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Anneli Julander

Senior researcher

Visiting address : Scheelelaboratoriet Nobelsväg 13 Solna, Sweden
Postal address : Institute of Environmental Medicine (IMM), C6, Occupational and environmental dermatology , Box 210 171 77 Stockholm, Sweden
Delivery address : Schelelaboratoriet Nobelsväg 13 Solna, Sweden

About me

I work as an Accociate Professor at the Unit of Occupational and Envrionmental Dermatology. My research area is mainly how metals in different forms interact and affect the skin.


2000 Master of Science in Biology, Stockholm University, Sweden.

Title: Bioaccumulation and elimination of flame retardant PBDE-47 in the Baltic tellenid clam, Macoma Baltica.

2005 PhD in Environmental Science, Örebro University, Sweden.

Title: Exposure to brominated flame retardants in electronics recycling - air and human plasma levels. 

2014 Associate Professor of Occupational and Envrionmental Medicine

Research description

Skin exposure to hazardous substances, with emphasis on metals.

The aim of my research is to characterise skin exposure and processes leading to uptake of metals through skin.


Exposure to metals are common, but very little is known about how much metals that are present on the skin. Many metals are both allergenic and toxic and occur as alloys or surface coatings. Contact with skin occurs through manual handling or deposition onto the skin. In my research I characterize metal exposure, by sampling the skin surface, blood and urine of humans and I also collect air samples from the working environment. I also work with diffusion cells (in vitro). Using these one can study skin penetration and uptake of substances. 

Sampling of skin is performed using two methods – acid wipe sampling and tape stripping. The first method uses a dilute acid with which the skin is wiped. The metals in the wipe are analysed with ICP-MS which give a quantitative skin dose. In the second method, the outer layer of the skin is removed for analysis with electron microscopy to study particle size and composition. Combining these two methods with traditional sampling (blood/urine) and air monitoring allows us to understand the exposure scenario to metals. 


Allergy risks with laptop computers - nickel and cobalt release
Midander K, Hurtig A, Borg Tornberg A, Julander A
Contact dermatitis 2016;74(6):353-9

Cobalt allergy: suitable test concentration, and concomitant reactivity to nickel and chromium
Lidén C, Andersson N, Julander A, Matura M
Contact dermatitis 2016;74(6):360-7

Elicitation threshold of cobalt chloride: analysis of patch test dose-response studies
Fischer La, Johansen Jd, Voelund A, Lidén C, Julander A, Midander K, et al
Contact dermatitis 2016;74(2):105-9

Extracellular cadmium in the bronchoalveolar space of long-term tobacco smokers with and without COPD and its association with inflammation
Sundblad Bm, Ji J, Levänen B, Midander K, Julander A, Larsson K, et al
International journal of chronic obstructive pulmonary disease 2016;11():1005-13

Nickel on the market: a baseline survey of articles in 'prolonged contact' with skin
Ringborg E, Lidén C, Julander A
Contact dermatitis 2016;75(2):77-81

Nickel exposure when working out in the gym
Gumulka M, Matura M, Lidén C, Kettelarij Ja, Julander A
Acta dermato-venereologica 2015;95(2):247-9

Cobalt, nickel and chromium release from dental tools and alloys
Kettelarij Jab, Liden C, Axen E, Julander A
CONTACT DERMATITIS 2014;70(1):3-10

Cobalt skin dose resulting from short and repetitive contact with hard metals
Midander K, Julander A, Skare L, Lidén C
Contact dermatitis 2014;70(6):361-8

Formal recycling of e-waste leads to increased exposure to toxic metals: an occupational exposure study from Sweden
Julander A, Lundgren L, Skare L, Grandér M, Palm B, Vahter M, et al
Environment international 2014;73():243-51

Nickel release from white gold
Midander K, Kettelarij J, Julander A, Lidén C
Contact dermatitis 2014;71(2):109-11

Coin exposure may cause allergic nickel dermatitis: a review
Thyssen Jp, Gawkrodger Dj, White Ir, Julander A, Menné T, Lidén C
Contact dermatitis 2013;68(1):3-14

New UK nickel-plated steel coins constitute an increased allergy and eczema risk
Julander A, Midander K, Herting G, Thyssen Jp, White Ir, Odnevall Wallinder I, et al
Contact dermatitis 2013;68(6):323-30

The cobalt spot test--further insights into its performance and use
Midander K, Julander A, Skare L, Thyssen Jp, Lidén C
Contact dermatitis 2013;69(5):280-7

Cobalt release from implants and consumer items and characteristics of cobalt sensitized patients with dermatitis
Thyssen Jp, Menne T, Liden C, Julander A, Jensen P, Jakobsen Ss, et al
CONTACT DERMATITIS 2012;66(3):113-22

Assessment of nickel and cobalt release from 200 unused hand-held work tools for sale in Denmark - Sources of occupational metal contact dermatitis?
Thyssen Jp, Jensen P, Liden C, Julander A, Jellesen Ms, Menne T, et al

Nickel deposited on the skin-visualization by DMG test
Julander A, Skare L, Vahter M, Liden C
CONTACT DERMATITIS 2011;64(3):151-7

A spot test for detection of cobalt release - early experience and findings
Thyssen Jp, Menne T, Johansen Jd, Liden C, Julander A, Moller P, et al
CONTACT DERMATITIS 2010;63(2):63-9

Cobalt release from inexpensive jewellery: has the use of cobalt replaced nickel following regulatory intervention?
Thyssen Jp, Jellesen Ms, Menne T, Liden C, Julander A, Moller P, et al
CONTACT DERMATITIS 2010;63(2):70-6

Skin Deposition of Nickel, Cobalt, and Chromium in Production of Gas Turbines and Space Propulsion Components
Julander A, Skare L, Mulder M, Grander M, Vahter M, Liden C

Cobalt-containing alloys and their ability to release cobalt and cause dermatitis
Julander A, Hindsen M, Skare L, Liden C
CONTACT DERMATITIS 2009;60(3):165-70

Levels of brominated flame retardants in blood in relation to levels in household air and dust
Karlsson M, Julander A, Van Bavel B, Hardell L

Ah receptor agonists in UV-exposed toluene solutions of decabromodiphenyl ether (decaBDE) and in soils contaminated with polybrominated diphenyl ethers (PBDEs)
Olsman H, Hagberg J, Kalbin G, Julander A, Van Bavell B, Strid A, et al

Distribution of brominated flame retardants in different dust fractions in air from an electronics recycling facility
Julander A, Westberg H, Engwall M, Van Bavel B

Polybrominated diphenyl ethers - plasma levels and thyroid status of workers at an electronic recycling facility
Julander A, Karlsson M, Hagstrom K, Ohlson Cg, Engwall M, Bryngelsson Il, et al

Reply to 'Comment on: "Personal air sampling and analysis of polybrominated diphenyl ethers and other bromine containing compounds at an electronics recycling facility in Sweden"' by M. L. Hardy, JEM, 2005, 7, DOI: 10.1039/b418857h
Van Bavel B, Julander A

Solid-phase extraction of polybrominated diphenyl ethers in human plasma comparison with an open column extraction method
Karlsson M, Julander A, Van Bavel B, Lindstrom G
CHROMATOGRAPHIA 2005;61(1-2):67-73

Personal air sampling and analysis of polybrominated diphenyl ethers and other bromine containing compounds at an electronic recycling facility in Sweden
Pettersson-julander A, Van Bavel B, Engwall M, Westberg H

Polybrominated diphenylethers and methoxylated tetrabromodiphenylethers in cetaceans from the Mediterranean Sea
Pettersson A, Van Bavel B, Engwall M, Jimenez B

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