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Akira Kaneko

Professor

Visiting address : Nobels Väg 16 171 77 Stockholm, Sweden
Postal address : Department of Microbiology, Tumor and Cell Biology (MTC), C1, Mats Wahlgren group, Box 280 171 77 Stockholm, Sweden
Delivery address : Nobels Väg 16 171 77 Stockholm, Sweden

Publications

A prescription for sustaining community engagement in malaria elimination on Aneityum Island, Vanuatu: an application of Health Empowerment Theory
Watanabe N, Kaneko A, Yamar S, Taleo G, Tanihata T, Lum Jk, et al
Malaria journal 2015;14():291-

Impact of modernization on adult body composition on five islands of varying economic development in Vanuatu
Olszowy Km, Pomer A, Dancause Kn, Sun C, Silverman H, Lee G, et al
American journal of human biology : the official journal of the Human Biology Council 2015;27(6):832-44

Improved detection of malaria cases in island settings of Vanuatu and Kenya by PCR that targets the Plasmodium mitochondrial cytochrome c oxidase III (cox3) gene
Isozumi R, Fukui M, Kaneko A, Chan Cw, Kawamoto F, Kimura M
Parasitology international 2015;64(3):304-8

Novel Mutations in K13 Propeller Gene of Artemisinin-Resistant Plasmodium falciparum
Isozumi R, Uemura H, Kimata I, Ichinose Y, Logedi J, Omar Ah, et al
EMERGING INFECTIOUS DISEASES 2015;21(3):490-2

Plasmodium vivax and Plasmodium falciparum at the crossroads of exchange among islands in Vanuatu: implications for malaria elimination strategies
Chan Cw, Sakihama N, Tachibana S, Idris Zm, Lum Jk, Tanabe K, et al
PloS one 2015;10(3):e0119475-

Plasmodium vivax gametocyte proteins, Pvs48/45 and Pvs47, induce transmission-reducing antibodies by DNA immunization
Tachibana M, Suwanabun N, Kaneko O, Iriko H, Otsuki H, Sattabongkot J, et al
Vaccine 2015;33(16):1901-8

Repeated myiasis in a female vulvar squamous cell carcinoma caused by Lucilia sericata and Sarcophaga crassipalpis
Hiraoka H, Ozawa T, Sowa-osako J, Ichimura T, Kimata-teramoto I, Isozumi R, et al
The Journal of dermatology 2015;42(8):840-1

Characteristic age distribution of Plasmodium vivax infections after malaria elimination on Aneityum Island, Vanuatu
Kaneko A, Chaves Lf, Taleo G, Kalkoa M, Isozumi R, Wickremasinghe R, et al
Infection and immunity 2014;82(1):243-52

Determinants of the use of insecticide-treated bed nets on islands of pre- and post-malaria elimination: an application of the health belief model in Vanuatu
Watanabe N, Kaneko A, Yamar S, Leodoro H, Taleo G, Tanihata T, et al
MALARIA JOURNAL 2014;:441-

Single nucleotide polymorphisms in Plasmodium falciparum V type H(+) pyrophosphatase gene (pfvp2) and their associations with pfcrt and pfmdr1 polymorphisms
Jovel It, Ferreira Pe, Veiga Mi, Malmberg M, Mårtensson A, Kaneko A, et al
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases 2014;24():111-5

Behavioral Risk Factors for Obesity During Health Transition in Vanuatu, South Pacific
Dancause Kn, Vilar M, Wilson M, Soloway Le, Dehuff C, Chan C, et al
OBESITY 2013;21(1):E98-E104

Frequency of the Functionally Relevant Aryl Hydrocarbon Receptor Repressor (AhRR) Pro185Ala SNP in Papua New Guinea
Cavaco I, Hombhanje Fw, Gil Jp, Kaneko A
DRUG METABOLISM AND PHARMACOKINETICS 2013;28(6):519-21

When they don't bite, we smell money: understanding malaria bednet misuse
Honjo K, Chaves Lf, Satake A, Kaneko A, Minakawa N
PARASITOLOGY 2013;140(5):580-6

Geographic differentiation of polymorphism in the Plasmodium falciparum malaria vaccine candidate gene SERA5
Tanabe K, Arisue N, Palacpac Nmq, Yagi M, Tougan T, Honma H, et al
VACCINE 2012;30(9):1583-93

Iron Deficiency and Severe Plasmodium falciparum Malaria
Awah Nw, Kaneko A
CLINICAL INFECTIOUS DISEASES 2012;54(8):1145-7

Large-scale survey for novel genotypes of Plasmodium falciparum chloroquine-resistance gene pfcrt
Takahashi N, Tanabe K, Tsukahara T, Dzodzomenyo M, Dysoley L, Khamlome B, et al
MALARIA JOURNAL 2012;:92-

Patterns of childhood and adolescent overweight and obesity during health transition in Vanuatu
Dancause Kn, Vilar M, Chan C, Dehuff C, Wilson M, Soloway Le, et al
PUBLIC HEALTH NUTRITION 2012;15(1):158-66

The Plasmodium Apicoplast Genome: Conserved Structure and Close Relationship of P. ovale to Rodent Malaria Parasites
Arisue N, Hashimoto T, Mitsui H, Palacpac Nmq, Kaneko A, Kawai S, et al
MOLECULAR BIOLOGY AND EVOLUTION 2012;29(9):2095-9

Behavioral Changes Associated with Economic Development in the South Pacific: Health Transition in Vanuatu
Dancause Kn, Dehuff C, Soloway Le, Vilar M, Chan C, Wilson M, et al
AMERICAN JOURNAL OF HUMAN BIOLOGY 2011;23(3):366-76

Clues to Evolution of the SERA Multigene Family in 18 Plasmodium Species
Arisue N, Kawai S, Hirai M, Palacpac Nmq, Jia M, Kaneko A, et al
PLOS ONE 2011;6(3):e17775-

PfMDR1: Mechanisms of Transport Modulation by Functional Polymorphisms
Ferreira Pe, Holmgren G, Veiga Mi, Uhlen P, Kaneko A, Gil Jp
PLOS ONE 2011;6(9):e23875-

Spleen rates in children: an old and new surveillance tool for malaria elimination initiatives in island settings
Chaves Lf, Taleo G, Kalkoa M, Kaneko A
TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE 2011;105(4):226-31

Spontaneous Mutations in the Plasmodium falciparum Sarcoplasmic/Endoplasmic Reticulum Ca2+-ATPase (PfATP6) Gene among Geographically Widespread Parasite Populations Unexposed to Artemisinin-Based Combination Therapies
Tanabe K, Zakeri S, Palacpac Nmq, Afsharpad M, Randrianarivelojosia M, Kaneko A, et al
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2011;55(1):94-100

The Origins of African Plasmodium vivax; Insights from Mitochondrial Genome Sequencing
Culleton R, Coban C, Zeyrek Fy, Cravo P, Kaneko A, Randrianarivelojosia M, et al
PLOS ONE 2011;6(12):e29137-

Worldwide sequence conservation of transmission-blocking vaccine candidate Pvs230 in Plasmodium vivax
Doi M, Tanabe K, Tachibana Sl, Hamai M, Tachibana M, Mita T, et al
VACCINE 2011;29(26):4308-15

A community-directed strategy for sustainable malaria elimination on islands: Short-term MDA integrated with ITNs and robust surveillance
Kaneko A
ACTA TROPICA 2010;114(3):177-83

Malaria research-Diversity and control: A Sweden-Japan joint seminar Foreword
Kaneko A, Wahlgren M
ACTA TROPICA 2010;114(3):129-30

Plasmodium falciparum Accompanied the Human Expansion out of Africa
Tanabe K, Mita T, Jombart T, Eriksson A, Horibe S, Palacpac N, et al
CURRENT BIOLOGY 2010;20(14):1283-9

Effects of malaria control and modernization on health across the lifespan: the health transition in Vanuatu
Needham Kd, Vilar M, Chan C, Soloway Le, Dehuff C, Wilson M, et al
AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY 2009;:198-199

Human mediated dispersal of the Anopheles punctulatus group in the Pacific
Reiff Dm, Stellfox C, Wells M, Brunson C, Suguri S, Hombhanje F, et al
AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY 2009;:219-219

Indigenous evolution of Plasmodium falciparum pyrimethamine resistance multiple times in Africa
Mita T, Tanabe K, Takahashi N, Culleton R, Ndounga M, Dzodzomenyo M, et al
JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY 2009;63(2):252-5

Plasmodium falciparum Multidrug Resistance Protein 1 and Artemisinin-Based Combination Therapy in Africa
Dahlstrom S, Ferreira Pe, Veiga Mi, Sedighi N, Wiklund L, Martensson A, et al
JOURNAL OF INFECTIOUS DISEASES 2009;200(9):1456-64

Random, top-down, or bottom-up coexistence of parasites: malaria population dynamics in multi-parasitic settings
Chaves Lf, Kaneko A, Pascual M
ECOLOGY 2009;90(9):2414-25

Reconstructing the origin of Lapita: Microsatellite analyses of East Sepik Province, PNG.
Vilar Mg, Kaneko A, Hombhanje Fw, Tsukahara T, Hwaihwanje I, Lum Jk
AMERICAN JOURNAL OF HUMAN BIOLOGY 2009;21(2):272-273

REGULATION OF MALARIA POPULATION DYNAMICS IN SANTO, VANUATU
Chaves Lf, Kaneko A
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 2009;81(5):322-322

Antimalarial calcium-signaling induction in Plasmodium falciparum.
Ferreira Pe, Veiga Mi, Gil Jp, Uhlen P, Kaneko A
INTERNATIONAL JOURNAL FOR PARASITOLOGY 2008;:S79-S79

Changing patterns of forest malaria among the mobile adult male population in Chumkiri District, Cambodia
Dysoley L, Kaneko A, Eto H, Mita T, Socheat D, Borkman A, et al
ACTA TROPICA 2008;106(3):207-12

Diversity of the sarco/endoplasmic reticulum Ca2+-ATPase orthologue of Plasmodium falciparum (PfATP6)
Dahlstrom S, Veiga Mi, Ferreira P, Martensson A, Kaneko A, Andersson B, et al
INFECTION GENETICS AND EVOLUTION 2008;8(3):340-5

Failure to detect Plasmodium vivax in West and Central Africa by PCR species typing
Culleton Rl, Mita T, Ndounga M, Unger H, Cravo Pvl, Paganotti Gm, et al
MALARIA JOURNAL 2008;:174-

Health transition in Vanuatu: The effects of modernization and malaria control on child growth
Vilar M, Chan C, Soloway L, Dehuff C, Needham Kd, Wilson M, et al
AMERICAN JOURNAL OF HUMAN BIOLOGY 2008;20(2):237-237

Independent evolution of pyrimethamine resistance in Plasmodium falciparum in Melanesia
Mita T, Tanabe K, Takahashi N, Kita K, Krudsood S, Looareesuwan S, et al
INFECTION GENETICS AND EVOLUTION 2008;8(4):S40-S41

Malaria transmission pattern resilience to climatic variability is mediated by insecticide-treated nets
Chaves Lf, Kaneko A, Taleo G, Pascual M, Wilson Ml
MALARIA JOURNAL 2008;:100-

Reconstructing the origin of the lapita cultural complex: MtDNA analyses of east sepik province, PNG
Vilar Mg, Kaneko A, Hombhanje Fw, Tsukahara T, Hwaihwanje I, Lum Jk
JOURNAL OF HUMAN GENETICS 2008;53(8):698-708

REGIME SHIFTS IN MALARIA INCIDENCE PATTERNS ARE RELATED TO CLIMATIC VARIABILITY, BUT MEDIATED BY INSECTICIDE TREATED NET USE
Chaves Lf, Kaneko A, Pascual M, Wilson Ml
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 2008;79(6):9-10

The role of Plasmodium falciparum multidrug resistance-associated protein 1 (pfmrp1) in development of resistance to artemisinin-based combination therapies (ACTs).
Dahlstrom S, Ferreira P, Wiklund L, Veiga Mi, Sedighi N, Martensson A, et al
INTERNATIONAL JOURNAL FOR PARASITOLOGY 2008;:S72-S72

The sarco/endoplasmic reticulum Ca2+-ATPase orthologue of Plasmodium falciparum (PfATP6) harbours high SNP diversity.
Dahlstrom S, Veiga Mi, Ferreira P, Martensson A, Kaneko A, Andersson B, et al
INTERNATIONAL JOURNAL FOR PARASITOLOGY 2008;:S71-S71

Effect of artesunate plus sulfadoxine-pyrimethamine on haematological recovery and anaemia, in Kenyan children with uncomplicated, Plasmodium falciparum malaria
Obonyo Co, Taylor W, Ekvall H, Kaneko A, Ter Kuile F, Olliaro P, et al
ANNALS OF TROPICAL MEDICINE AND PARASITOLOGY 2007;101(4):281-95

Genetic diversity and gene flow of humans, Plasmodium falciparum, and Anopheles farauti s.s. of Vanuatu: Inferred malaria dispersal and implications for malaria control
Lum Jk, Kaneko A, Taleo G, Amos M, Reiff Dm
ACTA TROPICA 2007;103(2):102-7

Impact of artemisinin-based combination therapy and insecticide-treated nets on malaria burden in Zanzibar
Bhattarai A, Ali As, Kachur Sp, Martensson A, Abbas Ak, Khatib R, et al
PLOS MEDICINE 2007;4(11):e309-

Independent evolution of pyrimethamine resistance in Plasmodium falciparum isolates in melanesia
Mita T, Tanabe K, Takahashi N, Tsukahara T, Eto H, Dysoley L, et al
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY 2007;51(3):1071-7

Population pharmacokinetics of amodiaquine and desethylamodiaquine in pediatric patients with uncomplicated falciparum malaria
Hietala Sf, Bhattarai A, Msellem M, Roshammar D, Ali As, Stromberg J, et al
JOURNAL OF PHARMACOKINETICS AND PHARMACODYNAMICS 2007;34(5):669-86

Population structure and gene flow of Anopheles farauti s.s. (Diptera : Culicidae) among ten sites on five islands of Vanuatu: Implications for malaria control
Reiff Dm, Kaneko A, Taleo G, Amos M, Lum Jk
JOURNAL OF MEDICAL ENTOMOLOGY 2007;44(4):601-7

A SNP in the ABCC11 gene is the determinant of human earwax type
Yoshiura K, Kinoshita A, Ishida T, Ninokata A, Ishikawa T, Kaname T, et al
NATURE GENETICS 2006;38(3):324-30

Austronesian origin of the 27-bp deletion of the erythrocyte band 3 gene in East Sepik, Papua New Guinea inferred from mtDNA analysis
Tsukahara T, Hombhanje Fw, Lum Jk, Hwaihwanje H, Masta A, Kaneko A, et al
JOURNAL OF HUMAN GENETICS 2006;51(3):244-8

Flashback to the 1960s: Utility of archived sera to explore the origin and evolution of Plasmodium falciparum chloroquine resistance in the Pacific
Chan Cw, Lynch D, Spathis R, Hombhanje Fw, Kaneko A, Garruto Rm, et al
ACTA TROPICA 2006;99(1):15-22

Rapid selection of dhfr mutant allele in Plasmodium falciparum isolates after the introduction of sulfadoxine/pyrimethamine in combination with 4-aminoquinolines in Papua New Guinea
Mita T, Kaneko A, Hwaihwanje I, Tsukahara T, Takahashi N, Osawa H, et al
INFECTION GENETICS AND EVOLUTION 2006;6(6):447-52

Role of pfmdr1 mutations on chloroquine resistance in Plasmodium falciparum isolates with pfcrt K76T from Papua New Guinea
Mita T, Kaneko A, Hombhanje F, Hwaihwanje O, Takahashi N, Osawa H, et al
ACTA TROPICA 2006;98(2):137-44

Seroprevalence of human herpesvirus 8 in the Vanuatu islands in eastern Melanesia
Satoh M, Kaneko A, Kokaze A, Katano H, Sata T
JAPANESE JOURNAL OF INFECTIOUS DISEASES 2006;59(1):63-5

An epidemic and immunity in a population living in an island where malaria was eliminated for 10 years [MIM-MA-104720]
Kalkoa M, Osawa H, Perlmann H, Troyeblomberg M, Sakurai M, Bjorkman A, et al
ACTA TROPICA 2005;:S148-S149

Associations between frequencies of a susceptible TNF-alpha promoter allele and protective alpha-thalassaemias and malaria parasite incidence in Vanuatu
Ubalee R, Tsukahara T, Kikuchi M, Lum Jk, Dzodzomenyo M, Kaneko A, et al
TROPICAL MEDICINE & INTERNATIONAL HEALTH 2005;10(6):544-9

Blood transfusion practices and outcome in the management of severe malarial anemia at Kisii Hospital in the fringe highlands of western Kenya [MIM-WA-266532]
Akhwale W, Eto H, Lum K, Obonyo C, Kobayakawa T, Kaneko A
ACTA TROPICA 2005;:S74-S74

CYP2C8 polymorphism frequencies among malaria patients in Zanzibar
Cavaco I, Stromberg-norklit J, Kaneko A, Msellem Mi, Dahoma M, Ribeiro Vl, et al
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY 2005;61(1):15-8

Disposition of oral amodiaquine in Papua New Guinean children with falciparum malaria [MIMFH-997971
Hombhanje F, Hwaihwanje I, Tsukahura T, Saruwatari J, Lum J, Osawa H, et al
ACTA TROPICA 2005;:S240-S241

Ecological variability in malaria prevalence in two districts of East Sepik Province, Papua New Guinea [MIM-IH-8616]
Hwaihwanje I, Tsukahara T, Hombhanje F, Suguri S, Osawa H, Eto H, et al
ACTA TROPICA 2005;:S211-S212

IL4 polymorphisms and IgE levels on malaria-endemic islands in Vanuatu [MIM-MD-272385]
Dzodzomenyo M, Kaneko A, Kikuchi M, Ubalee R, Osawa H, Tsukahara T, et al
ACTA TROPICA 2005;:S151-S151

The disposition of oral amodiaquine in Papua New Guinean children with falciparum malaria
Hombhanje Fw, Hwaihwanje I, Tsukahara T, Saruwatari J, Nakagawa M, Osawa H, et al
BRITISH JOURNAL OF CLINICAL PHARMACOLOGY 2005;59(3):298-301

The involvement of neutrophils in the resistance to Leishmania major infection in susceptible but not in resistant mice
Chen L, Zhang Zh, Watanabe T, Yamashita T, Kobayakawa T, Kaneko A, et al
PARASITOLOGY INTERNATIONAL 2005;54(2):109-18

Anemia and malaria at different altitudes in the western highlands of Kenya
Akhwale Ws, Lum Jk, Kaneko A, Eto H, Obonyo C, Bjorkman A, et al
ACTA TROPICA 2004;91(2):167-75

Expansion of wild type allele rather than back mutation in pfcrt explains the recent recovery of chloroquine sensitivity of Plasmodium falciparum in Malawi
Mita T, Kaneko A, Lum Jk, Zungu Il, Tsukahara T, Eto H, et al
MOLECULAR AND BIOCHEMICAL PARASITOLOGY 2004;135(1):159-63

Malaria dispersal among islands: human mediated Plasmodium falciparum gene flow in Vanuatu, Melanesia
Lum Jk, Kaneko A, Tanabe K, Takahashi N, Bjorkman A, Kobayakawa T
ACTA TROPICA 2004;90(2):181-5

Stable SNPs in malaria antigen genes in isolated populations
Tanabe K, Sakihama N, Kaneko A
SCIENCE 2004;303(5657):493-

High prevalence of quintuple mutant dhps/dhfr genes in Plasmodium falciparum infections seven years after introduction of sulfadoxine and pyrimethamine as first line treatment in Malawi
Bwijo B, Kaneko A, Takechi M, Zungu Il, Moriyama Y, Lum Jk, et al
ACTA TROPICA 2003;85(3):363-73

Malaria on islands - Human and parasite diversities and implications for malaria control in Vanuatu
Kaneko Aa
TROPICAL DISEASES: FROM MOLECULE TO BEDSIDE 2003;:71-82

Recovery of chloroquine sensitivity and low prevalence of the Plasmodium falciparum chloroquine resistance transporter gene mutation K76T following the discontinuance of chloroquine use in Malawi
Mita T, Kaneko A, Lum Jk, Bwijo B, Takechi N, Zungu Il, et al
AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE 2003;68(4):413-5

Automated solid-phase extraction for determination of amodiaquine, chloroquine and metabolites in capillary blood on sampling paper by liquid chromatography
Lindegardh N, Forslund M, Green Md, Kaneko A, Bergqvist Y
CHROMATOGRAPHIA 2002;55(1-2):5-12

Mosaic organization and heterogeneity in frequency of allelic recombination of the Plasmodium vivax merozoite surface protein-1 locus
Putaporntip C, Jongwutiwes S, Sakihama N, Ferreira Mu, Kho Wg, Kaneko A, et al
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 2002;99(25):16348-53

Limited recombination events in merozoite surface protein-1 alleles of Plasmodium falciparum on islands
Sakihama N, Kaneko A, Hattori T, Tanabe K
GENE 2001;279(1):41-8

Long PCR amplification of Plasmodium falciparum DNA extracted from filter paper blots
Sakihama N, Mitamura T, Kaneko A, Horii T, Tanabe K
EXPERIMENTAL PARASITOLOGY 2001;97(1):50-4

Malaria eradication on islands
Kaneko A, Taleo G, Kalkoa M, Yamar S, Kobayakawa T, Bjorkman A
LANCET 2000;356(9241):1560-4

CD4(+) and/or gamma delta(+) T cells in the liver spontaneously produce IL-4 in vitro during the early phase of Leishmania major infection in susceptible BALB/c mice
Yamashita T, Miyata H, Miyaji C, Watanabe H, Abo T, Kobayakawa T, et al
ACTA TROPICA 1999;73(2):109-19

High and variable frequencies of CYP2C19 mutations: medical consequences of poor drug metabolism in Vanuatu and other Pacific islands
Kaneko A, Lum Jk, Yaviong J, Takahashi N, Ishizaki T, Bertilsson L, et al
PHARMACOGENETICS 1999;9(5):581-90

Intrinsic efficacy of proguanil against falciparum and vivax malaria independent of the metabolite cycloguanil
Kaneko A, Bergqvist Y, Takechi M, Kalkoa M, Kaneko O, Kobayakawa T, et al
JOURNAL OF INFECTIOUS DISEASES 1999;179(4):974-9

Proguanil disposition and toxicity in malaria patients from Vanuatu with high frequencies of CYP2C19 mutations
Kaneko A, Bergqvist Y, Taleo G, Kobayakawa T, Ishizaki T, Bjorkman A
PHARMACOGENETICS 1999;9(3):317-26

Improved method for the simultaneous determination of proguanil and its metabolites by high-performance liquid chromatography and solid-phase extraction of 100-mu 1 capillary blood samples dried on sampling paper
Bergqvist Y, Funding L, Kaneko A, Krysen B, Leek T
JOURNAL OF CHROMATOGRAPHY B 1998;719(1-2):141-9

Malaria epidemiology, glucose 6-phosphate dehydrogenase deficiency and human settlement in the Vanuatu Archipelago
Kaneko A, Taleo G, Kalkoa M, Yaviong J, Reeve Pa, Ganczakowski M, et al
ACTA TROPICA 1998;70(3):285-302

High frequencies of CYP2C19 mutations and poor metabolism of proguanil in Vanuatu
Kaneko A, Kaneko O, Taleo G, Bjorkman A, Kobayakawa T
LANCET 1997;349(9056):921-2

MULTIPLE GLUCOSE-6-PHOSPHATE DEHYDROGENASE-DEFICIENT VARIANTS CORRELATE WITH MALARIA ENDEMICITY IN THE VANUATU ARCHIPELAGO (SOUTHWESTERN PACIFIC)
Ganczakowski M, Town M, Bowden Dk, Vulliamy Tj, Kaneko A, Clegg Jb, et al
AMERICAN JOURNAL OF HUMAN GENETICS 1995;56(1):294-301

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