Bertrand Joseph's Group

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Life and death decisions at the cellular level.

We are interested in the molecular signaling which regulates the decision between life and death at the cellular level and how its deregulation is implicated in human diseases. Our investigations are performed in various models of human diseases ranging from cancers to neurodegenerative disorders. Our group has a well established national and international network of colleagues and collaborators which give use access to additional technical know-how and scientific expertise.

Our activities can be divided into three main, overlapping branches:

  • Role for killer caspases in the control of microglia pro-inflammatory phenotype (see e.g., Nature, 2011, Cell Reports, 2015, Lancet Neuro, 2015).
  • Influence of histone posttranslational modifications on cell life and death decisions (see e.g., Nature, 2013, Nature Reviews Mol Cell Biol, 2014, Current Biol, 2015.
  • Transcriptional and epigenetic regulation of microglia tumor promoting phenotype, especially in glioma.

Knowledge of the molecular mechanisms underlying the integration of the signaling pathways controlling cell survival and death decision may provide new principles for drug development and/or gene therapy-based treatment of human diseases.

Group Members

Mathilde Cheray, Postdoc
Pinelopi Engskog Vlachos, Senior lab manager
Patricia González Rodriguez, PhD student
Bertrand Joseph, Professor, Group leader
Olle Lindberg, Affiliated Postdoc
Johanna Rodhe, PhD student
Dalel Saidi, PhD student
Xianli Shen, PhD student
Vassilis Stratoulias, Postdoc

Selected Publications

Glioma-induced inhibition of caspase-3 in microglia promotes a tumor-supportive phenotype.
Shen X, Burguillos M, Osman A, Frijhoff J, Carrillo-Jiménez A, Kanatani S, et al
Nat. Immunol. 2016 Nov;17(11):1282-1290

Neuroinflammation in Alzheimer's disease.
Heneka M, Carson M, El Khoury J, Landreth G, Brosseron F, Feinstein D, et al
Lancet Neurol 2015 Apr;14(4):388-405

Microglia-Secreted Galectin-3 Acts as a Toll-like Receptor 4 Ligand and Contributes to Microglial Activation.
Burguillos M, Svensson M, Schulte T, Boza-Serrano A, Garcia-Quintanilla A, Kavanagh E, et al
Cell Rep 2015 Mar;():

The return of the nucleus: transcriptional and epigenetic control of autophagy.
Füllgrabe J, Klionsky D, Joseph B
Nat. Rev. Mol. Cell Biol. 2014 Jan;15(1):65-74

The histone H4 lysine 16 acetyltransferase hMOF regulates the outcome of autophagy.
Füllgrabe J, Lynch-Day M, Heldring N, Li W, Struijk R, Ma Q, et al
Nature 2013 Aug;500(7463):468-71

Caspase signalling controls microglia activation and neurotoxicity.
Burguillos M, Deierborg T, Kavanagh E, Persson A, Hajji N, Garcia-Quintanilla A, et al
Nature 2011 Apr;472(7343):319-24