Annelie Tjernlund

Publications
CV
Public outreach and news

Articles

Article: JOURNAL OF INFECTIOUS DISEASES. 2022;226(8):1428-1440

Preserved Mucosal-Associated Invariant T Cells in the Cervical Mucosa of HIV-Infected Women with Dominant Expression of the TRAV1-2-TRAJ20 T Cell Receptor α-Chain.

Gibbs A; Healy K; Kaldhusdal V; Sundling C; Franzén-Boger M; Edfeldt G; Buggert M; Lajoie J; Fowke KR; Kimani J; Kwon DS; Andersson S; Sandberg JK; Broliden K; Davanian H; Chen MS; Tjernlund A
Article: PLOS PATHOGENS. 2022;18(5):e1010494

Multi-omics analysis of the cervical epithelial integrity of women using depot medroxyprogesterone acetate.

Bradley F; Franzén Boger M; Kaldhusdal V; Åhlberg A; Edfeldt G; Lajoie J; Bergström S; Omollo K; Damdimopoulos A; Czarnewski P; Månberg A; Oyugi J; Kimani J; Nilsson P; Fowke K; Tjernlund A; Broliden K
Article: JOURNAL OF INFECTIOUS DISEASES. 2022;225(7):1151-1161

Regular Use of Depot Medroxyprogesterone Acetate Causes Thinning of the Superficial Lining and Apical Distribution of Human Immunodeficiency Virus Target Cells in the Human Ectocervix.

Edfeldt G; Lajoie J; Röhl M; Oyugi J; Åhlberg A; Khalilzadeh-Binicy B; Bradley F; Mack M; Kimani J; Omollo K; Wählby C; Fowke KR; Broliden K; Tjernlund A
Article: VACCINES. 2021;9(3):217

HIV-Exposed Seronegative Sex Workers Express Low T-Cell Activation and an Intact Ectocervical Tissue Microenvironment.

Röhl M; Tjernlund A; Lajoie J; Edfeldt G; Bradley F; Bergström S; Kaldhusdal V; Åhlberg A; Månberg A; Omollo K; Boily-Larouche G; Asghar M; Kwon DS; Oyugi J; Kimani J; Nilsson P; Fowke KR; Broliden K
Article: METHODS IN MOLECULAR BIOLOGY. 2020;2098:83-94

In Situ Detection of MAIT Cells and MR1-Expressing Cells in Tissue Biopsies Utilizing Immunohistochemistry.

Gibbs A; Sobkowiak MJ; Sandberg JK; Tjernlund A
Article: SCIENTIFIC REPORTS. 2019;9(1):18120

Impact of Q-Griffithsin anti-HIV microbicide gel in non-human primates: In situ analyses of epithelial and immune cell markers in rectal mucosa.

Günaydın G; Edfeldt G; Garber DA; Asghar M; Noȅl-Romas L; Burgener A; Wählby C; Wang L; Rohan LC; Guenthner P; Mitchell J; Matoba N; McNicholl JM; Palmer KE; Tjernlund A; Broliden K
Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2019;35(3):236-246

Increased Cervical CD4+CCR5+ T Cells Among Kenyan Sex Working Women Using Depot Medroxyprogesterone Acetate.

Lajoie J; Tjernlund A; Omollo K; Edfeldt G; Röhl M; Boily-Larouche G; Cheruiyot J; Kimani M; Kimani J; Oyugi J; Broliden K; Fowke KR
Article: EUROPEAN JOURNAL OF IMMUNOLOGY. 2019;49(1):133-143

Tissue-resident MAIT cell populations in human oral mucosa exhibit an activated profile and produce IL-17.

Sobkowiak MJ; Davanian H; Heymann R; Gibbs A; Emgård J; Dias J; Aleman S; Krüger-Weiner C; Moll M; Tjernlund A; Leeansyah E; Sällberg Chen M; Sandberg JK
Article: PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2018;115(49):E11513-E11522

The CD4-CD8- MAIT cell subpopulation is a functionally distinct subset developmentally related to the main CD8+ MAIT cell pool.

Dias J; Boulouis C; Gorin J-B; van den Biggelaar RHGA; Lal KG; Gibbs A; Loh L; Gulam MY; Sia WR; Bari S; Hwang WYK; Nixon DF; Nguyen S; Betts MR; Buggert M; Eller MA; Broliden K; Tjernlund A; Sandberg JK; Leeansyah E
Article: JOURNAL OF INFECTIOUS DISEASES. 2018;218(3):453-465

Human Immunodeficiency Virus-Infected Women Have High Numbers of CD103-CD8+ T Cells Residing Close to the Basal Membrane of the Ectocervical Epithelium.

Gibbs A; Buggert M; Edfeldt G; Ranefall P; Introini A; Cheuk S; Martini E; Eidsmo L; Ball TB; Kimani J; Kaul R; Karlsson AC; Wählby C; Broliden K; Tjernlund A
Article: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2018;80(1):e12863

The vaginal microbiome amplifies sex hormone-associated cyclic changes in cervicovaginal inflammation and epithelial barrier disruption.

Bradley F; Birse K; Hasselrot K; Noël-Romas L; Introini A; Wefer H; Seifert M; Engstrand L; Tjernlund A; Broliden K; Burgener AD
Article: PLOS PATHOGENS. 2017;13(5):e1006402

Seminal plasma induces inflammation and enhances HIV-1 replication in human cervical tissue explants.

Introini A; Boström S; Bradley F; Gibbs A; Glaessgen A; Tjernlund A; Broliden K
Article: IMMUNITY. 2017;46(2):287-300

CD49a Expression Defines Tissue-Resident CD8+ T Cells Poised for Cytotoxic Function in Human Skin.

Cheuk S; Schlums H; Gallais Sérézal I; Martini E; Chiang SC; Marquardt N; Gibbs A; Detlofsson E; Introini A; Forkel M; Höög C; Tjernlund A; Michaëlsson J; Folkersen L; Mjösberg J; Blomqvist L; Ehrström M; Ståhle M; Bryceson YT; Eidsmo L
Article: MUCOSAL IMMUNOLOGY. 2017;10(1):35-45

MAIT cells reside in the female genital mucosa and are biased towards IL-17 and IL-22 production in response to bacterial stimulation.

Gibbs A; Leeansyah E; Introini A; Paquin-Proulx D; Hasselrot K; Andersson E; Broliden K; Sandberg JK; Tjernlund A
Article: JOURNAL OF IMMUNOLOGY. 2016;197(5):1843-1851

Innate Invariant NKT Cell Recognition of HIV-1-Infected Dendritic Cells Is an Early Detection Mechanism Targeted by Viral Immune Evasion.

Paquin-Proulx D; Gibbs A; Bächle SM; Checa A; Introini A; Leeansyah E; Wheelock CE; Nixon DF; Broliden K; Tjernlund A; Moll M; Sandberg JK
Article: PLOS ONE. 2016;11(3):e0149907

In Situ Staining and Laser Capture Microdissection of Lymph Node Residing SIV Gag-Specific CD8+ T cells--A Tool to Interrogate a Functional Immune Response Ex Vivo.

Tjernlund A; Burgener A; Lindvall JM; Peng T; Zhu J; Öhrmalm L; Picker LJ; Broliden K; McElrath MJ; Corey L
Article: BIOLOGY OF REPRODUCTION. 2015;92(3):68-10

Progesterone-based intrauterine device use is associated with a thinner apical layer of the human ectocervical epithelium and a lower ZO-1 mRNA expression.

Tjernlund A; Carias AM; Andersson S; Gustafsson-Sanchez S; Röhl M; Petersson P; Introini A; Hope TJ; Broliden K
Article: BMJ OPEN. 2015;5(2):e006627

Comparable mRNA expression of inflammatory markers but lower claudin-1 mRNA levels in foreskin tissue of HSV-2 seropositive versus seronegative asymptomatic Kenyan young men.

Röhl M; Tjernlund A; Mehta SD; Pettersson P; Bailey RC; Broliden K
Article: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2014;72(5):475-484

Expression profiles of antimicrobial peptides in the genital tract of women using progesterone intrauterine devices versus combined oral contraceptives.

Introini A; Kaldensjö T; Hirbod T; Röhl M; Tjernlund A; Andersson S; Broliden K
Article: JOURNAL OF IMMUNOLOGY. 2014;192(8):3947-3957

Presence of CD8+ T cells in the ectocervical mucosa correlates with genital viral shedding in HIV-infected women despite a low prevalence of HIV RNA-expressing cells in the tissue.

Gibbs A; Hirbod T; Li Q; Bohman K; Ball TB; Plummer FA; Kaul R; Kimani J; Broliden K; Tjernlund A
Article: JOURNAL OF IMMUNOLOGY. 2013;191(7):3948-3954

Stable CD4 expression and local immune activation in the ectocervical mucosa of HIV-infected women.

Hirbod T; Kimani J; Tjernlund A; Cheruiyot J; Petrova A; Ball TB; Mugo N; Jaoko W; Plummer FA; Kaul R; Broliden K
Article: JOURNAL OF VIROLOGY. 2013;87(9):5141-5150

A systems biology examination of the human female genital tract shows compartmentalization of immune factor expression.

Burgener A; Tjernlund A; Kaldensjo T; Abou M; McCorrister S; Westmacott GR; Mogk K; Ambrose E; Broliden K; Ball B
Article: BLOOD. 2011;117(20):5391-5402

HIV-specific CD8+ T cells from HIV+ individuals receiving HAART can be expanded ex vivo to augment systemic and mucosal immunity in vivo.

Chapuis AG; Casper C; Kuntz S; Zhu J; Tjernlund A; Diem K; Turtle CJ; Cigal ML; Velez R; Riddell S; Corey L; Greenberg PD
Article: RETROVIROLOGY. 2010;7:12

In situ detection of Gag-specific CD8+ cells in the GI tract of SIV infected Rhesus macaques.

Tjernlund A; Zhu J; Laing K; Diem K; McDonald D; Vazquez J; Cao J; Ohlen C; McElrath MJ; Picker LJ; Corey L
Article: HIV MEDICINE. 2009;10(2):94-102

Kinetics of plasma cytokines and chemokines during primary HIV-1 infection and after analytical treatment interruption.

Barqasho B; Nowak P; Tjernlund A; Kinloch S; Goh L-E; Lampe F; Fisher M; Andersson J; Sönnerborg A; QUEST study group
Article: AIDS RESEARCH AND HUMAN RETROVIRUSES. 2007;23(3):398-406

Leukemia inhibitor factor (LIF) inhibits HIV-1 replication via restriction of stat 3 activation.

Tjernlund A; Walther-Jallow L; Behbahani H; Screpanti V; Nowak P; Grandien A; Andersson J; Patterson BK
Article: AIDS. 2006;20(1):11-19

Early induction of leukemia inhibitor factor (LIF) in acute HIV-1 infection.

Tjernlund A; Barqasho B; Nowak P; Kinloch S; Thorborn D; Perrin L; Sönnerborg A; Walther-Jallow L; Andersson J
Article: AIDS. 2003;17(9):1303-1310

Suppression of leukemia inhibitor factor in lymphoid tissue in primary HIV infection: absence of HIV replication in gp130-positive cells.

Tjernlund A; Fleener Z; Behbahani H; Connick E; Sönnerborg A; Broström C; Goh L-E; Spetz A-L; Patterson BK; Andersson J
Article: JOURNAL OF NEUROIMMUNOLOGY. 2002;126(1-2):161-171

Monocyte-derived dendritic cells express and secrete matrix-degrading metalloproteinases and their inhibitors and are imbalanced in multiple sclerosis.

Kouwenhoven M; Ozenci V; Tjernlund A; Pashenkov M; Homman M; Press R; Link H
Article: NEUROREPORT. 2002;13(1):53-56

African trypanosomes activate human fetal brain cells to proliferation and IFN-gamma production.

Bakhiet M; Hamadien M; Tjernlund A; Mousal A; Seiger A
Article: APMIS. 2001;109(11):791-796

Mechanisms of resistance to imipenem in imipenem-resistant, ampicillin-sensitive Enterococcus faecium.

El Amin N; Lund B; Tjernlund A; Lundberg C; Jalakas K; Wretlind B
Article: NATURE CELL BIOLOGY. 2001;3(2):150-157

RANTES promotes growth and survival of human first-trimester forebrain astrocytes.

Bakhiet M; Tjernlund A; Mousa A; Gad A; Strömblad S; Kuziel WA; Seiger A; Andersson J
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All other publications

Review: AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY. 2014;71(1):12-23

The role of serpin and cystatin antiproteases in mucosal innate immunity and their defense against HIV.

Aboud L; Ball TB; Tjernlund A; Burgener A
Review: CURRENT MOLECULAR MEDICINE. 2002;2(8):713-722

Endogenous inhibitors of HIV: potent anti-HIV activity of leukemia inhibitory factor.

Patterson BK; Tjernlund A; Andersson J

Employments

Senior Research Specialist, Department of Medicine, Karolinska Institutet, 2022-

Degrees and Education

Docent, Karolinska Institutet, 2016
Doctor Of Philosophy, Department of Medicine, Huddinge, Karolinska Institutet, 2006

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