I am a Neuropsychologist and Clinical Psychologist from the University of La Laguna (Spain). I graduated as a PhD in 2012 also at the University of La Laguna (Spain). I have been working at Karolinska Institutet as a postdoc since 2012. I work together with Associate Professor Eric Westman (http://ki.se/en/people/eriwes) and Professor Lars-Olof Wahlund (http://ki.se/people/larwah). Currently I am leading several lines of research and I supervise several PhD students, Master students and Degree students. I also collaborate with other research groups from KI, other centers in Sweden, and other International groups. I am Co-Director of GENIC (Group of Neuropsychological Studies of the Canary Islands, University of La Laguna, Spain).
My main research interest is Normal Aging and neurodegenerative disorders such as Alzheimer’s disease. The main focus is put in cognition and neuroimaging but genetic factors, CSF biomarkers, and clinical and socio-demographic variables are part of my research as well.
Projects available for students (Master, Degree, Guests, etc.):
- “Subjective Cognitive Decline”: You will investigate the clinical value of subjective cognitive complaints in cognitively normal people, and their association with neuroimaging, CSF biomarkers, cognition, and emotion.
- “Brain atrophy and subtypes of Alzheimer’s disease”: You will study brain atrophy by different techniques. You will also study different subtypes of Alzheimer’s disease, looking at prevalence, clinical characterization, and progression over time.
- "Cognitive reserve": You will investigate the fascinating topic of cognitive reserve. We will study the neuroanatomical basis of cognitive reserve but also how this can be used clinically.
Measuring Global Brain Atrophy with the Brain Volume/Cerebrospinal Fluid Index: Normative Values, Cut-Offs and Clinical Associations
NEURODEGENERATIVE DISEASES 2016;16(1-2):77-86
Quantitative validation of a visual rating scale for frontal atrophy: associations with clinical status, APOE e4, CSF biomarkers and cognition
European radiology 2016;26(8):2597-610
Targeted delivery of nerve growth factor to the cholinergic basal forebrain of Alzheimer's disease patients: application of a second-generation encapsulated cell biodelivery device
Alzheimer's research & therapy 2016;8(1):30-
The Effect of Age Correction on Multivariate Classification in Alzheimer's Disease, with a Focus on the Characteristics of Incorrectly and Correctly Classified Subjects
Brain topography 2016;29(2):296-307
Brain changes in Alzheimer's disease patients with implanted encapsulated cells releasing nerve growth factor
Journal of Alzheimer's disease : JAD 2015;43(3):1059-72
Changes in CSF cholinergic biomarkers in response to cell therapy with NGF in patients with Alzheimer's disease
Alzheimer's & dementia : the journal of the Alzheimer's Association 2015;11(11):1316-28
Cognitive decline before the age of 50 can be detected with sensitive cognitive measures
Fund of Information is More Strongly Associated with Neuropsychological Functioning Than Education in Older Spanish Adults
Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists 2015;30(4):310-21
Practical cut-offs for visual rating scales of medial temporal, frontal and posterior atrophy in Alzheimer's disease and mild cognitive impairment
Journal of internal medicine 2015;278(3):277-90
Preclinical Cerebrospinal Fluid and Volumetric Magnetic Resonance Imaging Biomarkers in Swedish Familial Alzheimer's Disease
JOURNAL OF ALZHEIMERS DISEASE 2015;43(4):1393-402
Cognitive decline is mediated by gray matter changes during middle age
Neurobiology of aging 2014;35(5):1086-94
Improving CSF Biomarkers' Performance for Predicting Progression from Mild Cognitive Impairment to Alzheimer's Disease by Considering Different Confounding Factors: A Meta-Analysis
Frontiers in aging neuroscience 2014;6():287-
Meta-review of CSF core biomarkers in Alzheimer's disease: the state-of-the-art after the new revised diagnostic criteria
FRONTIERS IN AGING NEUROSCIENCE 2014;:47-
Multiple sclerosis patients lacking oligoclonal bands in the cerebrospinal fluid have less global and regional brain atrophy
Journal of neuroimmunology 2014;274(1-2):149-54
Evolution of global and local grey matter atrophy on serial MRI scans during the progression from MCI to AD
Current Alzheimer research 2012;9(4):516-24
Low PiB PET retention in presence of pathologic CSF biomarkers in Arctic APP mutation carriers