Farasat Zaman
Senior Research Specialist
E-mail: farasat.zaman@ki.se
Visiting address: Bioclinicum J9:30, Akademiska stråket 1, 17164 Solna
Postal address: K6 Kvinnors och barns hälsa, K6 Barnendokrinologi Sävendahl, 171 77 Stockholm
Research
- *Osteoporosis and bone growth failure in chronic paediatric diseases*
The overall aim of these studies is to address unanswered core bone health
questions such as osteoporosis/bone growth failure in the paediatric patients
with chronic diseases and exposed to high dose glucocorticoid therapy. Some
20% of paediatric patients treated with GCs experience multiple peripheral
fractures, bone pain and vertebral compression fractures. We are currently
investigating following disorders in which GCs are frequently used:
* /Inflammation/
* /Acute Lymphoblastic Leukemia (ALL)/
* /Duchenne Muscular Dystrophy (DMD)/
Impaired bone health is often present at diagnosis in these disorders, but
poorly understood Severe osteoporosis is a frequent finding 1-3 years post
diagnosis. Understanding the pathophysiology of disordered bone
health/osteoporosis following glucocorticoids treatement in chronic
conditions such as ALL, inflammation and DMD will lead to development of
better treatment strategies in affected children. We are also investigating
novel molecules/peptides in combination with GCs to prevent osteoporosis and
bone growth failure in infllamtion, ALL and DMD.
Articles
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Article: BONE. 2022;154:116186
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Journal article: SCIENTIFIC REPORTS. 2021;11(1):21507
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Article: MATERIALS SCIENCE AND ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS. 2020;108:110456
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Article: CLINICAL ORTHOPAEDICS AND RELATED RESEARCH. 2020;478(3):668-678
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Article: CLINICAL AND EXPERIMENTAL RHEUMATOLOGY. 2020;38(1):129-135
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Article: FASEB JOURNAL. 2019;33(4):4962-4974
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Article: NATURE MEDICINE. 2014;20(11):1279-1288
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Article: TOXICOLOGY LETTERS. 2014;224(2):196-200
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Article: PLOS ONE. 2012;7(11):e50523
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Article: PLOS ONE. 2012;7(3):e33168
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Article: JOURNAL OF BIOLOGICAL CHEMISTRY. 2010;285(5):3462-3469
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Article: CANCER RESEARCH. 2007;67(20):10078-10086
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Article: ENDOCRINOLOGY. 2007;148(1):128-139
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Article: ENDOCRINOLOGY. 2005;146(3):1391-1397
All other publications
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Review: JOURNAL OF ENDOCRINOLOGY. 2018;236(1):R69-R91
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Letter: LANCET ONCOLOGY. 2016;17(8):e319-e320
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Letter: NEW ENGLAND JOURNAL OF MEDICINE. 2016;374(22):2185
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Review: JOURNAL OF MOLECULAR ENDOCRINOLOGY. 2014;53(1):T35-T44
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Editorial comment: ANNALS OF THE RHEUMATIC DISEASES. 2013;72(10):e24-E25
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Letter: EUROPEAN JOURNAL OF HAEMATOLOGY. 2013;90(6):533-534
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KI thesis / dissertation: 2010
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Letter: LEUKEMIA. 2008;22(4):883-884
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Published paper: INTERNATIONAL JOURNAL OF ANDROLOGY. 2007;30(4):366-376
Employments
- Senior Research Specialist, Department of Women's and Children's Health, Karolinska Institutet, 2021-
Degrees and Education
- Degree Of Doctor Of Philosophy, Department of Women's and Children's Health, Karolinska Institutet, 2010