My passion for science and my interest in infection biology and the magic world host-parasite interaction, has taken me from initial projects as an undergrad on Hepatitis C replication and virulence factors in Toxoplasma gondii and Plasmodium falciparum (malaria), through a PhD at Uppsala university on the molecular mechanisms of how the gastrointestinal parasite Giardia establishes infection, to New Zealand and hookworm infections in ruminants and their effect on the immune system of sheep. After a 2-year post doc period in the lab of Professor Judith E. Allen at the University of Edinburgh, I am now starting up my research at the inspiring and welcoming Respiratory Medicine unit, Professor Johan Grunewald research group and Magnus Nord/Intracellular signalling research Team, Karolinska Institutet.
2010. PhD in Microbiology. Uppsala University. Thesis title: Host-Pathogen Responses during Giardia infections. Supervisor: Prof. Staffan G. Svärd, Department of Cell and Molecular Biology.[PMID:16299316]. [PMID:18359106]. [PMID:21074536]. [PMID:21276445].
2003. MSc in Molecular Biology. Södertörn University College.
My reserach focus on pathways to emphysema development and molecular mechanisms of emphysema progression. I have been using a mouse model of acute lung injury, immune activation and wound healing (N. brasiliensis infection) to evaluate non-essential immune mechanisms for emphysema development in this setting.
We are currently continuing to elucidate the molecular pathways of emphysema formation in this specific model, and move towards translational research by comparing our findings with the molecular pattern in emphysematic lung tissue of human chronic obstructive pulmonary disease patients.
Academic honors, awards and prizes
2015. Wenner-Gren Research Fellow (2 year salary including research funding)
2010. Wenner-Gren Postdoctoral Fellow (3 year international postdoc). Application and interview process, 5% success rate.
- 2012-2015. Institute of Immunology and Infection Research, Universtiy of Edinburgh. Professor Judith E. Allen group. Project: The molecular and immunological basis of emphysema development in a rodent hookworm model.
- 2010-2012. AgResearch, Palmerston North, New Zealand. Equivalent of 1 year full time. Project: Immunomodulation of Dendritic Cells by ruminant helminths.
2009. Scholarship. Lennanders stiftelse. 3 months post-doctoral research project funding including living cost scholarship.
Sarah Mwangi, PhD in Bioinformatics from SANB, South Africa, has joined my research project. Sarah will combine large scale RNA-sequencing data with genomics to furhter elucidate emphysema progressive traits in COPD and emphysema models. Welcome Sarah!
Madeleine Sjösten has joined the lab for her Bachelor Thesis project. Madeleine will do a 10-week project on immunohistopathology of damage resolution and emphysema initiation in the N. brasiliensis mouse model. Welcome Madeleine!