Oral contraceptives linked to reduced risk of rheumatoid arthritis
Publication. Taking oral contraceptives is associated with a lowered risk of developing rheumatoid arthritis, finds a new observational study by researchers at Karolinska Institutet published in Annals of the Rheumatic Diseases. But no significant link was found for breastfeeding after accounting for various potentially influential factors.
Killing bacteria by hacking plastics with silver and electricity
Publication. Researchers at the Swedish Medical Nanoscience Center at Karolinska Institutet have developed an innovative way of hacking conducting plastics so as to prevent bacterial growth using silver nanoparticles and a small electrical current. The method, which could prove to be useful in preventing bacterial infections in hospitals, is presented in the scientific journal Advanced Healthcare Materials.
New insight into how immune cells are formed
Publication. In contrast to what has been previously believed, development of blood stem cells to mast cells, a type of specialised immune cell, does not depend on a growth factor called stem cell factor. This has been demonstrated in a new collaborative study by researchers at Karolinska Institutet and Uppsala University, and published in the scientific journal Blood. The results could pave the way for new treatments for certain types of blood diseases.
Receptor dynamics provide new potential for pharmaceutical developments
Publication. The dynamics among certain so-called G protein-coupled receptors, of vital importance for the function of cells in the body, are different than previously believed. This has been reported by researchers from Karolinska Institutet in the journal Nature Communications.
New potential treatment for aggressive types of childhood cancer
Study. A combination of substances that impacts chemical modifications in the DNA of tumours and triggers the tumours to differentiate into harmless nerve cells could represent a new method of treating aggressive forms of neuroblastoma. The new method has been proposed by researchers at KI, after studies using mice showed that the combination treatment resulted in a significant suppression in tumour growth.
High impact publications
Recent publications in high impact journals where researchers from Karolinska Institutet are main authors.
Distrust in the End-Of-Life Care Provided to a Parent and Long-Term Negative Outcomes Among Bereaved Adolescents: A Population-Based Survey Study
Beernaert K, Kreicbergs U, Furst CJ, Nyberg T, Steineck G, Bylund-Grenklo T, Journal of Clinical Oncology (2017) 8 August, Original report
Association of genetic variants related to serum calcium levels with coronary artery disease and myocardial infarction
Larsson SC, Burgess S, Michaëlsson K, JAMA (2017) 25 July. Original investigation.
KI News: Higher calcium levels and risk of coronary artery disease
Antidepressants during pregnancy and autism in offspring: population based cohort study
Rai D, K Lee B, Dalman C, Newschaffer C, Lewis G, Magnusson C, BMJ, 2017, online 19 July. Article.
KI in the media
Improving anaesthesia care for children
Per-Arne Lönnqvist’s research aims to improve anaesthesia care for children. He has helped to develop the use of ultrasound for improving the precision of local anaesthetic administration and has been a pioneer in the use of alpha-2 agonists in paediatric anaesthesia and intensive care.
Reducing risk during pregnancy and childbirth
Anna-Karin Wikström researches pregnancy-related complications, especially preeclampsia. Two important lines of her research involve registry studies of risk factors during pregnancy and childbirth, and MRI studies of the placenta and the maternal brain during preeclampsia.