Dzevad Belkic's Group

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Dževad Belkić

Dževad Belkić is a theoretical physicist. He is professor of Mathematical Radiation Physics at Karolinska Institutet in Stockholm, Sweden. His current research activities are in atomic collision physics, radiation physics, radiobiology, magnetic resonance physics and mathematical physics. In atomic heavy-particle collision physics, his past and current work encompasses many problems reflecting major challenges in this research field, such as theory of charge exchange and ionization at high non-relativistic energies.

He is one of the world’s leading experts on the Coulomb asymptotic convergence problem, distorted wave representations and perturbation expansions methods. He is known for furthering the powerful and versatile continuum distorted wave method and its derivatives that were advantageously exported to ion-atom and photon-atom collisions and also found their useful applications in medical physics.  In radiation physics, Dževad Belkić works on the passage of fast electrons and multiply-charged ions through tissue, as needed in radiation therapy in medicine. Here he furthers both deterministic methods through the Boltzmann equation and stochastic simulations via Monte Carlo computations. In radiobiology, his research entails mathematical modeling for cell survival, with the main emphasis on mechanistic approaches by including the chief pathways for survival of cells under irradiation during radiotherapy.

In magnetic resonance physics, Dževad Belkić works on magnetic resonance spectroscopy with the main applications to medical diagnostics, aided critically by high-resolution parametric signal processors that go beyond the conventional shape estimations of spectra and fitting approaches to quantification. The leading processor here is his fast Padé transform for exact spectral analysis of generic time signals and unequivocal signal-noise separation via Froissart doublets or pole-zero cancellations in response functions. In mathematical physics, he works on many problems including the derivation of analytical expressions for scattering integrals or bound-free form factors, for rational response functions in signal processing, and for coupling parameters in the nearest neighbour approximation, which is one of the most frequently used methods in physics and chemistry.

Dževad Belkić has published more than 200 scientific works, which have received over 3000 citations. His six books “Principles of Quantum Scattering Theory”, “Quantum Mechanical Signal Processing and Spectral Analysis” “Quantum Theory of High-Energy Ion-Atom Collisions” and “Signal Processing in Magnetic Resonance Spectroscopy with Biomedical Applications”, “Fast Ion-Atom and Ion-Molecule Collisions” and Magnetic Resonance Imaging and Spectroscopy Vol. 3 of the Comprehensive Biomedical Physics    were published by the Institute of Physics Publishing, Taylor & Francis, World Scientific and Elsevier in 2003, 2004, 2008, 2010, 2012 and 2014 respectively.  Among these have been the top-selling physics books. Professor Belkić has received numerous international awards for his scientific research, including the triple guest professorship in Atomic Physics from the Nobel Foundation and the Royal Swedish Academy of Sciences.

Full list of publications August 2014

Karen Belkić

Karen (maiden name Edinger) Belkić is a clinical scientist with a PhD in neuroscience and physician specialist in internal medicine. She is adjunct professor of preventive medicine at the University of Southern California, School of Medicine, Institute for Health Promotion and Disease Prevention Research and at the Claremont Graduate University School of Community and Global Health. She is also affiliated to the Oncology and Pathology Department of Karolinska Institutet, where she holds a scientific tenure position.  She earned her M.D. degree at University of Southern California School of Medicine.

Her research activities are broad within several areas including preventive medicine, diagnostics and rehabilitation. In stress research and in molecular imaging, she has five published books and over 100 full length papers in peer-reviewed journals with over 2000 citations. She has twice been co-editor of special topical issues in peer-reviewed international journals. Her work has strived to bridge clinical and basic scientific domains, seeking to answer to both these callings, by addressing difficult questions raised by multi-disciplinary, translational research. Her major goal has been to find non-invasive, sensitive and specific tools that can identify initial and often reversible changes, at a stage when timely intervention could be most effective.  Her interest and expertize is in early detection, risk assessment and prevention with a focus on cancer and heart disease, with attention to psychosocial factors and the potential mediating mechanisms. Her current scientific activity is focused upon improvement of early cancer detection through in vivo magnetic resonance by enhancing the diagnostic information obtained by applying modern advances in signal and imaging processing to signals encoded from patients with cancers, and comparing these to findings from non-malignant tissue. Younger women at high risk for breast and ovarian cancer are a particular target group.  With her concern for vulnerable groups, Dr. Belkić also addresses diagnostic issues among children, focusing upon pediatric neuro-oncology.

Karen Belkić has taken a broad view, looking not just at the immediate (i.e., proximal) markers of risk, but taking into account the more distal, and potentially key, determinants of disease. Thus, she has been very interested in how the environment (especially the work environment) impacts upon target organs, often mediated by the central nervous system. Within this framework, she has developed multi-level models. These incorporate, inter alia, non-linear, parametric methods in signal processing in relation to multiple physiological time signals for functional diagnostic testing. She is the originator of the widely implemented “Occupational Stressor Index”, a practical diagnostic tool for assessment and subsequent modification of the work environment. She is involved in risk assessment and determinants of adherence to cancer screening guidelines among vulnerable groups as well as design, implementation and testing of interventions for patients with cancer to return to health-promoting work conditions.

Karen Belkić has a special interest in pedagogy, in particular to help medical students and physicians at various levels of training acquire an appreciation of the importance of signal processing for medical diagnostics and to be able to identify situations in which this could be of critical significance in the clinical context, especially for cancer diagnostics.

Full list of publications August 2014

 

Karen and Dzevad Belkic are arranging the PhD Course "Basic principles in molecular imaging for medical diagnosis through magnetic resonance physics"

Course credits: 3
Time and location: Weeks 12-13 (March 16-26, 2015); Monday-Thursday 13:00 -- 17:00, altogether 8 days, including the exam. Lecture hall, ground floor of CCK

Course description

Interested students should contact the teachers about enrolling: Dzevad.belkic@ki.se, Karen.Belkic@ki.se (tel. 517 72494, 517 72184)

 

Group members

Dzevad Belkic, Professor

Karen Belkic, MD, PhD

Selected Publications 2013-16

Publications in Scientific Journals:

Alder S, Perinetti C, Mints M, Belkić K, Sundström K, Sandin S, Weiderpass E, Andersson S.  Acceptance of human papillomavirus (HPV) vaccination among young women in a country with a high prevalence of HPV infection. Int J Oncol 2013; 43: 1310 - 1318.

Andisheh B, Edgren M, Belkić Dž, Mavroidis P, Brahme A, Lind BK. A comparative analysis of radiobiological models for cell surviving fractions at high doses. Technol Cancer Res Treat 2013; 12: 183 - 192.

Andisheh B, Belkić Dž, Mavroidis P, Alahverdi M, Lind BK. Improving the therapeutic ratio in stereotactic radiosurgery: Optimizing treatment protocols based on kinetics of repair of sublethal radiation damage, Technol Cancer Res Treat 2013; 12: 349 - 361.

Belkić Dž, Belkić K.  Mechanistic radio-biological models with chemical kinetics-based repair for cell survival after heavy ion irradiation. Adv Quantum Chem 2013; 65: 339 - 362.

Belkić Dž, Mančev I, Milojević N.  Four-body theories for transfer ionization in fast ion-atom collisions. Adv Quantum Chem 2013; 65: 407 - 449.

Belkić Dž, Belkić K.  Resolution enhancement as a key step towards clinical implementation of Pade-optimized magnetic resonance spectroscopy for diagnostic oncology.  J Math Chem   2013; 51: 2608 - 2637.

Belkić Dž, Belkić K.  Mechanistic description of survival of irradiated cells: Repair kinetics in Padé Linear-Quadratic or Differential Michaelis-Menten Model. J Math Chem   2013; 51: 2572 - 2607.

Belkić Dž, Belkić K.  Molecular imaging in the framework of personalized cancer medicine. Isr Med Assoc J 2013; 15: 665 - 672.

Mančev I, Milojević N, Belkić Dž. State-selective and total single-capture cross sections for fast collisions of multiply charged ions with helium atoms. Few-Body Syst  2013; 54: 1889 - 1900.

Mančev I, Milojević N, Belkić Dž. Electron capture from H-  by H+. Eur Phys Letters 2013; 103 23001 (6 pp.)

Mančev I, Milojević N, Belkić Dž. Electron correlations in single-electron capture into any state of fast projectiles from heliumlike atomic systems. Phys Rev A 2013; 88: 052706 (15 pp.)

Belkić Dž. Repair of irradiated cells by Michaelis-Menten enzyme catalysis: the Lambert function for integrated rate equations in description of surviving fractions. J Math Chem 2014; 52: 1253 – 1291.

Belkić Dž. Survival of radiation-damaged cells via mechanism of repair by pool molecules: the Lambert function as the exact analytical solution of coupled kinetic equations. J Math Chem 2014; 52: 1201 – 1252.

Belkić Dž. The role of high-energy ion-atom/molecule collisions in radiotherapy. J Physics: Conf Series 2014; 565: 012003 (11 pp.)

Belkić Dž, Belkić K. Padé optimization of noise-corrupted magnetic resonance spectroscopic time signals from fibroadenoma of the breast. J Math Chem 2014; 52: 2680 – 2713.

Belkić Dž, Belkić K.  The role of optimized molecular imaging in personalized cancer medicine.  Diag Imaging Eur 2014; 30: 28 – 31.

Belkić K, Nedić O, Occupational medicine—then and now: Where we could go from here. Med Pregl 2014; 67: 139 - 147.

Belkić K, Belkić Dž. Optimized spectral analysis in magnetic resonance spectroscopy for early tumor diagnostics. J Physics: Conf Series 2014; 565: 012002 (11 pp.)                         

Savić Č, Belkić K.  Why are job stressors relevant for psychiatry?  Br J Psychiatry 2014; 205: 425 – 427.

Belkić Dž, Belkić K. Mechanistic radiobiological models for repair of cellular radiation damage. Adv Quantum Chem 2015; 70: 163 – 263.

Belkić Dž, Belkić K.  Strategic steps for advanced molecular imaging with magnetic resonance-based diagnostic modalities. Technol Cancer Res Treat 2015; 14: 119 – 142.

Belkić Dž, Belkić K, Proof-of-the-concept study on mathematically optimized magnetic resonance spectroscopy for breast cancer diagnostics. Technol. Cancer Res. Treat. 2015; 14, 277–297.

Belkić K, Cohen M, Wilczek B, Andersson S, Berman AH, Márquez M, Vukojević V and Mints M: Imaging surveillance programs for women at high breast cancer risk in Europe: Are women from ethnic minority groups adequately included? Int J Oncol 2015; 47: 817-839.

Mančev I, Milojević N, Belkić Dž. Theoretical state-selective and total cross sections for electron capture from helium atoms by fully stripped ions. Atomic Data Nuclear Data Tables 2015; 102: 6 - 41.

Belkić Dž, Belkić K, How the fast Padé transform handles noise for MRS data from the ovary: Importance for ovarian cancer diagnostics, J Math Chem 2016; 54: 149-185.

Belkić Dž, Belkić K, Mathematically-optimized magnetic resonance spectroscopy in breast cancer diagnostics: Implications for personalized cancer medicine, J Math Chem 2016; 54: 186-230.

Belkić Dž, Belkić K, Quantification by the fast Padé transform of magnetic resonance spectroscopic data encoded at 1.5T: Implications for brain tumor diagnostics, J Math Chem 2016; 54: 602-655.

Belkić Dž, Belkić K, The fast Padé transform for noisy magnetic resonance spectroscopic data from the prostate: Potential contribution to individualized prostate cancer care, J Math Chem, 2016; 54: 707-764.

Belkić Dž, Belkić K, Improving the diagnostic yield of magnetic resonance spectroscopy for pediatric brain tumors through  mathematical optimization. J Math Chem, 2016, DOI 10.1007/s10910-016-0632-9.

 

Books:

Belkić K, Savić Č. Job Stressors and Mental Health: A Proactive Clinical Perspective. London, World Scientific Publishers, 2013

Belkić Dž, Belkić K, editors Magnetic Resonance Imaging and Spectroscopy. Volume 3 within the 10 Volume Comprehensive Biomedical Physics, Amsterdam, Elsevier 2014

 

Book Chapters:

Belkić Dž.  Mathematically-optimized MR. In: Belkić Dž, Belkić K, editors. Magnetic Resonance Imaging and Spectroscopy. Volume 3 within the 10 Volume Comprehensive Biomedical Physics, Amsterdam, Elsevier 2014, pp. 399 - 416.

Belkić K. Inter-disciplinarity of MR and future perspectives with a focus on screening. In: Belkić Dž, Belkić K, editors. Magnetic Resonance Imaging and Spectroscopy. Volume 3 within the 10 Volume Comprehensive Biomedical Physics, Amsterdam, Elsevier 2014, pp. 417 - 433.

Williams S, Belkić Dž, Belkić K. Potential and Obstacles of MRS in the Clinical Setting. In: Belkić Dž, Belkić K, editors. Magnetic Resonance Imaging and Spectroscopy. Volume 3 within the 10 Volume Comprehensive Biomedical Physics, Amsterdam, Elsevier 2014, pp.  315 - 329.

 

Editorial preface to special topical issue of journal:

Belkić Dž. Theory of heavy ion collision physics in Hadron therapy-Preface. Adv Quantum Chem 2013; 65: xiii-xv.

 

Conference abstracts:

Belkić Dž, Belkić K:  Breakthrough in MRS for breast cancer diagnostics aided by advanced signal processing. Karolinska Institutet – Weizmann Institute of Science 2nd Joint Meeting (June 13-15, 2014) Karolinska Institute.

Belkić Dž, Belkić K. New mechanistic radiobiological models for cell response to radiation. Karolinska Institutet – Weizmann Institute of Science 2nd Joint Meeting (June 13-15, 2014) Karolinska Institute.

Belkić Dž: “The Role of High-Energy Ion-Atom/Molecule Collisions in Radiotherapy”,  (Invited plenary lecture August 28, 2014), Eds. Marić D, Milsavljević A, Mijatović A. Proceedings 27th Summer School and International Symposium on the Physics of Ionized Gases. Institute of Physics, Belgrade, 2014, p. 3.

Belkić Dž, Belkić K: Spectral Analysis for Optimization of Magnetic Resonance Spectroscopy in Early Tumor Diagnostics. Invited plenary lecture August 26, 2014 by K Belkić to the Workshop on Non-Equilibrium Processes), Eds. Marić D, Milosavljević A, Mijatović A. Proceedings 27th Summer School and International Symposium on the Physics of Ionized Gases. Institute of Physics, Belgrade, 2014, p. 543.

Belkić K, Belkić Dž.  Improved distinction by MR spectroscopy of suspicious lesions after radiation therapy among children with primary brain tumors. International Workshop: Biological basis of radiotherapy: where do we stand? Stockholm, September  2014.

Belkić Dž, Belkić K.  Three new mechanistic radiobiological models for cell response to radiation. International Workshop: Biological basis of radiotherapy: where do we stand? Stockholm, September 2014.

 

Communications for wider audiences:

Belkić Dž, Belkić K. Challenges and Steps towards Early Detection of Ovarian Cancer Radiumhemmet 

Belkić Dž, Belkić K. Förekomst av äggstockscancer i de skandinaviska länderna är bland de högsta i världen. Gynsam (Magazine of the Swedish Gynaecological Cancer Patients National Coalition, 2014; 13: 18 -19.

Older publications

Quantum Mechanical Signal Processing and Spectral Analysis
Belkić Dž
Institute of Physics Publishing, Bristol, 2004

Exact quantification of time signals in Padé-based magnetic resonance spectroscopy.
Belkić D
Phys Med Biol 2006 May;51(10):2633-70

Survival of radiation-damaged cells via mechanism of repair by pool molecules: the Lambert function as the exact analytical solution of coupled kinetic equations
Belkić Dž
J. Math. Chem.  52 (2014) 1201–1252.

Signal Processing in Magnetic Resonance Spectroscopy with Biomedical Applications
Belkić Dž, Belkić K
CRC Press Taylor & Francis Group, Boca Raton, 2010

Four-body methods for high-energy ion-atom collisions
Belkić Dž, Mančev I, Hanssen J
Rev. Mod. Phys. 80 (2008) 249-314. 

Molecular Imaging through Magnetic Resonance for Clinical Oncology
Belkić K
Cambridge International Science Publishing, Cambridge, 2004

Is job strain a major source of cardiovascular disease risk?
Belkic K, Landsbergis P, Schnall P, Baker D
Scand J Work Environ Health 2004 Apr;30(2):85-128

On-time mammography screening with a focus on Latinas with low income: a proposed cultural model.
Terán L, Baezconde-Garbanati L, Márquez M, Castellanos E, Belkić K
Anticancer Res. ;27(6C):4325-38

Radiology