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Education

  • PostDoc at Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA.
  • Ph.D. Karolinska Institute, Stockholm, Sweden.
  • MSc. Stockholm Research School in Molecular Life Science.
  • MSc. Uppsala University, Uppsala, Sweden.

Research description

We are mainly focusing on the following overarching topics:

1. Metabolic Adaptations to Oncogenes and Tumor Suppressors.
2. Metabolic Signal Transduction.
3. Metabolic Control of Epigenetics.
4. Molecular Regulators of Metabolic Heterogeneity

Research Group ' Cellular Metabolism:

Matilda Eriksson, PhD, Lab Manager

Boxi Zhang, PhD, PostDoc

Andre Lima Quieroz, PhD, PostDoc

Yiwei Ai, research student

Alumni:

Dawn E Comstock, research student, Harvard Medical School.
Dominique Smith, Masters student, Uppsala University.

Wirood Aldjezani, Masters Student, Uppsala University.

 

Select Publications:

1. Zhang B, Zheng A, Hydbring P, Ambroise G, Ouchida AT, Goiny M, Vakifahmetoglu-Norberg, H, Norberg E. PHGDH Defines a metabolic subtype in lung adenocarcinomas with poor prognosis. Cell Reports 2017 Jun 13;19(11):2289-2303.

Selected as 'Issue Highlight' by Cell Reports.

2. Eriksson M, Ambroise G, Ouchida AT, Queiroz AL, Smith D, Gimenez-Cassina A, Iwanicki MP, Muller PA, Norberg E#, Vakifahmetoglu-Norberg H#. The effect of Mutant p53 Proteins on Glycolysis and Mitochondrial Metabolism. 

Mol Cell Biol. 2017 Oct 9. pii: MCB.00328-17. doi: 10.1128/MCB.00328-17.

# Co-senior author.

3. Zhang B, Tornmalm J, Widengren J, Vakifahmetoglu-Norberg H, Norberg E. Characterization of the Role of the Malate Dehydrogenases to Lung Tumor Cell Survival. Journal of Cancer 2017; 8(11):2088-2096. 

4. Norberg E, Stanley IA, Zhou F, Ficarro S, Chapuy B, Chen L, Rodig S, Shipp MA, Marto JA, Danial NN. Differntial Contribution of the Mitochondrial Translation Pathway to the Survival of Diffuse Large B-Cell Lymphoma Subsets. Cell Death Differentiation. 2017 Feb;24(2):251-262 .

5. Vakifahmetoglu-Norberg H, Ouchida A, Norberg E. The role of Mitochondria in Metabolism and Cell Death. Biochem Biophys Res Commun. (2017) Jan 15;482(3):426-431

 

6. Wu R, Galan-Acosta L, Norberg E. Glucose Metabolism Provide Distinct Prosurvival Benefits to Non-Small Cell Lung Carcinomas.
Biochem Biophys Res Commun. 2015 May 8;460(3):572-7
 

7. Stanley I, Ribeiro S, Gimenez-Cassina A, Norberg E, Danial NN. Changing appetites: The adaptive advantages of fuel choice.
Trends in Cell Biology. 2014 Feb;24(2):118-27

8. Caro P#, Kishan AU#, Norberg E#,  Stanley IA, Chapuy B, Ficarro SB, Polak K, Tondera D, Gounarides J, Yin H, Zhou F, Green MR, Chen L, Monti S, Marto JA, Shipp MA, Danial NN. Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma.
Cancer Cell. 2012; 16;22(4):547-60.                              

Selected as 'Issue Highlight' by Cancer Cell.

# Co-First author.

 

Open Positions:

1 Master of Science Project, Profiling of Post translational modifications in tumor cells. (start date 2018.)

Academic honours, awards and prizes

  • Dimitris N Chorafas Prize - for best Ph.D. thesis at the Karolinska Institute 2011.
  • The  Lennart Philipson Award and Grant 2015 - Awarded biannuallly to one researcher at the Karolinska Institute.

 

 

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Presentations