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Beston Nore

Senior researcher

Visiting address : Molekylär Cell Genetik och Genterapiforskning (MCG); Novum, plan 5, hiss F, Lab 514; Hälsovägen 7-9, 14157 Huddinge, Sweden
Postal address : Department of Laboratory Medicine (LABMED), H5, Clinical research center, Molekylär Cell Genetik och Genterapiforskning (MCG); Novum, plan 5, hiss F, Lab 514; Hälsovägen 7-9, 14157 Huddinge, Sweden
Delivery address : KFC, MCG, Novum plan 5, Lab 514; Karolinska Universitetssjukhuset Huddinge; Vårdarvägen 1, 14152 Huddinge, Sweden

Research description

Research area/interest: Identification of Btk interactions and networks using proteomic and peptide screening techniques.

Publications

Btk29A promotes Wnt4 signaling in the niche to terminate germ cell proliferation in Drosophila
Hamada-kawaguchi N, Nore Bf, Kuwada Y, Smith Ci, Yamamoto D
Science (New York, N.Y.) 2014;343(6168):294-7

Glutathione transferase mu 2 protects glioblastoma cells against aminochrome toxicity by preventing autophagy and lysosome dysfunction
Huenchuguala S, Muñoz P, Zavala P, Villa M, Cuevas C, Ahumada U, et al
Autophagy 2014;10(4):618-30

Longitudinal plication--a surgical strategy for complete rectal prolapse management
Qaradaghy Sh, Hawramy Ta, Nore Bf, Abdullah Kh, Muhammad Ra, Zangana Mo, et al
BMC surgery 2014;14():17-

A novel missense mutation in the CLCN7 gene linked to benign autosomal dominant osteopetrosis: a case series
Rashid Bm, Rashid Ng, Schulz A, Lahr G, Nore Bf
Journal of medical case reports 2013;7():7-

Dual phosphorylation of Btk by Akt/protein kinase b provides docking for 14-3-3ζ, regulates shuttling, and attenuates both tonic and induced signaling in B cells
Mohammad Dk, Nore Bf, Hussain A, Gustafsson Mo, Mohamed Aj, Smith Ci
Molecular and cellular biology 2013;33(16):3214-26

Inhibitors of BTK and ITK: state of the new drugs for cancer, autoimmunity and inflammatory diseases
Vargas L, Hamasy A, Nore Bf, Smith Ci
Scandinavian journal of immunology 2013;78(2):130-9

Signaling of the ITK (interleukin 2-inducible T cell kinase)-SYK (spleen tyrosine kinase) fusion kinase is dependent on adapter SLP-76 and on the adapter function of the kinases SYK and ZAP70
Hussain A, Mohammad Dk, Gustafsson Mo, Uslu M, Hamasy A, Nore Bf, et al
The Journal of biological chemistry 2013;288(10):7338-50

Precursor T-cell acute lymphoblastic leukemia presenting with bone marrow necrosis: a case report
Khoshnaw Ns, Al-rawi Ha, Nore Bf
Journal of medical case reports 2012;6():349-

Regulation of nucleocytoplasmic shuttling of Bruton's tyrosine kinase (Btk) through a novel SH3-dependent interaction with ankyrin repeat domain 54 (ANKRD54)
Gustafsson Mo, Hussain A, Mohammad Dk, Mohamed Aj, Nguyen V, Metalnikov P, et al
Molecular and cellular biology 2012;32(13):2440-53

Sporadic incidence of Fascioliasis detected during hepatobiliary procedures: a study of 18 patients from Sulaimaniyah governorate
Hawramy Ta, Saeed Ka, Qaradaghy Sh, Karboli Ta, Nore Bf, Bayati Nh
BMC research notes 2012;5():691-

Stable Expression of Short Interfering RNA for DT-Diaphorase Induces Neurotoxicity
Lozano J, Munoz P, Nore Bf, Ledoux S, Segura-aguilar J
CHEMICAL RESEARCH IN TOXICOLOGY 2010;23(9):1492-6

Bruton's tyrosine kinase (Btk): function, regulation, and transformation with special emphasis on the PH domain
Mohamed Aj, Yu L, Backesjo Cm, Vargas L, Faryal R, Aints A, et al
IMMUNOLOGICAL REVIEWS 2009;:58-73

Phosphatidylinositol-3-kinase-dependent phosphorylation of SLP-76 by the lymphoma-associated ITK-SYK fusion-protein
Hussain A, Faryal R, Nore Bf, Mohamed Aj, Smith Cie
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2009;390(3):892-6

Phylogeny of Tec Family Kinases: Identification of a Premetazoan Origin of Btk, Bmx, Itk, Tec, Txk, and the Btk Regulator SH3BP5
Ortutay C, Nore Bf, Vihinen M, Smith Cie
ADVANCES IN GENETICS, VOL 64 2008;:51-80

Bruton's tyrosine kinase: cell biology, sequence conservation, mutation spectrum, siRNA modifications, and expression profiling
Lindvall Jm, Blomberg Kem, Valiaho J, Vargas L, Heinonen Je, Berglof A, et al
IMMUNOLOGICAL REVIEWS 2005;:200-15

Inducible H1 promoter-driven lentiviral siRNA expression by stuffer reporter deletion
Heinonen Je, Mohamed Aj, Nore Bf, Smith Cie
OLIGONUCLEOTIDES 2005;15(2):139-44

Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases
Nore Bf, Mattsson Pt, Antonsson P, Backesjo Cm, Westlund A, Lennartsson J, et al
BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS 2003;1645(2):123-32

Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx
Vargas L, Nore Bf, Berglof A, Heinonen Je, Mattsson Pt, Smith Cie, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2002;277(11):9351-7

Silencing of Bruton's tyrosine kinase (Btk) using short interfering RNA duplexes (siRNA)
Heinonen Je, Smith Cie, Nore Bf
FEBS LETTERS 2002;527(1-3):274-8

The Tec family of cytoplasmic tyrosine kinases: mammalian Btk, Bmx, Itk, Tec, Txk and homologs in other species
Smith Cie, Islam Tc, Mattsson Pt, Mohamed Aj, Nore Bf, Vihinen M
BIOESSAYS 2001;23(5):436-46

Nucleocytoplasmic shuttling of Bruton's tyrosine kinase
Mohamed Aj, Vargas L, Nore Bf, Backesjo Cm, Christenssonn B, Smith Cie
JOURNAL OF BIOLOGICAL CHEMISTRY 2000;275(51):40614-9

Redistribution of Bruton's tyrosine kinase by activation of phosphatidylinositol 3-kinase and Rho-family GTPases
Nore Bf, Vargas L, Mohamed Aj, Branden Lj, Backesjo Cm, Islam Tc, et al
EUROPEAN JOURNAL OF IMMUNOLOGY 2000;30(1):145-54

Signalling of Bruton's tyrosine kinase, Btk
Mohamed Aj, Nore Bf, Christensson B, Smith Cie
SCANDINAVIAN JOURNAL OF IMMUNOLOGY 1999;49(2):113-8

Mutation screening of the BTK gene in 56 families with X-linked agammaglobulinemia (XLA): 47 unique mutations without correlation to clinical course
Holinski-feder E, Weiss M, Brandau O, Jedele Kb, Nore B, Backesjo Cm, et al
PEDIATRICS 1998;101(2):276-84

XLA - Studies on the Btk tyrosine kinase
Smaith Cie, Backesjo Cm, Branden Lj, Islam T, Mattsson Pt, Mohamed Aj, et al
MOLECULAR IMMUNOLOGY 1998;35(11-12):669-670

X-linked agammaglobulinemia: lack of mature B lineage cells caused by mutations in the Btk kinase
Smith Cie, Backesjo Cm, Berglof A, Branden Lj, Islam T, Mattsson Pt, et al
SPRINGER SEMINARS IN IMMUNOPATHOLOGY 1998;19(4):369-81

Missense mutations affecting a conserved cysteine pair in the TH domain of Btk
Vihinen M, Nore Bf, Mattsson Pt, Backesjo Cm, Nars M, Koutaniemi S, et al
FEBS LETTERS 1997;413(2):205-10

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