My PhD project started in 2013 as a collaboration between Juha Kere and Peter Swoboda groups on Karolinska Institute Doktorand (KID) funding.
In Spring 2014 (3 months), Winter 2015 (2 weeks) and Summer 2016 (2 months), I had the priviledge to perform my research work in Junho Lee group at Seoul National University under STINT Sweden-Korea collaboration grant.
2013 - (expected) 2018
Karolinska Institutet: PhD education
Supervisors: Juha Kere and Peter Swoboda
2011 - 2012
Karolinska Institutet: Honours year/Master-level.
Supervisor: Peter Swoboda
2007 - 2010
Australian National University: Bachelor of Science, Major in Cell and Molecular Biology.
Bachelor project supervisor: Carolyn Behm.
RFX transcription factor (TF) family has a conserved DNA binding domain that recognises a sequence motif called the X-box. The group of Dr Juha Kere specialises in human population genetic studies of complex diseases including dyslexia. Dyslexia candidate genes have been associated with RFXs because they harbour X-box motifs. The group of Dr Peter Swoboda has a long standing experience in C. elegans’ RFX TF known as DAF-19 which is the major regulator of ciliogenesis (in particular, primary cilium as the sensing organelle).
My main project is the characterization of human RFX transcription factor (TF) family by regulatory and target gene analysis. My primary interest is in the role of the RFX TFs in neuronal cilia and in the human brain. I used both computational and molecular biology techniques, and human cell lines and the worm C. elegans as model systems.
List of publication and submmited manuscripts:
Tammimies K, Bieder A, Lauter G, Sugiaman-Trapman D, Torchet R, Hokkanen M-E, Burghoorn J, Castrén E, Kere J, Tapia-Páez I, Swoboda P: Ciliary dyslexia candidate genes DYX1C1 and DCDC2 are regulated by Regulatory Factor (RF) X transcription factors through X-box promoter motifs. The FASEB Journal 2016. [pubmed: 27451412]
Sugiaman-Trapman D, Vitezic M, Jouhihlahti EM, Mathelier A, Lauter G, Sougat M, Daub CO, Kere J, Swoboda P: Characterization of the human RFX transcription factor family by regulatory and target gene analysis. Submitted manuscript.
De Stasio EA, Mueller KP, Bauer RJ, Hurlburt AJ, Bice SA, Scholtz SL, Phirke P, Sugiaman-Trapman D, Stinson LA, Olson HB, Vogel SL, Ek-Vazquez Z, Esemen Y, Korzynski J, Wolfe K, Arbuckle BN, Zhang H, Lombard-Knapp G, Piasecki BP, Swoboda P: An expanded role for the RFX transcription factor DAF-19, with dual functions in ciliated and non-ciliated neurons. Submitted manuscript.