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Publications

A ribonucleotide reductase inhibitor with deoxyribonucleoside-reversible cytotoxicity
Crona M, Codó P, Jonna Vr, Hofer A, Fernandes Ap, Tholander F
Molecular oncology 2016;10(9):1375-1386

Bacterial thioredoxin and thioredoxin reductase as mediators for epigallocatechin 3-gallate-induced antimicrobial action
Liang W, Fernandes Ap, Holmgren A, Li X, Zhong L
The FEBS journal 2016;283(3):446-58

Glutaredoxin mediated redox effects of coenzyme Q10 treatment in type 1 and type 2 diabetes patients
Montano Sj, Grünler J, Nair D, Tekle M, Fernandes Ap, Hua X, et al
BBA clinical 2015;4():14-20

Metal- and Semimetal-Containing Inhibitors of Thioredoxin Reductase as Anticancer Agents
Gandin V, Fernandes Ap
Molecules (Basel, Switzerland) 2015;20(7):12732-56

Selenium compounds as therapeutic agents in cancer
Fernandes Ap, Gandin V
Biochimica et biophysica acta 2015;1850(8):1642-60

Alteration of thioredoxin and glutaredoxin in the progression of Alzheimer's disease
Arodin L, Lamparter H, Karlsson H, Nennesmo I, Björnstedt M, Schröder J, et al
Journal of Alzheimer's disease : JAD 2014;39(4):787-97

Expression of thioredoxins and glutaredoxins in human hepatocellular carcinoma: correlation to cell proliferation, tumor size and metabolic syndrome
Mollbrink A, Jawad R, Vlamis-gardikas A, Edenvik P, Isaksson B, Danielsson O, et al
International journal of immunopathology and pharmacology 2014;27(2):169-83

Protective effects of the thioredoxin and glutaredoxin systems in dopamine-induced cell death
Arodin L, Miranda-vizuete A, Swoboda P, Fernandes Ap
Free radical biology & medicine 2014;73():328-36

Selenium induces a multi-targeted cell death process in addition to ROS formation
Wallenberg M, Misra S, Wasik Am, Marzano C, Björnstedt M, Gandin V, et al
Journal of cellular and molecular medicine 2014;18(4):671-84

Effects of redox modulation by inhibition of thioredoxin reductase on radiosensitivity and gene expression
Selenius M, Hedman M, Brodin D, Gandin V, Rigobello Mp, Flygare J, et al
Journal of cellular and molecular medicine 2012;16(7):1593-605

Methylselenol formed by spontaneous methylation of selenide is a superior selenium substrate to the thioredoxin and glutaredoxin systems
Fernandes Ap, Wallenberg M, Gandin V, Misra S, Tisato F, Marzano C, et al
PloS one 2012;7(11):e50727-

Interaction of selenite and tellurite with thiol-dependent redox enzymes: Kinetics and mitochondrial implications
Rigobello Mp, Folda A, Citta A, Scutari G, Gandin V, Fernandes Ap, et al
FREE RADICAL BIOLOGY AND MEDICINE 2011;50(11):1620-9

Cancer cell death induced by phosphine gold(I) compounds targeting thioredoxin reductase
Gandin V, Fernandes Ap, Rigobello Mp, Dani B, Sorrentino F, Tisato F, et al
BIOCHEMICAL PHARMACOLOGY 2010;79(2):90-101

Chelation of lysosomal iron protects against ionizing radiation
Berndt C, Kurz T, Seleniuss M, Fernandes Ap, Edgren Mr, Brunk Ut
BIOCHEMICAL JOURNAL 2010;:295-301

Selenium and the Selenoprotein Thioredoxin Reductase in the Prevention, Treatment and Diagnostics of Cancer
Selenius M, Rundlof Ak, Olm E, Fernandes Ap, Bjornstedt M
ANTIOXIDANTS & REDOX SIGNALING 2010;12(7):867-80

Selenium compounds are substrates for glutaredoxins: a novel pathway for selenium metabolism and a potential mechanism for selenium-mediated cytotoxicity
Wallenberg M, Olm E, Hebert C, Bjornstedt M, Fernandes Ap
BIOCHEMICAL JOURNAL 2010;:85-93

Selenium in the prevention of human cancers
Björnstedt M, Fernandes Ap
The EPMA journal 2010;1(3):389-95

Effects of the antioxidant Pycnogenol((R)) on cellular redox systems in U1285 human lung carcinoma cells
Gandin V, Nystrom C, Rundlof Ak, Jonsson-videsater K, Schonlau F, Horkko J, et al
FEBS JOURNAL 2009;276(2):532-40

Expression profiles of thioredoxin family proteins in human lung cancer tissue: correlation with proliferation and differentiation
Fernandes Ap, Capitanio A, Selenius M, Brodin O, Rundlof Ak, Bjornstedt M
HISTOPATHOLOGY 2009;55(3):313-20

Extracellular thiol-assisted selenium uptake dependent on the x(c)(-) cystine transporter explains the cancer-specific cytotoxicity of selenite
Olm E, Fernandes Ap, Hebert C, Rundlof Ak, Larsen Eh, Danielsson O, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2009;106(27):11400-5

Phenotype-dependent apoptosis signalling in mesothelioma cells after selenite exposure
Nilsonne G, Olm E, Szulkin A, Mundt F, Stein A, Kocic B, et al
JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH 2009;:92-

Selenite and tellurite in combination with auranofin in cisplatin sensitive and resistant cancer cells: effects on TrxR and on cellular redox environment
Gandin V, Rigobello Mp, Fernandes Ap, Rundlof A, Bindoli A, Marzano C, et al
FREE RADICAL RESEARCH 2009;:74-75

Selenite is a potent cytotoxic agent for human primary AML cells
Olm E, Jonsson-videsater K, Ribera-cortada I, Fernandes Ap, Eriksson Lc, Lehmann S, et al
CANCER LETTERS 2009;282(1):116-23

Treatment of human cancer cells with selenite or tellurite in combination with auranofin enhances cell death due to redox shift
Rigobello Mp, Gandin V, Folda A, Rundlof Ak, Fernandes Ap, Bindoli A, et al
FREE RADICAL BIOLOGY AND MEDICINE 2009;47(6):710-21

Treatment of lung cancer cells with cytotoxic levels of sodium selenite: Effects on the thioredoxin system
Selenius M, Fernandes Ap, Brodin O, Bjornstedt M, Rundlof Ak
BIOCHEMICAL PHARMACOLOGY 2008;75(11):2092-9

Increased expression of specific thioredoxin family proteins; A pilot immunohistochemical study on human hepatocellular carcinoma
Cunnea P, Fernandes Ap, Capitanio A, Eken S, Spyrou G, Bjornstedt M
INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY 2007;20(1):17-24

Quantification of alternative mRNA species and identification of thioredoxin reductase 1 isoforms in human tumor cells
Rundlof Ak, Fernandes Ap, Selenius M, Babic M, Shariatgorji M, Nilsonne G, et al
DIFFERENTIATION 2007;75(2):123-32

Selenite is a superior cytotoxic agent to human primary leukemia cells
Olm E, Jonsson-videsaler K, Rundlof Ak, Fernandes Ap, Ribera I, Eriksson L, et al
EJC SUPPLEMENTS 2007;5(4):347-347

Selenite mediated cytotoxcicity in human lung cancer and the role of thioredoxin reductase 1
Fernandes Ap, Selenius M, Capitanio A, Brodin O, Bjornstedt M, Rundlof A
EJC SUPPLEMENTS 2007;5(4):369-369

The reducing activity of glutaredoxin 3 toward cytoplasmic substrate proteins is restricted by methionine 43
Porat A, Lillig Ch, Johansson C, Fernandes Ap, Nilsson L, Holmgren A, et al
BIOCHEMISTRY 2007;46(11):3366-77

Selenite induces apoptosis in sarcomatoid malignant mesothelioma cells through oxidative stress
Nilsonne G, Sun X, Nystrom C, Rundlof Ak, Fernandes Ap, Bjornstedt M, et al
FREE RADICAL BIOLOGY AND MEDICINE 2006;41(6):874-85

Targeting thioredoxin reductase - a possible new treatment for malignant mesothelioma
Nilsonne G, Stein A, Rundlof Ak, Fernandes Ap, Bjornstedt M, Hjerpe A, et al
LUNG CANCER 2006;:S52-S52

A novel monothiol glutaredoxin (Grx4) from Escherichia coli can serve as a substrate for thioredoxin reductase
Fernandes Ap, Fladvad M, Berndt C, Andresen C, Lillig Ch, Neubauer P, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2005;280(26):24544-52

Molecular mapping of functionalities in the solution structure of reduced Grx4, a monothiol glutaredoxin from Escherichia coli
Fladvad M, Bellanda M, Fernandes Ap, Mammi S, Vlamis-gardikas A, Holmgren A, et al
JOURNAL OF BIOLOGICAL CHEMISTRY 2005;280(26):24553-61

Overexpression of glutaredoxin 2 attenuates apoptosis by preventing cytochrome c release
Enoksson M, Fernandes Ap, Prast S, Lillig Ch, Hohngren A, Orrenius S
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2005;327(3):774-9

Cellular and plasma levels of human glutaredoxin 1 and 2 detected by sensitive ELISA systems
Lundberg M, Fernandes Ap, Kumar S, Holmgren A
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 2004;319(3):801-9

Glutaredoxins: Glutathione-dependent redox enzymes with functions far beyond a simple thioredoxin backup system
Fernandes Ap, Holmgren A
ANTIOXIDANTS & REDOX SIGNALING 2004;6(1):63-74

Short interfering RNA-mediated silencing of glutaredoxin 2 increases the sensitivity of HeLa cells toward doxorubicin and phenylarsine oxide
Lillig Ch, Lonn Me, Enoksson M, Fernandes Ap, Holmgren A
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2004;101(36):13227-32

Redox regulation of 3 '-phosphoadenylylsulfate reductase from Escherichia coli by glutathione and glutaredoxins
Lillig Ch, Potamitou A, Schwenn Jd, Vlamis-gardikas A, Holmgren A
JOURNAL OF BIOLOGICAL CHEMISTRY 2003;278(25):22325-30

Characterization of Escherichia coli null mutants for glutaredoxin 2
Vlamis-gardikas A, Potamitou A, Zarivach R, Hochman A, Holmgren A
JOURNAL OF BIOLOGICAL CHEMISTRY 2002;277(13):10861-8

Expression of Escherichia coli glutaredoxin 2 is mainly regulated by ppGpp and sigma(S)
Potamitou A, Neubauer P, Holmgren A, Vlamis-gardikas A
JOURNAL OF BIOLOGICAL CHEMISTRY 2002;277(20):17775-80

Protein levels of Escherichia coli thioredoxins and glutaredoxins and their relation to null mutants, growth phase, and function
Potamitou A, Holmgren A, Vlamis-gardikas A
JOURNAL OF BIOLOGICAL CHEMISTRY 2002;277(21):18561-7

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