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Research description

Selected publications

Feedback control of AHR signalling regulates intestinal immunity. Schiering C, Wincent E, Metidji A, Iseppon A, Li Y, Potocnik AJ, Omenetti S, Henderson CJ, Wolf CR, Nebert DW, Stockinger B. Nature. 2017 Feb 9;542(7640):242-245.

 

Biological effects of 6-formylindolo[3,2-b]carbazole (FICZ) in vivo are enhanced by loss of CYP1A function in an Ahr2-dependent manner. Wincent E, Kubota A, Timme-Laragy A, Jönsson ME, Hahn ME, Stegeman JJ. Biochem Pharmacol. 2016 Jun 15;110-111:117-29

 

Induction and inhibition of human cytochrome   P4501 by oxygenated polycyclic aromatic hydrocarbons. Wincent E, Le Bihanic F, Dreij K. Toxicol. Res. 2016 Mar 5:788-99

 

Evidence for new light-independent pathways for generation of the endogenous aryl hydrocarbon receptor agonist FICZ. Smirnova A, Wincent E, Vikström Bergander L, Alsberg T, Bergman J, Rannug A, Rannug U. Chem Res Toxicol. 2016 Jan 19;29(1):75-86.

 

Combination effects of AHR agonists and Wnt/β-catenin modulators in zebrafish embryos: Implications for physiological and toxicological AHR functions. Wincent E, Stegeman JJ, Jönsson ME. Toxicol Appl Pharmacol. 2015 Apr 15;284(2):163-79

 

Quercetin, resveratrol, and curcumin are indirect activators of the aryl hydrocarbon receptor (AHR). Mohammadi Bardbori A, Bengtsson J, Rannug U, Rannug A, Wincent E. Chem Res Toxicol. 2012 Sep 17;25(9):1878-84.

 

Inhibition of cytochrome P4501 as a novel mechanism of Ah receptor activation. Wincent E, Bengtsson J, Mohammadi Bardbori A, Alsberg T, Luecke S, Rannug U, Rannug A. Proc Natl Acad Sci U S A. 2012 Mar 20;109(12):4479-84.

 

Cytochrome P450 1A1 gene regulation by UVB involves crosstalk between the aryl hydrocarbon receptor and nuclear factor kappa B. Luecke S, Wincent E, Backlund M. Rannug U, Rannug A. Chem. Biol. Interact. 2010 Mar 30;184(3):466-73.

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