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Research description

Investigation of mechanism and functional and biochemical aspects of Tartrate resistant acid phosphatase (TRAP) during cancer progression. 
Specifically, I study TRAP´s influence on cancer cell functions and signaling pathways involved. Additionally, we screen for novel small molecule inhibitors against TRAP as a tool to unravel TRAP´s mechanism of action and for a possible pharmacological application. Early discovery of the risk for growth and metastasis of a tumor can influence the choice of therapy and the outcome of the patient. We propose TRAP as a marker for the decision of treatment to predict the patient´s outcome and as a potential therapeutic target.

Publications

A Potent Tartrate Resistant Acid Phosphatase Inhibitor to Study the Function of TRAP in Alveolar Macrophages
Boorsma Ce, Van Der Veen Ta, Putri Kss, De Almeida A, Draijer C, Mauad T, et al
Scientific reports 2017;7(1):12570-

Tartrate-resistant acid phosphatase (TRAP/ACP5) promotes metastasis-related properties via TGFβ2/TβR and CD44 in MDA-MB-231 breast cancer cells
Reithmeier A, Panizza E, Krumpel M, Orre Lm, Branca Rmm, Lehtiö J, et al
BMC cancer 2017;17(1):650-

High-throughput screening for small chemical inhibitors: Investigation and intervention in tartrate-resistant acid phosphatase's role during cancer progression
Reithmeier A, Lundback T, Ek-rylander B, Andersson G
EUROPEAN JOURNAL OF CANCER 2016;:S77-S78

Collagen type V promotes the malignant phenotype of pancreatic ductal adenocarcinoma
Berchtold S, Grunwald B, Kruger A, Reithmeier A, Hahl T, Cheng T, et al
CANCER LETTERS 2015;356(2):721-32

The small chemical enzyme inhibitor 5-phenylnicotinic acid/CD13 inhibits cell migration and invasion of tartrate-resistant acid phosphatase/ACP5-overexpressing MDA-MB-231 breast cancer cells
Krumpel M, Reithmeier A, Senge T, Baeumler Ta, Frank M, Nyholm Pg, et al
Experimental cell research 2015;339(1):154-62