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Azadeh Karami

Graduate Student

Visiting address : Novum Pl 5, Hälsovägen 7/Blickagången 6 141 57 Huddinge, Sweden
Postal address : Department of Neurobiology, Care Sciences and Society (NVS), H1, Division of Clinical geriatrics, Novum Pl 5, Blickagången 6/Hälsovägen 7 14157 Huddinge, Sweden
Delivery address : Novum Pl 5, Hiss G, Hälsovägen 7/Blickagången 6 141 57 Huddinge, Sweden

About me

I am a PhD student passionate about pharmacology and the complexity of the brain. Following the completion of my university studies in pharmacy at Uppsala University, I gained further experience in Alzheimer´s disease (AD) research at Novum Science Park. I appreciated the challenges of research and new discoveries in drug treatment for AD. In order to pursue my strong interest at the basic science level, I worked as a research assistant for one year. This experience ultimately inspired me to become a doctoral student at the Division of Clinical Geriatrics/ Division of Translational Alzheimer Neurobiology at Karolinska Institutet, a research laboratory internationally known for leading-edge research on AD.


2012 Master of Science in Pharmacy, Uppsala University

Research description

My project; To characterize and evaluate the feasibility of ChAT and the ratio of AChE/BChE as early and longitudinal therapeutic biomarkers of AD drug therapies targeting the cholinergic system.

We have recently proved that choline acetyltransferase (ChAT) is present in both plasma and cerebrospinal fluid (CSF) and we have also invented a unique, simple, non-radioactive and highly sensitive fluorometric/colorimetric assay of ChAT activity together with a sensitive ELISA assay for determining ChAT protein levels. This assay will be a useful tool to investigate short- and long-term effects of drugs aimed at the central cholinergic system.

Academic honors, awards and prizes


Brain changes in Alzheimer's disease patients with implanted encapsulated cells releasing nerve growth factor
Ferreira D, Westman E, Eyjolfsdottir H, Almqvist P, Lind G, Linderoth B, et al
Journal of Alzheimer's disease : JAD 2015;43(3):1059-72

Regulated Extracellular Choline Acetyltransferase Activity- The Plausible Missing Link of the Distant Action of Acetylcholine in the Cholinergic Anti-Inflammatory Pathway
Vijayaraghavan S, Karami A, Aeinehband S, Behbahani H, Grandien A, Nilsson B, et al
PLOS ONE 2013;8(6):-

Cell therapy with NGF in patients with Alzheimer's disease: changes in CSF cholinergic markers
Karami A, Eyjolfsdottir H, Vijayaraghavan S, Kadir A, Linderoth B, Lind G, et al

Nerve growth factor treatment in Alzheimer's disease: EEG changes and relation to FDG-PET
Eyjolfsdottir H, Eriksdotter M, Almqvist P, Almqvist O, Kadir A, Karami A, et al