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About me

I am a PhD student passionate about pharmacology and the complexity of the brain. Following the completion of my university studies in pharmacy at Uppsala University, I gained further experience in Alzheimer´s disease (AD) research at Novum Science Park. I appreciated the challenges of research and new discoveries in drug treatment for AD. In order to pursue my strong interest at the basic science level, I worked as a research assistant for one year. This experience ultimately inspired me to become a doctoral student at the Division of Clinical Geriatrics/ Division of Translational Alzheimer Neurobiology at Karolinska Institutet, a research laboratory internationally known for leading-edge research on AD.

Education

2012 Master of Science in Pharmacy, Uppsala University

Research description

My project; To characterize and evaluate the feasibility of ChAT and the ratio of AChE/BChE as early and longitudinal therapeutic biomarkers of AD drug therapies targeting the cholinergic system.

We have recently proved that choline acetyltransferase (ChAT) is present in both plasma and cerebrospinal fluid (CSF) and we have also invented a unique, simple, non-radioactive and highly sensitive fluorometric/colorimetric assay of ChAT activity together with a sensitive ELISA assay for determining ChAT protein levels. This assay will be a useful tool to investigate short- and long-term effects of drugs aimed at the central cholinergic system.

Academic honours, awards and prizes

http://www.sverigesfarmaceuter.se/Aktuellt_och_press/Nyhetsarkiv/Nyheter-2013/Oktober/Azadeh-Karami-far-forskningsanslag-fran-Odd-Fellow/

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