Christopher Grigsby

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About me

Postdoctoral researcher since 2016 investigating the role of biomaterials in
direct cellular reprogramming for the treatment of neurodegenerative disease.
*Previously*
* PhD in Biomedical Engineering from Duke University [2007-2014]
* BS in Bioengineering from the University of California, Berkeley
[2001-2005]

Articles

Article: ADVANCED HEALTHCARE MATERIALS. 2023;12(27):e2301148

Hybrid Polypyrrole and Polydopamine Nanosheets for Precise Raman/Photoacoustic Imaging and Photothermal Therapy.

Geng H; Lupton EJ; Ma Y; Sun R; Grigsby CL; Brachi G; Li X; Zhou K; Stuckey DJ; Stevens MM
Article: ADVANCED MATERIALS. 2023;35(41):e2300305

Microfibrous Scaffolds Guide Stem Cell Lumenogenesis and Brain Organoid Engineering.

Ritzau-Reid KI; Callens SJP; Xie R; Cihova M; Reumann D; Grigsby CL; Prados-Martin L; Wang R; Moore AC; Armstrong JPK; Knoblich JA; Stevens MM
Article: SMALL. 2022;18(36):e2202303

Polysaccharide-Polyplex Nanofilm Coatings Enhance Nanoneedle-Based Gene Delivery and Transfection Efficiency.

Hachim D; Zhao J; Bhankharia J; Nuñez-Toldra R; Brito L; Seong H; Becce M; Ouyang L; Grigsby CL; Higgins SG; Terracciano CM; Stevens MM
Journal article: CIRCULATION. 2021;144(Suppl_1):a10747

Abstract 10747: Genetic Enhancement of Epicardial Paracrine Signalling for Cardiac Regeneration

Brito L; Mylonaki I; Grigsby CL; Seong H; Higgins SG; Smart N; Noseda M; Rosenthal N; Harding S; Stevens M
Article: BIOMATERIALS SCIENCE. 2021;9(15):5175-5191

Enhanced efficiency of nonviral direct neuronal reprogramming on topographical patterns.

Mattiassi S; Rizwan M; Grigsby CL; Zaw AM; Leong KW; Yim EKF
Article: ADVANCED FUNCTIONAL MATERIALS. 2020;30(42):2003710

An Electroactive Oligo-EDOT Platform for Neural Tissue Engineering.

Ritzau-Reid KI; Spicer CD; Gelmi A; Grigsby CL; Ponder JF; Bemmer V; Creamer A; Vilar R; Serio A; Stevens MM
Article: ACS CENTRAL SCIENCE. 2020;6(5):695-703

Photoswitchable gRNAs for Spatiotemporally Controlled CRISPR-Cas-Based Genomic Regulation.

Moroz-Omori EV; Satyapertiwi D; Ramel M-C; Høgset H; Sunyovszki IK; Liu Z; Wojciechowski JP; Zhang Y; Grigsby CL; Brito L; Bugeon L; Dallman MJ; Stevens MM
Article: ACS NANO. 2020;14(5):5711-5727

Big Is Beautiful: Enhanced saRNA Delivery and Immunogenicity by a Higher Molecular Weight, Bioreducible, Cationic Polymer.

Blakney AK; Zhu Y; McKay PF; Bouton CR; Yeow J; Tang J; Hu K; Samnuan K; Grigsby CL; Shattock RJ; Stevens MM
Article: CELL REPORTS. 2020;31(5):107601

Srebf1 Controls Midbrain Dopaminergic Neurogenesis.

Toledo EM; Yang S; Gyllborg D; van Wijk KE; Sinha I; Varas-Godoy M; Grigsby CL; Lönnerberg P; Islam S; Steffensen KR; Linnarsson S; Arenas E
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2020;117(6):2978-2986

Modeling the transport of nuclear proteins along single skeletal muscle cells.

Taylor-Weiner H; Grigsby CL; Ferreira DMS; Dias JM; Stevens MM; Ruas JL; Teixeira AI
Article: ACS NANO. 2014;8(10):10026-10034

Shape-controlled synthesis of hybrid nanomaterials via three-dimensional hydrodynamic focusing.

Lu M; Yang S; Ho Y-P; Grigsby CL; Leong KW; Huang TJ
Article: ACS NANO. 2014;8(1):332-339

Three-dimensional hydrodynamic focusing method for polyplex synthesis.

Lu M; Ho Y-P; Grigsby CL; Nawaz AA; Leong KW; Huang TJ
Article: SCIENTIFIC REPORTS. 2013;3:3155

Microfluidic preparation of polymer-nucleic acid nanocomplexes improves nonviral gene transfer.

Grigsby CL; Ho Y-P; Lin C; Engbersen JFJ; Leong KW
Article: MOLECULAR THERAPY-NUCLEIC ACIDS. 2012;1(7):e32

Nonviral direct conversion of primary mouse embryonic fibroblasts to neuronal cells.

Adler AF; Grigsby CL; Kulangara K; Wang H; Yasuda R; Leong KW
Article: JOURNAL OF CONTROLLED RELEASE. 2012;160(1):48-56

Comparative study of nanoparticle-mediated transfection in different GI epithelium co-culture models.

Loo Y; Grigsby CL; Yamanaka YJ; Chellappan MK; Jiang X; Mao H-Q; Leong KW
Article: CIRCULATION. 2011;124(17):1838-U159

Cardiomyocyte-specific deletion of the vitamin D receptor gene results in cardiac hypertrophy.

Chen S; Law CS; Grigsby CL; Olsen K; Hong T-T; Zhang Y; Yeghiazarians Y; Gardner DG
Article: NANO LETTERS. 2011;11(5):2178-2182

Tuning physical properties of nanocomplexes through microfluidics-assisted confinement.

Ho Y-P; Grigsby CL; Zhao F; Leong KW
Article: JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY. 2010;122(5):326-332

A role for the cell cycle phosphatase Cdc25a in vitamin D-dependent inhibition of adult rat vascular smooth muscle cell proliferation.

Chen S; Law CS; Grigsby CL; Olsen K; Gardner DG
Article: JOURNAL OF CLINICAL INVESTIGATION. 2009;119(6):1647-1658

Tonicity-dependent induction of Sgk1 expression has a potential role in dehydration-induced natriuresis in rodents.

Chen S; Grigsby CL; Law CS; Ni X; Nekrep N; Olsen K; Humphreys MH; Gardner DG
Article: HYPERTENSION. 2008;52(6):1106-1112

Expression of the vitamin d receptor is increased in the hypertrophic heart.

Chen S; Glenn DJ; Ni W; Grigsby CL; Olsen K; Nishimoto M; Law CS; Gardner DG
Article: KIDNEY INTERNATIONAL. 2007;72(3):300-306

Vitamin D activates type A natriuretic peptide receptor gene transcription in inner medullary collecting duct cells.

Chen S; Olsen K; Grigsby C; Gardner DG
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All other publications

Editorial comment: NATURE MATERIALS. 2022;21(9):989-992

Ascendancy of semi-synthetic biomaterials from design towards democratization.

Speidel AT; Grigsby CL; Stevens MM
Conference publication: TISSUE ENGINEERING PART A. 2022;28:S36-S37

POLYHYDROXYALKANOATES, NATURAL MATERIALS OF BACTERIAL ORIGIN, IDEAL FOR CARDIAC TISSUE ENGINEERING

Roy I; Dubey P; Majid Q; Fricker A; Gregory D; Grigsby C; Stevens MM; Terracciano C; Harding SE
Conference publication: TISSUE ENGINEERING PART A. 2022;28:S37

POLYSACCHARIDE-POLYPLEX ULTRATHIN COATINGS FOR NANONEEDLE-BASED GENE DELIVERY

Hachim D; Zhao J; Bhankharia J; Seong H; Brito L; Grigsby C; Becce M; Stevens M
Conference publication: CIRCULATION. 2021;144

Genetic Enhancement of Epicardial Paracrine Signalling for Cardiac Regeneration

Brito L; Mylonaki I; Grigsby CL; Seong H; Higgins SG; Smart N; Noseda M; Rosenthal N; Harding S; Stevens M
Conference publication: HUMAN GENE THERAPY. 2019;30(2):A9

Epicardial cell transfection with cationic polymeric nanocomplexes

Brito L; Mylonaki I; Moroz E; Grigsby C; Smart N; Rosenthal N; Harding SE; Stevens MM
Review: NANO TODAY. 2016;11(6):778-792

Microfluidic Hydrodynamic Focusing for Synthesis of Nanomaterials.

Lu M; Ozcelik A; Grigsby CL; Zhao Y; Guo F; Leong KW; Huang TJ
Review: NANOMEDICINE. 2012;7(4):565-577

Understanding nonviral nucleic acid delivery with quantum dot-FRET nanosensors.

Grigsby CL; Ho Y-P; Leong KW
Conference publication: CIRCULATION. 2011;124(21)

Induction of Modulatory Calcineurin Inhibitory Protein 1 as a Potential Mechanism Leading to Cardiac Hypertrophy in the Cardiomyocyte-Specific Vitamin D Receptor Gene-Deleted Mouse

Chen S; Law CS; Grigsby CL; Olsen K; Hong T-T; Zhang Y; Yeghiazarians Y; Gardner DG
Review: JOURNAL OF THE ROYAL SOCIETY INTERFACE. 2010;7 Suppl 1(Suppl 1):S67-S82

Balancing protection and release of DNA: tools to address a bottleneck of non-viral gene delivery.

Grigsby CL; Leong KW
Conference publication: HYPERTENSION. 2008;52(4):E47

Vitamin D-dependent suppression of rat aortic smooth muscle cell proliferation through key cell cycle phosphatase Cdc25A

Chen S; Law CS; Grigsby CL; Olsen K; Gardner DG
Review: HYPERTENSION. 2007;49(3):419-426

Molecular biology of the natriuretic peptide system: implications for physiology and hypertension.

Gardner DG; Chen S; Glenn DJ; Grigsby CL
Conference publication: HYPERTENSION. 2006;48(4):E58

NFAT5 mediates osmotic regulation of sgk1 gene transcription

Chen S; Nekrep N; Grigsby C; Olsen K; Gardner DG

Grants

Oral Factor VIII Gene Delivery: A Non-viral Therapy against Hemophilia A

American Heart Association

1 July 2010 - 30 June 2012

Employments

Affiliated to Research, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2023-2024
Researcher, Department of Medical Biochemistry and Biophysics, Karolinska Institutet, 2021-2023

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