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Barbara Leibiger

Senior researcher

Publications

Non-invasive cell type selective in vivo monitoring of insulin resistance dynamics
Paschen M, Moede T, Leibiger B, Jacob S, Bryzgalova G, Leibiger Ib, et al
Scientific reports 2016;6():21448-

Apolipoprotein CIII links islet insulin resistance to β-cell failure in diabetes
Åvall K, Ali Y, Leibiger Ib, Leibiger B, Moede T, Paschen M, et al
Proceedings of the National Academy of Sciences of the United States of America 2015;112(20):E2611-9

Outer Hair Cell Lateral Wall Structure Constrains the Mobility of Plasma Membrane Proteins
Yamashita T, Hakizimana P, Wu S, Hassan A, Jacob S, Temirov J, et al
PLoS genetics 2015;11(9):e1005500-

PI3K-C2α Knockdown Results in Rerouting of Insulin Signaling and Pancreatic Beta Cell Proliferation
Leibiger B, Moede T, Paschen M, Yunn No, Lim Jh, Ryu Sh, et al
Cell reports 2015;13(1):15-22

Adipsin is an adipokine that improves β cell function in diabetes
Lo Jc, Ljubicic S, Leibiger B, Kern M, Leibiger Ib, Moede T, et al
Cell 2014;158(1):41-53

Ciliary dysfunction impairs beta-cell insulin secretion and promotes development of type 2 diabetes in rodents
Gerdes Jm, Christou-savina S, Xiong Y, Moede T, Moruzzi N, Karlsson-edlund P, et al
Nature communications 2014;5():5308-

Glucagon regulates its own synthesis by autocrine signaling
Leibiger B, Moede T, Muhandiramlage Tp, Kaiser D, Vaca Sanchez P, Leibiger Ib, et al
Proceedings of the National Academy of Sciences of the United States of America 2012;109(51):20925-30

One-step purification of functional human and rat pancreatic alpha cells
Kohler M, Dare E, Ali My, Rajasekaran Ss, Moede T, Leibiger B, et al
INTEGRATIVE BIOLOGY 2012;4(2):209-19

Glucagon stimulates glucagon gene transcription in mouse and human islets by an autocrine feedback loop
Moede T, Leibiger Ib, Vaca-sanchez P, Berggren Po, Leibiger B
DIABETOLOGIA 2010;:S214-S215

Insulin-feedback via PI3K-C2 alpha activated PKB alpha/Akt1 is required for glucose-stimulated insulin secretion
Leibiger B, Moede T, Uhles S, Barker Cj, Creveaux M, Domin J, et al
FASEB JOURNAL 2010;24(6):1824-37

Knock-down of PI3K-C2 alpha leads to increased proliferation of pancreatic beta cells
Leibiger B, Moede T, Berggren Po, Leibiger Ib
DIABETOLOGIA 2010;:S219-S219

CREB3L2-PPAR gamma fusion mutation identifies a thyroid signaling pathway regulated by intramembrane proteolysis
Lui Wo, Zeng L, Rehmann V, Deshpande S, Tretiakova M, Kaplan El, et al
CANCER RESEARCH 2008;68(17):7156-64

Insulin signaling in the pancreatic beta-cell
Leibiger Ib, Leibiger B, Berggren Po
ANNUAL REVIEW OF NUTRITION 2008;:233-51

Noninvasive in vivo imaging of pancreatic islet cell biology
Speier S, Nyqvist D, Cabrera O, Yu J, Molano Rd, Pileggi A, et al
NATURE MEDICINE 2008;14(5):574-8

Arachidonic acid signaling is of imidazoline-induced K-ATP involved in the mechanism channel-independent stimulation of insulin secretion
Sharoyko Vv, Zaitseva Ii, Leibiger B, Efendic S, Berggren Po, Zaitsev Sv
CELLULAR AND MOLECULAR LIFE SCIENCES 2007;64(22):2985-93

Glucose-dependent short-term regulation of glucagon gene transcription in pancreatic alpha-cells
Moede T, Leibiger Ib, Kaiser D, Berggren Po, Leibiger B
DIABETOLOGIA 2007;:S203-S204

Requirement of inositol pyrophosphates for full exocytotic capacity in pancreatic beta cells
Illies C, Gromada J, Fiume R, Leibiger B, Yu J, Juhl K, et al
SCIENCE 2007;318(5854):1299-302

Selective gene activation by spatial segregation of insulin receptor B signaling
Uhles S, Moede T, Leibiger B, Berggren Po, Leibiger Ib
FASEB JOURNAL 2007;21(7):1609-21

Selective insulin signaling in pancreatic beta cells involves different classes of PI3 kinases
Leibiger B, Uhles S, Moede T, Domin J, Berggren Po, Leibiger Ib
DIABETOLOGIA 2007;:S217-S217

Single residue (K332A) substitution in Kir6.2 abolishes the stimulatory effect of long-chain acyl-CoA esters: indications for a long-chain acyl-CoA ester binding motif
Branstrom R, Leibiger Ib, Leibiger B, Klement G, Nilsson J, Arhem P, et al
DIABETOLOGIA 2007;50(8):1670-7

Insulin-stimulated c-fos gene transcription in pancreatic beta cells requires clathrin-dependent endocytosis of IR-B and signaling from early endosomes
Leibiger B, Moede T, Uhles S, Berggren Po, Leibiger Ib
DIABETOLOGIA 2006;:295-296

Loss of parafibromin expression in a subset of parathyroid adenomas
Juhlin C, Larsson C, Yakoleva T, Leibiger I, Leibiger B, Alimov A, et al
ENDOCRINE-RELATED CANCER 2006;13(2):509-23

A CREB3L2-PPARG fusion oncoprotein with unique activities in thyroid cancer
Lui W, Deshpande S, Michalewicz P, Leibiger I, Leibiger B, Thoppe S, et al
MODERN PATHOLOGY 2005;:93A-93A

A CREB3L2-PPARG fusion oncoprotein with unique activities in thyroid cancer
Lui W, Deshpande S, Michalewicz P, Leibiger I, Leibiger B, Thoppe S, et al
LABORATORY INVESTIGATION 2005;:93A-93A

Molecular mechanisms underlying the effect of all-trans retinoic acid on glucokinase gene transcription in insulin-producing cells
Leibiger B, Moede T, Yu M, Leibiger Ib, Berggren Po
DIABETOLOGIA 2005;:A156-A156

Monomeric G-protein, Rhes, is not an imidazoline-regulated protein in pancreatic beta-cells
Sharoyko Vv, Zaitseva Ii, Varsanyi M, Portwood N, Leibiger B, Leibiger I, et al
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2005;338(3):1455-9

Spatial segregation of insulin receptor B-type signaling allows selective and simultaneous activation of glucokinase and c-fos gene transcription
Uhles S, Moede T, Leibiger B, Berggren Po, Leibiger Ib
DIABETOLOGIA 2005;:A156-A157

The impact of alpha- to beta-cell ratio on in vitro and in vivo beta-cell function
Moede T, Nyqvist D, Kohler M, Leibiger B, Leibiger I, Berggren Po
DIABETOLOGIA 2005;:A159-A159

Insulin-regulated gene expression in pancreatic beta cells analyzed by oligonucleotide microaarray technique
Leibiger B, Berggren Po, Leibiger Ib
DIABETOLOGIA 2004;:A162-A162

Insulin-stimulated c-fos gene transcription in INS1 cells requires signaling via the C-terminal YTHM-motif of insulin receptor B-type, PI3 kinase class Ia and ERK1/2
Uhles S, Moede T, Leibiger B, Berggren Po, Leibiger Ib
DIABETOLOGIA 2004;:A162-A163

Removal of Ca2+ channel beta(3) Subunit enhances Ca2+ oscillation frequency and insulin exocytosis
Berggren Po, Yang Sn, Murakami M, Efanov Am, Uhles S, Kohler M, et al
CELL 2004;119(2):273-84

Cytosolic multiple inositol polyphosphate phosphatase in the regulation of cytoplasmic free Ca2+ concentration
Yu J, Leibiger B, Yang Sn, Caffery Jj, Shears Sb, Leibiger Ib, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2003;278(47):46210-8

Isoform-specific insulin receptor signaling involves different plasma membrane domains
Uhles S, Moede T, Leibiger B, Berggren Po, Leibiger Ib
JOURNAL OF CELL BIOLOGY 2003;163(6):1327-37

On-line monitoring of apoptosis in insulin-secreting cells
Kohler M, Zaitsev Sv, Zaitseva Ii, Leibiger B, Leibiger Ib, Turunen M, et al
DIABETES 2003;52(12):2943-50

Rapid association of protein kinase C-epsilon with insulin granules is essential for insulin exocytosis
Mendez Cf, Leibiger Ib, Leibiger B, Hoy M, Gromada J, Berggren Po, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2003;278(45):44753-7

Selective signaling via A- and B-type insulin receptors in insulin-producing cells involves different membrane microdomains
Uhles S, Moede T, Leibiger B, Berggren Po, Leibiger Ib
DIABETOLOGIA 2003;:A165-A165

A novel transcription factor, FTCF, is fused to PPAR in follicular thyroid carcinoma.
Lui Wo, Kroll Tg, Leibiger I, Liden J, Leibiger B, Thoppe S, et al
AMERICAN JOURNAL OF HUMAN GENETICS 2002;71(4):246-246

Characterization of a putative murine mitochondrial transporter homology of hMRS3/4
Li Fy, Leibiger B, Leibiger I, Larsson C
MAMMALIAN GENOME 2002;13(1):20-3

Inositol hexakisphosphate promotes dynamin mediated endocytosis
Hoy M, Efanov Am, Bertorello Am, Zaitsev Sv, Olsen Hl, Bokvist K, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2002;99(10):6773-7

Insulin feedback action on pancreatic beta-cell function
Leibiger Ib, Leibiger B, Berggren Po
FEBS LETTERS 2002;532(1-2):1-6

Online monitoring of apoptosis in living pancreatic beta-cells
Zaitsev Sv, Kohler M, Loiko Ii, Leibiger B, Leibiger I, Appelskog I, et al
DIABETOLOGIA 2002;:A149-A149

Phosphorylated inositol compounds in beta-cell stimulus-response coupling
Barker Cj, Leibiger Ib, Leibiger B, Berggren Po
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM 2002;283(6):E1113-22

Relevance of dopamine signals anchoring dynamin-2 to the plasma membrane during Na+,K+-ATPase endocytosis
Efendiev R, Yudowski Ga, Zwiller J, Leibiger B, Katz Ai, Berggren Po, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2002;277(46):44108-14

Short-term regulation of insulin gene transcription
Leibiger B, Moede T, Uhles S, Berggren Po, Leibiger Ib
BIOCHEMICAL SOCIETY TRANSACTIONS 2002;:312-7

Tyrosine 537 within the Na+,K+-ATPase alpha-subunit is essential for AP-2 binding and clathrin-dependent endocytosis
Done Sc, Leibiger Ib, Efendiev R, Katz Ai, Leibiger B, Berggren Po, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2002;277(19):17108-11

Characterization of a novel human putative mitochondrial transporter homologous to the yeast mitochondrial RNA splicing proteins 3 and 4
Li Fy, Nikali K, Gregan J, Leibiger I, Leibiger B, Schweyen R, et al
FEBS LETTERS 2001;494(1-2):79-84

Molecular cloning of a novel putative murine mitochondrial transporter.
Li Fy, Leibiger B, Leibiger I, Larsson C
AMERICAN JOURNAL OF HUMAN GENETICS 2001;69(4):357-357

Online monitoring of stimulus-induced gene expression in pancreatic beta-cells
Moede T, Leibiger B, Berggren Po, Leibiger Ib
DIABETES 2001;:S15-9

Regulation of glucokinase gene expression in pancreatic B-cells by retinoic acid and vitamin D3
Moede T, Leibiger I, Berggren Po, Leibiger B
DIABETOLOGIA 2001;:A121-A121

Selective insulin signaling through A and B insulin receptors regulates transcription of insulin and glucokinase genes in pancreatic beta cells
Leibiger B, Leibiger Ib, Moede T, Kemper S, Kulkarni Rn, Kahn Cr, et al
MOLECULAR CELL 2001;7(3):559-70

Selective signaling via A- and B-type insulin receptors in pancreatic B-cells involves different PI3K
Kemper S, Leibiger B, Moede T, Domin J, Berggren Po, Leibiger Ib
DIABETOLOGIA 2001;:A130-A130

Glucose-stimulated insulin biosynthesis depends on insulin-stimulated insulin gene transcription
Leibiger B, Wahlander K, Berggren Po, Leibiger Ib
JOURNAL OF BIOLOGICAL CHEMISTRY 2000;275(39):30153-6

Identification of a nuclear localization signal, RRMKWKK, in the homeodomain transcription factor PDX-1
Moede T, Leibiger B, Pour Hg, Berggren Po, Leibiger Ib
FEBS LETTERS 1999;461(3):229-34

Syntaxin 1 interacts with the L-D subtype of voltage-gated Ca2+ channels in pancreatic beta cells
Yang Sn, Larsson O, Branstrom R, Bertorello Am, Leibiger B, Leibiger Ib, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1999;96(18):10164-9

Cysteine string protein (CSP) is an insulin secretory granule-associated protein regulating beta-cell exocytosis
Brown H, Larsson O, Branstrom R, Yang Sn, Leibiger B, Leibiger I, et al
EMBO JOURNAL 1998;17(17):5048-58

Exocytosis of insulin promotes insulin gene transcription via the insulin receptor PI-3 kinase p70 s6 kinase and CaM kinase pathways
Leibiger Ib, Leibiger B, Moede T, Berggren Po
MOLECULAR CELL 1998;1(6):933-8

In situ activation of the type 2 ryanodine receptor in pancreatic beta cells requires cAMP-dependent phosphorylation
Islam Ms, Leibiger I, Leibiger B, Rossi D, Sorrentino V, Ekstrom Tj, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1998;95(11):6145-50

Long chain coenzyme A esters activate the pore-forming subunit (Kir6.2) of the ATP-regulated potassium channel
Branstrom R, Leibiger Ib, Leibiger B, Corkey Be, Berggren Po, Larsson O
JOURNAL OF BIOLOGICAL CHEMISTRY 1998;273(47):31395-400

Mapping of the human Ca2+ channel beta(4) subunit to 2q22-23 and its expression in developing mouse
Betz R, Leibiger B, Farnebo F, Lagercrantz S, Piehl F, Leibiger I, et al
MAMMALIAN GENOME 1998;9(4):310-1

Mechanisms underlying the short-term control of insulin gene transcription
Leibiger Ib, Leibiger B, Moede T, Berggren Po
DIABETOLOGIA 1998;:A130-A130

Secreted insulin stimulates glucokinase gene transcription in pancreatic beta-cells
Leibiger B, Moede T, Leibiger Ib, Berggren Po
DIABETOLOGIA 1998;:A145-A145

Short-term regulation of insulin gene transcription by glucose
Leibiger B, Moede T, Schwarz T, Brown Gr, Kohler M, Leibiger Ib, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 1998;95(16):9307-12

Characterization of the distal region of the beta-cell promoter of the rat glucokinase gene
Moede T, Leibiger Ib, Berggren Po, Leibiger B
DIABETOLOGIA 1997;:159-159

Cis-elements involved in transcriptional control of the rat glucokinase gene by vitamin D-3, retinoic acid and thyroid hormone T-3 in hit M2.22 cells
Leibiger B, Leibiger Ib
DIABETOLOGIA 1996;:421-421

Dual function of the intron of the rat insulin I gene in regulation of gene expression
Damert A, Leibiger B, Leibiger Ib
DIABETOLOGIA 1996;39(10):1165-72

Expression of ryanodine receptor genes in islets and effects of ryanodine receptor-agonists on cytoplasmic free Ca2+ concentration beta-cells
Islam Ms, Leibiger I, Leibiger B, Jacobsson G, Rossi D, Lucwebb D, et al
DIABETOLOGIA 1996;:180-180

Identification of transcription products in mouse pancreatic B-cells depending on transcription factor IPF-1
Leibiger Ib, Witt A, Leibiger B
DIABETOLOGIA 1996;:406-406

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