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Björn Pasternak

Senior researcher

Visiting address : Eugeniahemmet, T2, Karolinska Universitetssjukhuset, Solna 171 76 Stockholm, Sweden
Postal address : Department of Medicine, Solna (MedS), K2, Group J Askling, Eugeniahemmet, T2, Karolinska Universitetssjukhuset, Solna 171 76 Stockholm, Sweden
Delivery address : Eugeniahemmet, T2, Karolinska Universitetssjukhuset, Solna 171 76 Stockholm, Sweden

Education

2007   MD, Linköping University, Sweden

2008   PhD, Linköping University, Sweden

Research description

Thriving on substantial expertise in large-scale register studies of adverse drug effects, we have the overall objective of using high-quality epidemiology to help inform evidence-based decisions in clinical practice. We are currently launching research programs in pediatric pharmacoepidemiology and the area of expedited assessment of current drug safety concerns. My group’s scope is not limited to one single disease entity or therapeutic area; rather, we are in a constant process of seeking out and addressing emerging drug safety concerns with implications for clinical practice.  

 

I have recently joined Karolinska Institutet following a long period of service at Statens Serum Institut in Copenhagen and am building up a research team. Young academics as well as seasoned researchers looking to pursue research that aims to advance the safe use of medications in clinical practice are welcome to contact us!

 

Team members

 

Our research is funded by

  • Swedish Research Council
  • Swedish Cancer Society
  • Swedish Heart-Lung Foundation
  • Thrasher Research Foundation
  • Novo Nordisk Foundation
  • Nordic Cancer Union
  • Swedish Diabetes Foundation 
  • Strategic Research Area Epidemiology (SfoEpi) at Karolinska Institutet
  • Karolinska Institutet Foundations and Funds
  • Stiftelsen Frimurare Barnhuset
  • Åke Wibergs Stiftelse

 

Selected publications

Scheller NM, Pasternak B, Mølgaard-Nielsen D, Svanström H, Hviid A. Quadrivalent HPV Vaccination and the Risk of Adverse Pregnancy Outcomes. New England Journal of Medicine 2017

 

Molgaard-Nielsen D, Svanstrom H, Melbye M, Hviid A, Pasternak B. Association Between Use of Oral Fluconazole During Pregnancy and Risk of Spontaneous Abortion and Stillbirth. JAMA 2016

 

Scheller NM, Svanstrom H, Pasternak B, Arnheim-dahlstrom L, Sundstrom K, Fink K, et al. Quadrivalent HPV vaccination and risk of multiple sclerosis and other demyelinating diseases of the central nervous system. JAMA 2015

 

Scheller NM, Pasternak B, Svanstrom H, Hviid A. Quadrivalent human papillomavirus vaccine and the risk of venous thromboembolism. JAMA 2014

 

Nyboe Andersen N, Pasternak B, Basit S, Andersson M, Svanstrom H, Caspersen S, et al. Association between tumor necrosis factor-α antagonists and risk of cancer in patients with inflammatory bowel disease. JAMA 2014

 

Feenstra B, Pasternak B, Geller F, Carstensen L, Wang T, Huang F, et al. Common variants associated with general and MMR vaccine-related febrile seizures. Nature genetics 2014

 

Molgaard-Nielsen D, Pasternak B, Hviid A. Use of oral fluconazole during pregnancy and the risk of birth defects. New England Journal of Medicine 2013

 

Hviid A, Melbye M, Pasternak B. Use of selective serotonin reuptake inhibitors during pregnancy and risk of autism. New England Journal of Medicine 2013

 

Svanstrom H, Pasternak B, Hviid A. Use of azithromycin and death from cardiovascular causes. New England Journal of Medicine 2013

 

Pasternak B, Svanstrom H, Melbye M, Hviid A. Association between oral fluoroquinolone use and retinal detachment. JAMA 2013

 

Pasternak B, Svanstrom H, Molgaard-nielsen D, Melbye M, Hviid A. Metoclopramide in pregnancy and risk of major congenital malformations and fetal death. JAMA 2013

 

Pasternak B, Svanstrom H, Hviid A. Ondansetron in pregnancy and risk of adverse fetal outcomes. New England Journal of Medicine 2013

 

Pasternak B, Svanstrom H, Molgaard-nielsen D, Krause Tg, Emborg Hd, Melbye M, et al. Risk of adverse fetal outcomes following administration of a pandemic influenza A(H1N1) vaccine during pregnancy. JAMA 2012

 

Pasternak B, Svanstrom H, Molgaard-nielsen D, Krause Tg, Emborg Hd, Melbye M, et al. Vaccination against pandemic A/H1N1 2009 influenza in pregnancy and risk of fetal death: cohort study in Denmark. BMJ 2012

 

Svanstrom H, Pasternak B, Hviid A. Association of treatment with losartan vs candesartan and mortality among patients with heart failure. JAMA 2012

 

Pasternak B, Hviid A. Use of acyclovir, valacyclovir, and famciclovir in the first trimester of pregnancy and the risk of birth defects. JAMA 2010

 

Pasternak B, Hviid A. Use of proton-pump inhibitors in early pregnancy and the risk of birth defects. New England Journal of Medicine 2010

Publications

Neuraminidase inhibitors during pregnancy and risk of adverse neonatal outcomes and congenital malformations: population based European register study
Graner S, Svensson T, Beau Ab, Damase-michel C, Engeland A, Furu K, et al
BMJ (Clinical research ed.) 2017;356():j629-

Quadrivalent HPV Vaccination and the Risk of Adverse Pregnancy Outcomes
Scheller Nm, Pasternak B, Mølgaard-nielsen D, Svanström H, Hviid A
The New England journal of medicine 2017;376(13):1223-1233

Association Between Use of Oral Fluconazole During Pregnancy and Risk of Spontaneous Abortion and Stillbirth
Mølgaard-nielsen D, Svanström H, Melbye M, Hviid A, Pasternak B
JAMA 2016;315(1):58-67

Maternal use of oral contraceptives and risk of birth defects in Denmark: prospective, nationwide cohort study
Charlton Bm, Mølgaard-nielsen D, Svanström H, Wohlfahrt J, Pasternak B, Melbye M
BMJ (Clinical research ed.) 2016;352():h6712-

Oral fluoroquinolone use and serious arrhythmia: bi-national cohort study
Inghammar M, Svanström H, Melbye M, Pasternak B, Hviid A
BMJ (Clinical research ed.) 2016;352():i843-

Association between tumour necrosis factor-α inhibitors and risk of serious infections in people with inflammatory bowel disease: nationwide Danish cohort study
Nyboe Andersen N, Pasternak B, Friis-møller N, Andersson M, Jess T
BMJ (Clinical research ed.) 2015;350():h2809-

Comparative effectiveness of bisoprolol and metoprolol succinate in patients with heart failure
Pasternak B, Mattsson A, Svanström H, Hviid A
International journal of cardiology 2015;190():4-6

Improving vaccine safety through a better understanding of vaccine adverse events
Pasternak B, Feenstra B, Melbye M, Hviid A
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 2015;60(10):1586-7

Quadrivalent HPV vaccination and risk of multiple sclerosis and other demyelinating diseases of the central nervous system
Scheller Nm, Svanström H, Pasternak B, Arnheim-dahlström L, Sundström K, Fink K, et al
JAMA 2015;313(1):54-61

Risk of Demyelinating Diseases in the Central Nervous System in Patients With Inflammatory Bowel Disease Treated With Tumor Necrosis Factor Inhibitors
Nyboe Andersen N, Pasternak B, Andersson M, Nielsen Nm, Jess T
JAMA internal medicine 2015;175(12):1990-2

The use of valproic acid and multiple sclerosis
Nielsen Nm, Svanström H, Stenager E, Magyari M, Koch-henriksen N, Pasternak B, et al
Pharmacoepidemiology and drug safety 2015;24(3):262-8

Use of different types of angiotensin converting enzyme inhibitors and mortality in systolic heart failure
Svanström H, Pasternak B, Melbye M, Hviid A
International journal of cardiology 2015;182():90-6

Association Between Tumor Necrosis Factor-alpha Antagonists and Risk of Cancer in Patients With Inflammatory Bowel Disease
Andersen Nn, Pasternak B, Basit S, Andersson M, Svanstrom H, Caspersen S, et al
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION 2014;311(23):2406-13

Association of treatment with carvedilol vs metoprolol succinate and mortality in patients with heart failure
Pasternak B, Svanström H, Melbye M, Hviid A
JAMA internal medicine 2014;174(10):1597-604

Atypical antipsychotics olanzapine, quetiapine, and risperidone and risk of acute major cardiovascular events in young and middle-aged adults: a nationwide register-based cohort study in Denmark
Pasternak B, Svanström H, Ranthe Mf, Melbye M, Hviid A
CNS drugs 2014;28(10):963-73

Common variants associated with general and MMR vaccine-related febrile seizures
Feenstra B, Pasternak B, Geller F, Carstensen L, Wang T, Huang F, et al
Nature genetics 2014;46(12):1274-82

Multiple sclerosis and risk of Parkinson's disease: a Danish nationwide cohort study
Nielsen Nm, Pasternak B, Stenager E, Koch-henriksen N, Frisch M
European journal of neurology 2014;21(1):107-11

Quadrivalent human papillomavirus vaccine and the risk of venous thromboembolism
Scheller Nm, Pasternak B, Svanström H, Hviid A
JAMA 2014;312(2):187-8

Risk of congenital malformations among offspring of mothers and fathers with celiac disease: a nationwide cohort study
Zugna D, Richiardi L, Stephansson O, Pasternak B, Ekbom A, Cnattingius S, et al
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 2014;12(7):1108-1116.e6

Use of clarithromycin and roxithromycin and risk of cardiac death: cohort study
Svanström H, Pasternak B, Hviid A
BMJ (Clinical research ed.) 2014;349():g4930-

Use of macrolides in mother and child and risk of infantile hypertrophic pyloric stenosis: nationwide cohort study
Lund M, Pasternak B, Davidsen Rb, Feenstra B, Krogh C, Diaz Lj, et al
BMJ (Clinical research ed.) 2014;348():g1908-

Use of strontium ranelate and risk of acute coronary syndrome: cohort study
Svanström H, Pasternak B, Hviid A
Annals of the rheumatic diseases 2014;73(6):1037-43

Association between oral fluoroquinolone use and retinal detachment
Pasternak B, Svanström H, Melbye M, Hviid A
JAMA 2013;310(20):2184-90

Autoimmune, neurological, and venous thromboembolic adverse events after immunisation of adolescent girls with quadrivalent human papillomavirus vaccine in Denmark and Sweden: cohort study
Arnheim-dahlström L, Pasternak B, Svanström H, Sparén P, Hviid A
BMJ (Clinical research ed.) 2013;347():f5906-

Metoclopramide in pregnancy and risk of major congenital malformations and fetal death
Pasternak B, Svanström H, Mølgaard-nielsen D, Melbye M, Hviid A
JAMA 2013;310(15):1601-11

Ondansetron in pregnancy and risk of adverse fetal outcomes
Pasternak B, Svanström H, Hviid A
The New England journal of medicine 2013;368(9):814-23

The short- and long-term risk of stroke after herpes zoster - a nationwide population-based cohort study
Sreenivasan N, Basit S, Wohlfahrt J, Pasternak B, Munch Tn, Nielsen Lp, et al
PloS one 2013;8(7):e69156-

Use of azathioprine and the risk of cancer in inflammatory bowel disease
Pasternak B, Svanström H, Schmiegelow K, Jess T, Hviid A
American journal of epidemiology 2013;177(11):1296-305

Use of azithromycin and death from cardiovascular causes
Svanström H, Pasternak B, Hviid A
The New England journal of medicine 2013;368(18):1704-12

Use of oral fluconazole during pregnancy and the risk of birth defects
Mølgaard-nielsen D, Pasternak B, Hviid A
The New England journal of medicine 2013;369(9):830-9

Use of selective serotonin reuptake inhibitors during pregnancy and risk of autism
Hviid A, Melbye M, Pasternak B
The New England journal of medicine 2013;369(25):2406-15

Use of varenicline versus bupropion and risk of psychiatric adverse events
Pasternak B, Svanström H, Hviid A
Addiction (Abingdon, England) 2013;108(7):1336-43

Association of treatment with losartan vs candesartan and mortality among patients with heart failure
Svanström H, Pasternak B, Hviid A
JAMA 2012;307(14):1506-12

Risk of adverse fetal outcomes following administration of a pandemic influenza A(H1N1) vaccine during pregnancy
Pasternak B, Svanström H, Mølgaard-nielsen D, Krause Tg, Emborg Hd, Melbye M, et al
JAMA 2012;308(2):165-74

Use of amiloride and multiple sclerosis: registry-based cohort studies
Pasternak B, Svanström H, Nielsen Nm, Melbye M, Hviid A
Pharmacoepidemiology and drug safety 2012;21(8):890-5

Use of calcium channel blockers and Parkinson's disease
Pasternak B, Svanström H, Nielsen Nm, Fugger L, Melbye M, Hviid A
American journal of epidemiology 2012;175(7):627-35

Use of varenicline for smoking cessation and risk of serious cardiovascular events: nationwide cohort study
Svanström H, Pasternak B, Hviid A
BMJ (Clinical research ed.) 2012;345():e7176-

Vaccination against pandemic A/H1N1 2009 influenza in pregnancy and risk of fetal death: cohort study in Denmark
Pasternak B, Svanström H, Mølgaard-nielsen D, Krause Tg, Emborg Hd, Melbye M, et al
BMJ (Clinical research ed.) 2012;344():e2794-

Atovaquone-proguanil use in early pregnancy and the risk of birth defects
Pasternak B, Hviid A
Archives of internal medicine 2011;171(3):259-60

Use of Angiotensin Receptor Blockers and the Risk of Cancer
Pasternak B, Svanstrom H, Callreus T, Melbye M, Hviid A
CIRCULATION 2011;123(16):1729-36

Elevated intraperitoneal matrix metalloproteinases-8 and -9 in patients who develop anastomotic leakage after rectal cancer surgery: a pilot study
Pasternak B, Matthiessen P, Jansson K, Andersson M, Aspenberg P
Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland 2010;12(7 Online):e93-8

Elevation of systemic matrix metalloproteinases 2 and 7 and tissue inhibitor of metalloproteinase 2 in patients with a history of Achilles tendon rupture: pilot study
Pasternak B, Schepull T, Eliasson P, Aspenberg P
British journal of sports medicine 2010;44(9):669-72

Use of acyclovir, valacyclovir, and famciclovir in the first trimester of pregnancy and the risk of birth defects
Pasternak B, Hviid A
JAMA 2010;304(8):859-66

Use of proton-pump inhibitors in early pregnancy and the risk of birth defects
Pasternak B, Hviid A
The New England journal of medicine 2010;363(22):2114-23

Metalloproteinases and their inhibitors-diagnostic and therapeutic opportunities in orthopedics
Pasternak B, Aspenberg P
Acta orthopaedica 2009;80(6):693-703

Doxycycline-coated sutures improve mechanical strength of intestinal anastomoses
Pasternak B, Rehn M, Andersen L, Agren Ms, Heegaard Am, Tengvall P, et al
International journal of colorectal disease 2008;23(3):271-6

Doxycycline-coated sutures improve the suture-holding capacity of the rat Achilles tendon
Pasternak B, Missios A, Askendal A, Tengvall P, Aspenberg P
Acta orthopaedica 2007;78(5):680-6

Unloaded rat Achilles tendons continue to grow, but lose viscoelasticity
Eliasson P, Fahlgren A, Pasternak B, Aspenberg P
Journal of applied physiology (Bethesda, Md. : 1985) 2007;103(2):459-63

Doxycycline impairs tendon repair in rats
Pasternak B, Fellenius M, Aspenberg P
Acta orthopaedica Belgica 2006;72(6):756-60

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