The focus of the research activities is to study effects of different types of Traumatic Brain Injury (TBI), which is the leading cause of death and disability for people up to about 40 years of age. Damages may have been caused in traffic accidents, difficult childbirth or weapons – including shock waves after a bomb explosion.
One of the aims of the research is to be able to prevent and treat serious brain damage and map the mechanisms and processes on a molecular and cellular level upon damage to the nervous system. In close collaboration with Dr. Johan Davidsson at Chalmers in Gothenburg, the group has developed unique models for penetrating TBI and rotational acceleration injury. These models can be used to define thresholds for lesions such as diffuse axonal injury (DAI), which is an important component in TBI occurring after car collisions or detonation of roadside bombs. Important aspects include vascular function, edema and inflammation. Biomarkers for different injuries are searched for in the animal models as well as clinical material in collaboration with Dr. B-M Bellander at Neurosurgery at Karolinska University Hospital.
Also imaging techniques such as MRI (collaboration with KERIC) are used for translational studies. International collaborators include groups at USU and NIH in Bethesda and DSO in Singapore. Other projects incorporate studies on lesions on spinal nerve roots and effects of high-power microwaves on nerve cells.
This figure shows 6 images from a rat subjected to a TBI.
Fig A-D show ex-vivo DTI-MRI images. A&B show the edema (white).
C&D show the effects on fiber tracts.
The images E&F are from confocal microscopy (after the MRI scan)
in the border zone of the injury (blood vessels in red and glial cells in green).
Characterization of pressure distribution in penetrating traumatic brain injuries.
Front Neurol 2015 ;6():51
COX-2 regulation and TUNEL-positive cell death differ between genders in the secondary inflammatory response following experimental penetrating focal brain injury in rats.
Acta Neurochir (Wien) 2015 Apr;157(4):649-59
Neurotransmitter Systems in a Mild Blast Traumatic Brain Injury Model: Catecholamines and Serotonin.
J. Neurotrauma 2015 Aug;32(16):1190-9
The role of biomarkers and MEG-based imaging markers in the diagnosis of post-traumatic stress disorder and blast-induced mild traumatic brain injury.
Psychoneuroendocrinology 2016 Jan;63():398-409
Denes Agoston - Associated
Maria Angéria - Biomedical scientist
Ulf Arborelius - Senior researcher
Andreas Brännström - Research assistant
Jenny Gustavsson - Biomedical scientist
Mattias Günther - Associated
Anders Hånell - Postdoc
Lizan Kawa - PhD student
Stefan Plantman - Postdoc
Mårten Risling - Professor
David Rocksén - Senior researcher
Elham Rostami - Associated
Mattias Sköld - Associated
Niclas Wisén - PhD student