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Albert Siegbahn

Associated

Visiting address : Department of Medical Radiation Physics, ; P9:02 ; Karolinska University Hospital, 17176 Solna, Sweden
Postal address : Department of Oncology-Pathology (OnkPat), K7, Oncology other researchers, Department of Medical Radiation Physics, ; P9:02 ; Karolinska University Hospital, 17176 Solna, Sweden
Delivery address : Department of Medical Radiation Physics, ; P9:02 ; Karolinska University Hospital, 17176 Solna, Sweden

About me

I am employed as a Senior University Lecturer (Associate Professor) at the Department of Physics at Stockholm University, Stockholm, Sweden ( www.fysik.su.se ). I am also a researcher at the Department of Oncology and Pathology at Karolinska Institutet. My office is located at the Karolinska University Hospital where I also give most of my lectures.   

Education

2014 Associate Professor at the Department of Physics, Stockholm University

2007 Ph.D.-degree (Dr. rer. nat.) from the Technical University of Munich, Germany; academic distinction: magna cum laude

2004 – 2007 Ph.D. Student at the European Synchrotron Radiation Facility in Grenoble, France

2001 Physics studies: M.Sc.-degree from Stockholm University

Research description

Currently, I am the main supervisor of two Ph.D. Students Gracinda Mondlane and Toshiro Tsobouchi . They are both studying how to use ion-beam therapy more efficiently by using new beam-scanning teachniques. Gracinda is studing different approaches to treat moving targets in the gastro-intestinal tract. Toshiro is studying how carbon-ion beam grids can be used to reduce the side effects after the treatment of deep-seated, solid tumors. We are also collaborating with the future users of the Skandion proton-therapy clinic in Uppsala in different clinical projects.

I was earlier a co-supervisor of Danielle Anderson, a PhD student at the University of Alberta in Edmonton, Canada. She prepared a thesis on microbeam radiation therapy.

I am interested and involved in research related to applications of synchrotron radiation in medicine, in particular radiation therapy. I am a member of management committee for a EU-COST project called SYRA3 COST Action TD1205 "Innovative Methods in Radiotherapy and Radiosurgery
 using Synchrotron Radiation". https://www.syra3.eu/

 

Teaching portfolio

Interactions of radiation with matter

Radiation detection and measurements

Radiation protection

Dosimetry

Radiation therapy

Diagnostic radiology

Imaging systems and analysis

 

 

Publications

Comparative study of the calculated risk of radiation-induced cancer after photon- and proton-beam based radiosurgery of liver metastases
Mondlane G, Gubanski M, Lind Pa, Ureba A, Siegbahn A
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) 2017;():-

Comparison of gastric-cancer radiotherapy performed with volumetric modulated arc therapy or single-field uniform-dose proton therapy
Mondlane G, Gubanski M, Lind Pa, Ureba A, Siegbahn A
Acta oncologica (Stockholm, Sweden) 2017;56(6):832-838

Development of an interlaced-crossfiring geometry for proton grid therapy
Henry T, Bassler N, Ureba A, Tsubouchi T, Valdman A, Siegbahn A
Acta oncologica (Stockholm, Sweden) 2017;56(11):1437-1443

Proton Grid Therapy
Henry T, Ureba A, Valdman A, Siegbahn A
Technology in cancer research & treatment 2016;():1533034616681670-

Medical physics aspects of the synchrotron radiation therapies: Microbeam radiation therapy (MRT) and synchrotron stereotactic radiotherapy (SSRT)
Bräuer-krisch E, Adam Jf, Alagoz E, Bartzsch S, Crosbie J, Dewagter C, et al
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) 2015;31(6):568-83

Spatial and temporal distribution of gamma H2AX fluorescence in human cell cultures following synchrotron-generated X-ray microbeams: lack of correlation between persistent gamma H2AX foci and apoptosis
Anderson Dl, Mirzayans R, Andrais B, Siegbahn Ea, Fallone Bg, Warkentin B
JOURNAL OF SYNCHROTRON RADIATION 2014;:801-10

Comparison of two methods for measuring gamma-H2AX nuclear fluorescence as a marker of DNA damage in cultured human cells: applications for microbeam radiation therapy
Anderson D, Andrais B, Mirzayans R, Siegbahn Ea, Fallone Bg, Warkentin B
JOURNAL OF INSTRUMENTATION 2013;:-

Response of the rat spinal cord to X-ray microbeams
Laissue Ja, Bartzsch S, Blattmann H, Brauer-krisch E, Bravin A, Dallery D, et al
RADIOTHERAPY AND ONCOLOGY 2013;106(1):106-11

A misprint in a description of microbeam irradiations of rats' heads
Laissue Ja, Blattmann H, Siegbahn Ea, Slatkin Dn
VETERINARY OPHTHALMOLOGY 2012;15(3):210-1

Chalcone JAI-51 improves efficacy of synchrotron microbeam radiation therapy of brain tumors
Bouchet A, Boumendjel A, Khalil E, Serduc R, Brauer E, Siegbahn Ea, et al
JOURNAL OF SYNCHROTRON RADIATION 2012;:478-82

Evaluation of dose-volume metrics for microbeam radiation therapy dose distributions in head phantoms of various sizes using Monte Carlo simulations
Anderson D, Siegbahn Ea, Fallone Bg, Serduc R, Warkentin B
PHYSICS IN MEDICINE AND BIOLOGY 2012;57(10):3223-48

Sci-Sat AM: Brachy - 01: Evaluation of dose-volume metrics for microbeam radiation therapy
Anderson D, Siegbahn Ea, Fallone Bg, Serduc R, Warkentin B
Medical physics 2012;39(7Part4):4645-

DELINEATION OF GROSS TUMOR VOLUME (GTV) FOR RADIATION TREATMENT PLANNING OF LOCALLY ADVANCED RECTAL CANCER USING INFORMATION FROM MRI OR FDG-PET/CT: A PROSPECTIVE STUDY
Braendengen M, Hansson K, Radu C, Siegbahn A, Jacobsson H, Glimelius B
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 2011;81(4):e439-45

In-line phase-contrast stereoscopic X-ray imaging for radiological purposes: An initial experimental study
Siegbahn Ea, Coan P, Zhou Sa, Bravin A, Brahme A
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT 2011;629(1):345-349

Effects of pulsed, spatially fractionated, microscopic synchrotron X-ray beams on normal and tumoral brain tissue
Brauer-krisch E, Serduc R, Siegbahn Ea, Le Duc G, Prezado Y, Bravin A, et al
MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH 2010;704(1-3):160-6

High-Precision Radiosurgical Dose Delivery by Interlaced Microbeam Arrays of High-Flux Low-Energy Synchrotron X-Rays
Serduc R, Brauer-krisch E, Siegbahn Ea, Bouchet A, Pouyatos B, Carron R, et al
PLOS ONE 2010;5(2):e9028-

PREFERENTIAL EFFECT OF SYNCHROTRON MICROBEAM RADIATION THERAPY ON INTRACEREBRAL 9L GLIOSARCOMA VASCULAR NETWORKS
Bouchet A, Lemasson B, Le Duc G, Maisin C, Brauer-krisch E, Siegbahn Ea, et al
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 2010;78(5):1503-12

TOLERANCE OF ARTERIES TO MICROPLANAR X-RAY BEAMS
Van Der Sanden B, Brauer-krisch E, Siegbahn Ea, Ricard C, Vial Jc, Laissue J
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS 2010;77(5):1545-52

MOSFET dosimetry with high spatial resolution in intense synchrotron-generated x-ray microbeams
Siegbahn Ea, Brauer-krisch E, Bravin A, Nettelbeck H, Lerch Mlf, Rosenfeld Ab
MEDICAL PHYSICS 2009;36(4):1128-37

Synchrotron microbeam radiation therapy for rat brain tumor palliation-influence of the microbeam width at constant valley dose
Serduc R, Bouchet A, Brauer-krisch E, Laissue Ja, Spiga J, Sarun S, et al
PHYSICS IN MEDICINE AND BIOLOGY 2009;54(21):6711-24

Characterization and quantification of cerebral edema induced by synchrotron x-ray microbeam radiation therapy
Serduc R, De Looij Yv, Francony G, Verdonck O, Van Der Sanden B, Laissue J, et al
PHYSICS IN MEDICINE AND BIOLOGY 2008;53(5):1153-66

Irradiation of intracerebral 9L gliosarcoma by a single array of microplanar x-ray beams from a synchrotron: balance between curing and sparing
Regnard P, Le Duc G, Brauer-krisch E, Tropres I, Siegbahn Ea, Kusak A, et al
PHYSICS IN MEDICINE AND BIOLOGY 2008;53(4):861-78

The GEANT4 toolkit for microdosimetry calculations: Application to microbeam radiation therapy (MRT)
Spiga J, Siegbahn Ea, Brauer-krisch E, Randaccio P, Bravin A
MEDICAL PHYSICS 2007;34(11):4322-30

Characterization of a tungsten/gas multislit collimator (TMSC) for microbeam radiation therapy at the European Synchrotron Radiation Facility (vol 76, 064303, 2005)
Brauer-krisch E, Bravin A, Zhang L, Siegbahn E, Stepanek J, Blattmann H, et al
REVIEW OF SCIENTIFIC INSTRUMENTS 2006;77(3):-

Determination of dosimetrical quantities used in microbeam radiation therapy (MRT) with Monte Carlo simulations
Siegbahn Ea, Stepanek J, Brauer-krisch E, Bravin A
MEDICAL PHYSICS 2006;33(9):3248-59

Characterization of a tungsten/gas multislit collimator for microbeam radiation therapy at the European Synchrotron Radiation Facility
Brauer-krisch E, Bravin A, Zhang L, Siegbahn E, Stepanek J, Blattmann H, et al
REVIEW OF SCIENTIFIC INSTRUMENTS 2005;76(6):-

Dosimetric studies of microbeam radiation therapy (MRT) with Monte Carlo simulations
Siegbahn Ea, Brauer-krisch E, Stepanek J, Blattmann H, Laissue Ja, Bravin A
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT 2005;548(1-2):54-58

Edge-on face-to-face MOSFET for synchrotron microbeam dosimetry: MC modeling
Rosenfeld Ab, Siegbahn Ea, Brauer-krish E, Holmes-siedle A, Lerch Mlf, Bravin A, et al
IEEE TRANSACTIONS ON NUCLEAR SCIENCE 2005;52(6):2562-2569

Exploiting geometrical irradiation possibilities in MRT application
Brauer-krisch E, Requardt H, Regnard P, Corde S, Siegbahn Ea, Leduc G, et al
NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT 2005;548(1-2):69-71

New irradiation geometry for microbeam radiation therapy
Brauer-krisch E, Requardt H, Regnard P, Corde S, Siegbahn E, Leduc G, et al
PHYSICS IN MEDICINE AND BIOLOGY 2005;50(13):3103-11

Calculations of electron fluence correction factors using the Monte Carlo code PENELOPE
Siegbahn Ea, Nilsson B, Fernandez-varea Jm, Andreo P
PHYSICS IN MEDICINE AND BIOLOGY 2003;48(10):1263-75

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