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About me

2009- Senior Researcher/Group Leader, Department of Clinical Science and Education, Södersjukhuset, Karolinska Institutet.
In February 2009 I was recruited to Karolinska Institutet to start up a preclinical stroke research group. I am responsible for planning, coordinating and executing work in the area of experimental stroke in diabetes.
 

July 2013- present, Project Coordinator in degree projects in medicine (Läkarprogrammet I medicin, 30hp). Department of Medical Epidemiology and Biostatistics, Karolinska Institutet.
 
October 2013- present, Project Manager, Södersjukhuset, Internal medicine. The work aims at increasing collaborations and supervise PhD students within the unit and at developing translational projects within the cardiovascular diseases research area.

 

Education

2013  Docent in neuroscience, Karolinska Institutet
2011  Course in "Assessment in Higher Education", Karolinska Institutet
2011  Basic Course in Education for University Teachers, Karolinska Institutet
2010  Introductory Doctoral Supervision Course, Karolinska Institutet
2010  Work environment issues and manager responsibilities , Karolinska Institutet
2009  Laboratory Animal Science (FELASA) certificate, Karolinska Institutet
2008  Applied Project Management Courses, Wenell Management AB, Stockholm
2007  Courses in Clinical Trials, Trial Form Support AB, Lund

1998  PhD in Neurobiology, University of Milan, Italy.

1992  University of Milan, Italy, Laurea and M.Sc. Biological Sciences

 

Research description

Stroke, Neurodegeneration and Diabetes

The focus is along two major research lines:

  • The identification of efficacious preclinical therapies for the treatment of stroke.
  • The study of the cellular mechanisms at the basis of the neurological complications of diabetes.

Stroke affects several million people worldwide, of which a substantial proportion of cases present in patients suffering from diabetes. Diabetes is widespread and represents the fourth leading cause of death in the U.S. About 90 % of the medical and social costs associated with diabetes are dominated by care for macrovascular complications such as stroke.

Alzheimer's disease, dementia and cognitive dysfunction are also ove-represnted in diabetes. However, the underlying mechanisms at the basis of this are still largely unknown.

Recent data published by our research group indicate that the activation of  the glucagone-like receptor 1 (GLP-1R) is neuroprotective against stroke in normal and type 2 diabetic rodents.

We have also shown that a rat model of type 2 diabetes presents neuronal loss and neuroinflammation along aging. These results have the potential to help understanding how and when diabetes leads to neurodegeneration.

We also showed that diabetic glucolipotoxicity negatively impacts adult neural stem cells and that neuropeptides Galanin and PACAP can counteract diabetes-induced cell death.

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