Structural and functional neuroimaging play an important role in understanding the underlying mechanisms of different dementia disorders, potentially contributing to their management and diagnosis. Our research at the division of Clinical Geriatrics is focused on the assessment of the most common forms of dementia including Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), vascular dementia (VaD), frontotemporal lobar degeneration (FTD) and dementia in Parkinson’s disease (PDD).
We have a strong interest in different magnetic resonance imaging (MRI) techniques, such as structural MRI, magnetic resonance spectroscopy (MRS), functional MRI (task and resting state), diffusion tensor imaging (DTI), arterial spin labeling (ASL) and susceptibility weighted imaging (SWI). In addition to MRI, we work with other imaging modalities, such as positron emission tomography (PET) (amyloid and glucose) and computed tomography (CT). Currently we perform image analyses using several automated softwares (Freesurfer, FSL, SPM etc.) as well as in-house developed algorithms. We also have a strong tradition and extensive experience in manual outlining and visual assessment. Multivariate and machine learning techniques (support vector machines (SVM) and orthogonal partial least squares (OPLS)) are also used for analyzing large amounts of data from multimodal/multicenter studies.
We believe it is important to work with the latest neuroimaging techniques to obtain a better understanding of the underlying mechanisms of the different diseases, to improve early diagnosis and differential diagnosis.
These methods need to be carefully validated in large research cohorts such as AddNeuroMed, ADNI and AIBL as well as in heterogeneous memory clinic cohorts and population based cohorts.
My research interest is developing and usage of brain MR image processing methods in order to facilitate detection and monitoring Alzheimer’s Disease (AD) progression.
At the moment I am a PhD student at the Division of Clinical Geriatrics under supervision of Prof. Lars-Olof Wahlund and Dr. Gabriela Spulber. In addition to my PhD where I am studying the combined effects of White matter and Gray matter changes in progression of AD, I am involved in a European grid based image analysis platform (neugrid4you.eu).
During my works at KI, I've developed the CASCADE (github.com/Damangir/Cascade), for segmentation of the so-called white matter lesions. The software is now being used by several groups in Sweden, Norway, Finland, Spain and the Netherlands.
- Brain landmark localization
- Active shape model (ASM) and Active appearance model (AAM) of human brain in different MR image modalities
Please contact me if you are a master student interested in Computer Vision or Machine Learning, and looking for your master project (Exjobb) in Medical Image analysis.
Farshad Asramai Falahati
My main research interests are in the application of machine leaning techniques in neuroimaging data processing. I am particularly interested in utilizing advanced multivariate data analysis methods (kernel-based methods) and neuroimaging biomarkers (MRI and PET) for early detection of Alzheimer disease (AD). I am also doing some research on the Swedish Dementia Registry (SveDem), which is a national quality registry on dementia disorders. My education is in the field of electrical engineering (BSc) and biomedical engineering (MSc). I am currently a PhD student in the Neuroscience field at the division of clinical geriatrics.
- Develop and investigate multivariate classifiers to create an AD diagnostic index using multiple biomarkers (MRI, PET, CSF etc.)
- Baseline and longitudinal evaluation of the multivariate-based diagnostic index for early detection of AD
Neuropsychologist and Clinical Psychologist
PhD in Biomedical and Clinical Research (University of La Laguna, Spain)
My main research encompasses the study of Normal Aging and neurodegenerative disorders as Mild Cognitive Impairment and Alzheimer’s disease. I am also involved in a line of research on Multiple Sclerosis. The main focus is put in cognitive functioning and MRI measures, but genetic factors, CSF biomarkers, and clinical and socio-demographic variables are part of my research as well. I am currently a Postdoc Researcher at the Division of Clinical Geriatrics, working with Dr. Eric Westman and Dr. Lars-Olof Wahlund.
Projects available for Master and Degree students:
- “Subjective Cognitive Decline”
You will investigate the clinical value of subjective cognitive complaints and associations with neuroimaging, cognition, and emotion.
- “Visual rating scales of brain atrophy and subtypes of Alzheimer’s disease”
You will study brain atrophy by means of visual rating scales. You will also study different subtypes of Alzheimer’s disease, looking at prevalence, clinical characterization, and progression over time.
- “Effect of ApoE e2 genotype in brain and cognition”
You will study individuals with e2/e2 ApoE genotype with a special focus on cognition and brain structure.
- “Multiple Sclerosis”
You will study differences in brain integrity in MS patients in relation with cerebrospinal fluid biomarkers (OCB: oligoclonal bands), genetic variants, and clinical aspects.
Neurodegenerative disease, which is a varied assortment of central nervous system disorders, includes diseases such as Alzheimer’s disease (AD), Parkinson’s disease, multiple sclerosis (MS) and others. These diseases are relative common, especially for AD and MS. However, the mechanisms responsible for their pathologies are poorly understood, and there are currently no effective preventive therapies. In the past two decades, neuroimaging is increasingly playing a more important role in the study and clinical diagnosis of neurodegenerative disease. Novel MRI techniques from structure to function are widely used to investigate the brain abnormalities associating with vulnerability to develop neurodegenerative disease and its progression. The general aim of my project is to assess brain structural and functional changes in AD and MS at the early stage of neurodegenerative pathological procession with novel MRI techniques.
My previous research has mainly been focused on structural magnetic resonance imaging (MRI) on healthy aging and dementia, involving patients with Alzheimer´s disease or frontotemporal lobar degeneration and healthy elderly subjects.
- Structural MRI on patients with amyotrophic lateral sclerosis (ALS)
- The neuroanatomical correlates of empathy and social cognition in neurodegenerative diseases. A functional MRI study on patients with the behavioral variant of frontotemporal lobar degeneration
Neuropsychologist and Clinical Psychologist.
PhD in Biomedical and Clinical Research (University of La Laguna, Spain)
My research is focused on Normal Aging and Neurodegenerative disease, such as Alzheimer's Disease (AD). I'm especially interested in the multidimensional and integrated study of cognitive, emotional, functional and structural neuroimaging outcome. The aim of this approach is to investigate if different patterns of behavioural, cogntive or neurological changes during normal aging could precede a different pathway towards dementia. I am currently a Postdoc Researcher at the Division of Clinical Geriatrics, working with Dr. Eric Westman and Dr. Lars-Olof Wahlund.
Brain changes in AD patients with implantet Encapsulated Cells Releasing Nerve Growth Factor
White matter lesion segmentation on a population based cohort from Sweden
Using Multivariate analysis to investigate patterns of cognitive decline and brain atrophy in a Normal and Healthy Aging cohort.
My research is focused on studying structural and functional neurological alterations, particularly in preclinical stages of Alzheimer's Disease (AD). I am combining multivariate methods and graph analysis to study MRI and resting state fMRI data in large cohorts. The aim of my research is to advance the knowledge of neurological changes that precedes dementia and use this to develop prediction models of how the disease will progress in individuals to be used in a clinical setting.
I have a degree in Engineering Physics at Chalmers University of Technology and is currently a PhD student in neuroimaging at the Division of Clinical Geriatrics.
Joana Braga Pereira
I am interested in assessing cortical thickness, resting-state and diffusion tensor imaging measures in patients at early stages of Alzheimer’s disease using univariate and multivariate methods. I am currently working as a post-doctoral fellow at the Division of Clinical Geriatrics with Prof. Eric Westman and Prof. Lars-Olof Wahlund.
My current projects involve assessing the relationship between neuropsychological performance, CSF protein levels and structural and diffusion MRI in order to understand the relationship between different disease biomarkers.
My main research interest is the usage of structural MRI derived parameters in order to detect AD-related specific brain changes. Currently I am doing my Post Doc at the Division of Clinical Geriatrics and I am working with a web based project for MRI image analysis called N4U (www.neugrid4you.eu).
- White matter lesion segmentation using the CASCADE software on different datasets
- The relationship between AD-related brain atrophy (volume loss and cortical thinning) and white matter lesions
My overall interest is research into dementia, especially Alzheimer's disease. The focus is on imaging based research and mainly diagnostic but also studies to increase understanding of how dementia occurs and develops. I also have projects that test new treatments for Alzheimer's disease. Right now a large study in which polyunsaturated fatty acids supplements are tested for early Alzheimer's, another study seeks to examine the antiviral therapy against Alzheimer's disease. Several studies aimed at studying how different imagingmodalitet can be used for early diagnosis of Alzheimer's disease. The grant is broad in order to try to implement the methods in clinical practice and as automated as possible. Also combinations of various diagnostic tools are studied, such as MRI with volumetry and CSF diagnostics.
I work with many other research centers in Sweden and around the world and participates in several EU-funded projects . Several employees, both graduate students and postdocs are funded by the NIH and EU Marie Curie .
Currently ongoing projects :
• The relationship between MRI -based parameters , such as spectroscopic data , diffusion parameters and volumetry related to the CSF- based neurochemistry and psychometric parameters.
• Antiviral treatment for Alzheimer's disease. Supplements of multivitamin and nutrition topics for early Alzheimer's disease
I have an engineering background from the Royal Institute of Technology (KTH) in Stockholm and I obtained my PhD in 2009 at Karolinska Institutet. I did my postdoc at the Institute of Psychiatry, King’s College London. I am head of the Division for Clinical Geriatrics and I have my own research group within the section. I am main supervisor of three PhD student and three postdocs as well as co-supervisor for five PhD students.
The aim of my research is to combine different biomarkers looking at patterns of disease. Due to the complexity and heterogeneity of Alzheimer’s disease (AD) and other neurodegenerative disorder, using one biomarker is probably not enough. The focus of my research has long been on structural magnetic resonance imaging investigating patterns of atrophy, but my research extends to other imaging modalities such as MR-spectroscopy, resting state fMRI, MR-diffusion, positron emission tomography (PET) and computer tomography (CT) etc. Further, the combination of neuroimaging biomarkers with CSF and blood markers is of great interest. The need for advanced statistical tools is important when combing large amounts of data from multiple neuroimaging modalities. Combining multiple biomarkers with multivariate tools will hopefully aid in diagnosing the disease in an early stage which is important when effective treatments for AD can be administered, monitor disease progression, target the right population for clinical trial and understand the underlying mechanisms of different diseases.
My research interests lie in the applications of neuroimaging techniques and multivariate data analysis in patient groups and normal controls in order to establish biomarkers for early diagnosis, prognosis and progression of Alzheimer’s disease (AD). Currently I am enrolled as a PhD student at the Division of Clinical Geriatrics under the supervision of Dr. Eric Westman, Prof. Lars-Olof Wahlund and Dr. Andrew Simmons (King’s College, London).
- Investigation of in-vivo brain lactate concentrations in patients with suspected AD using MR-spectroscopy
- Using multivariate data analysis applied to structural MR data to investigate patterns of brain atrophy inherent to AD