I am a PhD student at Environmental Medicine, unit of Cardiovascular Epidemiology, since January 2014. My main supervisor is Lars Alfredsson and my co-supervisors are Camilla Bengtsson, Per Gustavsson and Lars Klareskog.
2014 Registered as PhD student in Epidemiology, Karolinska Institutet, Stockholm, Sweden
2013 Master of Medical Science (120 credits) with a major in Public Health Sciences, specialization in Epidemiology, Karolinska Institutet, Stockholm, Sweden
2011 Bachelor of Arts (180 credits) with a major in Public Health Sciences, Gävle University, Gävle, Sweden
Airborne occupational exposures and risk of rheumatoid arthritis
The overall goal of this PhD project is to explore different airborne occupational exposures and risk of developing rheumatoid arthritis. The exposures will be studied in relation to immunologically defined subtypes of rheumatoid arthritis. The gene-environment interaction between these exposures and genetic risk factors will be explored.
Rheumatoid arthritis (RA) is a systemic autoimmune disease causing chronic inflammation in the synovial membranes and the joints. The damage caused by the inflammation is irreversible and will have a negative impact on the structures of the joint capsule, the articular joint cartilage and adjacent arteries.
The disease development is believed to occur through a complex interaction between genes, environmental factors and immunity, with smoking being the major environmental risk factor. Due to the association between smoking and RA, and the potential lung involvement in the etiology of the disease, there is a need to evaluate whether other airborne exposures are related to the risk of developing RA. Exposures of interest are exposure to diesel exhaust and various types of dust. Such studies could provide further knowledge on the role of the lungs in the etiology of RA. This PhD project is based on the population-based case-control study EIRA (Epidemiological Investigation of Rheumatoid Arthritis).
Specific aims of the studies
Study I To explore the association between occupation and the risk of developing RA. Which occupations are associated with the risk of RA compared to the rest of the workforce, among men and women? Are different occupations differently associated with the risk of ACPA+ RA and ACPA- RA?
Study II To study occupational exposure to textile dust and risk of developing ACPA+ RA and ACPA- RA in women. We will use register data and a job-exposure matrix to study this association.
Study III To explore the associations between occupational exposure to diesel exhaust and risk of ACPA+ RA and ACPA- RA in men and women, by applying a job-exposure matrix to the EIRA study.
Study IV To study self-reported occupational exposure to welding fumes and risk of ACPA+ RA and ACPA- RA in men and women, by exploring ever exposure, exposure duration, exposure frequency and time since exposure to welding fumes.