Breakthrough in genetics of fibroids

Published 2011-08-29 00:00. Updated 2013-11-26 10:29

[NEWS 26 August 2011] Uterine leiomyomas, also called fibroids, cause a very significant burden to women's health but relatively little has been known about the mechanisms of tumorigenesis involved. Researchers at the University of Helsinki and Karolinska Institutet have found specific mutations in a gene called MED12, which is an important step towards understanding why fibroids arise and how they can be treated.


Netta Mäkinen, Miika Mehine, Jaana Tolvanen, Eevi Kaasinen, Yilong Li, Heli J. Lehtonen, Massimiliano Gentile, Jian Yan, Martin Enge, Minna Taipale, Mervi Aavikko, Riku Katainen, Elina Virolainen, Tom Böhling, Taru A. Koski, Virpi Launonen, Jari Sjöberg, Jussi Taipale, Pia Vahteristo, and Lauri A. Aaltonen

MED12, the Mediator Complex Subunit 12 Gene, Is Mutated at High Frequency in Uterine Leiomyomas

Science Published online 25 August 2011[DOI:10.1126/science.1208930]