996;26(8):1844-50

External glycopeptide binding to MHC class-I in relation to expression of TAP transporters, beta 2-microglobulin and to pH
Abdelmotal Um, Dahmen J, Liu Tm, Ljunggren Hg, Jondal M
IMMUNOLOGY LETTERS 1996;54(1):31-5

MHC class I molecules, their role in presenting peptide antigens, including tumor antigens, to cytotoxic T lymphocytes
Freland S, Chambers Bj, Ljunggren Hg
CANCER JOURNAL 1996;9(6):304-307

Natural killer cells in MTC class I deficient mice
Salcedo M, Ljunggren Hg
MOLECULAR BASIS OF NK CELL RECOGNITION AND FUNCTION 1996;:44-58

Natural resistance against tumors grafted into the brain in association with histocompatibility-class-I-antigen expression
Yamasaki T, Akiyama Y, Fukuda M, Kimura Y, Moritake K, Kikuchi H, et al
INTERNATIONAL JOURNAL OF CANCER 1996;67(3):365-71

Principles of MHC class I-mediated antigen presentation and T cell selection
Ljunggren Hg, Thorpe Cj
HISTOLOGY AND HISTOPATHOLOGY 1996;11(1):267-74

Reactivity and specificity of CD8+ T cells in MHC class 1 deficient mice
Ljunggren Hg, Chambers B, Freland S, Glas R, Sandberg J, Karre K
HUMAN IMMUNOLOGY 1996;47(1-2):P599-P599

Reactivity and specificity of CD8(+) T cells in mice with defects in the MHC class I antigen-presenting pathway
Ljunggren Hg, Glas R, Sandberg Jk, Karre K
IMMUNOLOGICAL REVIEWS 1996;:123-48

TAP1-deficient mice select a CD8(+) T cell repertoire that displays both diversity and peptide specificity
Sandberg Jk, Chambers Bj, Vankaer L, Karre K, Ljunggren Hg
EUROPEAN JOURNAL OF IMMUNOLOGY 1996;26(2):288-93

Triggering of natural killer cells by the costimulatory molecule CD80 (B7-1)
Chambers Bj, Salcedo M, Ljunggren Hg
IMMUNITY 1996;5(4):311-7

Xenograft rejection of porcine islet-like cell clusters in normal and natural killer cell-depleted mice
Karlssonparra A, Ridderstad A, Wallgren Ac, Moller E, Ljunggren Hg, Korsgren O
TRANSPLANTATION 1996;61(9):1313-20

ALTERED MHC CLASS-I PRESENTED PEPTIDE REPERTOIRE IS NOT SUFFICIENT TO INDUCE NK CELL-MEDIATED F-1-HYBRID RESISTANCE
Salcedo M, Hoglund P, Achour A, Thorpe Cj, Ljunggren Hg
MOLECULAR IMMUNOLOGY 1995;32(11):789-94

CHARACTERIZATION OF TAP-INDEPENDENT AND BREFELDIN A-RESISTANT PRESENTATION OF SENDAI VIRUS-ANTIGEN TO CD8(+) CYTOTOXIC T-LYMPHOCYTES
Zhou X, Liu T, Franksson L, Lederer E, Ljunggren Hg, Jondal M
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 1995;42(1):66-75

HEAT-INACTIVATED SENDAI-VIRUS CAN ENTER MULTIPLE MHC CLASS-I PROCESSING PATHWAYS AND GENERATE CYTOTOXIC T-LYMPHOCYTE RESPONSES IN-VIVO
Liu Tm, Zhou Xz, Orvell C, Lederer E, Ljunggren Hg, Jondal M
JOURNAL OF IMMUNOLOGY 1995;154(7):3147-55

INHIBITION OF NATURAL-KILLER CELL-MEDIATED BONE-MARROW GRAFT-REJECTION BY ALLOGENEIC MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I, BUT NOT CLASS-II MOLECULES
Ohlen C, Hoglund P, Sentman Cl, Carbone E, Ljunggren Hg, Koller B, et al
EUROPEAN JOURNAL OF IMMUNOLOGY 1995;25(5):1286-91

NATURAL-KILLER-CELL INTERACTION WITH MURINE ALLOGENEIC MHC CLASS-I MOLECULES
Salcedo M, Hoglund P, Ljunggren Hg
TRANSPLANTATION 1995;60(3):281-6

PEPTIDE INFLUENCES THE FOLDING AND INTRACELLULAR-TRANSPORT OF FREE MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I HEAVY-CHAINS
Machold Rp, Andree S, Vankaer L, Ljunggren Hg, Ploegh Hl
JOURNAL OF EXPERIMENTAL MEDICINE 1995;181(3):1111-22

REJECTION OF TUMORS IN MICE WITH SEVERE COMBINED IMMUNODEFICIENCY SYNDROME DETERMINED BY THE MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-I EXPRESSION ON THE GRAFT
Glas R, Waldenstrom M, Hoglund P, Klein G, Karre K, Ljunggren Hg
CANCER RESEARCH 1995;55(9):1911-6

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